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"Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression.This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research."

"This book is the first major work that addresses a core question in biomedical research. The acceptable level of risks is regulated by the requirement of proportionality in biomedical research law.This investigation addresses research on healthy volunteers, children, vulnerable subjects, and includes placebo controlled clinical trials. It represents a major contribution towards clarifying the most central, but also the most controversial and complex issue in biomedical research law and bioethics. "

"This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic."

"This book provides students and research workers in the biological, medical and social sciences with the statistical background needed to collect and analyse data in an intelligent and critical manner. Key examples and case studies are used to illustrate commonly encountered research problems and to explain how they may be solved or even avoided altogether. Professor Manly also presents a clear understanding of the opportunities and limitations of different research designs, as well as an introduction to some new methods of analysis that are proving increasingly popular. Topics covered include the differences between observational and experimental studies; the design of sample surveys; multiple regression and its generalizations to log-linear and logistic models; experimental and quasi-experimental designs; interrupted time series; computer intensive methods of statistical inference; and the ethical considerations of research. In the final chapter, there is a useful discussion of how the various components of a research study (including deciding on the objectives, planning, designing, and the collection and analysis of data) come together. This practical and well-structured book will be essential reading for graduate students and researchers in a wide range of disciplines, including biology, anthropology, medicine and the social sciences."