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"Kuersetin merupakan senyawa flavonoid yang memilki khasiat sebagai antioksidan. Fraksi etil asetat dalam daun jambu biji (Psidium guajava L.) memiliki kandungan senyawa kuersetin yang paling tinggi. Dalam penelitian ini, aktivitas antioksidan dari senyawa kuersetin diukur dengan metode peredaman DPPH (2,2-Difenil-1-pikrilhidrazil) untuk memperoleh nilai IC50 dari fraksi etil asetat ekstrak etanol 96% daun jambu biji. Aktivitas antioksidan yang dimiliki oleh daun jambu biji memiliki mekanisme sebagai peredam radikal bebas dengan mendonorkan elektron kepada senyawa radikal bebas. Penelitian ini bertujuan untuk menguji aktivitas antioksidan fraksi etil asetat pada ekstrak etanol daun jambu biji, membuat 3 formula krim anti kerut yang mengandung ekstrak daun jambu biji, dan menguji stabilitas fisik melalui pengamatan selama 12 minggu pada suhu kamar (28±2ºC), suhu rendah (4±2ºC), dan suhu tinggi (40±2ºC). Setelah itu, dilakukan juga pengukuran aktivitas antioksidan dari sediaan tersebut. Nilai IC50 yang didapat dari hasil fraksinasi etil asetat yaitu sebesar 10,3429 ppm. Kemudian dibuat ketiga formula dengan konsentrasi ekstrak daun jambu biji yang bervariasi yaitu 0,1%, 0,25%, dan 0,5%. Ketiga formulasi tersebut stabil secara fisik pada tiga kondisi suhu penyimpanan yang berbeda, yaitu pada suhu kamar (28±2ºC), suhu dingin (4±2ºC), dan suhu tinggi (40±2ºC).

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Quercetin which is a type of flavonoid is a compound that has antioxidant activity. The ethyl acetate fraction of guava leaves (Psidium guajava L.) contain the highest compound of quercetin. In this research, antioxidant activity assay of quercetin was measured using DPPH (2,2-Difenil-1pikrilhidrazil) method to obtain IC50 values of ethyl aceate fraction of ethanol extract of guava leaves. The mechanism of antioxidant cream of guava leaves is donating an electron to free radical compounds.

The aim of this research is to examine the antioxidant acivity of ethyl acetate fraction in the ethanol extract of guava leaves, to make three formulations of anti wrinkle cream which contain ethanol extract of guava leaves, and test its physical stability for twelve weeks at different temperatures; room temeperature (28 ± 2ºC), low temperature (4 ± 2ºC), and high temperature (40 ± 2ºC). After that, antioxidant activity assay of anti wrinkle cream was tested.

IC50 values of ethyl acetate fraction of ethanol extract guava leaves was 10.3429 ppm. Then, three formulas were made with guava leaf extract concentrations were varied at 0.1%, 0.25%, and 0.5%. All three formulations showed physical stability with three different temperature conditions; room temeperature (28 ± 2ºC), low temperature (4 ± 2ºC), and high temperature (40 ± 2ºC)."

"[ABSTRAKKegiatan PKP Praktek Kerja Profesi yang dilaksanakan di industri farmasi yaitu PT Guardian Pharmatama memiliki tujuan agar mahasiswa dapat memahami penerapan CPOB Cara Pembuatan Obat yang Baik di industri farmasi mengetahui secara garis besar gambaran pekerjaan kefarmasian di industri farmasi dan mendapatkan pengetahuan wawasan serta pengalaman praktis secara langsung dalam penerapan pekerjaan kefarmasian di industri farmasi Penerapan CPOB diperlukan sebagai syarat utama industri farmasi untuk melakukan kegiatan pembuatan obat dan PT Guardian Pharmatama telah menerapkan serta melakukan pelatihan CPOB dengan baik Tugas khusus yang diberikan saat Praktek Kerja Profesi di industri farmasi adalah pembutan prosedur tetap identifikasi bakteri patogen pada bahan baku dan sediaan sirup Tugas khusus ini memiliki tujuan untuk memberikan pengetahuan dan pemahaman mengenai pembuatan prosedur tetap sebelum pemeriksaan dan memahami proses pemeriksaan bakteri patogen yang memiliki dampak terhadap mutu produk

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ABSTRACTThe aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality ;ABSTRACT Name Carmelta Dissa WardhaniNPM 1406525016Study Program ApothecaryTitle Apothecary Internship Program at PT Guardian Pharmatama January ndash February 2015 The aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality , ABSTRACT Name Carmelta Dissa WardhaniNPM 1406525016Study Program ApothecaryTitle Apothecary Internship Program at PT Guardian Pharmatama January ndash February 2015 The aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality ]"

"[Kegiatan PKP (Praktek Kerja Profesi) dilaksanakan di Badan Pengawas Obat dan Makanan memiliki tujuan memahami peranan, tugas, dan tanggung jawab apoteker di instasi pemerintahan, menambah pengalaman praktis mengenai pekerjaan kefarmasian di Badan POM, serta memiliki gambaran nyata mengenai masalah kefarmasian di instansi pemerintah. Praktek kerja dilaksanakan di salah satu unit penunjang Badan POM yaitu Pusat Riset Obat dan Makanan (PROM). Mahasiswa melakukan pengkajian dokumen untuk meningkatkan mutu instansi dan kinerja dari personel. Mahasiswa juga melakukan verifikasi terhadap metode uji bahan tambahan pangan berbahaya dalam produk pangan yaitu, formalin dan rhodamin b . Tugas khusus yang diberikan adalah melakukan pengkajian terhadap riset penggunaan polimer nanokomposit biodegradable sebagai bahan kemasan pangan yang ramah lingkungan. Berdasarkan pengkajian riset tersebut dapat dibuktikan bahwa modifikasi antara polimer sintetik dan polimer alam dapat mempercepat degradasi polimer sehingga dapat mengatasi masalah pencemaran lingkungan.Apothecary Internship Program at the Food and Drug Administration (Badan POM) had the goal to understanding the role and responsibilities of pharmacists in government, gain experience about pharmacy jobs in Badan POM, and has a real picture of the pharmaceutical problem in government agencies. Apothecary internship program carried out in one of the supporting section in Badan POM namely Research Centre for Drugs and Food (PROM). Students had given task to review the documents to improve the quality performance of personnel agencies. Students also conducted verification of the identification method food additives in food products, for example to identification formalin and rhodamine b. Student had Given the special task is to reviewed a research study on the use of biodegradable polymer nanocomposite as a food packaging material. Based on these research studies can be proven that the modifications between synthetic polymers and natural polymers can accelerate the degradation of the polymer so as to overcome the problem of environmental pollution.; ABSTRACT Name Carmelita Dissa Wardhani NPM 1406525016 Study Program Apothecary Title Apothecary Internship Program at Badan Pengawas Obat dan Makanan March 2015 Apothecary Internship Program at the Food and Drug Administration Badan POM had the goal to understanding the role and responsibilities of pharmacists in government gain experience about pharmacy jobs in Badan POM and has a real picture of the pharmaceutical problem in government agencies Apothecary internship program carried out in one of the supporting section in Badan POM namely Research Centre for Drugs and Food PROM Students had given task to review the documents to improve the quality performance of personnel agencies Students also conducted verification of the identification method food additives in food products for example to identification formalin and rhodamine b Student had Given the special task is to reviewed a research study on the use of biodegradable polymer nanocomposite as a food packaging material Based on these research studies can be proven that the modifications between synthetic polymers and natural polymers can accelerate the degradation of the polymer so as to overcome the problem of environmental pollution ; ABSTRACT Name Carmelita Dissa Wardhani NPM 1406525016 Study Program Apothecary Title Apothecary Internship Program at Badan Pengawas Obat dan Makanan March 2015 Apothecary Internship Program at the Food and Drug Administration Badan POM had the goal to understanding the role and responsibilities of pharmacists in government gain experience about pharmacy jobs in Badan POM and has a real picture of the pharmaceutical problem in government agencies Apothecary internship program carried out in one of the supporting section in Badan POM namely Research Centre for Drugs and Food PROM Students had given task to review the documents to improve the quality performance of personnel agencies Students also conducted verification of the identification method food additives in food products for example to identification formalin and rhodamine b Student had Given the special task is to reviewed a research study on the use of biodegradable polymer nanocomposite as a food packaging material Based on these research studies can be proven that the modifications between synthetic polymers and natural polymers can accelerate the degradation of the polymer so as to overcome the problem of environmental pollution , ABSTRACT Name Carmelita Dissa Wardhani NPM 1406525016 Study Program Apothecary Title Apothecary Internship Program at Badan Pengawas Obat dan Makanan March 2015 Apothecary Internship Program at the Food and Drug Administration Badan POM had the goal to understanding the role and responsibilities of pharmacists in government gain experience about pharmacy jobs in Badan POM and has a real picture of the pharmaceutical problem in government agencies Apothecary internship program carried out in one of the supporting section in Badan POM namely Research Centre for Drugs and Food PROM Students had given task to review the documents to improve the quality performance of personnel agencies Students also conducted verification of the identification method food additives in food products for example to identification formalin and rhodamine b Student had Given the special task is to reviewed a research study on the use of biodegradable polymer nanocomposite as a food packaging material Based on these research studies can be proven that the modifications between synthetic polymers and natural polymers can accelerate the degradation of the polymer so as to overcome the problem of environmental pollution ]"