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"Kemoterapi merupakan salah satu modalitas terapi kanker payudara. Kombinasi dari 5-fluorourasil, doksorubisin, dan siklofosfamid (FAC) adalah protokol kemoterapi yang paling banyak digunakan. Penelitian ini bertujuan untuk mengidentifikasi masalah terkait obat pada pasien kanker payudara yang menjalani kemoterapi FAC di Rumah Sakit Kanker Dharmais dalam periode Juli-Desember 2019. Penelitian dilakukan menggunakan metode observasional deskriptif dengan desain penelitian potong lintang (cross-sectional) menggunakan data restropektif. Masalah terkait obat yang diidentifikasi pada penelitian ini, meliputi dosis dan interaksi obat. Hasil penelitian menunjukkan insiden kanker payudara tertinggi pada kelompok umur 44-54 tahun (43,70%) dan penggunaan obat penunjang tertinggi terdapat pada ondansetron (27,17%). Masalah terkait obat dengan dosis yang tidak sesuai sebesar 9,24%, di mana 7,56% dosis terlalu rendah dan 1,68% dosis terlalu tinggi, dan interaksi obat sebesar 9,24%, dimana 25% kategori mayor, 69,44% kategori moderat, dan 5,56% kategori minor. Penatatalaksana kemoterapi FAC pada pasien kanker payudara berpotensi menyebabkan masalah terkaitobat. Oleh karena itu, perlu pemantauan terapi obat pada pasien agar masalah terkait obat dapat diminimalisasi sehingga keberhasilan terapi dapat tercapai.

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Chemotherapy is one of the modalities of breast cancer therapy. The combination of 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) is the most widely use chemotherapy protocol. This study aims to identify drug-related problems in breast cancer patients undergoing FAC chemotherapy at Dharmais Cancer Hospital in the period July-December 2019. The study was conducted using descriptive observational methods with cross-sectional research designs using restropective data. Drug-related problems identified in this study included dosage and drug interactions.

The results showed the highest breast cancer incident showed in the age group 44-54 years old (43.70%) and the highest use of supportive therapy was found in ondansetron (27.17%). Percentage of inappropriate doses was 9.24% with 7.56% doses too low and 1.68% doses too high, and drug interactions by 9.24%, where 25% the major category, 69.44% the moderate category, and 5.56% the minor category. Management of FAC chemotherapy in breast cancer patients has the potential to cause drug-related problems. Therefore, it is necessary to monitor drug therapy in patients so that drug-related problems can be minimized andtherapeutic success can be achieved."

"Seorang apoteker harus memiliki fondasi dasar dalam profesinya, 2 diantaranya yaitu manajemen logistik obat dan pengendalian kualitas obat. Manajemen logistik yang efektif dan efisien diperlukan agar tidak terjadi masalah adanya stok obat kadaluwarsa (expired date). Kualitas obat salah satunya ditentukan oleh kelancaran proses produksi suatu obat. Berdasarkan hasil observasi yang dilakukan peneliti, ditemukan bahwa manajemen logistic obat di apotek belum maksimal. Ditemukan 105 jenis barang passive dan ED, dengan total perkiraan kerugian Rp 37,5 juta. Penulis memberikan solusi alternatif untuk penanganannya seperti label ?USE FIRST?, training management, penataan ulang rak obat. Pada faktor kualitas obat, ditemukan satu masalah khusus yang sering terjadi di pabrik, yaitu tablet molting dan melting. Investigasi menunjukkan bahwa ada masalah pada mesin Fluid Bed Dryer (FBD), sehingga dilakukan Performance Qualification (PQ) terhadap mesin. Hasil PQ dicantumkan dalam data dari pengujian Loss of Drying (LOD), Flowability, dan Particle Size Distribution (PSD).

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A pharmacist must have a basic foundation, 2 of which are drug logistics management and drug quality control. Effective and efficient logistics management is needed to avoid problems with expired drug stocks. The quality of a drug is determined by the smooth production process of a drug. Based on the results of observations made by researchers, it was found that the logistics management of drugs in pharmacies was not maximized. We found 105 types of passive and ED items, with a total estimated loss of IDR 37.5 million. The author provides alternative solutions for handling such as ?USE FIRST? label, training management, rearranging medicine shelves. In the drug quality factor, one particular problem was found that often occurs in factories, namely molting and melting tablets. The investigation showed that there was a problem with the Fluid Bed Dryer (FBD) machine, so a Performance Qualification (PQ) was carried out on the machine. PQ result are included in data from Loss of Drying (LOD), Flowability, and Particle Size Distribution tests."

"Seorang apoteker harus memiliki fondasi dasar dalam profesinya, 2 diantaranya yaitu manajemen logistik obat dan pengendalian kualitas obat. Manajemen logistik yang efektif dan efisien diperlukan agar tidak terjadi masalah adanya stok obat kadaluwarsa (expired date). Kualitas obat salah satunya ditentukan oleh kelancaran proses produksi suatu obat.Berdasarkan hasil observasi yang dilakukan peneliti, ditemukan bahwa manajemen logistic obat di apotek belum maksimal. Ditemukan 105 jenis barang passive dan ED, dengan total perkiraan kerugian Rp 37,5 juta. Penulis memberikan solusi alternatif untuk penanganannya seperti label “USE FIRST”, training management, penataan ulang rak obat.Pada faktor kualitas obat, ditemukan satu masalah khusus yang sering terjadi di pabrik, yaitu tablet molting dan melting. Investigasi menunjukkan bahwa ada masalah pada mesin Fluid Bed Dryer (FBD), sehingga dilakukan Performance Qualification (PQ) terhadap mesin. Hasil PQ dicantumkan dalam data dari pengujian Loss of Drying (LOD), Flowability, dan Particle Size Distribution (PSD).

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A pharmacist must have a basic foundation, 2 of which are drug logistics management and drug quality control. Effective and efficient logistics management is needed to avoid problems with expired drug stocks. The quality of a drug is determined by the smooth production process of a drug.

Based on the results of observations made by researchers, it was found that the logistics management of drugs in pharmacies was not maximized. We found 105 types of passive and ED items, with a total estimated loss of IDR 37.5 million. The author provides alternative solutions for handling such as “USE FIRST” label, training management, rearranging medicine shelves.

In the drug quality factor, one particular problem was found that often occurs in factories, namely molting and melting tablets. The investigation showed that there was a problem with the Fluid Bed Dryer (FBD) machine, so a Performance Qualification (PQ) was carried out on the machine. PQ result are included in data from Loss of Drying (LOD), Flowability, and Particle Size Distribution tests."