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"Pendahuluan: Perkembangan kota Tangerang menyebabkan perkembangan lalu lintas di jalan raya. Perkembangan jumlah kendaraan meningkatkan pajanan polusi udara seperti debu, asap dan zat polutan lain hasil pembakaran mesin kendaraan berpengaruh terhadap faal paru orang-orang yang berada di jalanan terutama pada polisi lalulintas yang sedang bekerja. Penelitian ini dilakukan untuk menilai pajanan zat polutan terhadap nilai faal paru seseorang. Penelitian ini menilai usia, Indeks Massa Tubuh (IMT), nilai faal paru, kebiasaan merokok, masa tugas, dan pemakaian masker pelindung. Metode: Dilakukan survei pada 112 anggota polisi lalu lintas yang bertugas di lapangan. Nilai faal paru di dapatkan dengan spirometri, kadar CO dengan CO meter, pemeriksaan fisis, foto toraks dan wawancara kuesioner. Indeks pencemaran dengan survei kualitas udara.Hasil : Penurunan faal paru pada 17% polisi lalu lintas. Penurunan nilai faal paru ini meliputi restriksi ringan 13% dan obtruksi ringan 4%. Seluruh foto toraks normal. Delapan puluh satu persen polisi mempunyai berat badan lebih atau obese, 60,7% perokok aktif dan 63 persen mempunyai kebiasaan penggunaan masker yang buruk. Kesimpulan: Kelompok umur mempunyai hubungan yang bermakna terhadap faal paru polisi lalu lintas. Tidak ada hubungan yang bermakna antara kebiasaan merokok, pemakaian masker , kadar CO dan gangguan faal paru.

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Introduction: The city of Tangerang has develop into big city. The government has built a new street to anticipating the raising amount of the vehicle.The street became busy street. The fumes, chemical and particles present in the emission are reported to be damaging of these people especially traffic policemen. Since there were no data available on the pulmonary fuction test (PFT) of Traffic Police personel in Tangerang, this study was taken up to assess the effect of air pollution to the PFT. The measurement were recorded in age, body weight, height, Forced Vital Capacity, Forced Expiratory Volume in first second, gender, smoking habit, Body Mass Index (BMI), year of duty, chest x ray and mask.

Method: We evaluated 112 traffic police personel.Subject of this study were interviewed to identify the clinical sign. Physical examination, pulmonary function test, chest x ray, measurement CO level by using CO smoker analyzer and air pollutant level were done. Result: Nineteen from 112 police personel have decrease of PFT. Fourteen (13%) police was indicated mild restriction to the lung expansion and 5 (4%) police mild obstruction. Total Suspended Particle (TSP) was 478,8 ug/Nm3 higher than normal limit 230 ug/Nm3. Weight and height were measure to calculate the Body Mass Index (BMI), we found that most of police personel have overweight and obese. Sixty percent of police were active smoker. All of the X ray in normal limit.

Conclusion: There was decrease in PFT in 19% of police personel. These indicate mild restriction and mild obstruction. There are significant correlation between age and PFT. There was no significant correlation between smoking habit, protection mask, CO level, level of air pollution, year of duty and pulmonary function test."

"ABSTRAKUntuk mengetahui hubungan antara variabel demografi, geografi, iklim, sosial ekonomi, fasilitas pelayanan kesehatan mikroskopis dan tenaga kesehatan terlatih dengan jumlah kasus TB paru BTA positif, perlu dilakukan penelitian di Jakarta Selatan tahun 2007-2009 dengan studi ekologi melalui pendekatan spasial dan menggunakan data sekunder. Data diolah secara statistik dengan uji korelasi Pearson, dan analisis spasial dengan tehnik Overlay. Hasil penelitian menunjukkan secara statistik tidak ada korelasi antara variabel yang diteliti, sedangkan secara spasial variabel kepadatan penduduk, keluarga miskin dan fasilitas pelayanan kesehatan mikroskopis berpengaruh terhadap jumlah kasus TB paru BTA positif di Kecamatan Tebet, dan di kecamatan lain variabel tidak berpengaruh.

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ABSTRACT

To determine the relationship between demographic variables, geography, climate, socio-economic, microscopic health facilities and health personnel trained with the number of BTA positive pulmonary TB cases, need to do research in South Jakarta in 2007-2009 with a spatial approach to ecological studies and to use secondary data. Data was statistically analyzed by Pearson correlation test, and spatial analysis techniques Overlay. The results showed no statistically significant correlation between the variables studied, whereas the spatially variable population density, poor families and microscopic health facilities effect on the number of BTA positive pulmonary TB cases in the District of Tebet, and in other districts did not influence the variables."

"Penyakit TB masih merupakan masalah kesehatan kesehatan masyarakat yang penting di Indonesia. Upaya diagnostik TB paru masih terus ditingkatkan. Pemeriksaan penunjang diagnosis TB yang sekarang digunakan masih mempunyai sensitiviti dan spesitiviti yang rendah. Tujuan penelitian mengetahui tingkat akurasi uji tuberkulin dan PCR terhadap penegakkan diagnosis TB serta hubungan uji tuberkulin dan PCR dengan BTA mikroskopis dan biakan M. Tb dalam diagnosis TB paru.Metode penelitian cross-sectional, uji diagnostik dan analisa data menggunakan Chi-Square. Kriteria inklusi penderita terdapat gejala klinik riwayat batuk 3 minggu disertai atau tanpa batuk darah, nyeri dada, sesak napas dan riwayat minum obat TB dalam jangka waktu kurang dari 1 bulan serta bukan TB (kontrol). Seluruh sampel dilakukan anamnesis, pemeriksaan fisik, lekosit, LEDI/II, foto toraks, uji tuberkulin, PCR, BTA mikroskopis 3X dan biakan M. Tb mctode kudoh. Baku emas yang digunakan biakan M. Tb metode kudoh. Data diolah menggunakan SPSS versi 11.00.Berdasar 127 sampel masuk kriteria inklusi 121. Sampel berjumlah 121 terdiri dari 61 sampel tersangka TB dan 60 sampel kontrol Sensitiviti dan spesivisiti uji tuberkulin terhadap biakakn metode Kudah menggunakan cut-off point 15,8 mm 33% dan 93%. Sensitiviti PCR terhadap biakab metode Kudoh 100%, spesitiviti PCR 78%. Didapatkan perbedaan bermakna dan hubungan lemah uji tuberkulin dengan biakan M. Tb dan PCR serta didapatkan perbedaan dan hubungan bermakna PCR dengan BTA mikroskopis biakan M. Tb.Kesimpulan basil keseluruhan penelitian mendapatkan basil 39 sampel biakan positif, 36 sampel BTA mikroskopis positif, 57 sampel PCR positif dan 18 sampel uji tuberkulin positif. Ditemukan sensitiviti basil uji tuberkulin lebih rendah daripada PCR, BTA mikroskopis dan biakan M. Tb mctode Kudoh. Meskipun terdapat perbedaan bermakna basil uji tuberkulin pada biakan positif clan negatif, BTA mikroskopis positif dan negatif, serta PCR positif dan negatif, akan tetapi uji tuberkulin (menggunakan cut-off point 15.8 mm) kurang dapat membantu penegakan diagnosis TB para. Berdasarkan hasil penelitian ditemukan bahwa diantara keempat pemeriksaan penunjang diagnosis TB paru PCR mempunyai nilai sensitivit dan spesitiviti tinggi ( 100% dan 78%). sehingga PCR dapat digunakan sebagai pemeriksaan penunjang diagnosis TB paru apabila didapatkan klinis dan radiology mendukung TB paru. Menggunkan pemeriksaan PCR akan didapatkan metode penegakan diagnosis TB paru yang cepat ( 1 hari ) dibandingkan dengan menunggu hasil biakan M. Tb hingga 8 minggu.

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Objective. In an attempt diagnosis pulmonary tuberculosis still increased continuously. Now additional examination pulmonary tuberculosis have been lack sufficient sensitivity and sensitivities. The aim of this study was to determine the validity of tuberculin skin testing (TST) and PCR toward assessment diagnosis pulmonary of tuberculosis with correlation between tuberculin skin testing to PCR with AFB microscopic and solid media culture of M. tuberculosis for the diagnosis of pulmonary tuberculosis.

Method. A cross-sectional study, diagnostic test and analysis with Chi-Square test. Inclusion criteria patient with pulmonary symptom include chronic cough 3 weeks with or without hemoptysis, chest pain, breathlessness and past history of ATA less than 1 month with non-tuberculosis patient (control). The general samples was examination Ro thorax, tuberculin skin testing, PCR, AFB microscopic and conventional culture. The golden standard is conventional culture test using Kudoh method. Analyze of the data with SPSS version 11.0.

Result. The study material comprised 121 samples from 127 samples. These samples include 61 samples from patient with probably active pulmonary tuberculosis and 60 control comprising healthy individuals. The sensitivity and specificity of tuberculin skin testing with cut-off point 15.8 mm greater was 33% and 93% on conventional culture test using Kudoh method. PCR sensitivity was 100% and spesitivity was 78%. It was showed the positivity correlation between pulmonary tuberculosis and conventional culture as well as PCR and AFB microscopic, the conventional culture test.

Conclusion. The sensitivity of tuberculin skin testing less than PCR, AFB microscopic and conventional culture test. So that not enough to assessment diagnosis pulmonary tuberculosis. The sensitivity and specificity PCR was I00% and 78%. With the use of PCR test, we were able to detect diagnosis pulmonary tuberculosis more rapidly in less than I day, compared to average 8 week required for detection by conventional culture."

"Latar belakang: Pneumonia rumah sakit adalah infeksi paru yang didiagnosis setelah rawat >48 jam setelah masuk rawat dan tanpa adanya tanda infeksi paru pada saat awal perawatan atau pneumonia yang didiagnosis pada saat awal masuk perawatan dengan riwayat perawatan di rumah sakit sebelumnya dengan jarak antar rawat inap 10-14 hari. Pneumonia rumah sakit merupakan salah satu infeksi nosokomial yang sering terjadi pada perawatan pasien anak di rumah sakit. Kasus pneumonia rumah sakit dapat berakibat meningkatkan angka kesakitan dan kematian, memperpanjang lama rawat inap serta biaya yang dikeluarkan. Tujuan: mengetahui karakteristik dan proporsi mortalitas pneumonia rumah sakit pada anak. Metode: Studi kohort retrospektif dilakukan terhadap subyek usia >1 bulan dan ≤18 tahun di RSCM selama 2015-2018 melalui telusur rekam medis. Hasil: Sebanyak 86 subyek didapatkan dengan karakteristik subyek dengan pneumonia rumah sakit terbanyak pada penelitian ini adalah usia 1-24 bulan, memiliki lebih dari satu komorbiditas status nutrisi gizi baik dan memiliki awitan lambat. Simpulan: Subyek dengan pneumonia rumah sakit terbanyak pada penelitian ini mempunyai karakteristik usia 1-24 bulan, memiliki lebih dari satu komorbiditas, status nutrisi gizi baik, memiliki lama rawat 8-14 hari, dan berawitan lambat. Proporsi mortalitas subyek dengan pneumonia rumah sakit pada penelitian ini sebesar 24,4%. Karakteristik mortalitas juga dapat dipengaruhi oleh status nutrisi yaitu gizi buruk, kelompok usia, jenis komorbiditas, lama rawat dan jenis awitan.

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Background: Hospital-acquired pneumonia (HAP) is defined as a pulmonary infection that occurs >48 hours after admission to hospital or within 10-14 days after discharge. It is the most common hospital-acquired infection in children. Its occurrence represents increase hospital stay, additional cost, morbidity and mortality. Objective: To investigate the characteristic and mortality of hospital-acquired pneumonia in children Methods: It is a retrospective cohort study involving 86 subjects through medical records, inclusive to >1 months old - ≤18 years old patients, in RSCM Jakarta within 2015-2018. Results: There are 86 subjects with characteristic of HAP in this study are age 1-24 months old, has more than one comorbidity, good nutritional status and late onset. Conclusion: General characteristic of HAP in this study are, age 1-24 months old, has more than one comorbidity, good nutritional status, length of stay 8-14 days and late onset. The mortality proportion of HAP in this study is 24.4%. The mortality characteristic was influenced by nutritional status (severe malnutrition), comorbidities, age, length of hospital stay and onset of the disease. "

"Pendahuluan: Tuberkulosis (TB) adalah penyebab utama kematian akibat infeksi di dunia. Sejak tahun 2008 - 2017 terdapat penurunan angka keberhasilan pengobatan TB di Indonesia (< 90%). Rekomendasi pengobatan TB di Indonesia adalah paduan obat antituberkulosis (OAT) dosis berselang sebagian (2RHZE/4R3H3) atau harian (2RHZE/4RH). Menurut WHO, paduan OAT RHZE/R3H3 mempunyai angka kegagalan dan kekambuhan yang lebih tinggi. Namun, penelitian meta-analisis RCT menyatakan bahwa kedua paduan OAT mempunyai angka kegagalan dan kekambuhan yang sama. Oleh karena itu, dilakukan penelitian untuk membandingkan hasil pengobatan dan efek samping antara paduan OAT 2RHZE/2RH dengan 2RHZE/4R3H3.Metode: Penelitian ini merupakan studi analitik observasional dengan desain cross sectional yang membandingkan hasil pengobatan dan efek samping antara paduan OAT 2RHZE/4RH dengan 2RHZE/4R3H3 pada pasien TB paru kategori I di RSUP Persahabatan periode Januari 2015 sampai Juni 2018. Data sekunder diambil dari rekam medik. Hasil pengobatan dinilai sesuai definisi dalam pedoman nasional penanggulangan TB di Indonesia dan WHO. Efek samping dinilai dari seluruh efek samping terkait OAT yang tercatat dalam rekam medik.Hasil: Terdapat 175 pasien pada masing-masing kelompok. Pada kelompok paduan OAT 2RHZE/4RH terdapat 89.1% pasien berhasil, 13.1% sembuh,76.0% pengobatan lengkap, 10.6% putus berobat, 0.6% gagal, dan tidak ada yang meninggal. Pada kelompok paduan OAT 2RHZE/4R3H3 terdapat 91.4% pasien berhasil, 39.4% sembuh, 52.0% lengkap, 8% putus berobat, tidak ada yang gagal, dan 0.6% meninggal. Tidak ada perbedaan bermakna untuk keberhasilan pengobatan (p=0.470, OR=1.299, IK95%;0.637-2.648), putus berobat (p=0.659 ,OR=0.758, IK95%;0.365-1.577), gagal (p=1.000), dan meninggal (p=1.000) di antara kedua kelompok. Namun, terdapat perbedaan bermakna untuk kesembuhan (p=0.003, OR=2.358, IK95%;1.375-5.206) dan pengobatan lengkap (p=<0.001, OR=0.342, IK95%;0.217-0.540). Sebagian besar pasien mengalami efek samping pengobatan (51.1%) terutama di tahap intensif (73.2%). Pada tahap lanjutan tidak ada perbedaan bermakna kejadian efek samping antara kedua kelompok (p= 0.324, OR=1.386, IK95%; 0.723-2.657).Kesimpulan: Kesembuhan kelompok paduan OAT 2RHZE/4R3H3 lebih baik daripada 2RHZE/4RH, sedangkan pengobatan lengkap sebaliknya. Tidak ada perbedaan bermakna untuk keberhasilan pengobatan, putus berobat, kegagalan, meninggal, dan kejadian efek samping pada tahap lanjutan di antara kedua kelompok.

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Introduction: Tuberculosis (TB) is the main cause of death for infectious disease in the world. Since 2008 - 2017, there was a decline of TB success rate (< 90%) in Indonesia. Treatment of TB in Indonesia are using antituberculosis drugs with part daily dose combination (2RHZE/4R3H3) or daily dose combination (2RHZE/4RH). WHO concluded that 2RHZE/4R3H3 combination had higher failure and recurrence rate. However, a meta-analysis study showed that both combinations had same failure and recurrence rate. Therefore, this study is conducted to compare treatment outcomes and adverse effects between 2RHZE/4RH combination and 2RHZE/4R3H3 combination.

Method: This was an observational analytic study with cross sectional design which compared treatment outcomes and adverse effects between 2RHZE/4RH combination and 2RHZE/4R3H3 combination in pulmonary tuberculosis patient at RSUP Persahabatan period January 2015 until June 2018. Secondary data was taken from medical record. Treatment outcomes were assessed using definition in Indonesia National Guideline of TB and WHO. Adverse effects were assessed from all adverse effects that written in medical record.

Result: There are 175 patients in each group. In 2RHZE/4RH combination group, there were 89.1% patients succeed, 13.1% cured, 76.0% completed treatment, 10.6% lost to follow up, 0.6% failed and no one died. In 2RHZE/4R3H3 combination group, there were 91.4% patients succeed, 39.4% cured, 52.0% completed treatment, 8% lost to follow up, no one failed, and 0.6% died. There was no significant difference for success (p=0.470, OR=1.299, IK95%;0.637-2.648), loss to follow up (p=0.659, OR=0.758, IK95%;0.365-1.577), failure (p=1.000), and death rate (p=1.000) between two groups. However, there was a significant difference for cure (p=0.003, OR=2.358, IK95%;1.375-5.206) and complete treatment rate (p=<0.001, OR=0.342, IK95%;0.217-0.540) between two groups. Most patients had adverse effects (51,5%), especially in intensive phase (73,2%). In continuation phase, there was no significant difference of adverse effects event between two groups (p = 0.324, OR= 1.386, IK95%; 0.723-2.657).

Conclusion: Cure rate was better in 2RHZE/4R3H3 group than 2RHZE/4RH group, for completed treatment on the contrary. There was no significant difference for success rate, loss to follow up rate, failure rate, death rate, and adverse effects event in continuation phase between two groups."

"ABSTRAKTujuan penelitian ini adalah mengetahui kadar 1,25-dihydroxyvitamin D serumdan hubungannya dengan interferon gamma, cathelicidin dan bacterial load padapenderita TB paru BTA positif serta hubungan cathelicidin dengan bacterial load.Rerata kadar IFN-γ adalah 10,8 ± 6,5 pg/mL, rerata kadar 1,25(OH)2D serumadalah 121,5 ± 38,6 pmol/L dan rerata kada cathelicidin plasma adalan 90,4 ±21,5 ng/mL. Pada penelitian ini tidak didapatkan hubungan kadar 1,25(OH)2Dserum dengan IFN-γ serum begitu juga dengan cathelicidin plasma. Kadarcathelicidin plasma tidak berhubungan bermakna dengan bacterial load. Reratakadar IFN-γ serum dan cathelicidin plasma pada lesi kavitas lebih rendah daripadalesi tanpa kavitas (masing-masing p = 0,031 dan p = 0,025). Rerata kadarcathelicidin plasma subjek dengan riwayat pengobatan TB sebelumnya lebihrendah daripada subjek kelompok kasus baru (p = 0,004). Pada penelitian inididapatkan juga hubungan bermakna kekuatan sedang antara kadar IFN-γ serumdengan cathelicidin plasma (r = 0,540; p < 0,05).

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ABSTRACTThe aim of study was to investigate levels of 1,25-dihydroxyvitamin D and itsrelationshio with IFN-γ or cathelicidin in active pulmonary tuberculosis patientsand relation of cathelicidin with bacterial load. The mean of serum 1,25(OH)2D,IFN-γ, and cathelicidin were 121,5 ± 38,6 pmol/L, 10,8 ± 6,5 pg/mL, 90,4 ± 21,5ng/mL, respectively. The was no relation 1,25(OH)2D to IFN-γ and cathelicidineither. The mean of serum IFN-γ and plasma cathelicidin in cavitary lession wasless than non cavitary lession. We also found that plasma cathelicidin level insubject with prior treatment was less than new cases. There was relation of serumIFN-γ to plasma cathelicidin (r = 0,540; p < 0,05)."

"Sejalan dengan meningkatnya harga BBM di Indonesia sejak tiga tahun terakhir tezjadi peningkatan penggunaan bahan bakar batubara sebagai pengganti solar dan residu dengan alasan ekonomi. Di Kabupaten Bandung penggunaan bahan bakar batubara yang berisi air, uapan hasil pemanasan ini dialirkan ke tiap ruangan unmk pmses indusui. Penggunaan batubara kakan berdampak terhadap kesehatan berupa keluhan sistem pernafasan, gangguan faal paru bersifat obtruktif restriktif dan campuran. Desain penelitian adalah Studi Cross Sectional lmtuk mengetahui hubungan dampak penggunaan bahau bakar batubara dengm keluhan sistem pemafasan dan gangguan faal pada pekerja pada industri di kecamatau Majalaya Kabupamen Bandung Tahun 2007. Dilakukan pengujian antara faktor dependen (keluhan sistem pernafasan dan gangguan faal paru) dengan independen (Radar NO2, SO; CO, CO;, PMN dan debu respirabel), dan faktor confouding ( kebiasan mkok, lama kerja, APD), karakteristik pekerja (status sizi, riwayat penyakit, umur.Hasil telitian menunjukkan bahwa kadar NO; SO; CO, dan CO2 semuanya (l00%) kurang atau sama dengan NAB sedangkan PM", semuanya (I00%) melebihi NAB, debu respirabel sebesar 97,l% melebihi NAB, nanmn di semna industli NAB gabungan melebihi angka l. Prevalensi keluhan sistem pemaihsan sebesar 7I,4%, gangguan hal pam l6,2%.Gangguan faal paru bC¥hl1b\lD@l1 bermakna dengan penggunaan APD. Sehinga dapat dibuat model yaitu logit gngguan faal paru=-1,946 + 5,266*APD. Dari model di atas dapat dijelaskan bahwa pekerja yang bekerja di ruangan boiler batubara yang tidak menggunakan APD akan mempunyai risiko terjadinya gangguan faal pam sebesar 5 kali dibanding pekerja yang bekezja di ruangan boiler batubara yang menggunakan APD. Untuk mengetahui lebil mendalam perlu di1akukan penelitian kohon minimal selama 10 tahm; yang mencakup debu respirabel, komposisi batubara, dan faktor genetika yang berpengaruh terhadap gangguan faal Pam Pekerja boiler mempnmyai gizi kurang sebesar 24,8%._ kebiasaan memkok 8l,9% dan tergolong perokok berat, perusahaan perlu menyediakan makanan tambahan dan penyuluhan tentang bahaya merokok terhadap kmehatan. Pemerintah perlu mempertimbangkan lebih lanjut tentang penggunaan batubara dan apabila penggunaannya dilanjutkan dengan syarat adanya minimasi kadar debu dan komitmen penggunaan APD yang benar.

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Align with the BBM price increase in Indonesia since the last three years,there has been an increase of coal use as a diesel substitute and residue due to economic reason. In Kabupaten Bandung this coal use is aimed to heat a boiler which contain of water, and the vapor which is released by the water is flowed to each chamber for the industry PTOCBSS. This industry has been using coal from 2003 until now. This coal use will give a negative impact on our health, especially on our respiratory system and could cause pulmonary disorders which are obstructive, restrictive, or mix of both. This research is using Cross Sectional design to know the relation of coal use and respiratory complaints and pulmonary disorders at Kecamatan Majalaya, Kabupaten Bandung in year 2007. Atesting was done on dependant factors (respiratory complain and pulmonary disorder) and independent factors (NO;, SOI, CO, CO; PMN level and repairable dust), and confounding lirctor (Smoking habit, service year , PPE), worlrfome characteristic (nutrition status, medical history, age).

The result of this research shows that NO; SO; CO, and C02 level, all (l00%) less or equal with the NAB, for PMN all 100% exceeds the NAB, repairable dust is 97,l% exceeds the NAB, but 100% of NAB combine industry exceeds 1. The prevalence of respiratory complaint is l,4%, pulmonary disordas l5,2%. Pulmonary disorders related significantly with the PPE use. We can formulate a model, The Model explain that worker who work in coal boiler room who do not use PPE will have lung function disorder risk S time greater thanworker who use PPE. To know this problem comprehensively, another cohort research will need to be married forward for next 10 years, which includes respirable dust, coal composition, and genetics factors which influence the pulmonary disorders. Boiler workers have several supporting factors, such as lack of nutrition 24,8%, smoking habit 8l,9% and categorized as heavy smokers, therefore the company will need to provide extra nutrients and health education on the danger of smoking on our health. Guidance and observation on the industry will need to bc done from cross programs and related sectors continuously!! still can be used if only there is a dust volume minimization and PPE usage commitment."

"Salah satu indikator program pengendalian TB secara Nasional strategi DOTS adalah angka keberhasilan pengobatan TB. Fokus utama pengendalian TB strategi DOTS adalah memutus mata rantai penularan TB oleh penderita TB paru sputum BTA positif. Berdasarkan penelitian penderita TB paru sputum BTA negatif dapat menularkan 13-20% (Tostmann A, et al, 2008). BBKPM Bandung sebagai salah satu UPK strategi DOTS pencapaian angka keberhasilan pengobatan masih dibawah target Nasional. Tujuan: mempelajari faktor yang mempengaruhi keberhasilan pengobatan pasien TB paru sputum BTA negatif dan pasien TB paru sputum BTA positif. Faktor yang mempengaruhi keberhasilan pengobatan TB antara lain faktor individu (umur, jenis kelamin, pekerjaan, kepatuhan berobat) dan obat dan penyakit (rejimen, dosis, lama pengobatan, komorbid HIV dan DM). Indikator keberhasilan pengobatan: pemeriksaan ulang sputum BTA menjadi/tetap negatif dan kenaikan berat badan. Desain penelitian: kohort retrospektif. Sampel: data pasien TB Paru yang tercatat di TB 01 tahun 2009-2011dijadikan 2 sub populasi, Pasien TB paru dengan sputum BTA negatif 292 kasus dan pasien TB paru dengan sputum BTA positif 461 kasus. Analisis: multivariabel regresi logistik. Hasil: OR keberhasilan pengobatan pasien TB paru sputum BTA negatif patuh berobat 1,4 dibandingkan tidak patuh (CI : 0,7-3,0) dan pasien TB paru sputum BTA positif patuh berobat 1,1 di bandingkan tidak patuh (CI : 0,6-2,2) setelah dikontrol umur, jenis kelamin dan pekerjaan. Saran: Meningkatkan peran PMO, dan memperhatikan faktor komorbid dalam tatalaksana pengobatan pasien TB paru.

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Succes rate of TB treatment is an important indicator of the Natinal TB control program.The main focus of TB control program DOTS strategy is to break the chain of TB transmission. Tostmann A, et al (2008) showed that through 13-20% sputum smear negative pulmonary tuberculosis patients can spread TB the bacteria. BBKPM Bandung as one of CGU DOTS strategy has lower treatment succes rate of the national targets.

Purpose: To study factors that influence the treatment succes rate of compare with both smear positve and negative pulmonary tuberculosis patients. Those are age, gender, occupation, treatment compliance (factor individu) and regimen, dose, duration of treatment, comorbid HIV and DM (drug and disease). Indicator of treatment succes are the conversion of sputum result examination and the gain weight.

Study design: a retrospective cohort study.

Samples: the pulmonary TB patient data recorded at TB 01 yeras 2009-2011. The number of TB patients with sputum smear positive are 461 and negative are 292.

Analysis: Multivariable logistic regression.

Result: OR treatment succes among sputum smear-negative pulmonary TB patients 1,4 (CI: 0,7-3,0) and among sputum smear positive pulmonary Tb patients who adhere to treatment is 1,1 (CI:0,6-2,2) after controlling for age, sex, and occupation.

Suggestion: Enhancing the role of the PMO to increase the treatment adherence rate, treat the TB patients with HIV and DM co-infection."