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"Latar Belakang: Stroke merupakan penyebab kematian kedua dan penyebab disabilitas ketiga di dunia. Stroke menimbulkan ketidakmampuan dan kelemahan yang berakibat pada penurunan kemampuan fungsional. Kemandirian aktivitas hidup sehari-hari pasien stroke sangat penting karena dapat meningkatkan kualitas hidup. Dari tahun 1990 hingga 2019, telah terjadi peningkatan kejadian stroke sebesar 70%. Selanjutnya stroke sendiri akan menyebabkan peningkatkan angka kematian sebesar 43% dan disability adjusted lifeyears (DALY) sebesar 143%. Penelitian ini bertujuan untuk mehilat hubungan antara kadar vitamin D serum terhadap massa otot bebas lemak pada kedua ektremitas pada pasien stroke dan luaran klinis dengan pada pasien stroke.Metode: Penelitian menggunakan desain potong lintang pada subjek berusia diatas 18 tahun yang menjalani perawatan di RSUPN Dr. Cipto mangunkusumo dan RS Universitas Indonesia Depok. karakteristik demografi meliputi usia, jenis kelamin, status gizi, jenis kulit, jenis pakaian , asupan vitamin D, pemakaian tabir surya, Indeks Barthel, asupan energi total, asupan protein, asupan lemak, asupan karbohidrat, skor pajanan sinar matahari dan kadar vitamin D serum. Dilakukan analisis hubungan kadar vitamin D serum dengan ASMI dan Indeks Barthel Hasil: Sebagian besar subjek rerata berusia 59 tahun, dengan jenis kelamin perempuan terbanyak. Status gizi 33,3% mengalami obesitas derajat 1 dan 13,3% obesitas derajat 2. Karakteristik subjek memiliki jenis kulit tipe 4 (moderate brown), dan hampir seluruh subjek sebanyak 83,3% tidak memakai tabir surya. Untuk kecupukan asupan, bebagian besar subjek 81,7% memiliki asupan energi total yang cukup, 50% subjek mengalami asupan protein yang kurang, 5% subjek memiliki asupan lemak yang kurang, dan hanya 1,7% subjek yang mengalami asupan karbohidrat yang kurang, disamping itu didapatkan 65% yang mengalami kurangnya asupan bahan makanan sumber vitamin D. Skor pajanan sinar matahari pada hampir seluruh subjek sebesar 81,7% termasuk dalam kategori rendah. Hasil penelitian ini juga didapatkan gambaran 30% sebagian subjek tergolong defisiensi vitamin D, dan 58,3% subjek yang mengalami insufisiensi vitamin D. Sebagian besar subjek pada hasil pemeriksaan ASMI menunjukkan gambaran 83,3% mengalami ASMI yang rendah, dengan proporsi pada subjek laki-laki sebanyak 86,2% dan perempuan sebanyak 80,6%. Untuk Indeks Barthel didapatkan 48,3% subjek mengalami ketergantungan sedang dalam menjalani akitivitas sehari-hari. Kesimpulan: Terdapat korelasi yang bermakna antara kadar vitamin D serum dengan ASMI dan Indeks Barthel.

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Background: Stroke is the second leading cause of death and the third leading cause of disability in the world. Stroke causes disability and weakness which results in decreased functional ability. Independence of daily living activities of stroke patients is very important because it can improve the quality of life. From 1990 to 2019, there has been a 70% increase in the incidence of stroke. Furthermore, stroke itself will cause an increase in mortality by 43% and disability adjusted lifeyears (DALY) by 143%. This study aims to investigate the relationship between serum vitamin D levels and fat-free muscle mass in both extremities in stroke patients and clinical outcomes with stroke patients.

Methods: The study used a cross-sectional design on subjects aged over 18 years who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital Depok. Demographic characteristics include age, gender, nutritional status, skin type, clothing type, vitamin D intake, sunscreen use, Barthel Index, total energy intake, protein intake, fat intake, carbohydrate intake, sun exposure score and serum vitamin D levels. The association of serum vitamin D level with ASMI and Barthel Index was analyzed.

Results: Most of the subjects had an average age of 59 years, with the most female gender. The subjects had a skin type of type 4 (moderate brown), and almost all subjects as much as 83.3% did not wear sunscreen. For intake adequacy, most subjects 81.7% had sufficient total energy intake, 50% of subjects experienced insufficient protein intake, 5% of subjects had insufficient fat intake, and only 1.7% of subjects experienced insufficient carbohydrate intake, besides that 65% experienced insufficient intake of food sources of vitamin D. The sun exposure score in almost all subjects of 81.7% was in the low category. The results of this study also obtained a picture of 30% of subjects classified as vitamin D deficiency, and 58.3% of subjects who experienced vitamin D insufficiency. Most subjects in the ASMI examination results showed a picture of 83.3% experiencing low ASMI, with a proportion in male subjects as much as 86.2% and women as much as 80.6%. For the Barthel Index, 48.3% of subjects experienced moderate dependence in carrying out daily activities.

Conclusion: There is a significant correlation between serum vitamin D levels with ASMI and Barthel Index."

"Latar Belakang: Vitamin D memiliki efek non-skeletal dalam mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar lemak viseral dan kadar vitamin D serum pada pasien stroke akut.Metode: Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia selama bulan November -Desember 2023. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis (BIA) bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay (CMIA). Analisis bivariat dan multivariat digunakan untuk menilai korelasi dan hubungan antara variable bebas dan terikat, serta mengidentifikasi faktor perancu lain yang berhubungan dengan kadar vitamin D serum.Hasil: Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan dengan regresi linear untuk faktor perancu lain, hanya didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) yang menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.Kesimpulan: Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.

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Background: Vitamin D has non-skeletal effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Until now, studies that discuss the correlation between these two factors are still inconsistent. This study aims to determine the correlation between visceral fat levels and serum vitamin D levels in acute stroke patients.

Methods: A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital during November - December 2023. Measurement of visceral fat levels using bioelectrical impedance analysis (BIA) bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay (CMIA) method. Bivariate and multivariate analyses were used to assess the correlation and relationship between independent and dependent variables, as well as identify other confounding factors associated with serum vitamin D levels.

Results: In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis with linear regression for other confounding factors, only visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels.

Conclusion: There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."

"Latar Belakang: Stroke iskemik merupakan penyebab kematian terbanyak kedua dan penyebab utama disabilitas di seluruh dunia. Beberapa faktor risiko yang sudah diketahui diantaranya pola hidup, penyakit komorbid, usia, jenis kelamin, dan ras. Namun, kadar serum vitamin D yang kurang ternyata juga dikaitkan dengan penyakit neurodegeneratif, serta luaran klinis yang lebih buruk. Penelitian ini dilakukan untuk mengetahui korelasi kadar serum vitamin D dengan derajat keparahan pada stroke iskemik yang dinilai berdasarkan NIHSS. Pada penelitian ini juga akan menilai asupan vitamin D serta pajanan sinar matahari.Metode: Penelitian ini merupakan studi potong lintang pada pasien stroke iskemik di RSUPN dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Karakteristik subjek penelitian berupa usia, jenis kelamin, faktor risiko, penyakit komorbid dengan komplikasi, asupan protein, asupan lemak, asupan vitamin D, pajanan sinar matahari, kadar serum vitamin D, serta derajat keparahan. Dilakukan analisis korelasi kadar serum vitamin D dengan derajat keparahan berdasarkan NIHSS.Hasil: Terdapat 59 subjek dengan diagnosis stroke iskemik dengan rerata usia 63 tahun dan mayoritas laki-laki (62,7%). Faktor risiko terbanyak adalah hipertensi (83,1%), berat badan lebih dan obesitas (64,4%), merokok (57,6%), dan diabetes melitus (42,4%). Penyakit komorbid dengan komplikasi tersering yang ditemukan adalah gangguan jantung (35,6%). Sebanyak 79,7% subjek penelitian memiliki asupan protein yang kurang, sedangkan asupan lemak seluruhnya tergolong cukup. Sebagian besar (52,5%) subjek penelitian memiliki status asupan vitamin D kurang, 5 orang mengonsumsi suplementasi vitamin D secara rutin, derajat pajanan sinar matahari rendah (89,8%). Sebanyak 59,3% memiliki status kadar serum vitamin D defisiensi dengan derajat keparahan terbanyak adalah skor NIHSS 5-15 (76,3%). Terdapat korelasi antara asupan vitamin D dengan derajat keparahan stroke iskemik (r -0,307, p 0,018).Kesimpulan: Kadar serum vitamin D memiliki korelasi dengan derajat keparahan stroke iskemik (r -0,469, p <0,001). Kadar serum vitamin D yang kurang berbanding terbalik dengan skor NIHSS yang didapatkan pada penderita stroke iskemik onset akut.

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Background: Ischemic stroke is the second leading cause of death and the leading cause of disability worldwide. Some of the known risk factors include lifestyle, comorbid diseases, age, gender, and race. However, deficient serum vitamin D levels are also associated with neurodegenerative diseases, as well as worse clinical outcomes. This study was conducted to determine the correlation of serum vitamin D levels with severity in ischemic stroke as assessed by the NIHSS. This study will also assess vitamin D intake and sunlight exposure.

Methods: This study is a cross-sectional study on ischemic stroke patients at RSUPN dr. Cipto Mangunkusumo and University of Indonesia Hospital. Characteristics of the study subjects included age, gender, risk factors, comorbid diseases with complications, protein intake, fat intake, vitamin D intake, sun exposure, serum vitamin D levels, and severity. Correlation analysis of serum vitamin D levels with severity based on NIHSS was conducted.

Results: There were 59 subjects with a diagnosis of ischemic stroke with an average age of 63 years and the majority were male (62.7%). The most common risk factors were hypertension (83.1%), overweight and obesity (64.4%), smoking (57.6%), and diabetes mellitus (42.4%). Comorbid disease with the most common complication found were cardiac disorders (35.6%). A total of 79.7% of the study subjects had insufficient protein intake, while the fat intake was entirely considered adequate. Most (52.5%) of the study subjects had deficient vitamin D intake status, 5 people took vitamin D supplementation regularly, the degree of sun exposure was low (89.8%). A total of 59.3% had vitamin D deficiency serum level status with the most severity being NIHSS score 5-15 (76.3%). There was a correlation between vitamin D intake and ischemic stroke severity (r -0,307, p 0,018).

Conclusion: Serum vitamin D levels have a correlation with ischemic stroke severity (r -0,469, p <0,001). Insufficient serum vitamin D levels are inversely proportional to the NIHSS score obtained in patients with acute onset ischemic stroke."

"Salah satu peran sistem imunitas terhadap infeksi M.leprae adalah respons makrofag melalui interaksinya dengan vitamin D dan reseptor vitamin D (RVD). Interaksi vitamin D dengan RVD pada berbagai sel imun akan menstimulasi ekspresi katelisidin. Penelitian ini bertujuan untuk menganalisis kadar serum 25-hydroxyvitamin D (25(OH)D) dan kadar plasma RVD serta hubungannya dengan IB pada pasien kusta. Penelitian ini berupa observasional-analitik dengan desain potong lintang. Sebanyak 28 subjek penelitian (SP) menjalani pemeriksaan slit-skin smear kemudian diagnosis kusta ditegakkan berdasarkan tanda kardinal kusta. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan. Kadar serum 25(OH)D diperiksa dengan metode chemiluminescent immunoassay (CLIA) dan kadar plasma RVD dilakukan dengan metode enzyme linked immunosorbent assay (ELISA). Median kadar serum 25(OH)D adalah 12,68 ng/ml (4,88 – 44,74). Median kadar plasma RVD adalah 1,36 ng/ml (0,26 – 8,04). Berdasarkan analisis regresi multivariat, tidak terdapat hubungan antara IB dengan kadar serum 25(OH)D dan kadar plasma RVD (R square = 0,055). Tedapat korelasi positif kuat antara kadar serum 25(OH)D dengan skor pajanan sinar matahari (r = 0,863; p < 0,001).

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One of many immunity system’s roles against M. leprae infection is macrophage response through its interaction with vitamin D and vitamin D receptor (VDR). The interaction between vitamin D and VDR in various immune cells will stimulate the expression of cathelicidin. The objective is to analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with IB in leprosy patients. This observational analytic study was performed with cross-sectional design. A total of 28 subjects underwent a slit-skin smear examination and then the diagnosis of leprosy was made based on the cardinal signs. This study also assessed the patient’s sun exposure with weekly sun exposure questionnaire. Serum 25(OH)D level was assessed with chemiluminescent immunoassay (CLIA) method and RVD plasma level was measured by enzyme linked immunosorbent assay (ELISA). Median serum level of 25(OH)D was 12.68 ng/ml (4.88 – 44.74). Median plasma level of VDR was 1.36 ng/ml (0.26 – 8.04). Based on multivariate regression analysis, there was no significant association between BI and serum level of 25(OH)D and plasma level of VDR (R square = 0.055). There was strong positive correlation between serum level of 25(OH)D and sun exposure score (r = 0.863; p < 0.001)."

"Vitamin D memiliki efek mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay. Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan, didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.

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Vitamin D has effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Studies that discuss the correlation between these two factors are still inconsistent.  A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital. Measurement of visceral fat levels using bioelectrical impedance analysis bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay method.  In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis, visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels. There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."

"Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut (usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5 (0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi. Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan kadar hsCRP pada usila (r=0,168, p=0,162).

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The prevalence of cardiovascular disease (CVD) increases in the elderly. Atherosclerosis is a major cause of CVD which stimulate inflammation and followed by increase production of C-reactive protein (CRP). Vitamin D is a vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The aim of this cross sectional study was to find the correlation between serum vitamin D level and hsCRP in elderly. Data collection was conducted during December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling method. A total of 71 elderly subjects had met the study criteria. Data were collected through interviews including age, vitamin D intake and weekly score of sunlight exposure. Anthropometry measurements to assess the nutritional status and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the subjects were less than recommended dietary allowances (RDA). Majority of the subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels 38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects were at moderate and high risk of CVD. No significant correlation was found between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162)."

"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat  85% subjek memiliki asupan vitamin D yang kurang dan  94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum  adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).

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Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."

"Latar belakang: Saat ini, peran vitamin D dalam berbagai penyakit kronis banyak diteliti. Vitamin D dianggap memiliki efek imunomodulator sehingga diduga berkaitan dengan beberapa penyakit alergi dan autoimun, termasuk urtikaria kronik. Terdapat laporan kadar vitamin D yang rendah pada pasien urtikaria kronik dan suplementasi vitamin D terbukti memperbaiki gejala urtikaria kronik yang dinilai dengan kuesioner yang sudah tervalidasi Urticaria activity score 7 (UAS7). Namun, penelitian mengenai korelasi kadar vitamin D serum dengan aktivitas penyakit urtikaria masih terbatas, terutama di Indonesia.Tujuan: Menganalisis korelasi kadar vitamin D (25[OH]D) serum dengan aktivitas penyakit pada pasien urtikaria kronik.Metode: Penelitian deskriptif-analitik dengan desain potong lintang. Tiga puluh pasien urtikaria kronik usia 18–59 tahun yang memenuhi kriteria penerimaan dan penolakan direkrut dalam penelitian ini. Penilaian aktivitas penyakit menggunakan UAS7 dan dilakukan pengukuran kadar 25(OH)D serum. Korelasi kadar 25(OH)D serum dan aktivitas penyakit dilakukan dengan menggunakan analisis Spearman. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan.Hasil: Rerata skor UAS7 adalah 14,63±7,8, median durasi penyakit adalah 12 (2–120) bulan, median skor pajanan matahari mingguan adalah 8 (2–34), dan median kadar 25(OH)D serum adalah 12,10 ng/mL (6,85–29.87). Mayoritas subjek mengalami defisiensi vitamin D (80%). Tidak terdapat korelasi antara kadar 25(OH)D serum dengan aktivitas penyakit (r=0,151; p=0,425), tetapi didapatkan korelasi negatif kuat yang bermakna pada kelompok defisiensi vitamin D berat (r=-0,916; p=0,001). Terdapat korelasi positif sedang bermakna antara aktivitas penyakit dan durasi penyakit (r=0,391; p=0,033). Pada kuesioner pajanan sinar matahari mingguan, didapatkan perbedaan bermakna skor bagian tubuh yang terpajan matahari antar kelompok insufisiensi dan defisiensi vitamin D (p=0,031).Kesimpulan: Tidak terdapat korelasi kadar 25(OH)D serum dengan aktivitas penyakit pasien urtikaria kronik, namun terdapat kecenderungan peningkatan aktivitas penyakit pada kelompok defisiensi berat vitamin D.

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Background: Nowadays, the role of vitamin D in various chronic diseases is a matter of great interest. Vitamin D is thought to have an immunomodulatory effect so it is thought to be associated with several allergic and autoimmune diseases, including chronic urticaria. There have been reports of low vitamin D levels in patients with chronic urticaria and vitamin D supplementations has been shown to improve symptoms of chronic urticaria which was assessed by a validated questionnaire Urticaria activity score 7 (UAS7). However, data on the correlation between serum vitamin D levels and disease activity in chronic urticaria are still limited, especially in Indonesia.

Objective: To analyze the correlation between vitamin D (25[OH]D) serum and disease activity in chronic urticaria patients.

Methods:

This is an analytic-descriptive cross-sectional study. Thirty chronic urticaria patients age 18 – 59 years old who meet all inclusion and exclusion criterias were recruited in this study. Assessment of disease activity using UAS7 and measurement of 25(OH)D serum levels were performed. Correlation of 25(OH)D serum levels and disease activity was done using Spearman analysis. In this study, an assessment of sun exposure adequacy was carried out using a weekly sunlight exposure questionnaire.

Results: The mean of UAS7 was 14.63±7.8, median duration of illness was 12 (2 – 120) month, median weekly sunlight exposure score was 8 (2 – 34), and the median serum 25(OH)D was 12.10 ng/mL (6.85 – 29.87). The majority of subjects had vitamin D deficiency (80%). There was no correlations between serum 25(OH)D levels and disease activity (r=0.151; p=0.425). However, a significant negative correlation was found in severe deficiency vitamin D group (r=-0.916; p=0.001). There was also significant moderate correlation between disease activity and duration of illness (r=0.391; p=0.033). In weekly sunlight exposure questionnaire, we found that body surface area score was significantly different between insufficiency and deficiency vitamin D groups (p=0,031).

Conclusion: There was no correlation between serum 25(OH)D levels and disease activity in chronic urticaria patients, however there was a tendency of increasing disease activity in severe deficiency vitamin D group"

"Hipovitaminosis D selama masa kehamilan dapat menimbulkan komplikasi selama kehamilan dan pada janin. Selain itu data mengenai status vitamin D pada ibu hamil terutama trimester 1 di Indonesia masih terbatas. Oleh karena itu penelitian ini dilakukan untuk mengetahui kadar kalsidiol serum pada ibu hamil trimester 1 dan korelasinya dengan asupan vitamin D dan skor paparan sinar matahari. Penelitian ini menggunakan metode studi potong lintang pada ibu hamil sehat usia 20-35 tahun dengan usia kehamilan <12 minggu. Hasil penelitian menunjukkan rerata usia subyek 27,36+3,91 tahun dengan median usia kehamilan 9 minggu. Sebagian besar subyek berpendidikan tinggi (68,1%), status bekerja (70,2%) dengan pendapatan >UMP (59,6%) dan rerata IMT 23,74+3,83 kg/m2. Asupan lemak, protein, dan kalsium subyek