Hasil Pencarian  ::  Simpan CSV :: Kembali

"Melanoma malignum (MM) kulit merupakan tumor ganas dengan mortalitas tinggi. Karakteristik histopatologik merupakan faktor prediktif prognostik MM kulit, tebal tumor >2 mm dan jumlah mitosis ≥5/mm² berkorelasi dengan angka kesintasan yang lebih buruk. Mutasi pada MM antara lain terjadi pada promoter telomerase reverse transcriptase (TERT), sehingga proliferasi sel menjadi tidak terbatas. Telomerase juga meningkatkan risiko metastasis. Penelitian ini bertujuan untuk mengetahui hubungan karakteristik histopatologik dan imunoekspresi TERT dengan angka kejadian metastasis pada MM kulit. Sampel penelitian adalah 30 kasus MM kulit dengan metastasis dan 30 kasus tanpa metastasis di Departemen Patologi Anatomik FKUI/RSCM, periode Januari 2011 sampai Juli 2023. Dilakukan penilaian karakteristik histopatologik (tebal tumor, indeks mitosis, invasi limfovaskular, invasi perineural) dan pulasan imunohistokimia TERT menggunakan antibodi TERT. Data karakteristik histopatologik dan imunoekspresi TERT dianalisis untuk mengetahui hubungannya dengan angka kejadian metastasis. Karakteristik histopatologik yang berhubungan secara signifikan dengan kejadian metastasis adalah tebal tumor >2 mm (p=0,006) dan indeks mitosis ≥5/mm² (p=0,008). Hasil analisis multivariat mendapatkan hubungan antara imunoekspresi TERT tinggi dengan metastasis yang bermakna secara statistik (p<0,001, aOR=56,1). Kesimpulan penelitian ini adalah imunoekspresi TERT tinggi meningkatkan angka kejadian metastasis pada MM kulit. Terdapat hubungan antara tebal tumor dan indeks mitosis dengan angka kejadian metastasis pada MM kulit.

---

Cutaneous malignant melanoma (MM) is a malignant tumor with high mortality rate. Histopathological characteristics are prognostic predictive factors of cutaneous MM, tumor thickness >2 mm and mitotic rate ≥5/mm² correlate with worse survival rate. Mutation in MM can occur at telomerase reverse transcriptase (TERT) promoter, which lead to unlimited cell proliferation. Telomerase also increases metastatic risk. This study aims to determine the association between histopathological characteristics and TERT immunoexpression with metastasis in cutaneous MM. The study samples are 30 metastatic and 30 non-metastatic cutaneous MM in Anatomical Pathology Department FKUI/RSCM, from January 2011 to Juli 2023. Histopathological characteristics (tumor thickness, mitotic index, limfovaskular invasion, perineural invasion) were assessed and anti-TERT antibodies were used for immunohistochemistry staining. Histopathological characteristics and TERT immunoexpression data were analyzed to determine their association with metastasis. Histopathological features that correlate significantly with metastasis are tumor thickness >2 mm (p=0,006) and mitotic index ≥5 mitosis/mm² (p=0,008). Multivariate analysis showed significant association between high TERT immunoexpression and metastasis in cutaneous MM (p<0,001, aOR=56,1). This study concludes that high TERT immunoexpression increases metastatic rate in cutaneous MM. Tumor thickness and mitotic index are associated with metastasis in cutaneous MM."

"The updated second edition of Cutaneous manifestations of infection in the immunocompromised host is an invaluable reference for physicians and ancillary medical professionals involved in the care of patients with impaired immune systems due to cancer, chemotherapy, systemic steroids and other immunosuppressive drugs, HIV/AIDS or organ transplantation. This volume will help you recognize skin lesions and diagnose their infectious cause. Textbook features include, over 350 color images demonstrating pathognomonic, atypical, rare and routine skin lesions. Tables for differential diagnosis of different skin lesions in the immunocompromised host. Complete coverage of infectious pathogens with the patterns of infection and the likely causes in different clinical settings (HIV/AIDS versus solid organ transplantation versus neutropenia post-chemotherapy versus bone marrow recovery post hematopoietic stem cell transplantation. New chapter discussing the role of viruses causing malignancies with cutaneous signs in the immunocompromised patient. "

"Latar Belakang : Pemahaman mengenai karakteristik biologik dan faktor prognostik melanoma malignum yang merupakan tumor ganas melanositik merupakan hal yang penting karena berhubungan dengan pemilihan terapi serta kesintasan penderita. Agresivitas tumor dapat dinilai dari beberapa faktor histopatologik, antara lain: ada tidaknya ulserasi, aktivitas mitosis, dan keterlibatan kelenjar getah bening. Ekspresi protein p16 dan ki67 merupakan beberapa marker yang memiliki peran dalam prediktif prognostik melanoma malignum. Tujuan : Mengetahui hubungan antara ekspresi protein p16 dan Ki67 pada beberapa faktor prognostik histopatologik yang dapat digunakan sebagai penanda agresivitas tumor yaitu ulserasi, aktivitas mitosis dan metastasis pada tumor primer melanoma malignum jenis nodular. Metode : Penelitian ini merupakan studi potong lintang dengan metode imunohistokimia menggunakan p16 dan Ki67 pada 25 kasus melanoma malignum jenis nodular. Hasil : Ekspresi protein p16 negatif pada 40% kasus melanoma ulseratif dan 52% kasus dengan aktivitas mitosis tinggi, dan 16% kasus pada metastasis kgb. Ekspresi Ki67 positif pada 44% kasus melanoma dengan aktivitas mitosis tinggi, dan 20 % kasus melanoma metastasis serta 32% kasus dengan ulserasi. Kesimpulan : Tidak terdapat hubungan yang bermakna antara ekspresi p16 dengan gambaran ulserasi, aktivitas mitosis tinggi, dan metastasis kgb pada melanoma malignum kulit jenis nodular. Tidak terdapat hubungan antara ekspresi Ki67 dengan gambaran ulserasi, aktivitas mitosis tinggi serta metastasis kgb pada melanoma malignum kulit jenis nodular.

---

Background : To understanding about biological behaviour and prognostic factor of melanoma malignum as a malignant tumor from melanocyte is important, because its relationship with choise of therapy and survival of the patiens. The aggresivity of the tumour, can be predicted from several prognostic factors: ulceration of the tumour, mitotic activity, and lymph nodes metastasis. P16 and Ki67 protein expressions can be used as a prognostic markers in cutaneous nodular melanoma malignum.

Aim : Assesing p16 and Ki67 protein expression and its relatinoship with several histopatological prognostic factors as a marker of aggressiveness of the tumors: ulceratin, mitotic activity, and lymph nodes metastasis in cutaneous nodular melanoma malignum.

Metode : This was a cross-sectional study on 25 cases of nodular melanoma, stained with p16 and ki67 antibody with immunohistochemical methods.

Result : P16 negative expression can be found in 40% of ulcerated melanoma cases, and 52% cases with high mitotic activity and 16% of cutaneous nodular melanoma with lymph nodes metastasis. Ki67 positive expression was found in 44% of cases with high mitotic activity, 20% cases of metastasis melanoma and 32% cases in ulcerated melanoma.

Conclusion : There was no statistically significant association between p16 expression with ulcerated melanoma, high mitotic activity,and metastatic melanoma in lymph nodes. Also no statistically significant between Ki67 expression with ulcerated melanoma, high mitotic activity and lymph nodes metastatic melanoma."

"Latar Belakang: Kanker kepala dan leher merupakan penyakit yang disebabkan oleh proliferasi sel tidak terkontrol yang terpicu oleh faktor genetik dan lingkungan. Telomerase Reverse Transcriptase (TERT) merupakan gen untuk menginstruksikan pembuatan telomerase yang mencegah terjadinya pemendekan telomer. Tujuan: Penelitian ini bertujuan untuk menganalisis distribusi polimorfisme gen TERT pada kanker kepala dan leher dan non-kanker kepala dan leher. Metode: 50 sampel kanker kepala dan leher sebagai kelompok kasus dan 50 sampel non-kanker kepala dan leher sebagai kelompok kontrol. TERT VNTR MNS16A dicampur dengan ddH2O, enzim polimerase dan template DNA, lalu dianalisis menggunakan teknik PCR-VNTR dilanjutkan dengan elektroforesis untuk dianalisis. Dilanjutkan dengan analisis statistik menggunakan uji Continuity Correction. Hasil: Genotip LL ditemukan lebih tinggi pada kanker kepala dan leher dan non-kanker kepala dan leher. Genotip dan alel polimorfik ditemukan lebih tinggi pada kanker kepala dan leher (100% dan 88%) daripada nonkanker kepala dan leher (82% dan 47%). Uji Continuity Correction antara kanker kepala dan leher dan non-kanker kepala dan leher menunjukkan tidak adanya perbedaan bermakna (p-value=0.242). Kesimpulan: Terdapat hubungan antara polimorfisme TERT VNTR MNS16A dan kanker kepala dan leher.

---

Background: Head and neck cancer is a disease caused by uncontrolled cell proliferation triggered by genetic and environmental factors. Telomerase Reverse Transcriptase (TERT) is a gene to instruct the manufacture of telomerase which prevents telomere shortening. Objective: This study aimed to analyze the distribution of the TERT gene polymorphisms in head and neck cancer and non-head and neck cancer. Methods: 50 samples of head and neck cancer as the case group and 50 samples of non-head and neck cancer as the control group. TERT VNTR MNS16A was mixed with ddH2O, polymerase enzyme and DNA template, then analyzed using PCR-VNTR technique followed by electrophoresis for analysis. Followed by statistical analysis using the Continuity Correction test. Results: The LL genotype was found to be higher in head and neck cancer and non-head and neck cancer. Polymorphic genotypes and alleles were found to be higher in head and neck cancers (100% and 88%) than in non-head and neck cancers (82% and 47%). Continuity Correction test between head and neck cancer and non-head and neck cancer showed no significant difference (p-value=0.242). Conclusion: There is a relationship between the TERT VNTR MNS16A polymorphism and head and neck cancer."

""Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. Features: More than 3000 full-color photographs ; DVD with image bank includes downloadable figures from the text ; New illustration style makes difficult concepts easier to understand ; Therapeutic ladders with first, second, and third line therapies ; New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation ; Expanded medical and surgical therapeutics sections guide you through all treatment options."--Publisher's website. "

""Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. Features: More than 3000 full-color photographs ; DVD with image bank includes downloadable figures from the text ; New illustration style makes difficult concepts easier to understand ; Therapeutic ladders with first, second, and third line therapies ; New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation ; Expanded medical and surgical therapeutics sections guide you through all treatment options."--Publisher's website."

"Analisis antara kesejahteraan dengan kesehatan pada negara berkembang menjadi fokus dalam berbagai kebijakan. Kesehatan penduduk yang buruk akibat penyakit kronis dapat menjadi bahaya dan ancaman bagi kestabilan perekonomian suatu negara. Salah satu penyakit kronis penyebab morbiditas dan mortalitas terbesar di dunia adalah hipertensi. Beban atau cost akibat hipertensi tidak hanya merugikan bagi penderita saja namun juga art lainnya yang turut menanggung biaya pengobatan bagi si penderita. Sehingga tujuan penelitian ini adalah melakukan estimasi kerentanan (forward looking) sebagai dampak hipertensi dengan mengunakan metode kerentanan vulnerability expected to poverty (VEP). Studi ini menggunakan data IFLS wave 4 dan 5. Penghitungan VEP diselesaikan dengan menggunakan metode estimasi Feasible Generalized Least Square (FGLS). Hasil penelitian menunjukkan rumah tangga yang terkena hipertensi cenderung memiliki expected consumption yang lebih rendah dibandingkan rumah tangga yang tidak hipertensi dan signifikan memengaruhi peningkatan peluang terjadinya kerentanan rumah tangga.

---

Analysis among the well beings and the health on the developed countries have become as the main focus on th evarious policies. The poor of the health population due to the chronic diseases appear as the hazard and the threat to the countries stability economy. One of the chronic diseases cause the largest morbidity and mortality in the world namely as hypertension. The burden or the cost happened after hypertension is not only affected to the victims and the others received the impact, as example is to pay the health treatment for the sufferer. Thus the purpose of this study is to estimate vulnerability as the result of hypertension with using the methods of the vulnerability expected to poverty (VEP). This study utilize the data from IFLS waves 4 and 5. The VEP calculation is completed by adding the method of three-step feasible generalized least squares (FGLS). The results have shown that the households in which retrieve the impact of the hypertensions tend to have a lower of expected consumption compared to the other households that have not hypertensions and it is significantly increasing the opportunities for household vulnerability influence."

"Penelitian ini bertujuan mengetahui manifestasi oral, status kesehatan rongga mulut HIV anak dan hubungannya dengan status supresi imun di RSCM. Penelitian potong-lintang terhadap 70 anak HIV yang diterapi HAART di RSCM pada bulan April dan Mei 2014. Hasilnya, frekuensi manifestasi oral rendah. Yang terbanyak lesi SAR minor ditemukan pada 4 anak. Lebih separuh subyek memiliki tingkat kebersihan mulut baik (53,5%). Nilai rerata deft < 6 tahun, nilai DMFTdeft > 6 tahun lebih dari 1 gigi per individu. Tidak dijumpai hubungan antara manifestasi oral dengan supresi imun pada HIV anak yang mendapat terapi HAART.

---

The purpose of this cross-sectional study was to determine oral manifestations, oral health status of HIV in children and their relationships with immune suppression status at RSCM. Seventy children treated with HAART at RSCM in April and May 2014 had low frequency of oral manifestations with RAS minor as the frequent lesions consist of 4 lesions. More than half of children had good oral hygiene (53.5%). The mean score of deft < 6 years, DMFT-deft > 6 years were more than 1 tooth per individual.There is no relationship between oral manifestations with immune suppression status of children treated with HAART. "

"In menopausal women, there are physiological changes as a consequence of the decrease in the secretion of oestrogen and ovary function that produce oestrogen. Numerous metabolic, psychological and physical changes have been associated with this event. In this paper we described oral discomfort in menopausal women. Dentist should know about oral discomfort in menopause including oral dryness, burning sensation, altered taste perception and ulceration, because this symptoms could become a reason for menopausal women to see a dentist. In the management of oral discomfort in menopausal women dentist should collaborate with gynecologist."