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"Latar Belakang: Pandemi COVID-19 yang saat ini sedang terjadi meningkatkan kesadaran akan risiko penularan di ruang operasi dari virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Dokter spesialis bedah mulut dan maksilofasial pada khususnya merupakan profesi yang rentan terhadap transmisi SARS-CoV-2 hal tersebut disebabkan karena ruang lingkup pekerjaan yang erat kaitannya dengan reservoir SARS-CoV-2 yaitu rongga mulut dan orofaring. American Dental Association (ADA), Centers for Disease Control and Prevention (CDC) dan petunjuk klinis Kementrian Kesehatan Republik Indonesia menganjurkan berkumur dengan iodin povidon sebelum tindakan kedokteran gigi. Nilai cycle threshold (CT) dari hasil pemeriksaan real time reverse transcription polymerase chain reaction (RT-PCR) merepresentasikan secara semikuantitatif viral load. Tujuan Penelitian: Menganalisis pengaruh berkumur iodin povidon 1% dan iodin povidon 0.5% terhadap nilai CT RT-PCR SARS-CoV-2 dan nilai saturasi oksigen. Metode Penelitian: 42 subjek penelitian diambil dari pasien Rumah Sakit Umum Pusat Persahabatan yang terinfeksi SARS-CoV-2 sesuai kriteria inklusi dan ekslusi. Subjek penelitian dibagi ke dalam kelompok iodin povidon 1%, kelompok iodin povidon 0.5%, dan kelompok kontrol. Subjek penelitian berkumur 30 detik di rongga mulut dan 30 detik di tenggorokan belakang dengan 15 ml sebanyak 3 kali sehari selama 5 hari. Analisis nilai CT dilakukan melalui pemeriksaan RT-PCR pada hari ke-1, hari ke-3, dan hari ke-5 setelah berkumur. Hasil: perbedaan bermakna didapatkan pada hasil uji Friedman dan tampak peningkatan nilai CT RT-PCR mulai dari awal, hari ke-1, hari ke-3, dan hari ke- 5 pada keseluruhan kelompok dan masing-masing kelompok perlakuan. Hasil uji Post- Hoc dengan Wilcoxon menunjukkan perbedaan bermakna pada keseluruhan kelompok hari nilai CT RT-PCR dari keseluruhan kelompok dan kelompok iodin povidon 1%. Perbedaan bermakna sebagian besar kelompok hari nilai CT RT-PCR ditemukan dari hasil uji Post-Hoc dengan Wilcoxon pada kelompok iodin povidon 0.5% dan kelompok iodin povidon 1%. Peningkatan tertinggi nilai CT RT-PCR awal hingga hari ke-1 ditemukan pada kelompok iodin povidon 0.5% sedangkan antara hari ke-1 hingga ke-3 dan hari ke-3 hingga hari ke-5 ditemukan pada kelompok iodin povidon 1%. Usia dan jenis kelamin ditemukan tidak memiliki hubungan yang bermakna terhadap perubahan nilai CT RT-PCR.Peningkatan nilai CT RT-PCR tidak menyebabkan pengaruh terhadap nilai saturasi oksigen. Kesimpulan: Berkumur iodin povidon 1% dan iodin povidon 0.5% berpengaruh terhadap peningkatan nilai CT RT-PCR SARS-CoV-2 dan berkumur dengan iodin povidon 1% atau iodin povidon 0.5% dapat mempertahankan saturasi oksigen dalam rentang normal 96%-99%.

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Background: The current COVID-19 pandemic is raising awareness of the risk of transmission in the operating room from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Oral and maxillofacial surgeons in particular are professions that are vulnerable to the transmission of SARS-CoV-2, this is because the scope of work is closely related to the SARS-CoV-2 reservoir, namely the oral cavity and oropharynx. The American Dental Association (ADA) and the Centers for Disease Control and Prevention (CDC) and the clinical guidelines of the Ministry of Health Republic of Indonesia recommend gargling with iodine povidon before commencing any surgical treatment. The cycle threshold (CT) value from the real time reverse transcription polymerase chain reaction (RT-PCR) examination semi-quantitatively represents the viral load. Low blood oxygen levels or hypoxia can be defined as a measurable oxygen saturation below 94% in patients without lung disease.

Objective: To analyze the effect of mouthrinsing and gargling with iodine povidone 1% and iodine povidone 0.5% on the CT value of SARS-CoV-2.

Methods: 42 subjects were patients recruited from Persahabatan General Hospital infected with SARS-CoV-2 according to the inclusion and exclusion criteria. The subjects were divided into iodine povidone 1% group, iodine povidone 0.5% group, and the control group. The subjects were instructed to rinse their mouths for 30 seconds and gargle for 30 seconds at the back of the throat with 15 mL of the mouthrinse 3 times a day for 5 days. Analysis of CT values were carried out using RT-PCR on day 1, day 3 and day 5 after mouthrinsing and gargling.

Results: Significant differences were found in the results of the Friedman test, and the CT value demonstrated increases from the initial, day 1, day 3 and day 5 in the whole group and each group. The results of the Post-Hoc test with Wilcoxon showed significant differences in the whole day group of the CT value of the whole group and the iodine povidone 1% group. Significant differences in most of the day group were found from the results of the Post-Hoc test with Wilcoxon in the iodine povidone 0.5% group and the iodine povidone 1%, except between day 1 and day 3 and between day 3 and day 5 in the iodine povidone 0.5% group and between day 3 and day 5 in the control group. The highest increase in the initial CT value until day 1 was found in the iodine povidone 1%. Age and gender showed no significant correlation with changes in CT values. The increasing of CT value of RT-PCR did not cause any effect on oxgen saturation values, the saturation values remain normal.

Conclusion: Mouthrinsing and gargling with iodine povidone 1% and iodine povidone 0.5% had an effect on increasing the CT value of RT-PCR SARS-CoV-2 and also could maintain oxygen saturation in the normal range between 96-99%."

"Latar Belakang: Coronavirus disease 2019 (COVID-2019) disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dan menjadi tantangan karena menyebar luas secara cepat. Jumlah virus SARS-CoV-2 ditemukan tinggi pada awal infeksi di rongga mulut dan saluran pernapasan bagian atas. Tindakan bedah di rongga mulut memiliki potensi tinggi untuk transmisi SARS-CoV-2. American Dental Association (ADA) dan Centers for Disease Control and Prevention (CDC) merekomendasikan berkumur hidrogen peroksida 1,5% atau iodin povidon 0,2% sebelum tindakan medis. Mengurangi jumlah virus di saluran pernapasan bagian atas pada awal infeksi menurunkan keparahan perkembangan penyakit dan risiko transmisi. Nilai cycle threshold (CT) dari hasil pemeriksaan real time reverse transcription polymerase chain reaction (RT-PCR) merepresentasikan secara semikuantitatif viral load. Tujuan Penelitian: Menganalisis pengaruh berkumur iodin povidon 1% dan hidrogen peroksida 3% terhadap nilai CT RT-PCR SARS-CoV-2. Metode Penelitian: 45 subjek penelitian diambil dari pasien Rumah Sakit Umum Pusat Persahabatan yang terinfeksi SARS-CoV-2 sesuai kriteria inklusi dan ekslusi. Subjek penelitian dibagi ke dalam kelompok iodin povidon 1%, kelompok hidrogen peroksida 3%, dan kelompok kontrol. Subjek penelitian berkumur 30 detik di rongga mulut dan 30 detik di tenggorokan belakang dengan 15 ml sebanyak 3 kali sehari selama 5 hari. Analisis nilai CT dilakukan melalui pemeriksaan RT-PCR pada hari ke-1, hari ke-3, dan hari ke-5 setelah berkumur. Hasil: Didapatkan perbedaan bermakna pada hasil uji Friedman dan tampak peningkatan nilai CT RT-PCR mulai dari awal, hari ke-1, hari ke-3, dan hari ke- 5 pada keseluruhan kelompok dan masing-masing kelompok perlakuan. Hasil uji Post- Hoc dengan Wilcoxon menunjukkan perbedaan bermakna pada keseluruhan kelompok hari nilai CT RT-PCR dari keseluruhan kelompok dan kelompok iodin povidon 1%. Perbedaan bermakna sebagian besar kelompok hari nilai CT RT-PCR ditemukan dari hasil uji Post-Hoc dengan Wilcoxon pada kelompok hidrogen peroksida 3% dan kelompok kontrol, kecuali antara hari ke-1 dengan hari ke-3 dan antara hari ke-3 dengan hari ke-5 pada kelompok hidrogen peroksida 3% dan antara hari ke-3 dengan hari ke-5 pada kelompok kontrol. Peningkatan tertinggi nilai CT RT-PCR awal hingga hari ke-1 ditemukan pada kelompok hidrogen peroksida 3%, sedangkan antara hari ke-1 hingga ke-3 dan hari ke-3 hingga hari ke-5 ditemukan pada kelompok iodin povidon 1%. Usia dan jenis kelamin ditemukan tidak memiliki hubungan yang bermakna terhadap perubahan nilai CT RT-PCR. Kesimpulan: Berkumur iodin povidon 1% dan hidrogen peroksida 3% berpengaruh terhadap peningkatan nilai CT RT-PCR SARS-CoV-2. Peningkatan tertinggi nilai CT RT-PCR awal hingga hari ke-1 ditemukan pada kelompok hidrogen peroksida 3%, sedangkan antara hari ke-1 hingga ke-3 dan hari ke-3 hingga hari ke-5 ditemukan pada kelompok iodin povidon 1%.

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Background: Coronavirus disease 2019 (COVID-2019) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses a challenge because it can spread rapidly. The number of SARS-CoV-2 was found to be high at the beginning of infection in the oral cavity and upper respiratory tract. Surgery in the oral cavity poses high transmission risk of SARS-CoV-2. The American Dental Association (ADA) and the Centers for Disease Control and Prevention (CDC) recommend the use of mouthrinse either 1.5% hydrogen peroxide or 0.2% povidone iodine before commencing any surgical treatment. Reducing the viral load in the upper respiratory tract at the early of infection may decrease the severity of disease progression and the risk of transmission. The cycle threshold (CT) value from the real time reverse transcription polymerase chain reaction (RT-PCR) examination semi-quantitatively represents the viral load.

Objective: To analyze the effect of mouthrinsing and gargling with 1% povidone iodine and 3% hydrogen peroxide on the CT value of SARS-CoV-2.

Methods: 45 subjects were patients recruited from Persahabatan General Hospital infected with SARS-CoV-2 according to the inclusion and exclusion criteria. The subjects were divided into 1% povidone iodine group, the 3% hydrogen peroxide group, and the control group. The subjects were instructed to rinse their mouths for 30 seconds and gargle for 30 seconds at the back of the throat with 15 mL of the mouthrinse 3 times a day for 5 days. Analysis of CT values were carried out using RT-PCR on day 1, day 3 and day 5 after mouthrinsing and gargling.

Results: Significant differences were found in the results of the Friedman test, and the CT value demonstrated increases from the initial, day 1, day 3 and day 5 in the whole group and each group. The results of the Post-Hoc test with Wilcoxon showed significant differences in the whole day group of the CT value of the whole group and the 1% povidone iodine group. Significant differences in most of the day group were found from the results of the Post-Hoc test with Wilcoxon in the 3% hydrogen peroxide group and the control group, except between day 1 and day 3 and between day 3 and day 5 in the 3% hydrogen peroxide group and between day 3 and day 5 in the control group. The highest increase in the initial CT value until day 1 was found in the 3% hydrogen peroxide group, while the increase between days 1 to 3 and day 3 to day 5 was found in the 1% povidone iodine group. Age and gender showed no significant correlation with changes in CT values.

Conclusion: Mouthrinsing and gargling with 1% povidone iodine and 3% hydrogen peroxide were found to increase the CT value of SARS-CoV-2. The highest increase in the initial CT value until day 1 was found in the 3% hydrogen peroxide group, while between days 1 to 3 and day 3 to day 5 was found in the 1% povidone iodine group."

"Salah satu terapi COVID-19 adalah plasma konvalesen yang disiapkan Unit Transfusi Darah dari donor yang telah sembuh dari COVID-19. Plasma konvalesen mengandung antibodi netralisasi yang menghambat interaksi antara protein S dengan reseptor ACE2 dengan persyaratan minimal titer 1:160 sehingga diperlukan sistem deteksi antibodi netralisasi seperti tes serologi berbasis ELISA kompetitif yang mudah, murah, cepat dan tidak membutuhkan BSL 3 atau 2. Uji ini membutuhkan protein rekombinan spike S1 yang dapat diekspresikan pada sistem ekspresi mamalia. Penelitian ini bertujuan untuk mendeteksi antibodi spesifik SARS-CoV-2 pada plasma konvalesen COVID-19 menggunakan protein rekombinan Spike S1.Penelitian ini menggunakan plasmid pD609 sebagai vektor ekspresi yang terdapat gen spike S1. DNA ditransfeksi secara transien ke sel CHO. Immunostaining dilakukan setelah transfeksi untuk melihat ekspresi protein rekombinan spike S1 pada sel CHO. Supernatan media sel CHO post transfeksi dianalisis dengan western blot dan ELISA untuk melihat reaktifitas terhadap serum konvalesen COVID-19. Hasil immunostaining menunjukkan plasmid pD609 S1 Spike Foldon-His dapat mengekspresikan protein rekombinan spike S1 SARS-CoV-2 pada sel CHO. Hasil Western Blot dan ELISA menunjukkan supernatan media sel kultur CHO post transfeksi reaktif terhadap serum konvalesen COVID-19. Protein rekombinan spike S1 memiliki potensi untuk dikembangkan dan digunakan dalam uji antibodi spesifik namun hasil ekspresi protein masih rendah.

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One of the therapies for COVID-19 is convalescent plasma prepared by the Blood Transfusion Unit from donors who have recovered from COVID-19. Convalescent plasma contains neutralizing antibodies that inhibit the interaction between S protein and ACE2 receptors with a minimum requirement of a titer of 1:160 so that a neutalizing antibody detection system is needed such as a competitive ELISA-based serological test that is easy, inexpensive, fast, and does not require BSL 3 or 2. S1 spike recombinant protein that can be expressed in mammalian expression systems. This study aims to detect SARS-CoV-2 specific antibodies in COVID-19 convalescent plasma using recombinant Spike S1 protein. This study used the pD609 plasmid as an expression vector containing the spike S1 gene. DNA was transiently transfected into CHO cells. Immunostaining was performed after transfection to see the expression of the S1 spike recombinant protein in CHO cells. The post-transfected CHO cell media supernatans were analyzed by western blot and ELISA to see the reactivity to COVID19 convalescent serum. Immunostaining results showed that the plasmid pD609 S1 Spike Foldon-His could express the SARS-CoV-2 spike S1 recombinant protein in CHO cells. The results of Western blot and ELISA showed that the post-transfection CHO cell culture media supernatant was reactive to COVID-19 convalescent serum. S1 spike recombinant protein has the potential to be developed and used in specific antibody assays, but the results of protein expression is still low."

"Penelitian ini menjelaskan tentang gambaran pengetahuan, sikap, persepsi risiko, dan perilaku pencegahan COVID-19 pada mahasiswa S1 Universitas Indonesia angkatan 2020. Penelitian ini menggunakan metode kuantitatif dengan desain studi cross-sectional. Pengambilan sampel dilakukan dengan teknik purposive sampling yang diikuti sebanyak 118 responden dengan mengisi kuesioner daring menggunakan Google Form. Hasil penelitian menunjukkan bahwa pengetahuan responden tentang pencegahan COVID-19 sudah tinggi, tetapi masih rendah mengenai jaga jarak dan kontak erat. Responden pada umumnya memiliki sikap positif dalam mencegah COVID-19, tetapi masih terdapat 28% responden yang takut ketika ingin melakukan tes PCR. Sebagian besar responden mempersepsikan COVID-19 sebagai penyakit yang serius dan khawatir ketika mendengar informasi tentang COVID-19. Responden telah melakukan sebagian besar perilaku pencegahan COVID-19 dengan baik, seperti etika batuk, memakai masker ke luar rumah saat pandemi dan di tempat keramaian, menjaga jarak di tempat keramaian, dan mencuci tangan dengan sabun setelah dari tempat keramaian, sebelum makan, dan sesudah makan. Hasil penelitian menunjukkan bahwa tidak ada hubungan yang signifikan antara pengetahuan, sikap, dan perilaku pencegahan COVID-19. Perlu meningkatkan edukasi atau sosialisasi yang efektif dan konsisten dan menguatkan penerapan perilaku pencegahan yang masih kurang, terutama menjaga jarak dan mencuci tangan dengan sabun minimal 40 detik.

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This research explained about the description of knowledge, attitude, risk perception, and behavior of COVID-19 prevention among undergraduate students of University of Indonesia Batch 2020. This research used the quantitative method with cross-sectional study. Sampling was carried out by purposive sampling technique that were joined by 118 respondents with filling out an online questionnaire based on Google Form. The results showed that the respondent’s knowledge about COVID-19 prevention was high, but still low regarding physical distancing and close contact. In general, respondents have a positive attitude in preventing COVID-19, but there are still 28% who are afraid to do a PCR test. Most of the respondents perceived COVID-19 as a serious disease and were worried when they heard information about COVID-19. Respondents have done most of the prevention of COVID-19 well, such as cough etiquette, wearing masks outside the house during pandemic and in crowded places, maintaining distance in crowded places, and washing hands with soap and after going to crowded places, before and after eating. The results showed that there was no significant association between knowledge, attitude, and behavior of COVID-19 prevention. It is necessary to increase effective and consistent education or socialization and strengthen the implementation of prevention behavior that still lack, especially maintaining distance and washing hands with soap for at least 40 seconds."

"Tesis ini membahas tentang analisa implementasi pencegahan dan pengendalian COVID-19 di rumah sakit yang ada di empat provinsi, yaitu Aceh, Bengkulu, Gorontalo dan Nusa Tenggara Timur pada tahun 2021. Penelitian ini merupakan penelitian dengan metode campuran (mix method) antara kuantitatif yaitu menggunakan data sekunder hasil evaluasi self assessment oleh narasumber kunci di tiap rumah sakit serta kualitatif melalui wawancara mendalam untuk melengkapi informasi yang ada. Alat ukur penilaian implementasi pencegahan dan pengendalian COVID-19 menggunakan kuesioner yang terdiri dari 12 komponen dalam KMK 413 tahun 2020. Hasil penelitian menunjukkan karakteristik RS sebagian besar merupakan tipe RS C, proporsi RS Pemerintah dan RS Swasta memiliki proporsi yang sama (50%), median Tempat Tidur (TT) yang dimiliki sesudah dinyatakan pandemi sebanyak 32,50 TT dan median TT untuk perawatan yang digunakan sebanyak 28 TT. Jumlah pekerja mencapai 7.248 orang dimana median pekerja yang positif dan sembuh adalah 37 orang dimana ada 1 kasus pekerja yang positif COVID meninggal dunia. 3 (tiga) komponen terendah dalam penilaian kesiapan meliputi komponen Administrasi, Keuangan dan Keberlanjutan Bisnis (AKKB), Kesehatan Kerja, Kesehatan Mental dan Dukungan Psikososial (KKKMDP) dan Surge Capacity (SC) dimana nilainya di bawah 50. Nilai skoring kesiapan rumah sakit secara keseluruhan dalam mengimplementasikan pencegahan dan pengendalian COVID-19, diketahui sebagian besar RS sudah masuk ke dalam kategori baik dan cukup. Hanya 1 RS yang termasuk kategori kurang dan 1 RS yang termasuk kategori sangat baik

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This thesis discusses the analysis of the implementation of COVID-19 prevention and control in hospitals in four provinces, namely Aceh, Bengkulu, Gorontalo and East Nusa Tenggara in 2021. This research is a research with a mixed method between quantitative, namely using secondary data from self-assessment evaluation results by key speakers in each hospital and qualitative through in-depth interviews to complement existing information. The measuring instrument for assessing the implementation of COVID-19 prevention and control uses a questionnaire consisting of 12 components in KMK 413 of 2020. The results showed that the characteristics of hospitals are mostly type C hospitals, the proportion of government hospitals and private hospitals has the same proportion (50%), the median beds owned after the pandemic were declared as much as 32.50 beds and the median beds for the treatment used was 28 beds. The number of workers reached 7,248 people where the median of positive and recovered workers was 37 people where there was 1 case of workers who were positive for COVID died. The 3 (three) lowest components in the readiness assessment include the components of Administration, Finance and Business Sustainability (AFBS), Occupational Health, Mental Health and Psychosocial Support (OHMHPS) and Surge Capacity (SC) where the value is below 50. The overall hospital readiness scoring score in implementing the prevention and control of COVID-19, it is known that most hospitals have entered the good and sufficient category. Only 1 hospital belongs to the less category and 1 hospital belongs to the excellent category"

"Periode masa pandemi Covid-19 masih terjadi di Indonesia bahkan di seluruh dunia. Hingga tgl 16 September 2021, data kejadian konfirmasi positif Covid-19 di seluruh dunia telah mencapai 226.236.577 kasus yang tersebar di 224 negara, dengan 4.654.548 kasus diantaranya meninggal dunia (WHO, 2021). Di Indonesia, pada periode yang sama, jumlah kasus positif mencapai 4.181.309 kejadian, dengan kasus kematian sebanyak 139.919 jiwa dan kasus sembuh sebanyak 3.968.152 orang (covid19.go.id). COVID-19 adalah penyakit menular yang disebabkan oleh virus SARS-CoV-2. Berbagai kebijakan telah dilakukan pemerintah untuk mencegah dan mengendalikan penularan, namun tingginya interaksi dan mobilitas masyarakat masih menjadi faktor yang berkontribusi mengakibatkan adanya kasus baru setiap harinya. Kelompok pekerja adalah salah satu kelompok masyarakat dengan persentase yang cukup besar, yakni 69.17% (BPS, Februari 2020). Tempat kerja merupakan salah satu lokasi yang berpotensi mengakibatkan penularan COVID-19 dikarenakan interaksi dan mobilitas pekerja yang sangat tinggi. Dengan kata lain risiko penularan yang terdapat di tempat kerja akan sangat berdampak baik secara langsung maupun tidak langsung kepada lingkungan masyarakat dan rumah tangga. Sektor tempat kerja yang termasuk dalam risiko tinggi penularan COVID-19 adalah sektor transportasi publik karena menjadi tempat interaksi dan bertemunya sejumlah orang dengan berbagai kondisi yang berbeda-beda. Berdasarkan latar belakang tersebut dapat dilihat bahwa penerapan manajemen pencegahan dan pengendalian COVID-19 di lingkungan tempat kerja memiliki kontribusi yang sangat penting guna memutus rantai penularan di masyarakat. Karakteristik risiko dan proses bisnis di perusahaan PT. X yang merupakan tempat kerja sekaligus tempat umum, yakni sebagai moda transportasi publik tentu menjadi keunikan tersendiri dibandingkan dengan tempat kerja pada sektor indsutri lainnya. Selain itu lokasi tempat kerja yang berada tepat di pusat kota menjadi tantangan tersendiri. Untuk itu PT. X sangat perlu memiliki upaya-upaya pengendalian risiko yang baik dan dapat diandalkan. Kegagalan dalam pencegahan dan pengendalian infeksi COVID-19 dapat mengakibatkan berbagai kerugian, baik berupa korban jiwa, gangguan operasional, penurunan citra dan kepercayaan publik pada perusahaan, hingga gangguan bisnis yang dapat berdampak tidak hanya dalam lingkup internal PT. X namun juga ke pihak-pihak terkait lainnya. Penelitian ini ditujukan untuk melihat sejauh mana PT. X selaku perusahaan yang bergerak di sektor transportasi publik perkeretaapian melakukan upaya pencegahan dan pengendalian infeksi COVID-19 di tempat kerja. Penelitian ini menggunakan desain studi cross-sectional deskriptif analitik dengan pendekatan mixed method (kualitatif & kuantitatif) melalui metode wawancara mendalam, observasi, kuesioner dan telaah dokumen untuk meninjau penerapan manajemen pencegahan dan pengendalian infeksi COVID-19 di tempat kerja sektor transportasi publik perkeretaapian, PT. X. Data kuantitatif yang akan dikumpulkan oleh peneliti di antaranya berupa data perusahaan terkait status COVID-19 di tempat kerja, mencakup profil risiko pekerja, riwayat infeksi COVID-19 di tempat kerja, gambaran pengetahuan dan sikap terhadap upaya pengendalian risiko COVID-19, serta ketersediaan sarana-prasarana pencegahan dan pengendalian COVID-19. Penelitian ini dilakukan di PT. X yang bergerak di sektor transportasi publik perkeretaapian dan berada di Provinsi DKI Jakarta. Penelitian dilakukan pada periode bulan Oktober hingga Desember 2021. Responden penelitian adalah manajemen dan pekerja PT. X yang terlibat langsung dalam mendesain, membuat perencanaan, pelaksanaan, hingga mengevaluasi penerapan manajemen pencegahan dan pengendalian infeksi COVID-19 di perusahaan. Responden tersebut di antaranya adalah perwakilan manajemen perusahaan, unit kerja Divisi Risk, Quality, Safety, and Security Management (RQSM), Departemen Quality, Safety, Health, and Environment (QSHE), dan beberapa perwakilan pekerja worksite dari unit kerja terkait. Management pencegahan dan pengendalian infeksi COVID-19 di PT. X merupakan bagian dari komitmen dan kebijakan K3 perusahaan yang tertuang dalam Kebijakan Sistem Manajemen Terintegrasi (Keselamatan Perkeretaapian, K3, Mutu, Lingkungan, dan Pengamanan). Tujuan dari penerapan Sistem Manajemen Terintegrasi tersebut di antaranya adalah untuk meningkatkan perlindungan tenaga kerja dan orang lain yang berada di tempat kerja, menyediakan lingkungan yang aman, efisien, dan produktif untuk mencegah terjadinya kecelakaan kerja dan penyakit akibat kerja, serta komitmen untuk menghilangkan setiap potensi bahaya K3 dan mengurangi risiko K3. Risiko K3 mencakup risiko keselamatan kerja dan risiko kesehatan kerja. Salah satu risiko kesehatan yang dikelola adalah risiko penularan COVID-19 di lingkungan PT. X melalui penerapan manajemen pecegahan dan pengendalian infeksi COVID-19. Berdasarkan penelitian yang telah dilakukan, diperoleh gambaran implementasi penerapan manajemen pencegahan dan pengendalian infeksi COVID-19 di tempat kerja yang mencakup risiko terhadap pekerja, pengguna jasa, dan keberlangsungan usaha. PT. X melakukan berbagai upaya sistematis untuk mengendalikan risiko transmisi virus SARS-CoV-2 di tempat kerja dan juga di seluruh fasilitas sarana dan prasarana perkeretaapian. Pencegahan dan pengendalian risiko yang dilakukan mencakup dari beberpa pendekatan, yaitu melalui kebijakan dan upaya-upaya strategis yang ditetapkan manajemen, optimalisasi peran pekerja moda transportasi, dan juga partisipasi kerjasama dari pengguna jasa. Meskipun berbagai upaya telah dilakukan, terdapat sejumlah kasus konfirmasi positif COVID-19 di PT. X. Secara keseluruhan, ositivity rate sepanjang tahun 2021 adalah sebesar 22%, dengan kejadian tertinggi berada pada periode Juni 2021 sebesar 38% dan Juli 2021 sebesar 29% sejalan dengan tingginya trend kasus “second wave” varian delta di Indonesia. Namun sejak periode pandemi COVID-19 dimulai pada Maret 2020, tidak terjadi cluster baru transmisi SARS-CoV-2 di tempat kerja maupun di wilayah operasional PT. X. Hal ini mencerminkan upaya penerapan manajemen pencegahan dan pengendalian infeksi COVID-19 yang dilakukan di PT. X sudah cukup efektif. Pencapaian tersebut tidak terlepas dari upaya dan kerjasama berbagai pihak dalam menjalankan arahan yang ditetapkan oleh perusahaan juga penerapan prosedur 3T (testing, tracing, dan treatment) dalam setiap kasus suspect ataupun konfirmasi positif yang ditemukan, baik yang bergejala ringan, sedang, hingga berat.

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The period of the Covid-19 pandemic still occurs in Indonesia and even throughout the world. As of September 16, 2021, positive confirmed cases of Covid-19 worldwide have reached 226,236,577 cases spread across 224 countries, with 4,654,548 death cases (WHO, 2021). In Indonesia, during the same period, the number of positive cases reached 4,181,309 cases, with 139,919 deaths and 3,968,152 recovered cases (covid19.go.id). COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Various policies have been carried out by the government to prevent and control transmission, but the high interaction and mobility of the community is still a contributing factor resulting new cases every day. Workers is one of the community groups with a fairly large percentage, namely 69.17% (BPS, February 2020). The workplace is one of the locations that has the potential to cause COVID-19 transmission due to the very high interaction and mobility among the workers. In other words, the risk of transmission in the workplace will have a direct or indirect impact on the community and household environment. The workplace sector that is included in the high risk of COVID-19 transmission is the public transportation sector because it is a place for interaction and meeting point of peoples with different conditions. Based on this background, the implementation of COVID-19 prevention and control management in the workplace environment has a very important contribution to break the chain of transmission in the community. Characteristics of risk and business processes in the company PT. X which is a workplace as well as a public place, namely as a mode of public transportation, is certainly unique compared to workplaces in other industrial sectors. In addition, the location of the workplace which is in the city center is a huge challenge. For that PT. X really needs to have good and reliable risk control efforts. Failure to prevent and control COVID-19 infection can result in various losses, both in the form of fatalities, operational disruptions, a decline in public image and trust in the company, to business disruptions that can have an impact not only within the of PT. X internally but also to other related parties. This research is intended to see how PT. X, as a company engaged in the railway public transportation sector, has made efforts to prevent and control COVID-19 infections in the workplace. This study uses an analytical descriptive cross-sectional study design with a mixed method approach (qualitative & quantitative) through in-depth interviews, observation, questionnaires and document review methods to review the implementation of COVID-19 infection prevention and control management in the workplace of the railway public transportation sector, PT. X. Quantitative data that will be collected by researcher include company data regarding the status of COVID-19 in the workplace, including worker risk profiles, history of COVID-19 infection in the workplace, description of knowledge and attitudes towards COVID-19 risk control efforts, and availability of COVID-19 prevention and control facilities. This research was conducted at PT. X which is engaged in the railway public transportation sector located in DKI Jakarta Province. The research was conducted in the period from October to December 2021. The research respondents were the management and workers of PT. X who is directly involved in designing, planning, implementing, and evaluating the implementation of COVID-19 infection prevention and control management in the company. The respondents included representatives of company management, the work unit of the Risk, Quality, Safety, and Security Management (RQSM) Division, the Department of Quality, Safety, Health, and Environment (QSHE), and several representatives of worksite workers from related work units. Management of prevention and control of COVID-19 infection at PT. X is part of the company's Occupational Health and Safety (OSH) commitments and policies as stated in the Integrated Management System Policy (Railway Safety, OSH, Quality, Environment, and Security). The objectives of implementing the Integrated Management System include increasing the protection of workers and other people in the workplace, providing a safe, efficient, and productive environment to prevent work accidents and occupational diseases, as well as a commitment to eliminate any potential hazards related OSH and reduce the risk of OSH, innclude occupational safety risks and occupational health risks. One of the health risks that is managed is the risk of transmission of COVID-19 in the PT. X through the implementation of management of prevention and control of COVID-19 infection. Based on the research that has been carried out, an overview of the implementation of the management of prevention and control of COVID-19 infection in the workplace is obtained, which includes risks to workers, passengers, and business continuity. PT. X made various systematic efforts to control the risk of transmission of the SARS-CoV-2 virus in the workplace and in all railway facilities and infrastructure. The risk prevention and control carried out cover several approaches, namely through policies and strategic efforts determined by management, optimizing the role of workers in transportation modes, as well as collaborative participation from passengers. Although various efforts have been made, there are a few positive confirmed cases of COVID-19 at PT. X. Overall, the positivity rate throughout 2021 is 22%, with the highest percentage was occurred in the period of June 2021 at 38% and July 2021 at 29% in line with the high trend of “second wave” delta variant cases in Indonesia. However, since the COVID-19 pandemic period began in March 2020, there have been no new clusters of SARS-CoV-2 transmission in the workplace or in the operational area of ​​PT. X. This reflects the efforts to implement the management of prevention and control of COVID-19 infection carried out at PT. X is already quite effective. This achievement is inseparable from the efforts and cooperation of various parties in carrying out the directions set by the company as well as the implementation of 3T procedures (testing, tracing, and treatment) in every suspect or positive confirmed cases, whether with minor, moderate, to severe symptoms."

"Skripsi ini membahas mengenai gambaran perilaku pencegahan covid-19 pada pedagang pasar tradisional. Informan dalam penelitian berjumlah 13 orang yang terdiri dari 10 orang informan utama dan 3 orang informan kunci. Penelitian ini adalah penelitian kualitatif dengan pendekatan rapid assessment procedures (RAP). Teori yang digunakan adalah Health Belief Model. Hasil penelitian menunjukkan sebagian besar informan tidak merasa rentan terhadap covid-19 dan tidak menganggap covid-19 penyakit yang dapat menimbulkan bahaya karena gejala yang ditimbulkan dianggap sudah sering dijumpai. Namun informan masih menganggap penerapan pencegahan penting dilakukan sebagai langkah antisipasi. Adanya kendala berupa ketidaknyamanan penggunaan masker dan kendala dalam melakukan jaga jarak di pasar membuat praktik pencegahan covid-19 menjadi kurang optimal. Disamping itu, praktik cuci tangan, konsumsi sayur dan buah, serta aktifitas fisik sudah cukup bagus.

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This thesis discusses the description of Covid-19 prevention behavior in traditional market traders. The number of informants in the study was 13 people consisting of 10 main informants and 3 key informants. This study is a qualitative study using a rapid assessment procedures (RAP) approach. The theory used is the Health Belief Model. The results showed that most informants did not feel vulnerable to Covid-19 and did not consider Covid-19 a disease that could cause harm because the symptoms it caused were considered to be common. However, the informants still considered the implementation of prevention as important as an anticipatory step. The existence of obstacles in the form of discomfort using masks and obstacles in maintaining distance in the market make the practice of preventing Covid-19 less optimal. Besides that, the practice of washing hands, consuming vegetables and fruits, and physical activity is quite good."

"Pada masa COVID-19, karyawan garis depan dituntut untuk tetap mempertahankan kinerjanya dalam lingkungan kerja yang menantang. Karyawan garis depan, yaitu setiap orang yang tetap perlu melayani banyak orang dalam keadaan pandemi dihadapkan pada berbagai tantangan yang dapat menurunkan kinerjanya. Penelitian ini bertujuan untuk melihat hubungan antara kreasi pekerjaan dengan kinerja karyawan garis depan COVID-19 yang dimedisasi keterikatan kerja. Penelitian ini juga menguji hubungan variabel kreasi pekerjaan dengan keterikatan kerja dan kinerja. Selain itu, penelitian ini juga menguji hubungan antara keterikatan kerja dengan kinerja karyawan garis depan. Kreasi pekerjaan diukur dengan menggunakan Job Crafting Scale (Tims et al., 2012), keterikatan kerja diukur dengan menggunakan versi pendek UWES (Schaufeli et al., 2002) dan kinerja diukur dengan versi pendek Job Performace (Mastenbroek et al., 2014). Partisipan penelitian ini adalah 216 karyawan garis depan yang bergerak di bidang non medis dengan usia 20-64 tahun di Indonesia. Hasil penelitian ini menunjukkan bahwa kreasi pekerjaan berhubungan dengan kinerja karyawan garis depan secara langsung. Penelitian ini juga menunjukkan hubungan kreasi pekerjaan dengan keterikatan kerja karyawan garis depan serta hubungan antara keterikatan kerja garis depan dengan kinerjanya. Terakhir, hasil penelitian ini menunjukkan hubungan tidak langsung antara kreasi pekerjaan yang dilakukan karyawan garis depan dengan kinerjanya, yaitu melalui mediasi dari keterikatan kerja karyawan.

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Frontline workers are expected to perform well under difficult work environment during the times of COVID-19 pandemic. Frontline workers, a group of workers who still needs to do their job serving other people needs in public areas, struggles to maintain their job performance during the COVOD-19 pandemic. This study aims to investigate the relationship between job crafting and job performance through the mediating role of work engagement in COVID-19 frontline workers in Indonesia. This study also aims to investigate the relationship between job crafting and work engagement and the direct relationship between job crafting and job performance. Job Crafting is measured using the Job Crafting Scale constructed by Tims et al. (2012), Work Engagement is measured using the short version of UWES (Schaufeli et al., 2002), and Job Performance is measured using the short version of Job Performance Scale originally used by Mastenbroek et al., (2014). Data were collected from 257 Indonesian COVID-19 frontline workers age 20-64. The results show that job crafting directly relates to job performance. This study also shows that job crafting relates to work engagement and frontline workers’ work engagement relates to their job performance. Lastly, the results shows that job crafting indirectly relates to job performance through the mediating effect of work engagement."

"Latar Belakang: Melihat potensi tingginya jumlah virus didalam rongga mulut, dengan bukti bahwa SARS-CoV-2 ditemukan pada reseptor ACE2, perlu upaya untuk mencegah penularan dari pasien ke praktisi melalui saliva yang terkontaminasi. Virus ini menyebar lebih cepat karena SARS-CoV-2 bereplikasi disaluran pernapasan bagian atas dengan melepaskan patogen yang berpindah dari satu orang ke orang lain saat bersin dan batuk melalui penyebaran pernapasan. Diperkirakan waktu penularan bisa terjadi sebelum gejala muncul (sekitar 2,5 hari lebih awal dari munculnya gejala). Berkumur dengan hidrogen peroksida dapat menghilangkan lapisan permukaan epitel pada mukosa mulut yang diketahui terdapat reseptor ACE2 tempat terikatnya SARS- CoV-2 dan dapat menginaktivasi virus tersebut. Pedoman sementara American Dental Association (ADA) menyarankan penggunaan 1,5% Hidrogen peroksida sebagai pilihan untuk pembilasan mulut preoperatif sebagai obat kumur antiseptik. Nilai cycle threshold yang diperoleh RT – PCR bersifat semi-kuantitatif dan mampu membedakan antara viral load tinggi dan rendah. Tujuan Penelitian: Mengevaluasi perbedaan pengaruh penggunaan obat kumur diantara berkumur hidrogen peroksida 1,5% dan hidrogen peroksida 3% terhadap nilai cycle threshold RT-PCR pada pasien COVID - 19. Metode Penelitian: 42 subjek penelitian diambil dari pasien RSUP Persahabatan yang terinfeksi SARS-CoV-2 sesuai dengan kriteria inklusi dan ekslusi. Setelah dilakukan informed consent, subjek penelitian dibagi menjadi 3 kelompok, yaitu kelompok hidrogen peroksida 1,5%, kelompok hidrogen peroksida 3% dan kelompok kontrol. Subjek penelitian berkumur 30 detik di rongga mulut dan 30 detik di tenggorokan belakang dengan 15 ml sebanyak 3 kali sehari selama 5 hari. Analisis menggunakan nilai cycle threshold pada pemeriksaan RT-PCR pada hari ke-1, hari ke-3 dan hari ke-5 setelah berkumur. Hasil: Terdapat perbedaan bermakna pada hasil uji Friedman dan peningkatan nilai cycle threshold RT-PCR dari awal, hari ke-1, hari ke-3 dan hari ke-5 di keseluruhan kelompok dan masing – masing kelompok perlakuan. Peningkatan tertinggi nilai cycle threshold RT-PCR awal hingga hari ke-1 ditemukan pada kelompok hidrogen peroksida 3%, kemudian antara hari ke-1 hingga ke-3 dan hari ke-3 hingga hari ke-5 ditemukan pada kelompok hidrogen peroksida 1,5%. Kesimpulan: Berkumur hidrogen peroksida 1,5% dan hidrogen peroksida 3% berpengaruh terhadap peningkatan nilai cycle threshold RT-PCR SARS-CoV-2. Kedua konsentrasi hidrogen peroksida 1,5% dan hidrogen peroksida 3% memberikan pengaruh positif dalam menurunkan jumlah virus di rongga mulut, sehingga pilihan penggunaan konsentrasi hidrogen peroksida yang lebih kecil bisa menjadi pilihan untuk digunakan untuk berkumur.

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Background: Given the potential high number of viruses in the oral cavity, with evidence that SARS-CoV-2 is found at the ACE2 receptor, efforts are needed to prevent transmission from patient to practitioner through contaminated saliva. This virus spreads faster because SARS-CoV-2 replicates in the upper respiratory tract by releasing pathogens that are passed from one person to another when sneezing and coughing through respiratory spread. It is estimated that the time of transmission can occur before symptoms appear (about 2.5 days earlier than the onset of symptoms). Mouth rinse and gargling with hydrogen peroxide can remove the epithelial surface layer on the oral mucosa which is known to have ACE2 receptors where SARS-CoV-2 binds and can inactivate the virus. Interim guidelines of the American Dental Association (ADA) recommend the use of 1.5% hydrogen peroxide as an option for preoperative oral rinse as an antiseptic mouth rinse. The cycle threshold value obtained by RT-PCR is semi-quantitative and able to distinguish between high and low viral loads.

Objective: To evaluate the difference in the effect of using mouth rinse between 1.5% hydrogen peroxide and 3% hydrogen peroxide mouth rinse and gargling on the RT-PCR cycle threshold value in COVID-19 patients.

Methods: 42 subjects were patients recruited from Persahabatan General Hospital infected with SARS-CoV-2 according to the inclusion and exclusion criteria. Following informed consent procedure, the research subjects were divided into 3 groups, namely the 1.5% hydrogen peroxide group, the 3% hydrogen peroxide group and the control group. The subjects were instructed to rinse their mouths for 30 seconds and gargle for 30 seconds at the back of the throat with 15 ml of the mouth rinse 3 times a day for 5 days. Analysis of cycle threshold values was carried out using RT-PCR on day 1, day 3 and day 5 after mouth rinse and gargling.

Results: There were significant differences in the results of the Friedman test and an increase in the RT-PCR cycle threshold value starting from the beginning, day 1, day 3 and day 5 in the whole group and each treatment group. The highest increase RT-PCR cycle threshold value at day 1 was found in the 3% hydrogen peroxide group, while the increase between day 1 to 3 and day 3 to day 5 was found in the 1.5% hydrogen peroxide group.

Conclusion: Mouth rinse and gargling with 1.5% hydrogen peroxide and 3% hydrogen peroxide has an effect on increasing the cycle threshold value of the SARS-CoV-2 RT-PCR. Both 1.5% and 3% hydrogen peroxide concentration have a positive effect in reducing the number of viruses in the oral cavity, so the choice of using a lower hydrogen peroxide concentration can be an option to use for mouth rinse and gargling."

"In deep periodontal lesions, scaling and root planning (SRP) failed to complete elimination of periodontal bacteria, so chemical antimicrobial agents are used topically to destroy microorganism. Povidon-iodin 10% is one of antimicrobial agents that can be applied topically anddirectly in the pocket. The aim of the research were evaluated the efficacy of povidon-iodin l0% as chemical antimicrobial agents locally applied into periodontal pocket. The data are obtained from patients with chronic adult periodontitis baseline periodontal pocket depth (PPD) are 5-7 mm. The teeth are scaled and root planed after clinical examinations ( plaque index, papilla bleeding index and periodontal pocket depth ) and test sites or control sites are assisned randomly. Topically application of povidon-iodin 10% at test sites and aquabides at control sites is applied at day 1st and day 7th. The clinical parameters are assessed at day 14th. The results of the research showed that application of povidon-iodin l0% afer SRP provide statistically significant more favorable papilla bleeding index reduction than SRP + aquabides after 14 days. The pocket depth reduction at testsites are greater than control sites ( baseline PPD=6 and 7 mm). The conclusions of the research showed that application subgingival povidon-iodin 10% as adjunctive to SRP significantly reducePBI and PPD ( 6 & 7 mm ) than without application povidon-iodin 10%."