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Ditemukan 117 dokumen yang sesuai dengan query
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The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the...
Hoboken, New Jersey: Wiley-VCH, 2008
e20394504
eBooks  Universitas Indonesia Library
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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability...
Weinheim, Germany: Wiley-VCH, 2003
e20394591
eBooks  Universitas Indonesia Library
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Ruthven, Douglas M., author
New York: Wiley-VCH, 1994
660.284 23 RUT p
Buku Teks  Universitas Indonesia Library
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Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. The authors discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining...
Weinheim: Wiley-VCH, 2006
e20395921
eBooks  Universitas Indonesia Library
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The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism, from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. Here, the authors, all of them employed at...
Weinheim, Germany: Wiley-VCH, 2001
e20394494
eBooks  Universitas Indonesia Library
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Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in...
Weinheim, Germany: Wiley-Vch, 1997
e20377187
eBooks  Universitas Indonesia Library
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Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right...
Weinheim, Germany: Wiley-VCH, 2003
e20385324
eBooks  Universitas Indonesia Library
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This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries,...
Weinheim, Germany: Wiley-VCH, 2008
e20395825
eBooks  Universitas Indonesia Library
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The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. Following a brief introduction to the necessities of filtering and risk assessment of potential new...
Weinheim, Germany: Wiley-VCH, 2009
e20394190
eBooks  Universitas Indonesia Library
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Weinheim: Wiley VCH, 2009
615.19 HIT
Buku Teks  Universitas Indonesia Library
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