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"lingkungan kondusif untuk proses penyembuhan. Biological sealing dapat diperoleh melalui sifat bioaktivitas suatu material, salah satunya kemampuan biomineralisasi material, yaitu kemampuan material dalam membentuk apatite like layer pada permukaan ketika berkontak dengan cairan fisiologis. Karakteristik tersebut dapat diperoleh dari material bioaktif, seperti kalsium silikat. Siler berbasis kalsium silikat pre- mixed saat ini telah banyak berkembang, di antaranya adalah Ceraseal® (Metabiomed, Korea) dan AH Plus® Bioceramic (Dentsply, USA). Komposisi masing-masing siler yang bervariasi menghasilkan perbedaan karakteristik, salah satunya kemampuan biomineralisasi. Tujuan: Menganalisis potensi biomineralisasi antara siler berbasis kalsium silikat pada dentin saluran akar dengan perendaman phosphate buffered saline (PBS). Metode: Siler berbasis kalsium silikat Ceraseal® dan AH Plus® Bioceramic diaplikasikan ke dalam dentin saluran akar gigi premolar yang telah dilakukan prosedur preparasi saluran akar, dan dilanjutkan dengan perendaman dalam PBS selama 14 hari. Analisis biomineralisasi dilakukan dengan menganalisis pembentukan lapisan apatit setelah 14 hari perendaman melalui penghitungan ketebalan deposit lapisan apatit menggunaan Scanning Electron Microscope (SEM), serta peningkatan pH larutan yang dihitung pada waktu observasi hari-ke 0, 7 dan 14 menggunakan pH-meter. Hasil: Terdapat perbedaan deposisi apatit pada interfacial layer antara Ceraseal® dan AH Plus® Bioceramic dalam waktu observasi 14 hari. Terdapat perbedaan bermakna antara nilai pH Ceraseal® dan AH Plus® Bioceramic pada waktu observasi 7 dan 14 hari.

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Background: Endodontic treatment currently refers to the concept of biological sealing to form an environment conducive to the healing process. Biological sealing can be obtained through the bioactivity properties of a material, one of which is its biomineralization ability to form an apatite-like layer on the surface when in contact with physiological fluids. This characteristic is present in bioactive materials like calcium silicate. There are currently many developed pre-mixed calcium silicate based sealers, including Ceraseal® (Metabiomed, Korea) and AH Plus® Bioceramic (Dentsply, USA). The variation in their composition results in different characteristics, including biomineralization ability. Objective: To analyze the biomineralization potential of calcium silicate-based sealers on root canal dentine by phosphate-buffered saline (PBS) immersion. Methods Calcium silicate based sealer Ceraseal® and AH Plus® Bioceramic were applied to the root canal dentin of premolar teeth that had undergone root canal preparation procedures. The samples were then immersed in PBS for 14 days. Biomineralization analysis was performed by measuring the apatite layer thickness formed after 14 days of immersion using a Scanning Electron Microscope (SEM). Additionally, the pH of the solution was measured at observation times of 0,7 and 14 days using a digital pH-meter. Results: There was a significant differences in in apatite deposition at the interfacial layer between Ceraseal® and AH Plus® Bioceramic during 14 days of observation. Furthermore, there was a significant difference in pH values between Ceraseal® and AH Plus® Bioceramic at 7 and 14 days of observation."

"This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general - including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products"

"Latar Belakang: Penggunaan bahan semen (siler) saluran akar dengan kandungan dan karakteristik berbeda diduga dapat memengaruhi retensi pasak fiber terhadap dinding saluran akar pasca perawatan endodontik. Tujuan : Mengetahui perbedaan kekuatan adhesi pasak fiber pada perawatan saluran akar yang menggunakan siler berbasis resin epoksi dan kalsium silikat. Metode: 30 gigi premolar bawah akar tunggal didekoronasi, dilakukan preparasi saluran akar, lalu dibagi menjadi 3 kelompok; Kelompok 1 (kontrol): gigi tanpa pengisian saluran akar, Kelompok 2: gigi yang menggunakan siler resin epoksi (AH-Plus), dan Kelompok 3: gigi yang menggunakan siler berbasis kalsium silikat (Ceraseal). Setelah pengisian saluran akar, preparasi, dan pemasangan pasak fiber. Selanjutnya gigi dipotong pada area sepertiga tengah akar setebal 2 mm kemudian dilakukan uji push-out bond strength menggunakan Universal Testing Machine. Data dianalisis dengan tes One-way Anova dan post hoc Bonferroni. Hasil: Terdapat perbedaan bermakna nilai push-out bond strength antar kelompok semen resin resin epoksi dan kalsium silikat. Kesimpulan: Gigi yang melalui perawatan saluran akar menggunakan siler resin epoksi memberikan kekuatan adhesi pasak fiber yang lebih baik dibandingkan gigi yang menggunakan siler kalsium silikat.

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Background: The use of root canal sealers with different composition and characteristics is thought to effect the retention of fiber post in root canal walls after endodontic treatment. Objective: To evaluate the difference of the fiber post adhesion strength after endodontic treatment using epoxy resin and calcium silicate based root canal sealer. Methods: 30 samples of single-rooted lower premolar were decoronated, got the root canal prepared, then divided into 3 groups; Group 1 (the controls): samples without root canal filling, Group 2 and 3, the canals were filled with gutta percha using epoxy resin (AH-Plus), and calcium silicate (Ceraseal)-based root canal sealer. After root canal obturation, the gutta percha were partly removed, prepared for post space, and then cemented with the fiber posts. Then 2 mm thick disk were cut from the middle root section and subjected to a push-out bond strength test. Data were analysed using the one-way ANOVA and post hoc Bonferroni test. Result: There was a significant difference in the push-out bond strength value between the epoxy resin and calcium silicate-based root canal sealer groups. Conclusion: The endodontic treated tooth previously using epoxy resin root canal sealer gave better fiber post adhesion strength compared to tooth that used calcium silicate based root canal sealer."

"Latar Belakang: Ketika perawatan saluran akar gagal, perawatan ulang saluran akar nonbedah, sedapat mungkin, adalah pilihan klinis pertama. Material pengisi saluran akar sebelumnya harus dibuang untuk kemudian dilakukan desinfeksi dan pengisian ulang saluran akar. Terdapat berbagai teknik pembuangan material pengisi, termasuk metode heat carrier, instrumen manual, putar, ultrasonik dan pelarut, atau kombinasi. Penghilangan sepenuhnya material pengisi tidak dapat dilakukan dengan hampir sebagian besar material yang tersisa dari perawatan ulang adalah siler. Siler biokeramik berikatan secara kimiawi dengan membentuk hidroksiapatit dan berpenetrasi ke tubulus dentin untuk menciptakan ikatan mikromekanis. Hal ini membuat pembersihan siler biokeramik sulit dilakukan. Tujuan: Mengevaluasi kebersihan saluran akar dengan berbagai metode pembuangan siler biokeramik menggunakan instrumen putar, kombinasi instrumen putarultrasonik, dan kombinasi instrumen putar-heat carrier pasca obturasi dengan teknik hidraulik dan WVC, yang dianalisis menggunakan Micro-CT. Metode: Empat puluh dua sampel gigi premolar rahang bawah pasca ekstraksi dengan akar lurus dan saluran akar tunggal yang diobturasi dengan siler biokeramik AH Plus® Bioceramic (Dentsply, USA) meggunakan dua teknik, hidraulik dan WVC. Pembuangan material pengisi menggunakan instrumen putar, kombinasi instrumen putar-ultrasonik, dan kombinasi instrumen putar-heat carrier. Pemindaian micro-CT setelah obturasi dan setelah pembuangan material dan dianalisis menggunakan perangkat lunak CTAn. Hasil: Terdapat perbedaan persentase kebersihan saluran akar (p<0,05) yang bermakna antara metode instrumen putar, kombinasi instrumen putar-ultrasonik, dan kombinasi instrumen putar-heat carrier. Kesimpulan: Pembuangan siler biokeramik menggunakan kombinasi instrumen putar-ultrasonik lebih efektif dibandingkan metode instrumen putar dan metode kombinasi instrumen putar-heat carrier. Teknik obturasi tidak mempengaruhi kebersihan saluran akar.

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Background: When root canal treatment fails, non-surgical retreatment, if possible, is the first clinical choice. Previous root canal filling materials must be removed for subsequent disinfection and obturation of the root canal. There are various techniques for removing filling materials, including heat carrier methods, manual instruments, rotary, ultrasonic and solvent, or combinations thereof. Complete removal of filling materials cannot be achieved with almost all remaining materials from retreatment being sealer. Bioceramic sealers chemically bond by forming hydroxyapatite and penetrate into dentin tubules to create micromechanical bonds. This makes cleaning of bioceramic sealer difficult. Objective: To evaluate the cleanliness of root canal walls in retreatment with various methods of removing bioceramic sealer using rotary instruments, combination of rotary-ultrasonic instruments, and combination of rotary-heat carrier instruments postobturation with hydraulic and WVC techniques, analyzed using Micro-CT. Methods: Forty-two extracted mandibular premolar samples with straight roots and single root canals obturated with AH Plus® Bioceramic sealer (Dentsply, USA) using two techniques, hydraulic and WVC. Removal of filling material using rotary instruments, combination of rotary-ultrasonic instruments, and combination of rotary-heat carrier instruments. Micro-CT scanning after obturation and after removal of material and analyzed using CTAn software. Results: There is a significant difference (p<0.05) in the percentage of root canal cleanliness between the rotary instrument, the combination with ultrasonic, and the combination with heat carrier.Conclusion: Bioceramic sealer removal methods using a combination of rotary-ultrasonic instruments are more effective than rotary instrument methods and combination of rotary-heat carrier methods. The obturation technique does not affect the cleanliness of root canal."

"Daun teh hijau Camellia sinensis L. mengandung senyawa polifenol katekin, dengan epigalokatekin galat EGCG sebagai katekin utama. Selain berfungsi sebagai antioksidan, EGCG juga merupakan penghambat tirosinase pada proses melanogenesis. EGCG bersifat hidrofil sehingga memiliki bioavailabilitas dan daya penetrasi kulit yang rendah. Pembawa berupa vesikel fitosom digunakan untuk meningkatkan penetrasi EGCG ke dalam kulit.Tujuan penelitian ini adalah memperoleh formula fitosom ekstrak daun teh hijau yang optimum untuk meningkatkan jumlah EGCG terpenetrasi, serta membandingkan uji iritasi dan uji efikasi pencerah kulit antara krim fitosom dan non fitosom mengandung ekstrak daun teh hijau. Empat formula fitosom ekstrak daun teh hijau dengan variasi perbandingan konsentrasi EGCG dan rasio mol ekstrak-fosfolipid dilakukan untuk mendapatkan kandungan EGCG optimal dalam fitosom.Analisis jumlah kumulatif EGCG terpenetrasi ke dalam kulit dilakukan dengan metode in vitro menggunakan sel difusi Franz. Uji iritasi kulit dilakukan dengan metode uji tempel tertutup tunggal selama 24 jam, sementara uji efikasi dilakukan pada 28 orang wanita yang memakai krim fitosom dan krim non fitosom ekstrak daun teh hijau selama 28 hari. Fitosom dengan kandungan EGCG 1 dan rasio mol ekstrak:fosfolipid 1:2 menunjukkan formula fitosom optimal dengan ukuran partikel sebesar 383,76 83,83 nm dmean volume, PDI sebesar 0,265 0,01, potensial zeta sebesar -48,933 1,002 mV, dan efisiensi penjerapan sebesar 72,32 0,20. Uji penetrasi in vitro dengan sel difusi Franz menunjukkan jumlah kumulatif EGCG terpenetrasi dari krim fitosom yang lebih besar dibandingkan krim non fitosom, masing-masing berturut-turut sebesar 5,58 0,078 g/cm2 dan 3,92 0,003 g/cm2.Hasil uji iritasi kulit memperlihatkan bahwa krim fitosom ekstrak daun teh hijau tidak menimbulkan iritasi. Hasil uji efikasi menggunakan uji-t menunjukkan penurunan indeks melanin kulit yang signifikan secara statistik p = 0,00, dimulai saat 14 hari pemakaian krim fitosom dan krim non fitosom ekstrak daun teh hijau. Tidak ada perbedaan bermakna dalam penurunan indeks melanin kulit yang ditemukan antara krim fitosom maupun krim non fitosom ekstrak daun teh hijau p > 0,05. Ekstrak daun teh hijau yang mengandung EGCG bermanfaat untuk mencerahkan kulit dan pembawa vesikel fitosom dapat meningkatkan kandungan EGCG yang terpenetrasi ke kulit.

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Green tea leaves Camellia sinensis L. mainly contains catechin flavonoid, with epigallocatechin gallate as the major catechin compound. In addition to acting as an antioxidant, EGCG also inhibits tyrosinase in melanogenesis. EGCG has a hydrophilic characteristic that leads to low skin penetration and bioavailability. Carrier like phytosomal vesicle could be used for enhancing skin penetration of EGCG.The aim of this study was to achieve an optimal formula of green tea leaves extract loaded phytosome in order to increase the amount of entrapped EGCG in the phytosomal vehicle, as well as comparison of the skin irritation and skin lightening efficacy between two cream preparations containing unmodified green tea leaves rsquo extract and green tea leaves rsquo extract incorporated in phytosome GTE PC. Four formulas of phytosome were investigated based on variation in the content of EGCG and molar ratio of extract phospholipid to obtain the optimum content of loaded EGCG.The analysis of cumulative amount of EGCG penetrated into the skin was conducted by in vitro method using Franz diffusion cell. The skin irritation test was carried out by single application closed patch method for 24 hours, while the efficacy test was performed on 28 women, applying phytosome cream of green tea leaves rsquo extract for 28 days, and then compared to cream of green tea leaves rsquo extract. Phytosome containing 1 of EGCG content and molar ratio of extract phospholipid 1 2 was found to be the most favorable formula with the finest characteristic amongst other on particle size 383.76 83.83 nm dmean volume, poly dispersity index 0.265 0.01, zeta potential 48.933 1.002 mV, and entrapment efficiency 72.32 0.20. The in vitro analysis by Franz diffusion cell of phytosome cream and unmodified cream of green tea leaves rsquo extract showed higher cumulative amount of penetrated EGCG in phytosome cream than unmodified cream, 5.58 0.078 g cm2 to 3.92 0,003 g cm2, respectively. The skin irritation result using closed patch method demonstrated that phytosome cream did not induce any skin irritation.The efficacy result using a t test analysis indicated a statistically significant reduction of skin melanin index p 0.00, which began to appear after 14 days of use. No statistically significant difference on skin melanin index decrease found between phytosome cream and the conventional one p 0.05. Thus, green tea leaves rsquo extract contained EGCG has a benefit as skin lightening compound and a phytosomal vesicle carrier could enhance the penetrated extent of EGCG into the skin."

"ABSTRAKLatar Belakang. Residu medikamen kalsium hidroksida yang tertinggal dalam saluran akar dapat memengaruhi kualitas pengisian saluran akar. Tujuan dari penelitian ini adalah untuk mengevaluasi dua metode pembersihan medikamen kalsium hidroksida. Metode. Tiga puluh dua premolar rahang bawah dipreparasi dengan ProTaper Next hingga X3. Gigi kemudian diberikan medikamen kalsium hidroksida dan dilakukan pemindaian awal menggunakan Micro-CT. Setelah diinkubasi selama 7 hari pada suhu 37 C, medikamen kalsium hidroksida dibersihkan dengan larutan irigasi yang diaktivasi menggunakan instrumen sonik EDDY trade;, VDW dan menggunakan instrumen ultrasonik Irrisave, Acteon Satelec . Setelah dibersihkan, dilakukan pemindaian kedua dengan Micro-CT untuk mengetahui voume residu kalsium hidroksida. Data kemudian di rekonstruksi dan dianalisis menggunakan perangkat lunak NRecon dan CTAn. Hasil. Kelompok ultrasonik memiliki rerata volume residu kalsium hidroksida yang lebih sedikit dibandingkan kelompok sonik. Namun secara statistik tidak memiliki perbedaan yang bermakna p=0,225 . Kesimpulan. Teknik sonik dan ultrasonik memiliki kemampuan yang sama dalam membersihkan medikamen kalsium hidroksida.

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ABSTRACTBackground. The residual calcium hydroxide medicinal residue in the root canal can affect the quality of root canal filling. The purpose of this study was to evaluate two methods of cleansing the calcium hydroxide medicaments. Method. Thirty two mandibular premolars were prepared with ProTaper Next to X3. The tooth was then given a calcium hydroxide medicament and an initial scan was performed using Micro CT. after incubation for 7 days at 37 C, the calcium hydroxide medicaments were cleaned with irrigation solution which was activated using sonic instrument EDDY trade , VDW and using ultrasonic instrument Irrisave, Acteon Satelec . After cleaning, a second scan with Micro CT is done to determine the voume of calcium hydroxide residue. The data were then reconstructed and analyzed using NRecon and CTAn software. Results. ultrasonic group had a lower mean residual volume of calcium hydroxide than the sonic group. However, statistically, there was no significant difference p 0,225 . Conclusion. Sonic and ultrasonic techniques have the same ability to clean the calcium hydroxide medicaments."

"Latar Belakang: Kemampuan adhesi siler terhadap dentin merupakan faktor penting dalam kesuksesan perawatan endodontik. Siler resin epoksi sebagai gold standart memiliki kemampuan adhesi yang superior, tetapi tidak memiliki sifat bioaktif sehingga berkembang siler kalsium silikat. Tujuan: Membandingkan kekuatan push-out bond strength dan failure mode siler AH Plus® Bioceramic dan Ceraseal dengan siler AH Plus®. Metode: Tiga puluh gigi premolar dibagi menjadi tiga kelompok untuk preparasi dan pengisian saluran akar menggunakan siler AH Plus® Bioceramic (kelompok 1), Ceraseal (kelompok 2) dan siler AH Plus® (kelompok 3). Sampel diinkubasi selama tujuh hari pada suhu 37oC, kemudian dipotong pada area sepertiga apikal dan medial. Nilai push-out bond strength dan failure mode dianalisis. Hasil: AH Plus® Bioceramic memiliki perbedaan nilai push-out bond strength dan failure mode yang signifikan dibanding AH Plus® dan Ceraseal. Ceraseal dan AH Plus® tidak memiliki perbedaan nilai secara signifikan. Analisis gambaran failure mode oleh dua orang observer menunjukkan reliabilitas data yang tinggi. AH Plus® Bioceramic memiliki dominasi kegagalan campuran, sedangkan Ceraseal dan AH Plus® memiliki persentasi kegagalan campuran dan kohesif yang seimbang. Kesimpulan: Seluruh kelompok siler menunjukkan kemampuan adhesi yang baik terhadap permukaan dentin, meskipun nilai push-out bond strength siler AH Plus® Bioceramic paling rendah diantara seluruh kelompok.

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Background: The adhesion of sealers to dentin is important for successful endodontic treatment. As the gold standard, epoxy resin sealers have superior adhesion, but lack bioactive properties, hence the development of calcium silicate sealers. Objective: To compare the push-out bond strength and failure mode of AH Plus® Bioceramic and Ceraseal sealers with AH Plus® Sealer. Methods: Thirty premolars were divided into three groups for root canal preparation and obturation with AH Plus® Bioceramic (group 1), Ceraseal (group 2), and AH Plus® (group 3). The samples were incubated at 37°C for seven days, then cut at the apical and medial third. Push-out bond strength and failure mode were analyzed. Results: AH Plus® Bioceramic demonstrated significant differences in push-out bond strength and failure mode values compared to AH Plus® and Ceraseal. Ceraseal and AH Plus® were not significantly different. Analysis of failure mode descriptions by two observers showed high data reliability. AH Plus® Bioceramic had a predominance of mixed failures, whereas Ceraseal and AH Plus® had equal percentages of mixed and cohesive failures. Conclusion: All sealer groups showed good adhesion to the dentin surface, although the push-out bond strength value of AH Plus® Bioceramic sealer was the lowest among the groups."

"Flavonoid, senyawa polifenol yang banyak terdapat di alam yang diketahui memiliki aktivitas farmakologi sebagai antifungi, diuretik, antihistamin, antihipertensi, insektisida, bakterisida, antivirus, antioksidan, dan menghambat kerja enzim. Kulit batang Caesalpinia ferrea C. Mart dilaporkan memiliki kandungan flavonoid.Penelitian bertujuan untuk menganalisis aktivitas penghambatan enzim arginase dan penetapan kadar flavonoid total pada ekstrak kulit batang Caesalpinia ferrea C. Mart dengan metode kalorimetri AlCl3. Simplisia kulit batang Caesalpinia ferrea C. Mart diekstraksi bertingkat dengan metode refluks menggunakan tiga pelarut yang berbeda kepolaran yaitu n-heksana, etil asetat, dan metanol. Tiap ekstrak diuji aktivitas penghambatannya terhadap enzim arginase dan dilakukan penetapan kadar flavonoid pada ekstrak yang memiliki nilai inhibisi tertinggi.Ekstrak metanol menunjukkan penghambatan terhadap aktivitas enzim arginase 12,81 pada kadar 100 g/mL dan kandungan flavonoid 2 mgQE/g ekstrak. Hasil penapisan fitokimia pada ekstrak etil asetat kulit batang Caesalpinia ferrea mengandung flavonoid, tanin, saponin, steroid, dan terpenoid. Sedangkan ekstrak metanol kulit batang Caesalpinia ferrea mengandung flavonoid, tanin, saponin, dan steroid.

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Flavonoids, polyphenolic compounds that are ubiquitous in nature, has known pharmacology active as antifungal, diuretic, antihistamin, antihypertension, insecticide, bactericide, antiviral, antioxidant, and enzim inhibitor. Previous research showed that Caesalpinia ferrea C. Mart stem bark contain flavonoid compound.The research aimed to analyze arginase inhibitory activity and determination of total flavonoid content from Caesalpinia ferrea C. Mart stem bark by AlCl3 colorimetric method. Dried Caesalpinia ferrea C. Mart stem barks were successively extracted by reflux method using three solvent with gradient polarity n hexane, ethyl acetate, and methanol. Each extract was tested for determining arginase inhibitory activity and total flavonoid content was conducted on extract with highest arginase inhibition.Methanolic extract showed arginase inhibitory activity of 12.81 at 100 g mL and flanonoid content 2 mgQE g respectively. Phytochemical screening shows that Caesalpinia ferrea stem bark ethyl acetate extract contains flavonoids, tannins, saponins, steroids, and terpenoids, meanwhile Caesalpinia ferrea stem bark methanolic extract contains flavonoids, tannins, saponins, and steroids."

"Latar Belakang: Kerapatan pengisian saluran akar merupakan hal yang penting bagi kesuksesan perawatan saluran akar. Pengambilan gutaperca dan preparasi pasak pada restorasi gigi pasca PSA dapat mengganggu kerapatan bahan pengisi yang tersisa. Siler saluran akar sebaiknya dapat mempertahankan kerapatan bahan pengisi setelah dilakukan pembuangan gutaperca dan preparasi pasak. Siler epoksi telah digunakan secara luas karena memiliki sifat adhesif dan kerapatan yang baik dengan dinding saluran akar. Baru-baru ini siler MTA juga telah dikembangkan dan dikatakan memiliki sifat adhesif dan kerapatan yang baik. Tujuan: Tujuan penelitian ini adalah untuk menganalisis kerapatan sepertiga apeks pengisian saluran akar dengan siler epoksi dan siler MTA setelah dilakukan preparasi pasak. Metode: Preparasi saluran akar dilakukan pada empat puluh gigi manusia dengan saluran akar tunggal dan dibagi menjadi dua kelompok secara acak, yaitu kelompok siler epoksi (SE) dan siler MTA (SM). Preparasi saluran akar dilakukan dengan ProTaper rotary, dan irigasi NaOCl 2,5% dan EDTA cair 17%. Preparasi pasak dengan peeso reamer dilakukan 7 hari pasca pengisian dengan menyisakan bahan pengisi sepanjang 5 mm di bagian apeks. Kerapatan sisa bahan pengisi diukur dengan menghitung penetrasi tinta pada sampel yang telah ditransparansi. Pengamatan dilakukan dengan mikroskop stereo perbesaran 20 kali. Skor 1 untuk penetrasi tinta 0-0,5 mm, skor 2 untuk penetrasi tinta 0,51-1mm, dan skor 3 untuk penetrasi tinta >1 mm. Hasil: Data penetrasi tinta pada kelompok SE: skor 1 sebanyak 35%, skor 2 sebanyak 30%, dan skor 3 sebanyak 35%. Sedangkan pada kelompok SM skor 1 sebanyak 25%, skor 2 sebanyak 30%, dan skor 3 sebanyak 45%. Uji Chi-Square menunjukkan terdapat perbedaan kerapatan yang tidak bermakna antara kelompok SE dan SM. Kesimpulan: Pengisian sepertiga apeks pasca preparasi pasak pada kelompok siler epoksi lebih rapat dibandingkan kelompok siler MTA, namun keduanya tidak berbeda bermakna.

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Background: Root canal obturation sealing ability is an important part of endodontic success. Restoration of endodontically treated teeth may sometimes need post and core. Post preparation procedure requires partial removal of the root canal filling to prepare adequate space for the post and retention of the intra canal post. Root canal sealer should be able to maintain obturation seal. Epoxy sealer has been widely used because its adhesive properties and sealing ability. Recently MTA sealer has also been developed and according to the manufacturer, MTA sealer also has adhesive properties and good sealing ability.

Aim: The aim of this study was to analyze the sealing ability of apical third of the root canal a with epoxy sealer and MTA sealer after post preparation.

Methods: Root canal preparation was performed on forty human teeth with a crown down technique; irrigation with 2,5% NaOCl and 17% EDTA, and lubrication with RC-Prep were used. The canals were then filled with gutta-percha and root canal sealer utilizing a cold lateral condensation technique. MTA Fillapex or AH-Plus were used in the experimental groups. The teeth were cleared with Robertson technique and examined under a stereomicroscope. Post preparation was performed with peeso reamer 7 days after obturation. Residual seal was measured by counting dye leakage. Observations were made with a stereo microscope magnification of 20 times. Score 1 for ink penetration 0-0.5 mm, a score of 2 to 0.51 - 1mm dye leakage, and a score of 3 for dye leakage > 1 mm.

Results: Dye leakage on the SE group: score1 : 35 %, score 2: 30 %, and score 3: 35 %. While the SM group: score 1: 25 %, score 2: 30 %, and score 3: 45 %. Chi-Square test showed no significant differences in density between the SE and SM group.

Conclusion: Dye leakage demonstrated that SE group show less leakage than SM group. Chi-Square test show there is no significant difference between both group."