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"Gliklazid (GL) merupakan obat hipoglikemia oral golongan sulfonilurea generasi kedua yang digunakan untuk perawatan diabetes militus tidak bergantung insulin (Non-Insulin Dependent Diabetes Mellitus). Permasalahan utama dalam formulasi gliklazid adalah sifat kelarutannya yang sangat rendah dalam air sehingga membatasi absorpsinya. Penelitian ini dimaksudkan untuk membandingkan peningkatan laju disolusi gliklazid dengan membentuk kompleks inklusi dengan betasiklodekstrin dan hidroksipropil betasiklodekstrin. Pembuatan kompleks inklusi dilakukan dengan metode spray drying. FTIR, XRD, dan DSC digunakan untuk mengkarakterisasi kompleks inklusi gliklazid betasiklodekstrin dan kompleks inklusi gliklazid hidroksipropil betasiklodekstrin. Laju disolusi gliklazid dan kompleks inklusi diuji dalam medium HCl dan dapar fosfat pH 6,8. Hasil analisis kompleks inklusi dengan FTIR, XRD, dan DSC menunjukkan terjadinya penurunan derajat kristalinitas dan terbentuknya kompleks inklusi. Pembentukan kompleks inklusi gliklazid betasiklodekstrin dapat meningkatkan laju disolusi dari serbuk sebesar 1,9 kali dan dari tablet sebesar 1,13 kali, sedangkan kompleks inklusi gliklazid hidroksipropil betasiklodekstrin dapat meningkatkan laju disolusi dari serbuk sebesar 2,1 kali dan dari tablet sebesar 1,44 kali.

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Gliclazide (GL) is a second-generation sulphonylurea of hypoglycemia drug which is used for nor insulin independent diabetes mellitus treatment (Non-Insulin Dependent Diabetes Mellitus). Primary problem in gliclazide formulation is its low solubility in water that limits its absorption. This study is intended to compare the enhancement of dissolution rate of gliclazide by forming inclusion complexes with betacyclodextrin and hydroxypropyl betacyclodextrin. Inclusion complexes were made by spray drying method. FTIR, XRD, and DSC were used to characterize inclusion complexes of gliclazide-β-cyclodextrin and gliclazidehydroxypropyl- β-cyclodextrin. Dissolution rate of gliclazide and inclusion complexes were examined in HCl and buffer phosphate pH 6,8. Analysis result of complexes with FTIR, XRD, and DSC showed reduction degree of crystalinity and formation of inclusion complexes. Formation of gliclazide-β-cyclodextrin inclusion complexes could increase dissolution rate from powder’s form about 1.9 times and from tablet dosage form about 1.13 times, however formation of gliclazide-hydroxypropyl-β-cyclodextrin inclusion complexes could increase dissolution rate from powder’s form about 2.1 times and from tablet dosage form about 1.44 times."

"Praktek Kerja Profesi Apoteker di Apotek Keselamatan bertujuan agar mahasiswa program profesi apoteker dapat (1) Mengetahui dan memahami peran dan tanggung jawab seorang apoteker dalam pengelolaan apotek, dan (2) Memahami dan melaksanakan kegiatan di apotek, baik secara teknis kefarmasian maupun non teknis kefarmasian. Selain itu, pembuatan tugas khusus bertujuan agar mahasiswa program profesi apoteker dapat (1) Memahami farmakoterapi faringitis, dan (2) Mengetahui aplikasi farmakoterapi faringitis dan pelayanan kefarmasian pada pasien faringitis di Apotek Keselamatan.

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Pharmacist Internship at Apotek Keselamatan aims to apothecary professional program student can get the information about (1) To know and understand about roles and responsibilities of apothecary in pharmacy management, and (2) Understand and implementing activities at pharmacy, both technically and non technically. Moreover, special assignment was made in order to apothecary professional program student can get the information about (1) To understand about pharyngitis's pharmacotherapy, and (2) To know pharyngitis's pharmacotherapy application and pharmaceutical care for pharyngitis patient at Apotek Keselamatan."

"Praktek Kerja Profesi Apoteker di PT. Kimia Farma Trading and Distribution bertujuan agar mahasiswa program profesi apoteker dapat (1) Mengetahui dan memahami Cara Distribusi Obat yang Baik di PT. Kimia Farma Trading and Distribution, dan (2) Memahami peran dan tanggung jawab apoteker di Pedagang Besar Farmasi (PBF). Selain itu, pembuatan tugas khusus bertujuan agar mahasiswa program profesi apoteker dapat (1) Mengetahui dan memahami penerapan Cara Distribusi Obat yang Baik, khususnya dalam manajemen penyimpanan obat yang efektif (sistem pergudangan), dan (2) Memahami peran dan tanggung jawab apoteker dalam menjamin penyimpanan obat yang efektif (peran logistik).

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Pharmacist Internship at PT. Kimia Farma Trading and Distribution aims to apothecary professional program student can get the information about (1) To know and understand about Good Distribution Practice at PT. Kimia Farma Trading and Distribution, and (2) To know about roles and responsibilities of apothecary at Pedagang Besar Farmasi (PBF). Moreover, special assignment was made in order to apothecary professional program student can get the information about (1) To know and understand about Good Distribution Practice, especially in effectiveness in drug logistic management (logistic system), and (2) To know and understand about roles and responsibilities of apothecary in guarantee effectiveness in drug logistic (logistic role)."

"Praktek Kerja Profesi Apoteker di Badan Pengawas Obat dan Makanan bertujuan agar mahasiswa program profesi apoteker dapat (1) Meningkatkan pemahaman tentang peran dan tanggung jawab apoteker di dalam lembaga pemerintahan, (2) Membekali calon Apoteker agar memiliki wawasan, pengetahuan, keterampilan dan pengalaman praktis untuk melakukan pekerjaan kefarmasian di lembaga pemerintahan, dan (3) Meningkatkan dan melatih keterampilan komunikasi dan interaksi dengan rekan sejawat. Selain itu, pembuatan tugas khusus bertujuan agar mahasiswa program profesi apoteker dapat (1) Menelusuri penyebab peredaran obat palsu di Indonesia berdasarkan aspek distribusi, (2) Mengetahui dan memahami penerapan Cara Distribusi Obat yang Baik, khususnya dalam rantai distribusi obat, dan (3) Memahami peran dan tanggung jawab apoteker dalam pendistribusian obat.

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Pharmacist Internship at National Agency Drug and Food Control aims to apothecary professional program student can get the information about (1) Improve understanding about roles and responsibilities of an apothecary at government institution, (2) To prepare the pharmacist trainee in order to have a knowledge, soft skill and practical experience to do the pharmacy's job at government institution, and (3) To improve and training communication and interaction skills with colleagues. Moreover, special assignment was made in order to apothecary professional program student can get the information about (1) To explore the cause of counterfeit drugs distribution in Indonesia based in distribution aspect, (2) To know and understand about Good Distribution Practice, especially in drug distribution chain supply, and (3) To understand about roles and responsibilities of apothecary in drug distribution."