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"Earl Mindell's Anti-Aging Bible shows you how to use the latest information to help you live a longer and healthier life, improve memory, build bones and muscles, smooth wrinkles, and avoid the ills of age from arthritis to osteoporosis to cancer."

"We’re living longer, and instead of wanting to grow old gracefully, we want to grow old youthfully. This handbook combines the latest scientific research and a comprehensive mind-body-spirit approach so that you can age beautifully—without using potentially harmful drugs. Every aspect of anti-aging is covered: nutrition, exercise, therapies, brain fitness, and spiritual wellbeing. Illustrations, graphics, tables, and fascinating facts highlight and expand upon the advice. Design an action plan for improving your health and lifestyle—including rejuvenating spa therapies, reducing stress through laughter, and playing bridge for mental stimulation. You’ll drive back the years, and begin living life to its fullest."

"In this detailed and indispensable guide, Dr Kyriazis also provides realistic and easy-to-follow advice on the prevention of a wide range of age-related problems using a combination of lifestyle guidelines and recommended medication. Today we are all increasingly aware that many facets of the ageing process and many chronic conditions often associated with age, such as stroke, dementia, artthritis and heart disease, are preventable. With this knowledge and the growing realization that we do not need to succumb to many of the problems associated with ageing, an insiatable demand has b"

"Penuaan adalah salah satu faktor resiko signifikan untuk sejumlah penyakit tidak menular degeneratif dan sering bermanifestasi sebagai penyakit kardiovaskular, kognitif dan metabolik. Studi terbaru telah mengidentifikasi peroxisome proliferator-activated receptor γ co-activator α (PGC-1α) sebagai pengatur utama fungsi mitokondria, yang sering dihubungkan dengan teori penuaan. Karena keterlibatannya dalam metabolisme energy, kegagalan energy akibat puasa mungkin dapat merangsang ekspresi PGC-1α, khususnya pada organ yang aktif secara metabolic seperti hati dan jantung. Penelitian ini bertujuan untuk menyelidiki manfaat anti-penuaan dari puasa dengan cara menganalisis ekspresi PGC-1α dalam sel hati kelinci yang dipuasakan. Tiga kelompok kelinci yang telah (1) diberi makan secara ad libitum; (2) dipuasakan selama 16 jam (puasa intermiten); (3) dipuasakan selama 40 jam (puasa berkepanjangan). RNA diekstraksi dari jaringan hati kelinci dari masing-masing kelompok. qRT-PCR dilakukan untuk mencari ekspresi relative gen PGC-1α sebagai biomarker anti-penuaan. Terdapat peningkatan signifikan ekspresi relative PGC-1α pada hati kelinci yang dipuasakan dibanding kelinci yang diberi makan ad libitum. Penelitian lebih lanjut yang melibatkan pemantauan kelinci diperlukan untuk mengamati sifat anti-penuaan pada kelinci yang telah dipuasakan dibandingkan kontrol untuk menyimpulkan sebesar apa efek puasa terhadap penundaan penuaan.

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Ageing is a significant risk factor for various of non-communicable diseases, often manifesting as cardiovascular, cognitive and metabolic degenerative diseases. Recent studies have identified peroxisome proliferator-activated receptor γ co-activator α (PGC-1α) as a major regulator of mitochondrial function, a common feature in the many theories of ageing. Due to its involvement in energy metabolism, it is theorised that energetic failures due to fasting may be able to stimulate the expression of PGC-1α. This research aims to investigate anti-ageing benefits of fasting by analysing the expression of PGC-1α in liver cells of fasted rabbits compared to rabbits fed ad libitum. Three groups of rabbits were (1) fed ad libitum; (2) subjected to intermittent (16-hour) fast; and (3) subjected to prolonged (40-hour) fast. RNA was extracted from the liver tissues of the rabbits. The relative expression of PGC-1α mRNA as a biomarker of anti-ageing was analysed by qRT-PCR. There was a significant increase in relative expression of PGC-1α in fasted rabbits than those fed ad libitum. Further research involving the monitoring of the rabbits is needed to observe for anti-ageing traits in fasted rabbits as opposed to the control to conclude the extent of the effect of fasting on delaying ageing."

"Leslie Kenton's Age Power turns our once negative view of ageing on its head. There has never been a more exciting time to live and now science and nature have come together to enhance health and improve your quality of life, no matter what your chronological age. This major new book, from the bestselling author of Passage to Power and The X Factor Diet, is an immensely practical and inspirational handbook that offers a unique and very positive perspective on the ageing process. From serotonin enhancers for handling depression and anxiety, to natural hormones for nurturing skin, smart nutrients that improve brain function and immune improvers that protect against illness and ageing, Age Power invites you to energize your life while gaining powerful protection from degenerative conditions such as cancer, heart disease and macular (eyesight) degeneration. Bringing together all the very latest in ageing research, along with the very best natural resources, Age Power will define how we approach the various stages of our lives, armed with knowledge and inspiration."

"What's even better than aging gracefully? Hardly aging at all! While no one can stop the chronological clock, natural remedies can dramatically slow down your biological one. New nutritional discoveries and ancient therapies used for hundreds, even thousands of years in the Far East can keep you vital, healthy, and youthful. They can also work miracles in stopping or reducing the effects of many chronic diseases associated with getting older. This comprehensive guide gives you a complete holistic approach to aging."

"Pendahuluan: Data Susenas tahun 2022 yang dikeluarkan oleh Badan Pusat Statistik (BPS) mencatat bahwa 10,48% penduduk Indonesia adalah lansia dengan 2 dari 5 lansia memiliki keluhan kesehatan. Hal ini bisa disebabkan karena banyaknya faktor ekstrinstik maupun intrinsik yang menyebabkan kerusakan seluler sehingga menginduksi protein p53 untuk melakukan cellular senescence. Senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dalam ekstrak tanaman Plectranthus amboinicus yang kaya akan antioksidan dipercaya dapat menghambat proses cellular senescence sehingga dapat menekan proses penuaan. Dengan itu, tujuan dari penelitian ini adalah untuk mengetahui interaksi antara komponen ligan pada senyawa aktif thymol, carvacrol, dan flavonoid yang terkandung dalam Plectranthus amboinicus dengan protein target p53 yang berkaitan dengan aktivitas cellular senescence pada proses penuaan. Metode: Studi in silico melalui molecular docking (penambatan molekuler) untuk menguji interaksi molekuler dari ligan senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dari tanaman Plectranthus amboinicus terhadap reseptor protein target p53 yang bertanggung jawab dalam proses cellular senescence. Hasil interaksi yang didapat merupakan sebuah histogram yang akan dianalisis dan diinterpretasikan untuk mengetahui afinitas ikatan (binding affinity) dari interaksi yang terjadi. Hasil: Terjadi interaksi antara ligan senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dari tanaman Plectranthus amboinicus terhadap reseptor protein target p53. Kesimpulan: Plectranthus amboinicus berpotensi menjadi agen anti-aging yang dapat menghambat dan memperlambat proses dari penuaan melalui studi in silico. Akan tetapi, perlu dilakukan penelitian lebih lanjut mengenai mengenai sifat-sifat dari Plectranthus amboinicus untuk mengetahui potensi tanaman ini terhadap tubuh manusia yang belum diketahui.

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Introduction: The 2022 Susenas data stated by the Central Statistics Agency (BPS) notes that 10.48% of Indonesia’s population are elderly with 2 out of 5 having health complaints. This could be due to the many extrinsic and intrinsic factors that causes cellular damage thereby inducing the p53 protein to perform cellular senescence. Compounds of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the extract of the Plectranthus amboinicus plant which are rich in antioxidants are believed to have the potential to inhibit the cellular senescence process so as to suppress the aging process. The purpose of this research is to investigate the interaction between the ligand of thymol, carvacrol, and flavonoid compounds from Plectranthus amboinicus with the p53 target protein which is associated with cellular senescence activity in the aging procress. Methods: In silico study through molecular docking to examine the molecular interactions of the ligands of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the Plectranthus amboinicus plant against the target protein receptor p53 which is responsible for the process of cellular senescence. The interaction results obtained is a histogram which will be analyzed and interpreted to determine the binding affinity of the interactions that occured. Results: Interactions existed between the ligands of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the Plectranthus amboinicus plant against the target protein receptor p53. Conclusion: Plectranthus amboinicus has the potential to be an anti-aging agent that can inhibit and slow down the process of aging through in silico studies. However, it is necessary to carry out further research regarding the properties of Plectranthus amboinicus to determine the unknown potential of this plant to the human body.

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"Stop the age clock! Learn how you can look and feel younger for longer. Written by a pioneer in the science of anti-aging, this comprehensive handbook examines the process and effects of aging, and then explains how to use both complementary and conventional therapies to prevent and treat age-related conditions. Incorporate anti-aging foods and nutritional supplements into your diet (recipes and menu suggestions are included), and see how to use nutrition to combat specific diseases, such as osteoporosis, cancer, heart disease, and cataracts. Manage stress using yoga, T'ai Chi, Chi Kung, and other techniques. Boost your brain power with mental exercises to ward off memory loss and confusion. Maintain a youthful appearance with proper skin and hair care. Discover the anti-aging benefits of acupuncture, aromatherapy, herbalism, massage, reflexology, and other complementary therapies. Take active strides to prevent common problems such as dementia, arthritis, menopause, prostate trouble, varicose veins, and more."