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"Expert contributors discuss the molecular basis of immune recognition, as well as eosinophils as effector cells in immunity and allergic disorders. Includes coverage of the evaluation of the allergic patient, manifestations of the allergic state, treatment of allergic diseases, allergic lung disease, and allergies to specific agents. Also features material on basic allergic mechanisms, including cellular immunity, allergic mediators, and immunodeficiency diseases."

""Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, this book provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management." -- Publisher. "

"Latar belakang: Penyakit alergi didasari reaksi hipersensitivitas yang diinisiasi mekanisme imunologi spesifik diperantarai oleh IgE. Warga kota Denpasar memiliki karakteristik spesifik, yaitu tingkat memelihara hewan berbulu anjing dan konsumsi daging babi yang tinggi. Data sensitisasi alergen pada anak di kota Denpasar belum ada. Penelitian sensitisasi alergen dapat memberikan gambaran sensitisasi spesifik untuk anak di kota Denpasar sehingga upaya pencegahan penyakit alergi dapat dilakukan dengan lebih efektif. Tujuan: Mengetahui sensitisasi alergen pada anak dengan penyakit alergi dermatitis atopi, asma, rinitis alergi yang dibuktikan melalui uji tusuk kulit di RSUP Sanglah Denpasar. Metode: Penelitian potong lintang di Poliklinik Rawat Jalan Alergi Imunologi Bagian/SMF Ilmu Kesehatan Anak, RSUP Sanglah, Denpasar, periode Januari 2017-Maret 2017. Anak usia 3-18 tahun dengan dermatitis atopi, asma, rinitis alergi dan orang tua setuju mengikuti penelitian akan diinklusi. Sensitisasi alergen dibuktikan melalui uji tusuk kulit terhadap alergen spesifik inhalan dan/atau ingestan, hasil positif bila diameter urtika 3 mm. Data dinyatakan sebagai proporsi, dilakukan pengelompokan berdasarkan jenis penyakit alergi dan umur. Hasil: Proporsi anak dengan penyakit alergi, yaitu dermatitis atopi 30,5, asma 57,9, dan rinitis alergi 56,8. Proporsi berdasarkan multimorbiditas penyakit adalah dermatitis atopi dengan asma 8,5, dermatitis atopi dengan rinitis alergi 4,2, asma dengan rinitis alergi 24,2, dermatitis atopi dengan asma dan rinitis alergi 4,2, dermatitis atopi 13,7, asma 21, rinitis alergi 24,2. Sensitisasi pada kelompok dermatitis atopi usia 3-6 tahun tersering terhadap alergen ingestan, usia sekolah baik pada dermatitis atopi, asma, maupun rinitis alergi sensitisasi terutama terhadap alergen inhalan D. farinae, D. pteronyssinus, kecoa. Simpulan: Proporsi penyakit alergi tertinggi pada anak di kota Denpasar adalah asma dengan rinitis alergi. Sensitisasi terutama terhadap alergen inhalan pada anak usia sekolah.

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Background: Allergic disease in children is based on hypersensitivity reactions initiated by specific immunologic mechanism mediated by IgE. Residents of Denpasar city have their own characteristics in terms of the level of having furry animals dogs and the level of consumption of pork is high. While allergen sensitization data for the children of Denpasar is still not available. Allergen sensitization research in Denpasar will give a picture of the sensitization type specifically for children in Denpasar in order for having more effective prevention programs.

Objectives: To study the sensitization of allergens in children with atopic dermatitis, asthma, and allergic rhinitis that proven through skin prick test at Sanglah Hospital Denpasar.

Methods: A cross sectional study was done in the Outpatient Immunology Allergy Polyclinic, Sanglah Hospital, Denpasar in the period of January to March 2017. Children 3 18 years who are diagnosed with atopic dermatitis, asthma, and allergic rhinitis, and the parents signed a letter of approval, will be included. Allergen sensitization proven by skin prick test against specific allergens inhalants and or ingestants, and it classified positive results when indicating wheal diameter ge 3 mm. The data is calculated as a proportion number and is grouped based on the type of allergy and age.

Results: The proportion of children with allergy was atopic dermatitis 30.5, asthma 57.9, and allergic rhinitis 56.8. While the proportion based on the multimorbidity of the disease is atopic dermatitis with asthma 8.5, atopy dermatitis with allergic rhinitis 4.2, asthma with allergic rhinitis 24.2, atopy dermatitis with asthma and allergic rhinitis 4.2, atopic dermatitis 13, 7, asthma 21, and allergic rhinitis 24.2. Sensitization in the atopy dermatitis at age 3 6 years group frequently to ingestant allergen, but at school age in both atopic dermatitis, asthma, and allergic rhinitis sensitization especially to inhalants allergen D. farinae, D. pteronyssinus, and cockroaches.

Conclusions: Children in Denpasar showed the highest proportion of allergies for asthma and allergic rhinitis, with the majority of allergen are inhaled at school age."

"This guide provides information on everything from how to detect allergies to how best to treat them, and what are and where to buy the most effective products for relieving them. It has an easy-to-follow cross-reference format and a section for parents coping with children's allergies."

"Perubahan gaya hidup seiring perkembangan zaman membuat kronotipe manusia semakin bervariasi. Kronotipe malam diketahui banyak dijumpai pada kalangan remaja akhir. Pola irama sirkadian memiliki hubungan dengan sistem imun dan penyakit alergi. Rinitis alergi merupakan penyakit alergi yang paling banyak dijumpai pada kalangan remaja dan dapat menurunkan kualitas hidup penderitanya. Penelitian ini bertujuan untuk mengetahui hubungan kronotipe dan rinitis alergi pada pelajar sekolah menengah atas.

Metode: Pada penelitian potong lintang ini, analisis dilakukan pada 196 pelajar sekolah menengah atas yang telah menjawab empat kuesioner: International Study of Asthma and Allergy in Childhood Core Questionnaire, Reduced Version Morningness-Eveningness Questionnaire, Epworth Sleepiness Scale dan Kuesioner Studi Kohort Faktor Risiko PTM Tahun 2011 Bagian Penggunaan Tembakau dan Kebiasaan Merokok. Data dianalisis menggunakan uji chi square dan analisis regresi logistik.

Hasil: Lebih banyak pelajar berkronotipe pagi (64,8%) dibandingkan tipe malam (35,2%). Sebanyak 28,1% pelajar mengalami rinitis alergi dalam 12 bulan terakhir. Kronotipe berhubungan signifikan dengan rinitis alergi (p<0,05; OR=2,273; CI 95% 1,198-4,311). Terdapat perbedaan proporsi rinitis alergi yang signifikan antara pelajar dengan kronotipe malam (39.1%) dan pelajar dengan kronotipe pagi (22%).

Kesimpulan: Terdapat perbedaan proporsi rinitis alergi yang signifikan antara pelajar sekolah menengah atas dengan kronotipe malam dan pelajar dengan kronotipe pagi.

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Changes in lifestyle over the times make human chronotypes more varied. The evening type are known to be frequently found among late adolescents. Circadian rhythm has a relationship with the immune system and allergic disease. Allergic rhinitis is the most common allergic disease among adolescents and can reduce the patient's quality of life. This study aims to determine the relationship between chronotype and allergic rhinitis in high school students.

Method: In this cross-sectional study, 196 high school students answered four different questionnaires: the International Study of Asthma and Allergy in Childhood Core Questionnaire, the Reduced Version Morningness-Eveningness Questionnaire, Epworth Sleepiness Scale and Kuesioner Studi Kohort Faktor Risiko Penyakit Tidak Menular Tahun 2011 Bagian Penggunaan Tembakau dan Kebiasaan Merokok. The data was analyzed using chi-square test and logistic regression.

Result: More students were morning type (64,8%) compared to evening type (35,2%). As many as 28.1% of students experienced allergic rhinitis in the last 12 months. Chronotype was significantly associated with allergic rhinitis (p<0,05; OR=2,273; CI 95% 1,198-4,311). There was a significant difference in the proportion of allergic rhinitis between high school students with evening chronotype (39,1%) and high school students with morning chronotype (22%).

Conclusion: There was a significant difference in the proportion of allergic rhinitis between high school students with evening chronotype and students with morning chronotype."