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"The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.Readership: Researchers in mathematical biology, mathematical modeling, biology, mathematical oncology."

"This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included."

"Cet ouvrage présente les communications du 12e Cours supérieur francophone sur le cancer du sein qui s’est déroulé du 19 au 22 Janvier 2011 au Palais des congrès de Nice. Ce cours réunit chaque année près de 200 conférenciers, experts francophones du domaine, et plus de 700 participants.L’objectif est de faire le point sur l’actualité de la prise en charge de cette pathologie de plus en plus fréquente. La première journée du cours était consacrée aux soins oncologiques de support et aux actualités en chirurgie. Trente oncologues ont présenté, à partir d’une veille bibliographique, l’état des connaissances dans toutes les disciplines couvertes : chirurgie, anatomopathologie, radiothérapie, traitements systémiques sans oublier d’aborder les prises en charge particulières des formes métastatiques, des patientes non ménopausées ou des patientes âgées."

"The seventh edition is the most radical revision of this textbook to date and now includes color figures, a visual transformation over the sixth edition. However, we were careful to retain the same format as the sixth edition, which divided the book into two parts. Part I contains 17 chapters and represents both a general introduction to radiation biology and a complete self-contained course in the subject, suitable for residents in diagnostic radiology and nuclear medicine. It follows the format of the Syllabus in Radiation Biology prepared by the Radiological Society of North America (RSNA), and its content reflects the questions appearing in recent years in the written examination for diagnostic radiology residents given by the American Board of Radiology. Part II consists of 11 chapters of more in-depth material designed primarily for residents in radiation oncology. We live in an exciting time, but yet a dangerous time as well. The threat of nuclear terror rears its head way too often. If such an event occurs, those trained in the radiation sciences will be called on to manage exposed individuals. For this reason, we have included a new chapter on Radiologic Terrorism (Chapter 14). The translation of molecular imaging into the clinic is moving at a rapid pace. Therefore, we also included a chapter on fundamental concepts in molecular imaging that involves ionizing radiation such as CAT scans and PET imaging to reflect these new advances and describe the underlying biologic principles for each of these technologies (Chapter 15). The subject of retreatment with radiotherapy is not covered in most textbooks, and, because of this void, we have dedicated a new chapter to this subject"

"Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature."

"Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained."

"It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described."

"The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained. "

"Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists."

"Colpiscono circa 170 mila italiani, con un trend in forte ascesa. Si chiamano Malattia di Crohn e colite ulcerosa: malattie autoimmuni, ovvero causate da un errore del sistema immunitario che si scatena contro se stesso. Perché? Come fermare questa furia distruttiva? Sono stati fatti grandi passi avanti ma molto resta ancora da scoprire e molte sono le questioni controverse: dalle cause della malattia ai metodi di diagnosi più tempestiva, alle terapie. Le malattie autoimmuni dell'intestino colpiscono in giovane età, tra i 15 e i 45 anni, hanno un impatto molto negativo sulla qualità della vita di chi si ammala e pongono questioni di primissimo piano: come si convive con una diagnosi di questo tipo, qual è il migliore accesso alle cure, quali le disposizioni di legge che facilitano la vita dei malati. Questo libro vuole raccontare la vita e la battaglia quotidiana delle persone colpite da queste malattie, le scelte che devono fare e gli ostacoli che si trovano ad affrontare, dal punto di vista di uno dei massimi esperti mondiali della materia, Silvio Danese, e da quello di un giovane paziente, Marco Greco, che ha trasformato la sua lotta quotidiana in una battaglia condotta a nome di tutti i malati. Gettando luce su uno dei più straordinari misteri della medicina moderna, le malattie autoimmuni, questo volume affronta senza omissioni il grande tema sanitario dell’Italia di oggi, la cronicità, la condizione sociale e medica di milioni di persone costrette a convivere con la malattia per decenni."