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Ditemukan 40159 dokumen yang sesuai dengan query

Irwan Widjaja

Efek ekstrak phaseolus vulgaris dalam menurunkan absorpsi karbohidrat setelah makan nasi = The effect of phaseolus vulgaris extract on reducing carbohydrate absorption after eat the rice

"Ekstrak Phaseolus vulgaris merupakan ekstrak dan kacang jenis White kidney bean. Ekstrak ini digunakan sebagai suplemen untuk menurunkan berat badan, dengan cara menghambat penyerapan karbohidrat melalui hambatan enzim aamilase. Sudah pemah dilakukan penelitian menggunakan ekstrak Phaseolus vulgaris terhadap penghambatan absorpsi karbohidrat dengan menggunakan roti putih, namun belum ada penelitian pada manusia yang menilai efek ekstrak Phaseolus vulgaris terhadap penyerapan karbohidrat setelah makan nasi.

Tujuan penelitian: Mengetahui berapa besar ekstrak Phaseolus vulgaris menurunkan absorpsi karbohidrat pada sukarelawan Indonesia yang makan nasi.

PeneIitian ini menggunakan desain menyilang, acak, tersamar ganda, berpembanding plasebo dengan washout 1 minggu. Dilakukan pada 18 orang sukarelawan sehat. Ekstrak Phaseolus vulgaris 1,5 gram atau plasebo diberikan tepat sebelum makan nasi. Sampel darah diambil pada waktu-waktu tertentu sampai 4 jam setelah makan nasi. Sebagai parameter absorpsi karbohidrat adalah luas area di bawah kurva kadar gula darah terhadap waktu (AUC 0-4 jam) yang dihitung secara trapezoidal. Absorpsi karbohidrat yang dimakan bersama ekstrak Phaseolus vulgaris dan absorpsi karbohidrat yang dimakan bersama plasebo, dibandingkan dengan menggunakan uji t berpasangan.

Hasil penelitian menunjukkan setelah pemberian ekstrak Phaseolus vulgaris, terjadi penurunan absorpsi karbohidrat yang ditunjukkan dengan penurunan AUC04 jam rerata 9,50 % dengan kisaran 1,05 % dan 19,37 % ,dibandingkan sewaktu mendapat plasebo. Penurunan ini bermakna secara statistik (p<0,001). Puncak kadar gula darah tercapai pada menit ke-60 setelah makan nasi, sedangkan hambatan absorpsi karbohidrat yang ditunjukkan dengan kadar gula darah sudah mulai terlihat pada menit ke-30, dengan penurunan kadar gula darah yang terlihat cukup besar pada menit ke-45 sampai menit ke-60 setelah makan nasi.

Kesimpulan : Penggunaan ekstrak Phaseolus vulgaris dengan dosis 1,5 gram pada sukarelawan sehat Indonesia yang makan nasi, dapat menurunkan absorpsi karbohidrat dengan kisaran 1,05 % dan 19,37%, rerata 9,50 %.

Background : Phaseolus vulgaris extract is a water-extract of a common white kidney bean. As supplement, this extract potentially promote weight loss. Its use is based on it inhibitors of amylase activity content that cause reduction of starch digestion and reduce carbohydrate uptake. Clinical studies have used Phaseolus vulgaris extract inhibit carbohydrate absorption of white bread, but .no clinical studies have been done after rice intake:

Purpose : To study how much Phaseolus vulgaris extract can reduce for carbohydrate absorption in healthy Indonesian volunteer rice intake.

Methods : Thirteen males and five males (ages 18 to 56) were screened to participate in a randomized, double-blind, placebo-controlled, crossover study after the informed consent. One and half gram Phaseolus vulgaris extract or placebo given concurrently by rice meal. Plasma glucose in IV blood were measured every 15 minutes on first hour, 20 minutes on second, and 30 minutes on third and fourth for 4 hours by a colorimetric enzyme kit (GOD FS Diasys®) after meal. The parameter for carbohydrate absorption is the Area Under Curve for 4 hours (AUC 0-4 hours). Carbohydrate absorption after Phaseolus vulgaris extract and after placebo were compared by paired-t test.

Result : After taking Phaseolus vulgaris extract, carbohydrate absorption was reduce, the Area Under Curve for 4 hours range (AUC0-4 hours) average 9.50 % ( 1.05 % and 19.37 %), compared with placebo. The reduction is statistically significant (p

Conclusion : One and half gram Phaseolus vulgaris extract can reduce the carbohydrate absorption with range 1.05 % and 19.37%, average 9.50 %, after rice meal in healthy Indonesian volunteer."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2006

T 17672

UI - Tesis Membership Universitas Indonesia Library

Carbohydrate chemistry / editor, J. Thiem

Berlin: Springer-Verlag, 1990

547.78 CAR

Buku Teks Universitas Indonesia Library

Widardo

Effect of selenium in addition to vitamin A and Iodine supplementation on the goiter size in school children in Central Java

"ABSTRACT
Goiter in school children is one of the symptoms of iodine deficiency for a long period. This condition will have a wide spectrum of mental, psychomotor and growth abnormalities if there is no correction immediately. According to many studies, there is an interaction between selenium, vitamin A and iodine. Indonesia has a program of iodine supplementation to eradicate IDD; however, there is still prevalence of IDD in endemic areas. It can be suspected that goiter is not only caused by low intake of iodine but also by other cause, trace elements such as selenium, calcium and other heavy metals. In Indonesia, the study of trace elements is still needed. Therefore, this study has the main objective to assess the effect of selenium and vitamin A supplementation on the goiter size among school children in Central Java.
The study was conducted in Cimanggu sub-district, Cilacap district, Central Java Province, Indonesia from November 1997 till January 1998. School children age 8 - 12 years with palpable goiter was allocated randomly into 2 groups? treatment and control. First group receive once 400 mg iodine capsule and vitamin A (200,000 [ti); Selenium (200p.gram) twice/week for 8 weeks. Second group receive once 400 mg iodine capsule and vitamin A (200,000 IU); placebo. At the beginning and the end of the study, serum selenium, goiter size, UIE, weight and height were measured.
The prevalence of goiter based on palpation was 40.5%. By using ultrasound, the subjects with palpable goiter were 57.3% in treatment and 46.7% in control who positively suffering from goiter. Mean of selenium status of both groups was low (29.lpgll in treatment and 30.1 pgll in control) compared with normal value (86-99 µgI1). After two-month supplementation, serum selenium was increased in treatment group (29.1 to 44.1µg11), but decreased in control group (30.1 to 23.2 p,gll). Median of Urinary Iodine Excretion before supplementation was already high, the prevalence of U1 E < 100 ggll was 5.3% in treatment and 6.7% in control. After supplementation the mean of UIE was increased significantly. The change of UlE was not different between treatment and control. Thyroid volume of both groups was decreased significantly (p

In conclusion, selenium supplementation had significant effect on the reduction of thyroid volume and the goiter prevalence determined by ultrasound. Further research is required to know the effect of selenium status on thyroid hormone metabolism in groups of iodine deficient and Vitamin A deficient human subjects."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 1998

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Mizoguchi, Toru

Mitos jahat karbohidrat: kepo untuk keto = Mazu "hakumai" wo yamenasai!

Bandung: Qanita, 2018

613.283 MIZ m

Buku Teks SO Universitas Indonesia Library

Effect of a combination of Phaseolus vulgaris L. extract and acarbose on postprandial glucose level after cooked rice intake in healthy volunteers

"Tujuan Penelitian ini bertujuan untuk mengukur besarnya efek kombinasi ekstrak Phaseolus vulgaris dan akarbose dibandingkan dengan akarbose saja dalam menurunkan kadar glukosa posprandial pada sukarelawan sehat setelah makan nasi. Metode Sampel darah diambil pada waktuwaktu tertentu sampai tiga jam setelah makan nasi. Parameter kadar glukosa posprandial adalah luas area di bawah kurva kadar glukosa terhadap waktu selama tiga jam setelah makan nasi. Hasil Setelah pemberian kombinasi ini terjadi penurunan luas area di bawah kurva sebesar 21.6%, sedangkan pada pemberian akarbose terjadi penurunan sebesar 22.9%. Simpulan Pemberian kom binasi ekstrak Phaseolus vulgaris dosis 1500 mg dan akarbose dosis 50 mg menghasilkan penurunan kadar glukosa posprandial yang tidak bermakna jika dibandingkan pemberian 50 mg akarbose saja.

Abstract

Aim: This study was aimed to measure the effects of combination Phaseolus vulgaris extract and acarbose compared to acarbose alone on postprandial glucose concentration in healthy volunteers after cooked rice intake. Methods: Blood sample were obtained at several time points up to three hours after cooked rice intake. The parameter for postprandial glucose concentration is the area under the curve (AUC) of glucose concentration vs.time for three hours after cooked rice intake. Results: After taking this combination, postprandial glucose concentration was reduced by 21.6%, while the reduction by acarbose alone was 22.9%. Conclusions: The reduction of postprandial glucose concentration after administration of this combination was not significantly different compared to that after administration of acarbose alone. Keywords: Phaseolus vulgaris extract, acarbose, postprandial glucose concentration."

[Fakultas Kedokteran Universitas Indonesia, Fakultas Kedokteran Universitas Indonesia], 2009

pdf

Artikel Jurnal Universitas Indonesia Library

Effect of a combination of phaseolus vulgaris L. extract and acarbose on postprandial glucose level after cooked rice intake in healthy volunteers

"Pemberian kombinasi ekstrak phaseolus vulgaris dosis 1500 mg dan akar bose dosis 50 mg menghasilkan penurunan kadar glukosa posprandial yang tidak bermakna jika dibandingkan pemberian 50 mg akarbose saja."

Artikel Jurnal Universitas Indonesia Library

Studi tanaman ganyong (Canna edulis) sebagai alternatif sumber karbohidrat dalam rangka meningkatkan ketahanan pangan (studi kasus di Desa Jlegiwinangun, Kecamatan Kutowinangun, Kabupaten Kebumen, Jawa Tengah)

"Ganyong (Canna edulis) is common alternative snack among villagers in southern part of central Java. Its starch content can be used for making "soon" (white noodle). In the future ganyong is potential for staple food and other usage due to its nutrition content. At the village of Jlegiwinangun, ganyong was planted as inter cropping plant in the field and in the home garden."

630 JMSTUT 5:1 (2004)

Artikel Jurnal Universitas Indonesia Library

Rikawati

Pengaruh kombinasi suplementasi vitamin E dan Vitamin C terhadap kadar malondialdehida plasma pada usia lanjut dengan hiperkolesterolemia = The effect of combined supplementation of vitamin E and C on plasma malondyaldehyde level elderly

"Mengetahui pcngaruh pemberian kombinasi suplementasi vitamin E dan C terhadap peroksidasi lipid pada usila dengan hiperkolesterolemia. Penelitian uji klinis paralel, tertutup timggai, alokasi acak, untuk membandingkan kadar malondialdehida usila 2,60 tahun dengan hiperkolesterolemia yang mendapatkan kombinasi supiementasi vitamin E 400 IU dan vitamin C 500 mg, masing~masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plascbo.Terdapat 42 subyek penelitian yang berasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing berjumlah 21 orang. Data yang diambil adalah : data dcmograti, antropometzi, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebelum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak bezpasangan bila distribusi nonnal dan uji Manmwhimey bila distribusi tidak normal dengan tingkat kemaknaan p<0.05.

Sebanyak 20 subyek penelitian dad masing-masing kelompok yang dapat mengikuti penelitian sampai sclesai. Sebelum perlakuan, nilai median kadar kolesterol LDL kelompolc vitamin E+plasebo dan vitamin E+C masing- masing adalah I46.50(l30-190) mg/dL dan 146.50(l3I-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E4-plasebo (151.9.+:2.2.l mg/dl.) meningkat sedangkan kelompok vitamin B+-C (l46.8i28.21 mg/dL) menurun. Sebelum p¢rIakuan, nilai median kadar MDA plasma kelornpok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E4-C masing-masing adalah 2.63(l.92-4.42) nmol/ml., dan 3.03:l:0.62 nmol/mL. Setelah 45 haii pcrlakuan rerata kadar MDA plasma kedua keiompok menunm menjadi 2.30i0.67 nmol/mL (p<0.01) pada kelompok vitamin E+plasebo dan 28810.88 nmol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plasebo lcbih besar (-0.5:!:0.55 nmol/mL) daripada kelompok vitamin E+C (-0.28(l.31-1.63) nmol/mL), tetapi dcngan uji statislik terhadap kedua nilai tersebut, tidalc berbeda bcrma!ma(p=0.09). Pembenan kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesternlemia tidak dapat rnenurunkan kadar MDA plasma lcbih besar dibandingl-can dengan hanya pemberian vitamin E.

This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehydc level in hypercholesterolemic elderly aged more than 60 years old. Forty two people from Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometric, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and alter period were taken. Statistical analyzes was performed by SPSS 11.5.
Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were 146.50(l30-190) mg/dL and l46.50( 130-190) mg/dL respectively. Alter 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group 15l.9i22.1 mg/dL while in vitamin E+C group was decreased to l46.8:l:28.2l mg/dl Before study, plasma MDA level in vitamin E + placebo group and vitamin E+C group were 2.63(l.92-4.42) and 3.031052 nmol/mL, respectively. After 45 days, mean MDA plasma in vitamin E + placebo group was 2.30i0.67 nmol/mL (p<0.01) and was 2.881088 nmol/ml.. (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin E+placebo group was higher (-0,510.55 nmol/mL) than vitamin E+C (-0.28(1.3l-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly couldnot decrease plasma MDA higher than supplementation of vitamin E alone."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2010

T32064

UI - Tesis Open Universitas Indonesia Library

Nina Rustiana

Preparasi dan karakterisasi eksipien maltodekstrin suksinat yang digunakan dalam film cepat hancur salbutamol sulfat = Preparation and characterization of maltodextrine succinate as excipient used in salbutamol sulfat fast disintegration film

"ABSTRAK

Film cepat hancur merupakan suatu bentuk sediaan padat yang larut atau

hancur dalam 1 menit dalam rongga mulut dengan adanya air liur tanpa minum

atau dikunyah. Penelitian ini bertujuan untuk membuat dan mengkarakterisasi

sediaan film cepat hancur salbutamol menggunakan maltodekstrin suksinat

sebagai eksipien. Maltodekstrin suksinat yang diperoleh dari suksinilasi

maltodekstrin menggunakan anhidrida suksinat memiliki derajat substitusi 0,18

± 0,01; pH (5% larutan dalam akuades) 6,76 ± 0,03; kadar air 7,33 ± 0,21 %;

ukuran partikel 355 – 710 µm; laju alir 4,51 ± 0,301 g/detik; indeks

mengembang selama 4 menit 17,99%; viskositas (25%) 29,14 cps. Film cepat

hancur yang menggunakan maltodekstrin suksinat 5% memberikan bobot 24,16 ±

2,1 mg; ketebalan 101,5 ± 5,025 µm; waktu hancur 41,5 ± 5,5 detik; kadar air

50,66 ± 0,09 %; kadar salbutamol sulfat 2,10 ± 0,03 mg/film; pH 5,87 ± 0,03;

pelepasan obat selama 1 menit 105,43 ± 0,68%; tensile strength 7,097 ± 0,582

kg/cm2; elongasi 1,5 ± 0,1 %; fluks penetrasi rata-rata 1,314 µg/cm2.menit;

sesuai uji kesukaan 66,67% responden menyukai penampilan film; 13,33%

responden menyukai rasa film serta waktu hancur rata-rata sebesar 13,47 ± 3,23

detik. Dapat disimpulkan bahwa eksipien maltodekstrin suksinat dapat digunakan

sebagai eksipien pembentuk film cepat hancur.

ABSTRACT

Fast disintegration film was the solid dosage form which dissolve or

disintegrate in 1 minute with saliva without water or chewing. The purposes of

this research were to prepare and characterize of salbutamol fast disintegration

film containing maltodextrin succinate as an excipient. Maltodextrine succinate

was obtained from succinilation of maltodextrine using succinat anhidride. The

maltodextrine succinate had the characterized as follows : degree of substitution

(DS), 0.18 ± 0.01; pH (5% in aquadest), 6.76 ± 0.03; moisture content, 7.33 ±

0.21%; particle size, 355-710 µm; flow rate, 4.51 ± 0.31 g/secon; swelling index

17.99% and viscosity (25%) 29.14 cps. The fast disintegration film that

containing maltodextrine succinate 5% had weight 24.16 ± 2.1 mg; thickness,

101.5 ± 5.025 µm; disintegration time, 41.5 ± 5.5 secon; moisture content, 50.66 ±

0.09%; assay, 2.10 ± 0,03 mg/film; pH, 5.87 ± 0.03; in vitro drug release, 1

minute, 105.43 ± 0.68 %; tensile strength, 7.007 ± 0.582 kg/cm²; elongation, 1.5

± 0.1%; penetration flux 1.314 µg/cm2.minute. According to hedonic test,

66.67% like the film appearence , 13.33% like the flavour, and disintegration time

were 13.47 ± 3.23%. The result of this study showed that maltodextrine succinate

can be used as excipient for fast disintegration film ."

2013

T35158

UI - Tesis Membership Universitas Indonesia Library

Dian Putri Anggraweni

Preparasi dan karakterisasi eksipien maltodekstrin suksinat yang digunakan dalam tablet cepat hancur ketoprofen = Preparation and characterization of maltodextrine succinate as exicipient used in ketoprofen fast disintegration tablet / Dian Putri Anggraweni

"Tablet cepat hancur merupakan suatu bentuk sediaan padat yang larut atau hancur dalam 1 menit dalam rongga mulut dengan adanya air liur tanpa minum atau dikunyah. Penelitian ini bertujuan untuk membuat dan mengkarakterisasi sediaan tablet cepat hancur ketoprofen menggunakan maltodekstrin suksinat sebagai eksipien. Maltodekstrin suksinat yang diperoleh dari suksinilasi maltodekstrin menggunakan anhidrida suksinat memiliki derajat substitusi 0,18 ± 0,01; pH (5% larutan dalam akuadest) 6,76 ± 0,03; kadar air 7,2275 ± 0,21%; ukuran partikel 355 – 710 μm; laju alir 4,51 ± 0,301 g/detik; indeks mengembang selama 4 menit 17,99%; viskositas (25%) 29,14 cps. Tablet cepat hancur yang menggunakan maltodekstrin suksinat 25% memberikan bobot 98,70 ± 3,91 mg; ketebalan 2,99 ± 0,04 mm; diameter 6,08 ± 0,02 mm; kekerasan 2,75 ± 0,54 Kp; keregasan 0,60 ± 0,12%; waktu hancur 15,67 ± 1,37 detik; kadar 104,53 ± 0,002%; pelepasan obat 83,57 ± 8,20% dalam 20 menit; fluks penetrasi rata-rata 0,5473 μg/cm2.menit, sesuai uji kesukaan 70% responden menyukai penampilan tablet; 6,67% responden menyukai rasa tablet serta waktu hancur rata-rata sebesar 225,47 ± 16,16 detik. Dapat disimpulkan bahwa eksipien maltodekstrin suksinat dapat digunakan sebagai eksipien utama tablet cepat hancur.

Fast disintegration tablet was the solid dosage form which dissolve or disintegrate in 1 minute with saliva without adding water or chewing. The purposes of this research were to prepare and characterize of ketoprofen fast disintegration tablet containing maltodextrin succinate as excipient. Maltodextrine succinate was obtained from succinylation of maltodextrine using succinate anhidride. The maltodextrine succinate had the parameters as follows: degree of substitution, 0.18 ± 0.01; pH (5% in aquadest), 6.76 ± 0.03; moisture content, 7.2275 ± 0.21%; particle size, 355-710 μm; flow rate, 4.51 ± 0.31 g/second; swelling index 17.99% and viscosity (25%) 29.14 cps. The fast disintegration tablet that contain maltodextrine succinate 25% had weight 98.70 ± 3.91 mg; thickness 2.99 ± 0.04 mm; diameter 6.08 ± 0.02 mm; hardness 2.75 ± 0.54 Kp; friability 0.60 ± 0.12%; disintegration time 15.67 ± 1.37 second; assay 104.53 ± 0.002%; in vitro drug release, 20 minutes, 83.57 ± 8.20%; penetration flux 0.5473 μg/cm2.minute. According to hedonic test, 70% like the tablet appearence, 6.67% like the flavour, and disintegration time were 225.47 ± 16.16%. The result of this study showed that maltodextrine succinate can be used as excipient for fast disintegration tablet."

Depok: Fakultas Farmasi Universitas Indonesia, 2014

T38953

UI - Tesis Membership Universitas Indonesia Library

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