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"ABSTRAKDiabetes Melitus Tipe 2 (DM Tipe 2) sering dikaitkan dengan penyakit komorbid yaitu hipertensi dan dislipidemia. Peran apoteker belum terlihat untuk mengendalikan penyakit DM tipe 2, komorbid serta kepatuhan terapi pasien dalam perawatan kesehatan primer Indonesia. Tujuan dari penelitian ini adalah untuk mengevaluasi pengaruh konseling apoteker disertai buklet terhadap luaran klinis dan kepatuhan terapi pasien rawat jalan DM Tipe 2. Penelitian dilakukan pada bulan Januari sampai September 2018 dengan desain pre-eksperimental dan pengambilan sampel secara konsekutif. Selama penelitian, subjek diberikan kuesioner sosiodemografi, Medication Adherence Questionnaire, melakukan penilaian pill count adherence, serta pengukuran luaran klinis yang dilakukan sebelum dan sesudah 3 kali diberikan intervensi apoteker. Hasil penelitian 51 pasien memenuhi kriteria inklusi dan eksklusi dan juga menyelesaikan penelitian. Proporsi pasien yang diuji menggunakan kai kuadrat memberikan hasil, pasien dengan kadar Gula Darah Puasa dan HbA1c yang terkontrol serta kepatuhan terapi yang tinggi signifikan lebih banyak dan berbeda bermakna setelah diberikan intervensi dengan nilai (p = <0,0001; 0,014; <0,0001). Analisis perbedaan rerata luaran klinis menggunakan uji T dependen dan Wilcoxon Sign menunjukkan hasil terdapat perbedaan yang signifikan pada kadar GDP (p= <0,0001), HbA1c (p= <0,0001), kolesterol total (p= 0,011), HDL (p= <0,0001), LDL (p= <0,0001) dan kepatuhan terapi (p= <0,0001) sedangkan trigliserida dan tekanan darah tidak berbeda (p >0,05). Penelitian ini menunjukkan bahwa intervensi apoteker yaitu konseling dan pemberian buklet dapat memperbaiki kadar glikemik, mencegah atau memperlambat progresivitas penyakit komorbid, dan efektif meningkatkan kepatuhan terapi pasien.

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ABSTRACTType 2 diabetes mellitus (DM) is often associated with comorbid diseases that is hypertension and dyslipidemia. The role of pharmacists has not been seen to control type 2 DM disease and its comorbidities in Indonesian primary health care. The aim of this study was to evaluate the influence of counseling by pharmacists with the booklet on clinical outcomes and adherence to therapy for outpatients type 2 DM. The study was conducted from January to September 2018 with pre-experimental design and consecutive sampling. During the study, subjects were given a sociodemographic questionnaire, Medication Adherence Questionnaire, do the Pill Adherence Count assessment, measurement clinical outcome before and after 3 times of pharmacy intervention. The study result was 51 patients who entered inclusion-exclusion criteria and had completed the study. The proportion of patients whose tested using chi-squared gave results that patients with controlled Fasting Blood Glucose, HbA1c levels, and high medication adherence was more significant and different after the intervention (p = <0,0001; 0,014; <0,0001). Difference analysis of clinical outcomes using T dependent test and Wilcoxon sign test showed there was a significant difference in FBS (p = <0,0001), HbA1c (p = <0,0001), total cholesterol (p = 0,011), HDL (p = <0,0001), LDL (p = <0,0001) and therapy adherence (p = <0,0001) while triglycerides levels and blood pressure has no difference. This study shows that pharmacist intervention can improve glycemic levels, prevent or decrease progression of comorbid and effective to improve patient compliance."

"ABSTRAKPraktek Kerja Profesi (PKP) di industri farmasi dilaksanakan di DepartemenQuality Control (QC) PT Medifarma Laboratories. Kegiatan ini berlangsungselama 2 bulan dari tanggal 1 Juli sampai dengan tanggal 31 Agustus 2015. PKP diindustri bertujuan agar mahasiswa apoteker mengerti peranan, tugas, dan tanggungjawab Apoteker di Industri Farmasi; memiliki wawasan, pengetahuan,keterampilan, dan pengalaman praktis untuk melakukan pekerjaan kefarmasian diIndustri Farmasi; memahami penerapan CPOB di Industri Farmasi; memilikigambaran nyata tentang permasalahan pekerjaan kefarmasian di Industri Farmasi.Berdasarkan kegiatan PKP yang dilakukan, dapat disimpulkan bahwa peranapoteker penting untuk menghasilkan obat-obatan yang aman, bermutu, danberkhasiat. Apoteker di Departemen QC bertanggung jawab untuk melakukanpengawasan mutu terhadap produk yang diproduski dan memastikan bahwapengujian yang diperlukan dan relevan telah dilakukan dan bahwa bahan yangbelum diluluskan tidak digunakan serta produk yang belum diluluskan tidak dijualatau dipasok sebelum mutunya dinilai dan dinyatakan memenuhi syarat. Mahasiswaapoteker telah berhasil memperoleh gambaran umum dari pelaksanaan pekerjaankefarmasian di PT Medifarma., khususnya di bidang QC yaitu melakukan analisisterhadap bahan awal, produk jadi, inspeksi bahan awal. Dalam melakukan tugasnyadi QC juga mahasiswa apoteker membuat Spreadsheet dan cara memvalidasinyauntuk mendukung analisis dan inspeksi bahan awal. Adanya PKP di PT MedifarmaLaboratories yang telah melaksanakan CPOB dengan baik di semua aspek, pesertaPKP lebih banyak mengetahui dan memahami seperti apa pelaksanaan CPOBsecara real dalam sebuah Industri. Seperti Industri yang lainnya PT MedifarmaLaboratories juga memiliki masalah seperti berpikir bagaimana mengatasi wastetime pada proses maupun para pekerja sehingga suatu proses berlangsung lebihcepat tetapi tetap menghasilkan hasil yang baik dan dapat dipertanggungjawabkan,Oleh karena itu, Apoteker harus memiliki wawasan, pengetahuan dan kreatifitassehingga dapat mengatasi masalah-masalah tersebut.

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ABSTRACTProfession Internship at pharmaceutical industry was held at Quality Control (QC)Department of PT Medifarma Laboratories. This activity was held for two monthfrom July 1st until August 31th 2015. Profession internship at pharmaceuticalindustry was intended to make apothecary student understand the role ofpharmacist, have insight into the implementation of pharmaceutical practice,understand the implementation of Cara Pembuatan Obat yang Baik (CPOB), andknow the issues in pharmaceutical practice in pharmaceutical industry. Based onthe activities, Apothecary at QC Department is responsible for supervising thequality of the product diproduski and ensure that the necessary and relevant testshave been conducted and that the materials have not been approved are not used aswell as products that have not been approved are not sold or supplied before thequality was assessed and found eligible. Apothecary student have obtained insightinto general routine activities in QC Department, those were an analysis of thestarting materials, finished products, inspection of the starting material. Inperforming the task in QC department, apothecary student make a spreadsheet andvalidate them to support the analysis and inspection of the starting material. PTMedifarma Laboratories that has implemented the GMP well in all aspects, giveapothecary student more aware and understand what the real implementation ofGMP in an industry. Such as Industrial others, PT Medifarma Laboratories also hasa problem such as find solution how to solve waste time in the process or theworkers, so that a process was faster but still produce good results. Therefore,pharmacists should have the insight, knowledge and creativity so that can overcomethe problems.;Profession Internship at pharmaceutical industry was held at Quality Control (QC)Department of PT Medifarma Laboratories. This activity was held for two monthfrom July 1st until August 31th 2015. Profession internship at pharmaceuticalindustry was intended to make apothecary student understand the role ofpharmacist, have insight into the implementation of pharmaceutical practice,understand the implementation of Cara Pembuatan Obat yang Baik (CPOB), andknow the issues in pharmaceutical practice in pharmaceutical industry. Based onthe activities, Apothecary at QC Department is responsible for supervising thequality of the product diproduski and ensure that the necessary and relevant testshave been conducted and that the materials have not been approved are not used aswell as products that have not been approved are not sold or supplied before thequality was assessed and found eligible. Apothecary student have obtained insightinto general routine activities in QC Department, those were an analysis of thestarting materials, finished products, inspection of the starting material. Inperforming the task in QC department, apothecary student make a spreadsheet andvalidate them to support the analysis and inspection of the starting material. PTMedifarma Laboratories that has implemented the GMP well in all aspects, giveapothecary student more aware and understand what the real implementation ofGMP in an industry. Such as Industrial others, PT Medifarma Laboratories also hasa problem such as find solution how to solve waste time in the process or theworkers, so that a process was faster but still produce good results. Therefore,pharmacists should have the insight, knowledge and creativity so that can overcomethe problems."

"ABSTRAKPraktek Kerja Profesi (PKP) di apotek bertempat di Apotek Kimia Farma No. 345Tebet. Kegiatan ini berlangsung selama empat minggu dari tanggal 1 sampaidengan tanggal 31 Oktober 2015. PKP di apotek bertujuan agar mahasiswa apotekermengerti peranan Apoteker Pengelola Apotek (APA), memiliki wawasan tentangpelaksanaan pekerjaan kefarmasian, dan memiliki gambaran nyata akanpermasalahan pekerjaan kefarmasian yang terjadi di apotek. Berdasarkan kegiatanPKP yang dilakukan, APA di Apotek Kimia Farma No. 345 Tebet secara umumtelah melaksanakan tugas dan tanggung jawab dalam pengelolaan apotek yaitusebagai pemimpin, manager yang dapat mengelola Apotek, mengelola SDM dalamhal ini karyawan dan berhubungan baik dengan pasien dan/atau pelanggan. Selainitu, dapat melakukan pelayanan kefarmasian dengan baik melalui penyediaan obatyang diperlukan oleh pasien dan/atau pelanggan. Mahasiswa apoteker telah berhasilmemperoleh wawasan mengenai kegiatan rutin yang dilakukan di apotekkhususnya dapat memahami strategi dan kegiatan-kegiatan seperti DC yangmemiliki keunggulan dan juga startegi menarik pasien menjadi pelanggan tetapdalam rangka mengembangkan praktek kefarmasian dan bisnis di Apotek. Masalahyang terjadi di Apotek Kimia Farma No. 345 terkait dengan praktek kefarmasianyaitu pengelolaan perbekalan farmasi khususnya sistem DC yang diterapkan diApotek Kimia Farma 345, namun kadang-kadang jumlah stok yang ada dalamsistem DC tidak sesuai dengan jumlah stok fisik yang ada. ;

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ABSTRACT

Profession Internship at pharmacy was held at Kimia Farma Pharmacy No. 345

Tebet. This activity was held for four weeks from October 1

th

until October 31

th

2015. Profession Internship at pharmacy was intended to make apothecary student

understand the role of pharmacist, have insight into the implementation of

pharmaceutical practice, and know the issues in pharmaceutical practice in

pharmacy. Based on the activities, pharmacist as Pharmacy Manager have been

carrying out the duties and responsibilities in pharmacy management. Apothecary

student have obtained insight into routine activities in pharmacy especially can

understand the strategies and activities such as DC that have benefit and strategy to

attract patients become regular costumers in order to develop the practice of

pharmacy and pharmacy?s business. Issue at Kimia Farma No. 345 associated with

the practice of pharmacy that is pharmaceutical supply management specifically

DC systems applied in Kimia Farma 345, but sometimes the number of existing

stock in the DC system does not correspond to the amount of physical stock.

;Profession Internship at pharmacy was held at Kimia Farma Pharmacy No. 345Tebet. This activity was held for four weeks from October 1th until October 31th2015. Profession Internship at pharmacy was intended to make apothecary studentunderstand the role of pharmacist, have insight into the implementation ofpharmaceutical practice, and know the issues in pharmaceutical practice inpharmacy. Based on the activities, pharmacist as Pharmacy Manager have beencarrying out the duties and responsibilities in pharmacy management. Apothecarystudent have obtained insight into routine activities in pharmacy especially canunderstand the strategies and activities such as DC that have benefit and strategy toattract patients become regular costumers in order to develop the practice ofpharmacy and pharmacy?s business. Issue at Kimia Farma No. 345 associated withthe practice of pharmacy that is pharmaceutical supply management specificallyDC systems applied in Kimia Farma 345, but sometimes the number of existingstock in the DC system does not correspond to the amount of physical stock."

"Praktek Kerja Profesi (PKP) di pemerintahan bertempat di Badan Pengawas Obat dan Makanan Jakarta Pusat. Khususnya di Direktorat Pengawasan Narkotika, Psikotropika dan Zat Adiktif. Kegiatan ini berlangsung selama tiga minggu dari tanggal 8 sampai dengan tanggal 30 September 2015. PKP di BPOM bertujuan agar mahasiswa apoteker mengerti tugas dan tanggung jawab apoteker, memiliki pengetahuan tentang tugas pokok dan fungsi BPOM, memiliki wawasan, pengetahuan, keterampilan dan pengalaman praktis melakukan pekerjaan di BPOM serta memiliki gambaran nyata akan permasalahan pekerjaan kefarmasian di BPOM. Berdasarkan kegiatan PKP yang dilakukan, Apoteker bertanggung jawab penuh atas seluruh kegiatan pengawasan obat dan makanan. Mahasiswa apoteker telah memiliki pengetahuan dan pengalaman mengenai proses inspeksi, sertifikasi dan pengaturan. Berdasarkan pengamatan selama pelaksanaan PKP masalah yang terjadi di BPOM khususnya di Direktorat Pengawasan Narkotika, Psikotropika dan Zat Adiktif salah satunya kurang responnya Dinas Kesehatan Provinsi atau Kabupaten/Kota terhadap Rekomendasi Tindak Lanjut Hasil Pengawasan yang dikirimkan Direktorat Pengawasan Narkotika, Psikotropika dan Zat Adiktif.

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Profession Internship at government at Badan Pengawas Obat dan Makanan, Jakarta Pusat especially at Direktorat Pengawasan Narkotika, Psikotropika dan Zat Adiktif. This activity was held for three weeks from September 8th until September 30th 2015. Profession Internship at BPOM aims to make apothecary student understand the duties and responsibilities of pharmacists, have knowledge of the basic tasks and functions of BPOM, insight, knowledge, skills and practical experience doing work in BPOM and have a real picture of the issues of pharmacy jobs in BPOM. Based on the activities, Pharmacists are fully responsible for all activities of drug and food control. Student pharmacists already have the knowledge and experience of the inspection, certification and regulation. Based on observations during the implementation of the PKP the problems that occur in BPOM especially in the Directorate of narcotics, psychotropic and addictive substances one less response to the Provincial Health Office or District / Town on Oversight Recommendations Follow-up results are sent Directorate of narcotics, psychotropic and addictive substances."