Hasil Pencarian  ::  Simpan CSV :: Kembali

"The key knowledge assembled in this book comprises today?s most comprehensive resource on Sjögren?s syndrome. Sjögren?s patients require the care of a wide variety of clinical and surgical specialists to treat their disease and improve their quality of life. This volume presents a broad multi-disciplinary approach, enlisting the expertise of well-respected authors from around the world, covering the specialties of rheumatology, ophthalmology, oral medicine, oral surgery, otolaryngology, hematology, and others.This practical clinical resource begins with an overview of Sjögren?s myths, pearls and tips, information for referring physicians, and diagnostic and classification and criteria. The second section covers pathogenesis, providing the backbone for our understanding current diagnostics and therapeutics. The third section is devoted to clinical manifestations and therapeutic considerations. It covers the entire spectrum of symptoms and treatment, infused with the experience and astute clinical observations of the book?s contributors. With system-wide coverage of local and systemic therapy, the book examines current therapy, biologics, and emerging therapeutic targets.Presenting many international perspectives, this book creates an inter-connective conduit for the global community of Sjögren?s patients and physicians."

"Sjögren’s syndrome : diagnosis and therapeutics provides a thorough, multisystemic overview of the clinical manifestations of Sjögren’s Syndrome. It contains chapters pertinent across the range of medical specialties that may encounter Sjögren’s Syndrome cases. Chapters are specialty-specific, for easy reference by the relevant medical specialist. In addition to being a diagnostic guide, Sjögren’s Syndrome: Diagnosis and Therapeutics includes a section on prognosis and outcomes of Sjögren’s Syndrome patients and provides an exhaustive therapeutic update, focused on new agents and experimental techniques.The inclusion of diagnostic/therapeutic algorithms illustrates the text with clinical photographs of the main organs involved and helps the reader to make guided diagnostic and therapeutic decisions through decision-based algorithms."

"Tesis ini bertujuan untuk menilai stabilitas LAM mata kering terkait sindrom Sj gren SS yang diberikan terapi kombinasi tetes mata sodium hialuronat 0,1 SH dan hydroxypropyl HP -guar, atau monoterapi tetes mata sodium hialuronat SH. Sebanyak 17 pasien SS dalam penelitian ini dibagi ke dalam 2 kelompok. Kelompok pertama mendapatkan kombinasi SH dan HP-guar sementara kelompok kedua mendapatkan terapi SH. NIKBUT, Schirmer, skor pewarnaan okular dan sitologi impresi, serta keluhan subjektif yang dilakukan sebelum dan sesudah pemberian obat. Setelah terapi selama 28 hari, terdapat peningkatan median NIKBUT, Schirmer, skor pewarnaan okular, densitas sel Goblet dan keluhan subjektif pada mata kering terkait SS.

---

The objectives of the study is to assess the stability of dry eye LAM associated with Sj gren syndrome SS given combination therapy of sodium hyaluronate 0.1 SH and hydroxypropyl HP guar, or monotherapy sodium hyaluronic SH. A total of 17 SS patients in this study were divided into 2 groups. The first group received a combination of SH and HP guar while the second group received SH therapy. NIKBUT, Schirmer, ocular staining score and impression cytology, as well as subjective complaints made before and after drug administration. After 28 days of therapy, there was a median increase in NIKBUT, Schirmer, ocular staining scores, Goblet cell density and subjective complaints on SS related dry eyes. "

"Latar belakang: Pemfigus merupakan penyakit autoimun yang ditandai lepuh pada kulit dan/atau mukosa akibat adanya imunoglobulin terhadap permukaan sel keratinosit. Kortikosteroid KS merupakan pilihan terapi utama. Dipikirkan pemfigus berhubungan dengan sindrom metabolik SM secara langsung maupun tidak langsung. Tujuan: Mengetahui proporsi SM pada pasien pemfigus dan faktor-faktor yang berhubungan di Rumah Sakit Cipto Mangunkusumo RSCM. Metode: Studi potong lintang pada bulan September November 2016 di Poliklinik Kulit dan Kelamin RSCM. Subjek dianamnesis, dilakukan pengukuran tekanan darah dan lingkar abdomen, lalu dilanjutkan pengambilan darah untuk pemeriksaan kadar trigliserida, high density lipoprotein HDL, serta gula darah puasa. Hasil: Didapatkan 30 subjek dengan rerata usia 41,6 10,3 tahun dan sebagian besar perempuan. Sebanyak 23 subjek 76,7 terdiagnosis pemfigus vulgaris dan 7 subjek 23,3 pemfigus foliaseus. Median durasi penyakit adalah 31 bulan. Median lama penggunaan steroid adalah 16,5 bulan. Ditemukan SM pada 40 dari total SP. Didapatkan proporsi obesitas sentral adalah 63,3 , hipertensi 50, hipertrigliseridemia 50, hiperglikemia 23,3, dan hipo-HDL 43,3. Simpulan: Ditemukan proporsi yang sama antara laki-laki dan perempuan di kelompok SM. Tidak ditemukan perbedaan bermakna jenis kelamin, tipe pemfigus, usia, lama sakit, dan lama penggunaan steroid antara kelompok SM dan tidak SM.

---

Background: Pemphigus is an autoimmune bullous disease characterized by blistering skin and or mucosa caused by presence of immunoglobulin against keratinocyte cell surface. Corticosteroid is the main therapy. Pemphigus has been related to metabolic syndrome MS lately.

Objective: Determine MS proportion in pemphigus patients and its associated factors.

Methods: This cross sectional study was conducted in September November 2016 in Dermatovenereology Outpatient Clinic in Cipto Mangunkusumo Hospital. Subjects history was taken then blood pressure, and abdominal circumference were measured. Patients trigliceryde, high density lipoprotein HDL, and fasting blood glucose level were also measured.

Results: There are 30 subjects with age mean 41,6 10,3 years and mostly women, 23 patients 76,7 are diagnosed as pemphigus vulgaris while 7 patients 23,3 are pemphigus foliaceus. Disease duration mean in all patients is 31 months and steroid duration mean is 16.5 months. MS was found in 40 subjects. Proportion of central obesity is 63,3, hypertension 50, hypertriglyceridemia 50, hyperglycemia 23,3, and hipo HDL 43,3.

Conclusion The same proportion of men and women are found in MS group. There is no statistically significant difference found in gender, pemphigus subtype, age, disease duration, and steroid usage duration between two groups."

"Penelitian ini dibuat untuk mengevaluasi hubungan antara LUTS/BPH dan sindrom metabolik pada pria Indonesia. Dua ratus dua puluh tujuh pasien dengan BPH diinklusi dalam penelitian ini. Pengukuran indeks masa tubuh, lingkar perut, volume prostat, dan international prostate symptom score (IPSS) dilakukan pada semua pasien. Berbagai pemeriksaan laboratorium seperti prostate specific antigen, gula darah puasa, trigliserida, lipoprotein densitas tinggi telah diuji. Diagnosa sindrom metabolik disesuaikan dengan kriteria dari The National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). IPSS disubkategorikan menjadi nilai keluhan obstruktif dan iritatif dan sindrom metabolik di kelompokkan sesuai dengan jumlah komponen kriteria (kurang dari 3, 3, 4, dan 5). Uji korelasi Spearman digunakan untuk menganalisa hubungan antara seluruh data kontinyu. Nilai rerata antara kelompok faktor resiko dianalisa menggunakan One-way ANOVA untuk data dengan nilai distribusi normal dan Kruskall Wallis untuk data dengan nilai distribusi tidak normal. Pada penelitian ini didapatkan sindrom metabolik pada 87 pasien (38.3 %). Pasien dengan sindrom metabolik memiliki nilai indeks masa tubuh, lingkar perut, tekanan darah sistolik, trigliserida, gula darah puasa, gejala iritatif, dan total IPSS lebih tinggi, dan lipoprotein densitas tinggi lebih rendah secara signifikan. Pasien dengan obesitas sentral memiliki resiko mengalami gejala LUTS/BPH sedang-berat lebih tinggi secara signifikan (RR 1.16, 95% CI: 1.01-1.4, p = <0.05) dan resiko memiliki nilai PSA yang tinggi (PSA ³ 20) (RR 0.41, CI 95%: 0. 23 -0.74, P = <0.001). Dari penelitian ini dapat disimpulkan bahwa sindrom metabolik memiliki dampak yang terbatas terhadap gejala LUTS/BPH pada pria Indonesia. Hubungan dan peningkatan resiko gejala LUTS/BPH hanya terlihat pada pasien dengan obesitas sentral.

---

This paper was made to evaluate the association between LUTS/BPH and MetS in Indonesian men. A total of 227 patients with histologic proven BPH were included in this study. Body mass index (BMI), waist circumference (WC), prostate volume, and international prostate symptom score (IPSS) were measured. Prostate specific antigen (PSA), fasting blood glucose (FBG), triglyceride (TG), high density lipoprotein (HDL) were tested. MetS were diagnosed using The National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). IPSS was subcategorized as irritative and obstructive scores and patients were classified into 4 groups according to the number of exhibited MetS components (less than 3, 3, 4, and 5). Spearman s correlation were used to analyses the association between all continuous variable. Mean difference between risk factor groups were analysed using One-way ANOVA for normally distributed variables and Kruskall Wallis for abnormally distributed variables. In this paper, MetS was diagnosed in 87 patients (38,3%). Patients with MetS have significantly higher BMI, WC, systolic blood pressure, triglyceride, fasting blood glucose, IPSS irritative score, total IPSS score, and lower HDL cholesterol. Patients with central obesity have significantly higher risk of having moderate-severe LUTS (RR 1.16, 95% CI: 1.01 -1.4, p = <0.05) and decreased risk in developing higher PSA level (PSA ³ 20) (RR 0.41, CI 95%: 0. 23-0.74, P = <0.001). From this paper we could conclude that MetS has limited impact towards LUTS/BPH in Indonesian men. Association and increase risk of LUTS/BPH were only seen in patients with central obesity."

"Metabolik sindrom merupakan suatu kondisi dimana tubuh memiliki minimal tiga dari empat gejala berikut: obesitas, hipertrigliseridimia, hipertensi, gula darah puasa yang tinggi, dan kadar HDL rendah. Di era modern ini, banyak orang memiliki pola hidup yang kurang sehat, seperti kurangnya olah raga maupun pola makan yang tidak seimbang, sehingga membuat mereka semakin rentan terhadap gejala-gejala tersebut. Tujuan studi ini adalah untuk mengidentifikasi prevalensi sindrom metabolic dan faktor-faktor terkaitnya, mencakup faktur demografis dan pola hidup, di Kelurahan Kayu Putih, Jakarta Timur. Riset ini menggunakan desain cross-sectional dengan masyarakat Kelurahan Kayu Putih sebagai subjek penelitian. Data diambil pada tanggal 20 dan 27 Maret 2011 menggunakan anamnesis, pemeriksaan fisik dan tes penunjang. Data kemudian dianalisis lebih lanjut menggunakan chi-square test berdasarkan kriteria metabolik sindrom ATP III. Terdapat 27(34.6%) orang dari 78 responden mengalami sindrom metabolik. Chi square test menunjukkan hubungan yang signifikan antara sindrom metabolik dengan jenis kelamin (p <0.001), umur (p=0.020), dan pekerjaan (p=0.023). Di sisi lain, faktor-faktor demografis dan pola hidup lainnya tidak menunjukkan hubungan yang berarti. Prevalensi sindrom metabolik di Kelurahan Kayu Putih Jakarta Timur adalah 34.6% dan faktor yang terkait dengan sindrom metabolik adalah jenis kelamin, umur, dan pekerjaan.

---

Metabolic syndrome is a condition of body which have at least three of this symptoms: abdominal obesity, hypertriglyceridemia, low level of high-density lipoproteins, hypertension, and high fasting plasma glucose level. The aim of this study is to identify the prevalence of metabolic syndrome and other factors including demographical factors and lifestyle factors that are related toit in Kelurahan Kayu Putih, East Jakarta. This research used cross-sectional design with some people living in Kelurahan Kayu Putih as the subjects. The data were taken upon anamnesis, body measurement, physical examination, and supporting tests. The data were analyzed by chi-square testbased on ATP III criteria for metabolic syndrome. The result illustrated that the prevalance of metabolic syndrome was 27(34.6%) people out of 78 respondents Chi square test showed meaningful difference in the prevalence of metabolic syndrome by gender (p <0.001), age (p=0.020), and occupation (p=0.023). In contrast, the test showed that there was no significant difference in other demographical factors and lifestyle. In conclusion, the prevalence of metabolic syndrome at KelurahanKayuPutih, East Jakarta is 34.6% and factors relating to metabolic syndrome is gender, age, and occupation."

"Latar Belakang. Perkembangan teknologi dan meningkatnya peran penggunaan tangan di bidang industri, rumah tangga dan perkantoran akan meningkatkan angka kejadian STK. Hal ini akan memiliki dampak negatif di bidang medis, sosial dan ekonomi. Pemeriksaan Ultrasonografi (USG) berguna sebagai penunjang dalam mendiagnosis STK. Kemajuan dalam kualitas dan portabilitas USG telah menempatkan USG sebagai alat pilihan dalam penelitian dan penerapan klinis di bidang neurologi. USG mudah dijumpai di pelayanan kesehatan, memiliki biaya yang murah, waktu pemeriksaan yang singkat dan tidak invasif, serta memiliki sensitivitas dan spesifisitas yang cukup baik dalam mendiagnosis STK. Metode. Desain penelitian berupa studi potong lintang. Subyek penelitian adalah pasien Poliklinik Neurologi RSCM yang memenuhi kriteria inklusi dan eksklusi. Subyek diperoleh secara konsekutif. Pada subyek dilakukan wawancara, pengisian kuesioner, pemeriksan fisik, elektroneurografi dan ultrasonografi di Poliklinik Neurologi RSCM. Dilakukan analisis data menggunakan perangkat SPSS 17.0. Hasil. Diperoleh 58 subyek tangan yang masuk kriteria inklusi. Sensitivitas dan spesifisitas kombinasi gambaran klinis dan USG adalah 86,04% dan 73,33%. Sedangkan akurasi kombinasi gambaran klinis dan USG sebesar 82,75%. Terdapat kesesuaian antara pemeriksaan kombinasi klinis dan USG dengan kombinasi klinis dan elektroneurografi dalam mendeteksi STK (kappa = 0,70). Kesimpulan. Nilai sensitivitas kombinasi gambaran klinis dan USG sama dengan elektroneurografi. Sedangkan spesifisitas kombinasi gambaran klinis dan USG lebih rendah daripada elektroneurografi. Kombinasi gambaran klinis dan USG dapat digunakan sebagai alternatif pemeriksan dalam mendiagnosis STK.

---

Background. Technological development and the increased use of hands in the fields of industrial, household and office space will increase the prevalence of Carpal Tunnel Syndrome (CTS). This will have a negative impact on medical science, social and economic. Ultrasonography (USG) is useful to support diagnosis of CTS. Progress in the quality and portability of ultrasound has placed ultrasound as a chosen instrument in research and clinical application in the field of neurology. USG is easily found at the health centers, has a lower cost, a short examination time and not invasive, as well as having superior specificity and sensitivity is good enough in diagnosing CTS.

Method. A cross-sectional sectional study was conducted. The research subject were patients of the Neurology Clinic of RSCM Hospital who meet all of the inclusion and exclusion criteria.

Result. Fifthy eight hands were included in this study. The sensitivity and specificity of the combination of clinical features and ultrasonography were 86.04% and 73.33%. While, the accuracy of the combination of clinical features and ultrasonography was 82.75%. There is a conformity between the combination of clinical features and ultrasound with a combination of clinical picture and electroneurography in diagnosing CTS (kappa = 0.70).

Conclusion. The combination of clinical features and ultrasonography has similar sensitivity with electroneurography. Meanwhile, the specificity of the combination of clinical features and ultrasonography is inferior to electroneurography. Thus, the combination of clinical features and ultrasonography can be used as an alternative to electroneurography in diagnosing CTS."

"Sindrom ovarium polikistik (SOPK) merupakan suatu kondisi umum endokrinopati yang ditandai dengan adanya oligoovulasi atau anovulasi, produksi androgen berlebih, dan adanya kista ovarium kecil multipel yang diidentifikasi secara sonografis (kriteria Rotterdam, 2004). SOPK ditemukan pada 10% populasi wanita usia reproduksi dan berhubungan erat dengan disfungsi ovulasi sehingga menurunkan angka fertilitas. Tujuan penelitian ini adalah untuk mengetahui pengaruh terapi kombinasi elektroakupunktur dan medikamentosa terhadap SOPK. Uji klinis acak tersamar ganda dengan kontrol dilakukan terhadap 44 subjek dengan SOPK yang dialokasikan secara acak ke dalam kelompok elektroakupunktur sejati dan medikamentosa (n=22), serta kelompok elektroakupunktur sham dan medikamentosa (n=22). Penilaian menggunakan pencitraan USG transvaginal dan perhitungan panjang siklus menstruasi sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan terdapat perbedaan bermakna rerata volume ovarium antara kedua kelompok sebelum dan sesudah perlakuan (p=0,002); penurunan jumlah folikel antral (p=0,005); angka kejadian menstruasi (p=0,001); dan pemendekan siklus menstruasi (p=0,003). Kesimpulan penelitian ini elektroakupunktur dan medikamentosa memberikan perbaikan terhadap keluhan dan gambaran ovarium pada pasien SOPK.

---

Polycystic Ovarian Syndrome (PCOS) is a general endocrinopathy condition that signed with oligoovulation or anovulation cycle, excess androgen production, and an image of multiple small cysts identified by transvaginal ultrasound (Rotterdam criteria, 2004). PCOS found in 10% of reproductive women and highly corresponded with ovulation dysfunction and finally decrease the fertility rate. The goal of this study is to know the effect of electroacupuncture combined with medical treatment in PCOS. A double blind randomized controlled trial is performed in 44 subjects with PCOS and divided into true electroacupuncture combined with medical treatment group (n=22) and sham electroacupuncture combined with medical treatment group (n=22). Ovarian volume and antral follicle are evaluated with transvaginal ultrasound and the length of menstrual cycle is counted before and after the treatment. The results show there are significant mean differences between ovarian volume in two groups before and after treatment (p=0,002); antral follicle count (p=0,005); menstrual incidence during the treatment (p=0,001); and shortened menstrual cycle (p=0,003). The conclusion of this study is electroacupuncture combined with medical treatment could improve PCOS patients’ compaint and ovarian image."

"

Sindrom Ovarium Polikistik (SOPK) merupakan gangguan pada sistem reproduksi wanita yang menjadi penyebab umum terjadinya infertilitas pada usia reproduktif. Etiologi dari SOPK belum diketahui dengan pasti, namun lebih dari 50% wanita SOPK mengalami obesitas. Single Nucleotide Polymorphism (SNP) rs9939609 gen Fat Mass and Obesity Associated (FTO) merupakan kandidat genetik yang dapat memengaruhi perkembangan obesitas dan kerentanan terhadap SOPK. Tujuan dari penelitian ini untuk mengetahui asosiasi SNP rs9939609 gen FTO dengan SOPK. Penelitian ini menggunakan 120 sampel darah dengan masing-masing 30 sampel untuk setiap kelompok, yaitu kelompok wanita normal obesitas, normal non-obesitas, SOPK obesitas, dan SOPK non-obesitas. Metode yang digunakan yaitu amplifikasi sekuens target dengan Polymerase Chain Reaction (PCR), validasi dengan elektroforesis, dan sekuensing dengan menggunakan Automated Sanger. Hasil sekuensing dianalisis menggunakan perangkat lunak Bioedit dan FinchTV. Hasil penelitian ini menunjukkan adanya frekuensi minor alel A sebesar 29,6% serta frekuensi genotipe AA, AT, dan TT secara berurutan sebesar 10%, 39,20%, dan 50,80%. Studi ini juga menunjukkan hasil tidak adanya asosiasi (p>0,05) antara SNP rs9939609 gen FTO dengan sindrom ovarium polikistik.

---

Polycystic Ovarian Syndrome (PCOS) is a female reproductive disorder which is a common cause of infertility at reproductive age. The etiology of PCOS is still unclear, however more than 50% of PCOS women are obese. Single Nucleotide Polymorphism (SNP) rs9939609 Fat Mass and Obesity Associated (FTO) gene is a genetic candidate that can affect the development of obesity and susceptibility to PCOS. This study aims to determine the association of FTO gene SNP rs9939609 with PCOS. Samples in this study was 120 blood samples divided into 30 samples for each group, normal with obesity, normal lean, PCOS with obesity, and PCOS lean. Amplification of target sequences using the PCR method, validation with electrophoresis, and sequencing was carried out using an Automated Sanger. Sequencing results were analyzed with Bioedit and FinchTV software. The results of this study showed that a minor allele A frequency was 29.6% and the genotype frequencies of AA, AT, and TT were 10%, 39.20%, and 50.80%, respectively. This study also showed no association (p>0.05) between SNP rs9939609 with polycystic ovarian syndrome.

 

"