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Ramadianty
Peran riwayat atopi pada keluarga terhadap risiko alergi obat = Family history of atopy as a risk factor of drug allergy
"[ABSTRAK
Tujuan Menganalisis peran riwayat atopi pada keluarga terhadap risiko kejadian alergi obat Metode Penelitian kasus kontrol dengan menggunakan data retrospektif pasien rawat inap dan rawat jalan Divisi Alergi dan Imunologi Departemen Ilmu Kesehatan Anak dan Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit Cipto Mangunkusumo tahun 2012 hingga 2014 yang didiagnosis alergi obat Kelompok kontrol adalah anak yang berdasarkan anamnesis tidak pernah mengalami alergi obat dengan usia dan diagnosis utama yang sama dengan subjek Hasil Sebanyak 29 38 2 dari 76 subjek yang mengalami alergi obat memiliki riwayat atopi pada keluarga dan hanya terjadi pada 16 subjek 21 1 pada kelompok kontrol OR 2 3 IK 95 1 13 4 75 Lima dari 6 kasus 83 3 dengan alergi obat berat sindrom Steven Johson nekrolisis epidermal toksik dan syok anafilaksis memiliki riwayat atopi dalam keluarga Riwayat atopi pada ibu merupakan faktor risiko yang dapat berpengaruh pada kejadian alergi obat OR 2 25 IK 95 1 01 5 087 Jika faktor perancu human imunodeffciency virus sepsis dan keganasan dikeluarkan terdapat 20 dari 46 pasien 43 5 anak dengan alergi obat memiliki riwayat atopi dalam keluarga sehingga masih terdapat hubungan yang bermakna antara riwayat atopi pada keluarga dengan alergi obat walaupun dengan power penelitian yang lebih rendah Subjek yang memiliki penyakit atopi tidak memiliki risiko lebih tinggi terhadap kejadian alergi obat dibandingkan dengan subjek yang tidak memiliki penyakit atopi Simpulan Pada penelitian ini subjek dengan risiko atopi pada keluarga memiliki risiko lebih besar untuk terjadinya alergi obat dibandingkan dengan anak non atopi Subjek dengan riwayat atopi pada ibu memiliki risiko lebih tinggi untuk terjadinya alergi obat dibanding dengan riwayat atopi pada ayah dan saudara kandung Kata kunci alergi obat riwayat atopi keluarga faktor risiko ABSTRACT Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors;Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors;Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors, Objective To analyze the role of atopy in the family in child with drug allergyMethods A case control study using retrospective data of inpatient and outpatient clinic Allergy and Immunology Division at Child Health Departement and Dermatovenereology Departement Control group were children who have never experienced drug allergy matched for age and primary diagnosis with the subjectResults A total of 29 subjects 38 2 of 76 patients with drug allergies have family history of atopy compared to 16 subjects 21 1 in the control group OR 2 3 95 CI 1 13 to 4 75 Five in 6 cases with severe drug allergy Steven Jhonson syndrome necrolysis epidermal toxic and anaphylactic shock had a family history of atopy Mother rsquo s atopy plays more important role OR 2 25 95 CI 1 01 to 5 087 compare to father rsquo s and sibling rsquo s atopy After all of confounding factors human immunodeficiency virus sepsis and malignancy were taken out there were 20 in 46 43 5 pasien with drug allergy have family history of atopy so the corelation between history atopy in family still found but power of study decreased Atopy subject were not in a greater risk of drug allergy compare with non atopy subject Conclusions In this study subject with family history of atopy were at greater risk for drug allergy compared to non atopic children Children with a history of atopy mothers have a higher risk for the occurrence of drug allergy history of atopy compared with the father and sibling Keywords drug allergy atopic family history risk factors]"
Fakultas Kedokteran Universitas Indonesia, 2015
TA-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Anesia Tania
Sebaran obat penyebab dan polimorfisme gen hla-b pada erupsi obat alergik tipe sindrom stevens-johnson dan nekrolisis epidermal toksik : studi pada lima rumah sakit di Jakarta = Causative drugs and hla-b polymorphism in drug induced stevens johnson syndrome and toxic epidermal necrolysis cutaneous : a study in five hospital in Jakarta
"ABSTRAK
Latar belakang: Erupsi obat alergik EOA tipe sindrom Stevens-Johnson dan nekrolisis epidermal toksik SSJ/NET adalah EOA berat yang jarang terjadi namun dapat mengancam nyawa. Tata laksana utama EOA tipe SSJ/NET saat ini adalah menghentikan pajanan obat penyebab. Di beberapa negara Asia, polimorfisme gen HLA-B telah digunakan sebagai metode skrining pada pemberian obat berisiko tinggi. Tujuan: Mengetahui sebaran obat penyebab dan polimorfisme gen HLA-B pada pasien EOA tipe SSJ/NET di Jakarta. Metode: Studi potong lintang ini dilakukan pada bulan April ndash; Juni 2017 di RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, dan RSUD Tarakan. Pemilihan sampel dilakukan secara total sampling pada pasien EOA tipe SSJ/NET di 5 RS tersebut selama 2 tahun. Dilakukan anamnesis dan penentuan obat dengan algoritma ALDEN dan pemeriksaan typing gen HLA-B dengan metode PCR ndash;SSOP. Hasil: Didapatkan 22 subjek dengan median usia 45,5 tahun dan sebagian besar perempuan. Obat penyebab tersering yang ditemukan adalah karbamazepin. Pada subjek, alel HLA-B yang tersering adalah HLA-B 15:02 dan HLA-B 18:01. Alel HLA-B 15:02 ditemukan pada lima 72 dari tujuh SP dengan obat penyebab karbamazepin. Simpulan: Obat penyebab EOA tipe SSJ/NET yang paling sering ditemukan pada SP adalah karbamazepin, dengan 5 dari 7 SP memiliki gen HLA-B 15:02.
ABSTRACT
Background Stevens Johnson syndrome and toxic epidermal necrolysis is a very rare but life threatening type of cutaneous drug eruption. The principle management of SJS TEN is withdrawal of causative drug and preventing reexposure to said drug. In other countries in Asia, spesific HLA B allele has already been utilized as a screening method to prevent SJS TEN. Objective to acquire data regarding causative drugs and HLA B allele polymorphism in SJS TEN patient in Jakarta. Method This cross sectional study was performed in RSCM, RS Persahabatan, RS Fatmawati, RSUD Koja, and RSUD Tarakan from April to June 2017. The sampling method is total sampling of all patient in all five hospital from March 2015 to March 2017. Subject fulfilling the inclusion and exclusion criteria was interviewed and their blood sample was taken for DNA extraction. The DNA was examined with PCR SSOP and Luminex technology for high resolution HLA B typing. Results We studied 22 subjects. The median age was 45,4 years old 14 74 and female gender predominate. The most common causative drug in this study is carbamazepine. HLA B 15 02 and HLA B 18 01 were the most common allele in all subjects. HLA B 15 02 was found in five 72 out of seven subjects whose condition was caused by carbamazepine. Conclusion The most common causative drug of SJS TEN in five hospitals in Jakarta is carbamazepine, with five 72 out seven subjects had HLA B 15 02 allele. "
2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Iris Rengganis
Penatalaksaan alergi obat dan Anafilaksis (artikel Pertemuan llmiah Tahunan llmu Penyakit Dalam 2015)
2015
MK-Pdf
UI - Makalah dan Kertas Kerja  Universitas Indonesia Library
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Dheasandra Nur Azzahra
Pemanfaatan Google Spreadsheet untuk Mendeteksi Kesesuaian Dosis Obat Antibiotik yang Tersedia di Puskesmas Kecamatan Pulogadung Menggunakan Rumus Clark = Utilization of Google Spreadsheet to Detect the Dose Compatibility of Antibiotic Drugs Using Clark Formula
"Saat ini, peresepan antibiotik terhadap pasien anak-anak maupun orang dewasa di Puskesmas Kecamatan Pulogadung terbilang cukup tinggi. Namun, pemastian kesesuaian dosis antibiotik di Puskesmas Kecamatan Pulogadung masih dilakukan secara manual sehingga tidak efisien dari segi tenaga dan waktu. Selain itu, terkadang human error seperti ketidaktelitian menghitung dosis tidak dapat dihindarkan. Tugas khusus ini bertujuan untuk membantu pihak farmasi dalam mengkonfirmasi kesesuaian dosis antibiotik yang telah diresepkan oleh dokter melalui Google Spreadsheet yang dapat diakses secara mudah dan real time sehingga dapat mengefisiensikan waktu dan tenaga, serta meminimalisir terjadinya medication error terhadap pasien Puskesmas Kecamatan Pulogadung. Perhitungan kesesuaian dosis ini dibuat berdasarkan metode Clark serta memanfaatkan beberapa formula pada Google Spreadsheet diantaranya formula VLOOKUP dan IF. Penggunaan Google Spreadsheet ini dapat dilakukan dengan melakukan pengisian tabel yang tertera pada sheet berupa data pasien dan aturan pakai yang tercantum pada resep dokter. Hasil pengecekan otomatis akan menyatakan dosis tersebut sesuai yang ditandai dengan warna hijau yang berarti pemakaian obat perhari kurang dari dosis maksimum dan apabila dosis tidak sesuai maka ditandai dengan warna merah atau pemakaian perhari lebih dari dosis maksimum. Adanya Google spreadsheet cek dosis resep dapat diimplementasikan oleh Puskesmas Kecamatan Pulogadung untuk mengetahui kesesuaian dosis obat racikan yang telah diresepkan sehingga meminimalisir kemungkinan terjadinya medication error.
At present, the prescription of antibiotics for both pediatric and adult patients at the Pulogadung Sub-District Community Health Center is quite high. However, ensuring the appropriateness of antibiotic dosage at the Pulogadung Sub-District Community Health Center is still done manually, which is inefficient in terms of manpower and time. Moreover, human errors such as inaccuracies in dosage calculation are sometimes unavoidable. This specific task aims to assist the pharmacy in confirming the suitability of antibiotic dosages prescribed by doctors through a Google Spreadsheet that can be easily accessed and updated in real-time, thereby optimizing time and effort and minimizing the occurrence of medication errors for patients at the Pulogadung Sub-District Community Health Center. The dosage suitability calculation is based on the Clark method and utilizes several formulas in Google Spreadsheet, including the VLOOKUP and IF formulas. The Google Spreadsheet is used by filling in the table provided on the sheet, containing patient data and the prescribed usage instructions from the doctor's prescription. The automatic checking result will indicate whether the dosage is appropriate, marked with a green color, meaning the daily drug usage is less than the maximum dosage. If the dosage is not appropriate, it will be marked with a red color, indicating daily usage exceeding the maximum dosage. The implementation of this Google Spreadsheet for prescription dosage checks can be adopted by the Pulogadung Sub-District Community Health Center to verify the suitability of prescribed compounded drug dosages, thereby minimizing the possibility of medication errors."
Depok: Fakultas Farmasi Universitas ndonesia, 2022
PR-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Suzy Maria
Faktor yang memengaruhi sensitisasi terhadap alergen hirup dan manifestasi klinis penyakit alergi pada populasi dewasa muda di Indonesia = Factors affecting sensitization to inhalant allergens and clinical manifestation of allergic diseases in Indonesian young adults
"ABSTRAK
Latar Belakang: Atopi yang ditandai dengan sensitisasi (produksi IgE) terhadap alergen merupakan faktor risiko untuk terjadinya penyakit alergi. Karena komposisi genetik cenderung stabil, peningkatan prevalensi penyakit alergi diduga disebabkan oleh faktor lingkungan yang berubah.
Tujuan: Mengetahui faktor yang memengaruhi sensitisasi terhadap alergen hirup dan munculnya manifestasi penyakit alergi pada populasi dewasa muda di Indonesia.
Metode: Penelitian potong lintang dilakukan pada mahasiswa baru Universitas Indonesia tahun 2019. Mahasiswa diminta mengisi kuesioner berisi data demografi, kuesioner International Study of Asthma and Allergies in Childhood (ISAAC), menjalani pemeriksaan fisik dan uji cukil kulit terhadap lima alergen hirup (kecoa, Dermatophagoides farinae, Dermatophagoides pteronyssinus, bulu kucing, epitel anjing). Sensitisasi ditandai dengan terdapat setidaknya satu hasil positif pada uji cukil kulit. Jika terdapat hasil positif pada dua atau lebih alergen, subyek disebut mengalami polisensitisasi. Manifestasi alergi yang dinilai berupa asma, rinitis alergi, dan dermatitis atopi.
Hasil: Proporsi sensitisasi adalah 44,8% (128 dari 286 subyek), sedangkan proporsi manifestasi penyakit alergi adalah 57,7% (165 dari 258 subyek). Manifestasi penyakit alergi didapatkan pada 84 (65,6%) subyek dari subkelompok yang tersensitisasi. Sensitisasi ditemukan lebih banyak pada laki-laki (OR 2,25; IK95% 1,38-3,71; p=0,001) dan subyek yang lahir secara caesar (OR 2,46; IK95% 1,22-5,06; p=0,013), sebaliknya lebih sedikit pada subyek yang berasal dari urban (OR 0,54; IK95% 0,32-0,90; p=0,019). Subyek yang tersensitisasi cenderung untuk memiliki manifestasi penyakit alergi (OR 1,79; IK95% 1,10-2,95; p=0,020). Pada subkelompok yang tersensitisasi, manifestasi penyakit alergi ditemukan lebih banyak pada subyek yang tinggal di urban (OR 2,58; IK95% 1,15-6,01; p=0,024), obese (OR 5,25; IK95% 1,35-34,92; p=0,036), dan mengalami polisensitisasi (OR 2,26; IK95% 1,01-5,10; p=0,046).
Simpulan: Sensitisasi terhadap alergen hirup dipengaruhi oleh jenis kelamin lakilaki, status urban, dan riwayat persalinan caesar. Munculnya manifestasi penyakit alergi dipengaruhi oleh adanya sensitisasi. Pada subkelompok yang tersensitisasi, munculnya manifestasi penyakit alergi dipengaruhi oleh status urban, obesitas, dan polisensitisasi.
ABSTRACT
Background: Atopy marked by allergen sensitization (IgE production) is a risk factor for allergic diseases. Since genetic composition tends to be stable, the increase of allergic diseases prevalence is suspected due to changing environment factors.
Purpose: To identify the factors affecting sensitization to inhalant allergen and allergic diseases manifestation in Indonesian young adults.
Methods: Cross-sectional study done on Universitas Indonesia 2019 new students. Students were asked to fill in a demographic questionnaire, an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, undergo physical examination and skin prick tests for five inhalant allergens (cockroach, Dermatophagoides farinae, Dermatophagoides pteronyssinus, cat hair, dog epithelium). Sensitization was marked by at least one positive result on the skin prick test. If there were two or more positive allergen results, subject was deemed as being polysensitized. Evaluated allergic manifestations were asthma, allergic rhinitis, dan atopic dermatitis.
Result: Sensitization was found in 44.8% (128 out of 286 subjects), while allergic diseases clinical manifestation was found in 57.7% (165 out of 258 subjects). The manifestation was found in 84 (65.6%) subjects from the sensitized subgroup. Sensitization was found more on male (OR 2.25; 95%CI 1.38-3.71; p=0.001) and subjects born by caesarean section (OR 2.46; 95%CI 1.22-5.06; p=0.013), whereas fewer on subjects from urban (OR 0.54; 95%CI 0.32-0.90; p=0.019). Sensitized subjects tended to demonstrate allergic diseases manifestation (OR 1.79; 95%CI 1.10-2.95; p=0.020). In the sensitized subgroup, allergic diseases manifestation was found more on subjects living in urban (OR 2.58; 95%CI 1.15-6.01; p=0.024), are obese (OR 5.25; 95%CI 1.35-34.92; p=0.036), and are polysensitized (OR 2.26;
95%CI 1.01-5.10; p=0.046).
Conclusion: Sensitization to inhalant allergens was affected by male sex, urbanstatus, and caesarean section birth. Allergic diseases manifestation was affected by presence of sensitization. In the sensitized subgroup, allergic diseases manifestation was affected by urban status, obesity, and polysensitization."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
T55537
UI - Tesis Membership  Universitas Indonesia Library
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Takumansang, Raynald Oktafianus
Sensitisasi alergen pada anak dengan penyakit alergi di RS Prof. dr. R. D. Kandou Manado = Allergen sensitization in children with allergic diseases in Prof. dr. R. D. Kandou hospital Manado
"Background The prevalence of allergic disease to be increasing across the world. More than 20 of the population worldwide suffer from diseases which mediated by immunoglobulin E, such as asthma, rhinoconjunctivitis, atopic dermatitis or eczema. There is no data about allergen sensitization of allergic disease in Manado.
Objective The purpose of this study is to know the allergen sensitization in children with allergic diseases atopic dermatitis, allergic rhinitis, asthma . Children were divided into group less than and more than or equal to 3 years old, which was evidenced by skin prick test or IgE Atopy test in Prof. Dr. R.D. Kandou Hospital Manado.
Methods This study was a descriptive cross sectional study, conducted from June until August 2016.
Results A total of 95 children were included in the study, of which 77 children were ge 3 years old and 18 children were 3 years old. Seventy five children underwent skin prick test and 20 children underwent IgEAtopy test. In 3 years old children, there were 14 children diagnosed with atopic dermatitis and 4 children diagnosed with atopic dermatitis and asthma. In ge 3 years old children, the most common diagnosis was allergic rhinitis, as many as 21 children. Allergen sensitization found in 3 years old children with atopic dermatitis and atopic dermatitis asthma was cow rsquo s milk, house dust mites and egg white. Sensitization to house dust mites most commonly found in patients with atopic dermatitis. The most common allergen sensitization in ge 3 years old children was house dust mites, egg white, potatoes, dog fur, cow 39 s milk, wheat flour and soya formula.
Conclusion The most common allergen sensitization in 3 years old children with atopic dermatitis is cow 39 s milk, while in children with asthma and atopic dermatitis is house dust mites, whereas in ge 3 years old children with atopic dermatitis, allergic rhinitis, asthma, or combination of the disease is house dust mites."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
T55684
UI - Tugas Akhir  Universitas Indonesia Library
cover
Hardini Tri Indarti
Analisis riwayat alergi antibiotik terhadap kejadian penyakit lupus eritematosus sistemik di RSUP dr Hasan Sadikin Kota Bandung = Analysis of antibiotics allergy as risk factors of systemic lupus erythematosus in dr Hasan Sadikin Hospital Bandung / Hardini Tri Indarti
"ABSTRAK
Lupus Eritematosus Sistemik (LES) merupakan penyakit autoimun yang
mengakibatkan peradangan di banyak organ. Prevalensi LES terus meningkat dan
angka mortalitasnya pun tinggi. Etiologi LES sampai saat ini belum diketahui
secara pasti. Namun, beberapa faktor risiko yang diduga dapat mempengaruhi
kejadian LES. Salah satunya adalah riwayat alergi obat, terutama antibiotik.
Penelitian ini bertujuan untuk mengetahui hubungan riwayat alergi antibiotik
dengan kejadian LES setelah dikontrol oleh variabel kovariat berupa riwayat
keluarga menderita LES, riwayat menderita penyakit autoimun lain, usia
menarche, dan perilaku merokok di RSUP Dr. Hasan Sadikin Kota Bandung.
Penelitian ini dilakukan bulan April-Juli 2014 dengan menggunakan desain kasus
kontrol. Kasus adalah pasien LES wanita yang berobat ke Poli Rematologi RSUP
Dr. Hasan Sadikin Kota Bandung. Kontrol merupakan pasien wanita yang berobat
ke Poli Penyakit Dalam dengan dilakukan individual matching dengan kasus pada
usia (rentang 3 tahun), dan asal daerah. Data dianalisis dengan analisis univariat,
bivariat, dan multivariat dengan uji regresi logistik conditional. Hasil penelitian
menunjukkan bahwa riwayat alergi antibiotik cenderung meningkatkan risiko
kejadian LES sebesar 2,34 kali (OR=2,34, 95% CI 0,66-8,22) setelah dikontrol
oleh riwayat keluarga LES, riwayat autoimun, dan perilaku merokok. Untuk kelas
antibiotik penisilin/sefalosporin, risiko meningkat menjadi 2,75 kali (OR=2,75,
95% CI 0,65-11,59).
ABSTRACT
Systemic Lupus Erythematosus ( SLE ) is an autoimmune disease that results in
inflammation in many organs. The prevalenceof SLE is increasing and the
mortality rate was high. Etiology of SLE has not known. However , several risk
factors could be expected to affect the incidence of SLE . One of them is a history
of drug allergies, especially antibiotics. This study aimed to determine the
relationship between antibiotic allergy history and SLE after controlled by family
history,other autoimmune disease, age of menarche, and smoking behavior in Dr.
Hasan Sadikin Hospital Bandung. This study was conducted from April to July
2014 using case-control design. Cases were women SLE patients who went to
Rheumatology Department Dr. Hasan Sadikin Hospital Bandung. Control were a
female patient who went to Internist Department with individually matched at the
age ( 3 years range ), and region. Data were analyzed with univariate, bivariate ,
and multivariate conditional logistic regression. The results showed that a history
of antibiotic allergy tends to increase the incidence of SLE for 2.34 times ( OR =
2.34 , 95 % CI 0.66 to 8.22 ) after controlled by SLE family history, history of
autoimmune, and smoking behavior. For the class of penicillin/cephalosporin, the
risk increased to 2.75 times ( OR = 2.75 , 95 % CI 0.65 to 11.59) ."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2014
T43364
UI - Tesis Membership  Universitas Indonesia Library
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Igor Ian Wiguna
Asosiasi antara status merokok orang tua dan beberapa faktor lain dengan reaksi alergi pada anak dibawah 5 Tahun di Jakarta = The association between parental smoking status and several other factors with allergic reactions in children under-five years old in Jakarta
"Pendahuluan: Alergi merupakan suatu kondisi yang sangat sering ditemukan pada anak-anak dan dapat mempengaruhi kondisi fisik serta sosial dari mereka yang terkena. Ada banyak faktor yang diduga dapat memengaruhi reaksi alergi pada anak-anak seperti, status merokok orang tua, konsumsi air susu ibu, metode melahirkan, dan lain-lain. Penelitian ini bertujuan untuk melihat hubungan antara berbagai faktor dari alergi dengan kejadian reaksi alergi pada anak dibawah lima tahun di Jakarta.
Metode: Penelitian ini menggunakan desain potong lintang dengan subjek terdiri atas ayah dan atau ibu beserta dengan anaknya. Sebanyak 120 subjek ikut dalam penelitian ini. Pemilihan subjek penelitian dilakukan secara acak di berbagai puskesmas di Jakarta. Penelitian ini menggunakan kuesioner yang dibuat berdasarkan UK’s diagnostic criteria of atopic dermatitis dan pedoman dari Kaiser Foundation Health Plan of Washington untuk menilai reaksi alergi pada anak. Pengisian kuesioner dilakukan oleh ibu atau ayah. Analisa data akan dilakukan dengan uji deskriptif chi-square dan regresi logistik multivariat menggunakan IBM SPSS versi 24.
Hasil: Hubungan yang signifikan terhadap alergi menurut uji chi-square ditemukan pada beberapa faktor seperti, konsumsi ASI dan status merokok ayah (p < 0,05). Hasil dari uji regresi logistik multivariat menunjukan bahwa faktor yang paling berperan dalam mengakibatkan reaksi alergi adalah durasi dari konsumsi ASI dan metode melahirkan (p<0,05).
Kesimpulan: Faktor risiko yang berperan mengakibatkan reaksi alergi pada anak di bawah lima tahun adalah durasi konsumsi ASI, metode kelahiran, status merokok ayah dan konsumsi ASI. Faktor yang paling berperan mengakibatkan reaksi alergi pada anak di bawah lima tahun adalah durasi konsumsi ASI dan metode kelahiran.
Introduction: Allergy is a condition that is very often found in children and could affect their physical and social condition. There are a lot of factors suspected to affect allergic reactions in children such as, parental smoking status, breastmilk consumption, mode of delivery, and etc. This research aims to see the association between several factors of allergy and the occurrence of allergic reaction in children-under five years old in Jakarta.
Methods: This research used cross-sectional design with the subject consist of father and or mother as well as their children. A group of 120 subjects participated in this research. The selection of the research subjects was done randomly in several health centers in Jakarta. This research used questionnaire that is structured based on UK’s diagnostic criteria of atopic dermatitis and principles from Kaiser Foundation Health Plan of Washington to assess allergic reactions in children. The filling of the questionnaire was done by father or mother. The data analysis was done using descriptive analysis chi-square and multivariate logistic regression using IBM SPSS version 24.
Results: Significance association towards allergy based on chi-square test was found in several factors such as, breastmilk consumption and father smoking status (p<0,05). The result of multivariate logistic regression test shows that the factor that affect the most in causing allergic reactions are duration of breastmilk consumption and mode of delivery.
Conclusion: The main factors that causes allergic reactions in children under-five years old from this research are duration of breastfeeding and mode of delivery. However, other than duration of breastfeeding and mode of delivery, father’s smoking status and breastfeeding were also found as risk factors of allergic reactions."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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Prasna Pramita
Faktor-faktor yang berpengaruh terhadap Cutaneous Adverse Drug Reaction (CADR) pada penggunaan Obat Anti Tuberkulosis (OAT) = Cutaneous Adverse Drug Reaction (CADR) due to anti tuberculosis drugs and its influencing factors
"Latar Belakang: Cutaneous Adverse Drug Reaction (CADR) dapat memengaruhi tatalaksana infeksi TB. Hal ini berdampak pada bukan hanya morbiditas dan mortalitas tapi juga resistensi kuman. Untuk itu, proporsi CADR dan faktor-faktor yang berhubungan pada penggunaan Obat Anti Tuberkulosis (OAT) perlu ditentukan demi tatalaksana pasien yang komprehensif.
Tujuan: Mengetahui gambaran kejadian CADR terkait pemberian OAT dalam bentuk proporsi, analisis peran faktor pejamu yang berkaitan dengan kejadian tersebut, dan OAT yang paling sering menimbulkan CADR. Metode: Desain penelitian ini adalah kohort retrospektif dengan menggunakan rekam medik pasien Rumah Sakit Cipto Mangunkusumo selama 1 Januari 2014
hingga 30 Juni 2015. Sampel diperoleh dengan metode konsekutif yang diseleksi berdasarkan kriteria penelitian. Data kemudian dianalisis untuk menilai hubungan antara CADR dengan usia, jenis kelamin, status HIV, status gizi, dan riwayatmlkojuujhjh Adverse Drug Reaction (ADR). Hasil: Proporsi CADR pada pemberian OAT mencapai angka 5,5%. Dari kelima variabel independen, variabel usia (RR=6,510; IK95% 2,036-20,819 p=0,008) dan riwayat ADR (RR=5,174; IK95% 1,500-17,838; p=0,009) berpengaruh terhadap kejadian CADR. OAT yang paling sering menyebabkan kejadian CADR adalah
rifampisin. Analisis Cochran Mantel-Haenszel menunjukkan bahwa risiko relatif terjadinya CADR untuk faktor usia adalah 7,267 (IK95% 2,093-25,235 p <0,001) dan risiko relatif terjadinya CADR untuk faktor riwayat ADR adalah 5,880 (IK95% 1,552-22,273 p=0,003). Simpulan: Proporsi kejadian CADR setelah pemberian OAT adalah 5,5%. Variabel usia dan riwayat ADR bermakna secara statistik dan klinis terhadap kejadian CADR. Rifampisin adalah OAT tersering yang menimbulkan CADR.
Background: Cutaneous Adverse Drug Reaction (CADR) affected the therapy of TB, which impacted not only its morbidity and mortality but also its resistance. Therefore, the incidence of CADR and the factors associated during the
administration of Anti Tuberculosis Drugs (ATDs) needed to be determined in order to achieve comprehensive treatment.
Objective: To know CADR events on ATD administration by finding the incidence, analyzing the host factors associated with those events, and searching the most common ATD that caused CADR. Methods: This study used retrospective cohort by accessing medical record registered in Cipto Mangunkusumo Hospital from January 1st 2014 until June 30th 2015. Samples were collected consecutively, selected by certain criteria. The data were then analyzed to determine the association between CADR and age, sex, HIV infection, nutritional status, and history of Adverse Drug Reaction (ADR). Results: The incidence of CADR after the administration of ATD was 5.5%. Among the five variables, age (RR=6.510; 95%CI 2.036-20.819, p=0.008) and past history of ADR (RR=5.174; 95%CI 1.500-17.838; p=0.009) were statistically and clinically correlated to CADR. The most frequent drug that triggered CADR was rifampicin. Cochran Mantel-Haenszel showed that the relative risk of CADR according to age was 7,267 (IK95% 2,093-25,235 p <0,001), while the relative
risk according to the past history of ADR was 5,880 (IK95% 1,552-22,273 p=0,003). Conclusions: The incidence of CADR after ATDs administration was 5.5%. Age and past history of ADR were significantly associated with CADR. The most common ATD causing CADR was rifampicin."
Depok: Fakultas Kedokteran Universitas Indonesia, 2016
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UI - Tesis Membership  Universitas Indonesia Library
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Indah Dewi Lestari
Praktik Kerja di Puskesmas Kecamatan Pulogadung Periode 17 - 28 Oktober 2022, Pemanfaatan Google Spreadsheet untuk Mendeteksi Kesesuaian Dosis Obat Antialergi yang Tersedia di Puskesmas Kecamatan Pulogadung Menggunakan Rumus Clark = Work Practice at The Pulogadung Sub-district Health Center on The Period 17 - 28 October 2022, Utilization of Google Spreadsheet to Detect Appropriate of Antiallergic Drug Doses in Puskesmas Kecamatan Pulogadung Using Clark Formula
"Obat antialergi merupakan salah satu obat yang paling banyak diresepkan di Puskesmas Kecamatan Pulogadung. Klorfeniramin maleat adalah obat antialergi yang menempati urutan kedua obat paling banyak diresepkan di puskesmas tersebut dengan penggunaan selama bulan Oktober 2022 sebanyak 19.003 peresepan. Tingginya jumlah penggunaan obat tersebut perlu menjadi perhatian agar tidak terjadi permasalahan terkait obat (DRPs), seperti ketidaktepatan dosis resep. Penelitian ini bertujuan untuk memanfaatkan Google Spreadsheet sebagai sarana pendeteksi kesesuaian dosis pada obat antialergi pada resep sehingga proses pelayanan resep dapat lebih efisien dan meminimalisir terjadinya DRP. Penyesuaian dosis racikan menggunakan sistem ini dilakukan berdasarkan pedoman dosis yang berlaku serta menggunakan rumus Clark untuk pasien anak. Hasilnya, sistem yang berbasis Google Spreadsheet ini dapat digunakan sebagai sarana penyesuaian dosis obat racikan di Puskesmas Kecamatan Pulogadung dengan lebih efektif dan efisien.
Anti-allergy drugs are one of the most prescribed drugs at Pulogadung District Health Center. Chlorpheniramine Maleate is an antiallergic drug that ranks as the second most prescribed drug at Pulogadung District Health Center prescribed 19,003 prescriptions on October 2022. The high amount of this drug use must be a concern so that drug-related problems (DRPs) do not occur, such as inaccurate prescription dosages. This study aims to utilize Google Spreadsheet to detect the suitability of dosages for anti-allergic drugs on prescriptions so that the prescription service process can be more efficient and minimize the occurrence of DRP. Adjustments to the dosage of concoctions using this system are based on the applicable dosage guidelines and use the Clark formula for pediatric patients. As a result, this Google Spreadsheet-based system can be used as a means of adjusting the dosage of concoction drugs at the Pulogadung District Health Center more effectively and efficiently."
Depok: Fakultas Farmasi Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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