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"Hipertensi merupakan masalah penting dalam kesehatan masyarakat secara global. Penelitian ini bertujuan mengetahui prevalensi hipertensi pada masyarakat kota Ternate dan menyelidiki hubungan antara perilaku masyarakat dengan prevalensi hipertensi. Sebuah studi potong lintang dilakukan pada penduduk berumur lebih dari 20 tahun di 3 kecamatan kota Ternate. Pengambilan sampel dilakukan dengan metode multi-stage random sampling. Secara umum, 32,6% dari populasi dewasa masyarakat kota Ternate mengidap hipertensi. Terdapat hubungan bermakna antara kebiasaan merokok (p=0,001), kebiasaan mengudap Chiki (p=0,007) dan mengudap gorengan (p=0,032) dengan prevalensi hipertensi. Dibandingkan dengan prevalensi hipertensi nasional, prevalensi hipertensi pada masyarakat kota Ternate masih terbilang tinggi.

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Hypertension is an important public-health challenge worldwide. This research aims to estimate the current prevalence of hypertension in Kota Ternate and to determine the correlation between behavior and prevalence of hypertension in adult population. A cross-sectional study was conducted to citizens over 20 years old in three sub districts of Kota Ternate. Research samples were selected through a multi-stage random sampling. Overall, 32.6% of adult population in Ternate had hypertension. We found significant correlations between prevalence of hypertension and smoking status (p=0,001); snacks consumption [Chiki (p=0,007) and fried food (p=0,032)]. Comparing to the national prevalence of hypertension launched by Ministry of Health, the local prevalence in Ternate was still high."

"Latar Belakang: Proprotein convertase subtilisin kexin-9 PCSK-9 merupakan protein yang menghancurkan reseptor low density lipoprotein LDL sehingga penurunan kadarnya dapat menurunkan kadar LDL. Sebagai bagian dari pencegahan sekunder, latihan resistensi direkomendasikan pada pasien pasca bedah pintas arteri koroner BPAK. Tujuan: Mengetahui efek tambahan latihan resistensi terhadap kadar PCSK-9 pada pasien pasca bedah pintas arteri koroner yang menjalani rehabilitasi fase II. Metode: Studi eksperimental randomisasi acak tersamar tunggal membagi 87 pasien pasca BPAK menjadi dua kelompok. Kelompok kontrol n=43 adalah pasien yang menjalani rehabilitasi fase II standar sementara kelompok intervensi n=44 adalah pasien yang menjalani rehabilitasi fase II ditambah dengan latihan resistensi tersupervisi. Kadar PCSK-9 diperiksa sebelum dan sesudah rehabilitasi fase II pada kedua kelompok. Hasil: Setelah menyelesaikan rehabilitasi fase II, didapatkan perbedaan kadar PCSK-9 yang bermakna antara kelompok kontrol dan intervensi 377,1 SD 125 vs 316,6 111,1 ng/ml, ?= -60,5 ng/ml, 95 CI -7,5 -113,4, p=0.026. Tidak didapatkan perbedaan bermakna pada kadar LDL p=0,07, kolesterol total p=0,99, high density lipoprotein HDL p=0,44, dan trigliserid p=0,56 antara kedua kelompok pada akhir rehabilitasi fase II. Kesimpulan: Tambahan latihan resistensi dapat menurunkan kadar PCSK-9 secara bermakna pada pasien pasca bedah pintas arteri koroner yang menjalani rehabilitasi fase II.

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Background: Pro protein Convertase Subtilisin Kexin 9 PCSK 9 is a protein degrading low density lipoprotein LDL receptor that lower LDL. As secondary prevention, resistance training is recommended after coronary artery bypass surgery CABG as a complement to aerobic exercise.

Objective: To determine the effects of additional resistance training on PCSK 9 levels and lipid profile in post CABG patients who undergo phase II cardiac rehabilitation.

Methods: A single blinded randomized clinical trial of 87 post CABG patients was devided into two groups. The control group n 43 consisted of patients who received standard phase II cardiac rehabilitation while intervention group n 44 received standard program and supervised resistance training. PCSK 9 level and lipid profile examination were performed pre and post training.

Results: After completion of phase II cardiac rehabilitation, mean PCSK9 levels in intervention group decrease significantly compared to control group control vs intervention, 377,1 SD 125 vs 316,6 111,1 ng ml, 60,5 ng ml, 95 CI 7,5 113,4 , p 0.026 . Nonetheless, there are still no significant changes in terms of LDL level p 0,07 , total cholesterol p 0,99 , high density lipoprotein p 0,44 and triglyseride levels p 0,56 pre and post intervention between two groups.

Conclusion: The additional resistance training can reduce significantly PCSK 9 levels in patients after CABG surgery who underwent phase II cardiac rehabilitation."