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Abstrak :
ABSTRAK
Esomeprazol merupakan salah satu obat penghambat pompa proton yang efektif untuk mempertahankan pH lambung. Esomeprazol dibuat dalam bentuk tablet salut selaput sehingga termasuk obat wajib Uji Bioekivalensi menurut Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia tentang Obat Wajib Uji Ekivalensi. Uji Bioekivalensi obat harus menggunakan metode bioanalisis yang tervalidasi. Penelitian ini bertujuan untuk mengembangkan metode analisis esomeprazol dalam plasma mulai dari kondisi kromatografi optimum, metode preparasi plasma optimum, hingga validasi metode analisis. Kondisi kromatografi optimum adalah kolom C-18 (Waters, SunfireTM 5 µm; 250 x 4,6 mm), suhu kolom 40 oC; fase gerak asetonitril ? dapar fosfat pH 7,6 (40 : 60 %v/v); laju alir 1,00 mL/menit; detektor photodiode array pada panjang gelombang 300 nm; dan lansoprazol sebagai baku dalam. Preparasi sampel menggunakan metode ekstraksi cair-cair dengan pelarut diklorometan lalu dikeringkan dengan gas nitrogen pada suhu 40 oC selama 30 menit; dan direkonstitusi dengan fase gerak sebanyak 100 µL. Hasil validasi terhadap metode analisis esomeprazol yang dilakukan memenuhi persyaratan validasi berdasarkan EMEA Bioanalytical Guideline tahun 2011. Metode yang diperoleh linear pada rentang konsentrasi 5,0 ? 450,0 ng/mL dengan r > 0,9997.

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ABSTRAK
Esomeprazole is a proton pump inhibitor drug that is effective to maintain the pH of the stomach. Esomeprazole was formulated as film coated tablet that includes mandatory drug testing bioequivalence according to Regulation Head of National Agency of Drug and Food of the Republic of Indonesia about Mandatory Drug Testing equivalences. Drug bioequivalence trials should use validated bioanalytical method. This research aimed to develop analytical methods esomeprazole in human plasma from optimum chromatographic conditions, the optimum plasma preparation method, until the validation of analytical methods. The optimum chromatographic condition was obtain using C-18 column (Waters, Sunfire? 5 μm; 250 x 4.6 mm), column temperature 40 °C; mobile phase acetonitrile - phosphate buffer pH 7.6 (40: 60% v/v); a flow rate of 1.00 mL/min; photodiode array detector at a wavelength of 300 nm; and lansoprazole as internal standard. Sample preparation using liquid-liquid extraction with dichloromethane as solvent and then dried with nitrogen gas at a temperature of 40 °C for 30 minutes; and reconstituted with mobile phase of 100 mL. The results of validation fulfilled the acceptance criteria of validation method based on EMEA Bioanalytical Guideline 2011. The method was linear at concentration range of 5.0 to 450.0 ng / mL with r > 0.9997.

Abstrak :
ABSTRAK
Praktik Kerja Profesi Apoteker di Apotek Kimia Farma No. 352 bertujuan agar mahasiswa Apoteker mampu memahami tugas dan tanggung jawab apoteker dalam pengelolaan apotek, serta melakukan praktik pelayanan kefarmasian sesuai dengan ketentuan perundang -undangan dan etika yang berlaku, memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan praktik kefarmasian di Apotek, dan memiliki gambaran nyata tentang permasalahan praktik kefarmasian serta mempelajari strategi dan kegiatan-kegiatan yang dapat dilakukan dalam rangka pengembangan praktik kefarmasian. Tugas khusus yang diberikan berjudul Kegiatan Pelayanan Kefarmasian Di Rumah Home Pharmacy Care Pada Pasien Hipertensi Di Apotek Kimia Farma No. 352 Depok. Tujuan dari tugas khusus ini agar mahasiswa Apoteker mampu memahami peran Apoteker dalam melakukan praktik pelayanan kefarmasian terutama home pharmacy care, memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan home pharmacy care, dan memiliki gambaran nyata tentang permasalahan home pharmacy care serta mempelajari strategi dan kegiatan-kegiatan yang dapat dilakukan dalam rangka meningkatkan pelayanan home pharmacy care.

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ABSTRACT
Professional Practices for Pharmacists in Apotek Kimia Farma No. 352 was performed so that pharmacists students understood the pharmacists rsquo duties and responsibilities in pharmacy management, also to performed pharmaceutical services according to the applied regulations and ethical standards, had knowledge, information, ability, and practical experience to performed pharmaceutical practices in a pharmacy, and had an actual picture about pharmaceutical problems usually occur and also to learned the strategies and activities which could be performed to develop the pharmaceutical practices. The additional task given was written and titled Pharmaceutical Services Activities at Home Home Pharmacy Care in Hypertension Patients in Apotek Kimia Farma No. 352 Depok. The purpose of this additional task was so that pharmacist students understood pharmacists rsquo role in pharmaceutical practices, especially in home pharmacy care, had knowledge, information, ability, and practical experience to perform home pharmacy care, and had an actual picture about problems usually occur in home pharmacy care, and also to learned the strategies and activities could be performed to develop home pharmacy care.

Abstrak :
ABSTRAK
Praktik Kerja Profesi Apoteker di PT. Bayer Indonesia ndash; Cimanggis Plant bertujuan agar mahasiswa Apoteker mampu mengerti peranan, tugas dan tanggung jawab apoteker di industri farmasi, memiliki wawasan, pengetahuan, ketrampilan, dan pengalaman praktis untuk melakukan pekerjaan kefarmasian di industri farmasi, serta memahami penerapan CPOB di industri farmasi. Tugas khusus yang diberikan berjudul Studi Data Validasi Proses Produk X Di PT. Bayer Indonesia ndash; Cimanggis Plant. Tujuan dari tugas khusus ini adalah mengetahui hasil validasi proses salah satu produk dan menarik kesimpulan dari hasil yang didapat dan agar mahasiswa Apoteker memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan validasi proses dan menganalisis hasilnya.

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ABSTRACT
Professional Practices for Pharmacists in PT. Bayer Indonesia ndash Cimanggis Plant was performed so that pharmacist students able to understood the roles, duties and responsibilities of pharmacist in pharmaceutical industry, had knowledge, information, ability, and practical experience to performed pharmaceutical work in pharmaceutical industry, and also to understood the GMP application in pharmaceutical industry. The additional task given was written and titled Validation Data Study on Product X Processing in PT. Bayer Indonesia ndash Cimanggis Plant. The aim of this additional task was to determine validation result on one product and make conclusion based on the obtained result and so that pharmacist students had knowledge, information, ability, and practical experience to perform processing validation and analyzing result obtained.

Abstrak :
ABSTRAK
Praktik Kerja Profesi Apoteker di Direktorat Jenderal Kefarmasian dan Alat Kesehatan bertujuan agar calon apoteker mampu memahami peranan, tugas dan tanggung jawab apoteker di Direktorat Jenderal Kefarmasian dan Alat Kesehatan, Direktorat Penilaian Alat Kesehatan dan PKRT. Selain itu agar calon apoteker Memiliki wawasan, pengetahuan, keterampilan dan pengalaman praktis serta gambaran nyata tentang permasalahan dalam melakukan pekerjaan di Direktorat Jenderal Kefarmasian dan Alat Kesehatan, Direktorat Penilaian Alat Kesehatan dan PKRT. Tugas khusus yang diberikan berjudul Studi Alur Registrasi Apoteker Di Komite Farmasi Nasional.

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ABSTRACT
Professional Practices for Pharmacists in General Directorate of Pharmacy and Medical Devices was performed so that pharmacist candidates able to understand the roles, duties and responsibilities of pharmacists in General Directorate of Pharmacy and Medical Devices, Assessment Directorate of Medical Devices and PKRT. Also, so that pharmacist candidates had knowledge, information, ability and practical experiences, also an actual picture about the problems usually occur in General Directorate of Pharmacy and Medical Devices and PKRT. The additional task given was written and titled Pharmacist Registration Plot Study in National Pharmaceutical Committee.