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"Pendahuluan: Lem fibrin telah secara rutin digunakan dalam prosedur bedah saraf. Substansi ini dapat diperoleh dengan beberapa metode, dua yang paling populer adalah lem fibrin komersial (LK) yang siap pakai dan lem fibrin sintesis mandiri (SM). Studi ini membantu dokter bedah memilih lem yang sesuai dengan kebutuhan mereka, berdasarkan perbandingan sifat lekat mereka dalam pengukuran yang terstandar. Metode: lem fibrin komersial yang siap pakai dan lem fibrin sintesis mandiri diuji dengan uji tromboelastograf. Kenormalan distribusi data diuji dengan Shapiro-Wilk. Uji perbandingan dilakukan menggunakan uji Mann Whitney. Hasil: SM memiliki waktu reaksi (R) yang lebih lama daripada LK, dengan median 17,4 (12,3-20,1) menit dibandingkan dengan 0,2 menit, nilai p <0,001. SM memiliki nilai K (K) yang lebih lama daripada LK, dengan median 2,2 (2,0-2,8) menit dibandingkan dengan 0,8 menit, nilai p <0,001. SM memiliki amplitudo maksimum kekuatan (MA) yang lebih rendah daripada LK, dengan median 67,4 (63,9-69,4)% dibandingkan dengan 87,4 (80,9-92,5)%, nilai p <0,001. Secara kualitatif, LK memiliki trombus yang lebih pejal sedangkan trombus SM terikat pada cangkir TEG sampai akhir uji. Kesimpulan: Penulis menyarankan menggunakan SM untuk menutup perdarahan atau kebocoran yang tidak memiliki tekanan tinggi karena memiliki MA yang lebih rendah. Teknik premixed dapat digunakan untuk mengatasi R dan K yang lebih lama.

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Introduction: Fibrin glues have been used routinely in Neurosurgery procedures. This substance can be obtainad by several method, two most popular are ready-to–use two-component fibrin glue and cryoprecipitate glue. However, the popularity between two products are not equal. This study help surgeon choose better glue suitable to their need, based on comparison of their adhesive properties in standarized measurement. Methods: cryoprecipitate glue (CG) and two-component fibrin glue (TG) was tested by thromboelastograph assay analyzer. The data’s normality of distribution was tested by Shapiro-Wilk. The comparison test was done using Mann Whitney test.

Results: CG has longer reaction time (R) than TG, with a median of 17.4 (12.3-20.1) minutes compared to 0.2 minutes, p value <0.001. CG has longer K value (K) than TG, with a median of 2.2 (2.0-2.8) minutes compared to 0.8 minutes, p value <0.001. CG has lower maximum amplitude of strength (MA) than TG, with a median of 67.4(63.9-69.4)% compared to 87.4(80.9-92.5)%, p value <0.001. Qualitatively, TG had more solid clot and CG’s clot attached to the TEG cup until the end of the test.

Conclusion: Authors recommend using CG to seal bleeding or leakage without high tension due to its lower MA. Premixed technique is more suitable to overcome longer R and K."

"Fibrin Tissue Adhesive (FTA), Fibrin Scalant (FS) or Fibrin Glue (FG) are names given to a group of product that lead to the formation clot at the site of application. Fibrin Glue represents a new revolution for local haemostatic, which produced by based on the understanding about blood coagulation process. The mechanism of FG mimics the last stage of blood coagulation process.Hemophilia, is a congenital inherited bleeding disorder, characterized by repeated bleeding episodes. The basic pathology is deficiency of factor VIII (hemophilia A) or factor IX (hemophilia B). A bleeding episodes, hemophilia patients need replacement therapy. Hemophilia patients need transfusion of cryoprecipitate, Fresh Frozen Plasma (FFP) or factor concentrate as replacement therapy. Oral surgery, dental extraction, circumcision, and orthopedic operations are the most important indications for fibrin glue in hemophilia care. A s haemostatic local, FG minimizes bleeding, reducing the need of transfusion or factor concentrate, reducing the complication of transfusion, hospitalization and cost."

"ABSTRAKImplan lemak dalam bidang plastik rekonstruksi sudah lama digunakan oleh para ahli bedah, namun dengan seiringnya waktu lemak dapat mengalami absorpsi 30-50 , terutama pada lemak yang disentrifugasi. Untuk itu diperlukan suatu bahan autologous untuk mempertahankan viabilitas lemak. Tujuan penelitian ini adalah membandingkan antara lemak mikrolobular, lemak yang disentrifugasi, lemak mikrolobular dengan penambahan PRF dan lemak yang disentrifugasi dengan penambahan PRF. Tiga puluh enam kelompok dilakukan implan lemak di daerah dorsal telinga kelinci sebanyak 0,5cc, dievaluasi selama 4 minggu. Penilaian dilakukan secara makroskopik dengan menilai hiperemis, nekrosis dan menghitung diameter pada minggu pertama, kedua, ketiga dan keempat. Pada penelitian ini didapatkan bahwa pada minggu pertama hingga minggu keempat terjadi penurunan jumlah kelompok yang mengalami hiperemis, semua jaringan tidak terdapat nekrosis sejak minggu pertama dan diameter lemak yang mengalami penyusutan hanya terdapat pada perlakuan lemak yang disentrifugasi sebanyak dua kelompok, namun secara statistik tidak didapat perbedaan bermakna p>0,05 . Evaluasi mikroskopik didapatkan bahwa jumlah adiposit median= 547,74 , fibroblas median= 600,52 , pada perlakuan lemak mikrolobular dengan penambahan PRF lebih banyak dibandingkan kelompok perlakuan lainnya, namun secara statistik tidak bermakna p>0,05 , sedangkan parameter neovaskularisasi lebih banyak ditemukan pada kelompok lemak mikrolobular mean= 12,67 , tetapi secara statistik tidak bermakna p=0,268 Namun analisis regresi membuktikan bahwa peningkatan neovaskularisasi sejalan dengan pertambahan jumlah adiposit, hal ini membuktikan bahwa viabiltas adiposit bergantung pada neovaskularisasi.

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ABSTRACTFat graft in plastic reconstructive surgery has been used for a long time by surgeons. However, problem lies with fat being absorbed up to 30 50 , especially centrifuged fats. Therefore, an autologous material is needed to maintain fat viability. This research aims to compare the viability of microlobular fat, centrifuged fat, microlobular fat with PRF, and centrifuged fat with PRF. As much as 0.5 mL of these fat were grafted to thirty six groups of rabbits at the dorsal area of rabbits rsquo ear, which were then evaluated for 4 weeks. Macroscopic evaluation was performed on the first, second, third, and fourth week while microscopic evaluation was performed only on fourth week. Macroscopic evaluation performed since the first to the fourth week on hyperemia parameter showed reduction of redness hyperemia in all treatment groups and necrosis parameter was not found since the first week in all treatment groups. Although the diameter parameter was seen in two centrifuged fat groups on fourth week, it showed no statistically significant difference p 0,05 . Upon microscopic evaluation, the amount of adipocytes in microlobular fat with PRF group showed a greater number median 547.74 and also fibroblast median 600,52 compared to other treatment groups, but it was also not statistically significant p 0,05 . Neovascularization parameter was greater on microlobular fat group mean 12,67 , but it was not statistically significant p 0,268 . Result of regression analysis proved that increase in neovascularization was in line with the increase amount of adipocytes. Therefore, it is proved that the viability of adipocytes depends on neovascularization"

"Fraktur tulang merupakan kondisi kerusakan pada sebagian atau seluruh kontinuitas tulang yang dapat menyebabkan beberapa komplikasi seperti infeksi, pendarahan, kerusakan pada saraf dan pembuluh darah, dan defek. graphine oxide/hidroksiapatit/fibrin, functionalized graphite/hidroksiapatit/fibrin, functionalized multiwalled carbon nanotubes/hidroksiapatit/fibrin, dan hidroksiapatit/fibrin perancah HAp/F memiliki ukuran pori 0,5 – 4,1 μm, GO/HAp/F 2,6 – 6,1 μm, fG/HAp/F 0,7 – 14,1 μm dan fMWCNT/HAp/F 1,5 – 11,1 μm. Terdapat gugus PO43- , O-H, C-H, C-O alifatik, dan amida I pada setiap kelompok perancah. Dengan penambahan gugus fungsi C=O pada perancah dengan penambahan material karbon. Nilai kekuatan tekan pada perancah GO/HAp/F, fG/HAp/F, dan fMWCNT/HAp/F sesuai dengan kekuatan tekan cancellous bone. Persentase porositas paling besar padaperancah GO/HAp/F sebesar 9,99 ± 2,85%. Perancah GO/HAp/F memiliki persentase swelling yang paling tinggi dan laju degradasi yang paling lambat. Sedangkan retensi yang paling baik ditunjukkan oleh perancah fG/HAp/F dengan persentase 8,27%. Berdasarkan keseluruhan hasil, perancah HAp/F dengan penambahan material GO mempunyai karakteristik fisika-kimia yang lebih baik pada penelitian ini dibandingkan dengan perancah fMWCNT atau fG.

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A fracture is a condition when the continuity of the bone is broken causing several complications such as infection, bleeding, damage to nerves and blood vessels, and disability. In this research, the solution offered is to fabricate a scaffold with a combination of biomaterials or composites in the form of graphine oxide/hydroxyapatite/fibrin, functionalized graphite/hydroxyapatite/fibrin, functionalized multiwalled carbon nanotubes/hydroxyapatite/fibrin, and hydroxyapatite/fibrin. Scaffolds were synthesized using the freeze-drying method. This study aims to determine the physico-chemical characteristics of the four groups of scaffolds. Based on the results of SEM-EDS, the HAp/F scaffold has a pore size of 0.5 – 4.1 μm, GO/HAp/F has 2.6 – 6.1 μm, fG/HAp/F has 0.7 – 14.1 μm and fMWCNT/HAp/F has 1.5 – 11.1 μm. There were PO43- , O-H, C-H, aliphatic C-O and amide I groups in each scaffold. Additionally the C=O functional group on the scaffold with the addition of carbon material. The compressive strength values of GO/HAp/F, fG/HAp/F, and fMWCNT/HAp/F scaffolds correspond to the compressive strength of the cancellous bone. The highest percentage of porosity is GO/HAp/F scaffolds with 9.99 ± 2.85%. GO/HAp/F scaffolds had the highest swelling percentage and the slowest degradation rate. Meanwhile, the best retention was shown by fG/HAp/F scaffold with a percentage of 8.27%. Based on the overall results, the HAp/F scaffold with the addition of GO material had better physico-chemical characteristics in this study than fMWCNT or fG scaffolds."

"ABSTRAKAbstrak. Inovasi terbaru untuk mendapatkan regenerasi jaringan periodontal adalah dengan bahan platelet rich fibrin (PRF) dan cangkok tulang. Penelitian ini merupakan penelitian eksperimental klinis. Tujuan: Mengevaluasi perbedaan tinggi tulang alveolar pada terapi bedah flep poket infraboni menggunakan Platelet rich fibrin dan kombinasi dengan cangkok tulang. Metode penelitian: Evaluasi radiografis periapikal sebelum dan sesudah perawatan menggunakan PRF dan kombinasi dengan cangkok tulang Hasil: secara statistik, terdapat perbedaan tinggi tulang yang bermakna pada terapi bedah poket infraboni dengan PRF dan kombinasi dengan cangkok tulang. Kesimpulan: Platelet rich fibrin dan kombinasi dengan cangkok tulang memiliki hasil yang sama pada evaluasi radiografis ketinggian tulang secara statistik

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ABSTRACTAbstract. The new innovation to enhance periodontal tissue regeneration are using PRF and bone graft material. The study was clinical experimental. Purpose:To evaluate the difference of alveolar bone heigh on periodontitis therapy using PRF and combination with bone graft.Research methods: periapical radiograph evaluation before and after periodontitis therapy using PRF compare to combination with bone graft. by assessing alveolar bone height. Results: Statistically, there were no significant difference between alveolar bone height on periodontitis therapy PRF compare to combination with bone graft. Conclusion: PRF and combination with bone graft has the same result statictically in radiographic evaluation of alveolar bone height."

"Luka kaki diabetes (LKD) adalah salah satu komplikasi diabetes melitus (DM). Terapi LKD adalah perawatan luka dan growth factor (GF) seperti advanced-platelet rich fibrin (A-PRF). Penyandang DM memiliki GF rendah, untuk mengoptimalkan GF yang dilepaskan oleh PRF, ditambahkan asam hialuronat (AH). Penelitian ini bertujuan menganalisis pengaruh A-PRF + AH terhadap penyembuhan LKD dengan mengkaji VEGF, PDGF, IL-6, dan indeks granulasi. Desain penelitian randomized control trial, dilaksanakan pada bulan Juli 2019 −Maret 2020 di RSPAD Gatot Soebroto dan RSUD Koja, Jakarta. Subjek penyandang LKD yang mengalami luka kronik, kriteria Wagner II, luas luka < 40 cm2. Subjek diambil berdasarkan rule of thumb dan dibagi tiga secara acak yaitu kelompok terapi topikal A-PRF + AH (n = 10), A-PRF (n = 10) dan kontrol NaCl 0,9% (n = 10). Pada kelompok A-PRF + AH dan A-PRF dilakukan pemeriksaan VEGF, PDGF, IL-6 dari usap LKD dan fibrin gel sedangkan kontrol hanya diperiksa usap LKD. Biomarker dan Indeks Granulasi (IG) diperiksa hari ke-0, ke-3, ke-7. Khusus IG pengukuran ditambah hari ke-14. Data dianalisis menggunakan SPSS versi 20 dengan uji Anova atau Kruskal Wallis. Pada kelompok A-PRF + AH, kadar VEGF usap LKD hari ke-0 adalah 232,8 meningkat menjadi 544,5 pg/mg protein pada hari ke-7. Pada kelompok A-PRF tejadi peningkatan dari 185,7 menjadi 272,8 pg/mg protein, namun kelompok kontrol terjadi penurunan dari 183,7 menjadi 167,4 pg/mg protein. Kadar PDGF usap LKD kelompok A-PRF + AH hari ke-0 adalah 1,9 pg/mg protein, meningkat menjadi 8,1 pg/mg protein hari ke-7, kelompok A-PRF dari 1,7 meningkat menjadi 5,4 pg/mg protein dan kontrol dari 1,9 meningkat menjadi 6,4 pg/mg protein. Kadar IL-6 usap LKD kelompok A-PRF + AH hari ke-0 adalah 106,4 menjadi 88,7 pg/mg protein hari ke-7, pada A-PRF dari 91,9 menjadi 48,8 pg/mg protein dan kontrol dari 125,3 menjadi 167,9 pg/mg protein. IG kelompok A-PRF + AH hari ke-0 adalah 42,1% menjadi 78,9% dan 97,7% hari ke-7 dan ke-14, pada kelompok A-PRF dari 34,8% menjadi 64,6% dan 91,6%. Kelompok kontrol dari 35,9% menjadi 66,0% dan 78,7% hari ke-7 dan ke-14. Pada kelompok A-PRF + AH dibandingkan A-PRF dan NaCl didapatkan peningkatan bermakna kadar VEGF pada hari ke-3 (p = 0,011) dan hari ke-7 (p < 0,001). Kadar IL-6 menurun bermakna (p = 0,041) pada hari ke-7 saja. Namun persentase IG meningkat bermakna pada hari ke-3 (p = 0,048), ke-7 (p = 0,012) dan hari ke-14 (p < 0,001). Disimpulkan penambahan AH pada A-PRF meningkatkan VEGF (marker angiogenesis) dan IG (tanda klinis penyembuhan luka), serta menurunkan IL-6 (marker inflamasi) secara bermakna sehingga mempercepat penyembuhan LKD.

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Diabetic foot ulcer (DFU) is one of complications of diabetes mellitus (DM). Advance wound treatment in DFU such as growth factors (GF) including Advanced-Platelet Rich Fibrin (A-PRF) topical has been developed . People with DM have low GF, so to optimize GF hyaluronic acid (AH) is added. This study analyzed the combination of A-PRF + AH combination in DFU recovery by examining VEGF, PDGF, IL-6, and granulation index (IG). The study used a randomized control design, done from July 2019−March 2020 at the Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU patients who had chronic wounds, area < 40 cm2 and Wagner II criteria. Subjects were recruited according to the rule of thumb and were randomly divided into three groups namely topical A-PRF + AH (n = 10), A-PRF (n = 10) and control NaCl 0.9% groups (n = 10). The A-PRF + AH and A-PRF groups underwent VEGF, PDGF, and IL-6 examinations of the DFS swabs and fibrin gel while the controls could only underwent the DFU swabs. Biomarkers and Granulation Index (GI) were measured on day 0, 3rd, 7th. Special GI measurements were added on day 14. Data were analyzed using SPSS version 20 with the Anova and Kruskal Wallis test. In the A-PRF + AH group the VEGF level from swab DFU day 0 was 232,8 pg/mg protein increase to 544,5 pg/mg protein on day 7. In the A-PRF group VEGF increase from 185,7 to 272,8 pg/mg protein and control decrease from 183.7 to 167.4 pg/mg protein. Increasing of PDGF levels in group A-PRF + AH day 0 was from 1,9 pg/mg protein to 8,1 pg/mg day 7, group A-PRF from 1,7 increased to 5,4 pg/mg protein and control from 1,9 to 6,4 pg/mg protein. Decreasing of IL-6 level of DFU swab in group A-PRF + AH day 0 was 106,4 pg/mg protein to 88,7 pg/mg protein day 7, in group A-PRF from 91,9 to 48,8 pg/mg protein and control from 125,3 to 167,9 pg/mg protein. The granulation index of DFU group A-PRF + AH on day 0 was 42,1% increased to 78,9% and 97,7% days 7 and 14. In the A-PRF group increased from 34,8% to 64,6 % and 91,6%. and controls from 35,9% to 66,0% and 78,7% on days 7 and 14. On the 7th day the VEGF level of the A-PRF + AH group increased significantly (p < 0.001), while IL-6 decreased and the granulation index increased significantly with p level of p = 0.041 and p = 0.012 respectively, compare with other group. It was concluded that on day 7 the AH to A-PRF increases VEGF (a marker of angiogenesis) and GI (a clinical sign of wound recovery), as well as a decrease in IL-6 (a marker of inflammation) which fully increase in DFU. "

"Luka kaki diabetes (LKD) adalah salah satu komplikasi diabetes melitus (DM). Terapi LKD adalah perawatan luka dan growth factor (GF) seperti advanced-platelet rich fibrin (A-PRF). Penyandang DM memiliki GF rendah, untuk mengoptimalkan GF yang dilepaskan oleh PRF, ditambahkan asam hialuronat (AH). Penelitian ini bertujuan menganalisis pengaruh A-PRF + AH terhadap penyembuhan LKD dengan mengkaji VEGF, PDGF, IL-6, dan indeks granulasi. Desain penelitian randomized control trial, dilaksanakan pada bulan Juli 2019 −Maret 2020 di RSPAD Gatot Soebroto dan RSUD Koja, Jakarta. Subjek penyandang LKD yang mengalami luka kronik, kriteria Wagner II, luas luka < 40 cm2. Subjek diambil berdasarkan rule of thumb dan dibagi tiga secara acak yaitu kelompok terapi topikal A-PRF + AH (n = 10), A-PRF (n = 10) dan kontrol NaCl 0,9% (n = 10). Pada kelompok A-PRF + AH dan A-PRF dilakukan pemeriksaan VEGF, PDGF, IL-6 dari usap LKD dan fibrin gel sedangkan kontrol hanya diperiksa usap LKD. Biomarker dan Indeks Granulasi (IG) diperiksa hari ke-0, ke-3, ke-7. Khusus IG pengukuran ditambah hari ke-14. Data dianalisis menggunakan SPSS versi 20 dengan uji Anova atau Kruskal Wallis.Pada kelompok A-PRF + AH, kadar VEGF usap LKD hari ke-0 adalah 232,8 meningkat menjadi 544,5 pg/mg protein pada hari ke-7. Pada kelompok A-PRF tejadi peningkatan dari 185,7 menjadi 272,8 pg/mg protein, namun kelompok kontrol terjadi penurunan dari 183,7 menjadi 167,4 pg/mg protein. Kadar PDGF usap LKD kelompok A-PRF + AH hari ke-0 adalah 1,9 pg/mg protein, meningkat menjadi 8,1 pg/mg protein hari ke-7, kelompok A-PRF dari 1,7 meningkat menjadi 5,4 pg/mg protein dan kontrol dari 1,9 meningkat menjadi 6,4 pg/mg protein. Kadar IL-6 usap LKD kelompok A-PRF + AH hari ke-0 adalah 106,4 menjadi 88,7 pg/mg protein hari ke-7, pada A-PRF dari 91,9 menjadi 48,8 pg/mg protein dan kontrol dari 125,3 menjadi 167,9 pg/mg protein. IG kelompok A-PRF + AH hari ke-0 adalah 42,1% menjadi 78,9% dan 97,7% hari ke-7 dan ke-14, pada kelompok A-PRF dari 34,8% menjadi 64,6% dan 91,6%. Kelompok kontrol dari 35,9% menjadi 66,0% dan 78,7% hari ke-7 dan ke-14. Pada kelompok A-PRF + AH dibandingkan A-PRF dan NaCl didapatkan peningkatan bermakna kadar VEGF pada hari ke-3 (p = 0,011) dan hari ke-7 (p < 0,001). Kadar IL-6 menurun bermakna (p = 0,041) pada hari ke-7 saja. Namun persentase IG meningkat bermakna pada hari ke-3 (p = 0,048), ke-7 (p = 0,012) dan hari ke-14 (p < 0,001).Disimpulkan penambahan AH pada A-PRF meningkatkan VEGF (marker angiogenesis) dan IG (tanda klinis penyembuhan luka), serta menurunkan IL-6 (marker inflamasi) secara bermakna sehingga mempercepat penyembuhan LKD.

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Diabetic foot ulcer (DFU) is one of complications of diabetes mellitus (DM). Advance wound treatment in DFU such as growth factors (GF) including Advanced-Platelet Rich Fibrin (A-PRF) topical has been developed . People with DM have low GF, so to optimize GF hyaluronic acid (AH) is added. This study analyzed the combination of A-PRF + AH combination in DFU recovery by examining VEGF, PDGF, IL-6, and granulation index (IG).

The study used a randomized control design, done from July 2019−March 2020 at the Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU patients who had chronic wounds, area < 40 cm2 and Wagner II criteria. Subjects were recruited according to the rule of thumb and were randomly divided into three groups namely topical A-PRF + AH (n = 10), A-PRF (n = 10) and control NaCl 0.9% groups (n = 10). The A-PRF + AH and A-PRF groups underwent VEGF, PDGF, and IL-6 examinations of the DFS swabs and fibrin gel while the controls could only underwent the DFU swabs. Biomarkers and Granulation Index (GI) were measured on day 0, 3rd, 7th. Special GI measurements were added on day 14. Data were analyzed using SPSS version 20 with the Anova and Kruskal Wallis test.

In the A-PRF + AH group the VEGF level from swab DFU day 0 was 232,8 pg/mg protein increase to 544,5 pg/mg protein on day 7. In the A-PRF group VEGF increase from 185,7 to 272,8 pg/mg protein and control decrease from 183.7 to 167.4 pg/mg protein. Increasing of PDGF levels in group A-PRF + AH day 0 was from 1,9 pg/mg protein to 8,1 pg/mg day 7, group A-PRF from 1,7 increased to 5,4 pg/mg protein and control from 1,9 to 6,4 pg/mg protein. Decreasing of IL-6 level of DFU swab in group A-PRF + AH day 0 was 106,4 pg/mg protein to 88,7 pg/mg protein day 7, in group A-PRF from 91,9 to 48,8 pg/mg protein and control from 125,3 to 167,9 pg/mg protein. The granulation index of DFU group A-PRF + AH on day 0 was 42,1% increased to 78,9% and 97,7% days 7 and 14. In the A-PRF group increased from 34,8% to 64,6 % and 91,6%. and controls from 35,9% to 66,0% and 78,7% on days 7 and 14. On the 7th day the VEGF level of the A-PRF + AH group increased significantly (p < 0.001), while IL-6 decreased and the granulation index increased significantly with p level of p = 0.041 and p = 0.012 respectively, compare with other group.

It was concluded that on day 7 the AH to A-PRF increases VEGF (a marker of angiogenesis) and GI (a clinical sign of wound recovery), as well as a decrease in IL-6 (a marker of inflammation) which fully increase in DFU."

"[Penelitian ini bertujuan untuk mengetahui pengaruh kekasaran, proses phosphating, serta ketebalan adhesive bonding terhadap ketahanan delaminasi komposit laminat. Variasi kekasaran substrat, yaitu pada rentang 5-8 μm dan 10-13 μm, variasi terhadap proses phosphating, yaitu ada yang melalui proses phosphating dan ada yang tidak, serta variasi ketebalan adhesive baik primer ataupun topcoat dengan rentang 1-5 μm, 6-10 μm, serta 11-15 μm. Pembentukan komposit laminat ini dilakukan melalui proses transfer moulding pada suhu 160 C selama 450 detik. Komposit laminat yang sudah terbentuk kemudian diuji peel-off untuk mengetahui kekuatan delaminasinya lalu dikarakterisasi dengan SEM-EDX. Hasil menunjukan bahwa kekasaran permukaan, lapisan zinc phosphate, serta ketebalan adhesive bonding mempengaruhi ketahanan delaminasi komposit laminat yang diinterpretasikan dengan kekuatan ikat antarlapisan dan visual delaminasi. Kekasaran optimum terjadi pada rentang 10-13 μm dengan kekuatan ikat 179,68 N dan visual delaminasi R-R sebanyak 35%. Adanya lapisan zinc phosphate memberikan nilai kekuatan ikat optimum sebesar 157,38 N dan visual delaminasi R-R sebanyak 50%. Ketebalan adhesive primer optimum terjadi pada rentang 1-5 μm dengan kekuatan ikat 163,35 N dan visual delaminasi R-R sebanyak 50%. Ketebalan adhesive topcoat optimum terjadi pada rentang 6-10 μm dengan kekuatan ikat sebesar 154,65 N dan visual delaminasi R-R sebanyak 41,6%.;This study aims to determine the effect of roughness, phosphating process, and the thickness of the adhesive bonding into delamination resistance of laminate composite. Variation of the substrate roughness are 5-8 μm and 10-13 μm. Some substrates are coated by zinc phosphate and other substrate are uncoated. Variations of the thickness of adhesive primer and adhesive topcoat are in a range of 1-5 μm, 6-10 μm, and 11-15 μm. The process of forming the laminate composite occurs through transfer molding process at 1600C in 450 seconds. Laminate composite that has been formed then tested by peel-off test to determine the strength of delamination. Visual of delamination was characterized by SEM-EDX. The results showed that the optimum surface roughness occurs in the range of 10-13 μm with bonding strength 179.68 N and 35% of R-R visual. The coated substrate has a higher bonding strength compared to uncoated substrate, which is 157.38 N and 50% of R-R visual. The optimum thickness of adhesive primer occurs in the range of 1-5 μm with bonding strength is 163.35 N and 50% of R-R visual. While the optimum thickness of adhesive topcoat occurs in the range of 6-10 μm with a bonding strength is 154.65 N and 41,6% of R-R visual;This study aims to determine the effect of roughness, phosphating process, and the thickness of the adhesive bonding into delamination resistance of laminate composite. Variation of the substrate roughness are 5-8 μm and 10-13 μm. Some substrates are coated by zinc phosphate and other substrate are uncoated. Variations of the thickness of adhesive primer and adhesive topcoat are in a range of 1-5 μm, 6-10 μm, and 11-15 μm. The process of forming the laminate composite occurs through transfer molding process at 1600C in 450 seconds. Laminate composite that has been formed then tested by peel-off test to determine the strength of delamination. Visual of delamination was characterized by SEM-EDX. The results showed that the optimum surface roughness occurs in the range of 10-13 μm with bonding strength 179.68 N and 35% of R-R visual. The coated substrate has a higher bonding strength compared to uncoated substrate, which is 157.38 N and 50% of R-R visual. The optimum thickness of adhesive primer occurs in the range of 1-5 μm with bonding strength is 163.35 N and 50% of R-R visual. While the optimum thickness of adhesive topcoat occurs in the range of 6-10 μm with a bonding strength is 154.65 N and 41,6% of R-R visual, This study aims to determine the effect of roughness, phosphating process, and the thickness of the adhesive bonding into delamination resistance of laminate composite. Variation of the substrate roughness are 5-8 μm and 10-13 μm. Some substrates are coated by zinc phosphate and other substrate are uncoated. Variations of the thickness of adhesive primer and adhesive topcoat are in a range of 1-5 μm, 6-10 μm, and 11-15 μm. The process of forming the laminate composite occurs through transfer molding process at 1600C in 450 seconds. Laminate composite that has been formed then tested by peel-off test to determine the strength of delamination. Visual of delamination was characterized by SEM-EDX. The results showed that the optimum surface roughness occurs in the range of 10-13 μm with bonding strength 179.68 N and 35% of R-R visual. The coated substrate has a higher bonding strength compared to uncoated substrate, which is 157.38 N and 50% of R-R visual. The optimum thickness of adhesive primer occurs in the range of 1-5 μm with bonding strength is 163.35 N and 50% of R-R visual. While the optimum thickness of adhesive topcoat occurs in the range of 6-10 μm with a bonding strength is 154.65 N and 41,6% of R-R visual]"

"Aplikasi sistem self adhesive pada sementasi pasak fiber sangat mudah dan penggunaanya meningkat pesat, tetapi penelitian mengenai kemampuan adhesinya masih terbatas. Penelitian ini dilakukan untuk menganalisis kemampuan adhesi sistem adhesif self etch dan self adhesive pada sementasi pasak fiber apakah sama besar atau tidak dengan total etch. Penelitian eksperimental laboratorik dilakukan menggunakan 27 gigi premolar satu mandibula yang telah disetujui oleh komisi etik, dibagi secara acak menjadi 3 kelompok. Pasak fiber disementasi dengan 3 sistem adhesif berbeda. Pada setiap gigi dilakukan pemotongan setebal 5 mm dari bagian servikal ke arah medial akar gigi, seluruh spesimen disimpan selama 24 jam dalam larutan salin pada suhu kamar, lalu dilakukan push out test menggunakan Universal Testing Machine (Shimidzu AG-5000E) dengan kecepatan 0,5 mm/menit. Hasil analisis univariat dan bivariat Anova satu arah menunjukkan kemampuan adhesi sistem total etch dan self etch sama besar (p<0.05), sedangkan sistem self adhesive memiliki kemampuan adhesi yang paling rendah (p>0.05). Aplikasi yang lebih mudah pada sistem self etch mampu memberikan kemampuan adhesi yang sama dengan sistem total etch.

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Application of self adhesive system on fiber post cementation is very simple and their use increase rapidly, however study in the adhesion capability is limited and insufficient. The aim of this study was to analyze whether self etch and self adhesive system are comparable to total etch system.

The experimental laboratory study was performed using 27 mandibular premolar teeth approved by ethics committee, randomly divided into 3 groups, fibre post were cemented in 3 different adhesive system. Specimen were prepared 5 mm in thickness from cervical to medial of the root, stored for 24 hours in saline solution at room temperature, push out test was performed using Universal Testing Machine (Shimidzu AG-5000E) with crosshead speed at 0.5 mm/min.

The results of univariat and one way Anova bivariat test showed that total etch and self etch system have a comparable adhesion capability (p<0.05), and self adhesive system has the lowest adhesion capability (p>0.05). With easier application, self etch system has a comparable adhesion capability to total etch system. Key Word: adhesion capability, fiber post, push out test, total etch, self etch, self adhesive."