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"Glimepirid diklasifikasikan sebagai obat dalam sistem klasifikasi biofarmasetika kelas II yang memiliki kelarutan rendah dan permeabilitas tinggi. Penelitian ini dilakukan dengan memformulasikan dispersi padat menggunakan PEG 6000 dan Poloxamer 188 sebagai polimer dengan perbandingan bobot 1:2; dibandingkan dengan kokristal dari glimepirid menggunakan nikotinamid dengan perbandingan molar 1:2. Penelitian ini bertujuan membandingkan efisiensi disolusi tablet dipersi padat glimepirid dengan tablet kokristal glimepirid. Dispersi padat disiapkan dengan metode peleburan dan kokristal disiapkan dengan metode solvent drop grinding. Dispersi padat dan kokristal dikarakterisasi menggunakan Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), difraksi sinar-X, dan kadar air. Formulasi tablet dievaluasi untuk persyaratan kekerasan tablet, keregasan tablet, kandungan obat, waktu hancur, dan efisiensi disolusi. Peningkatan disolusi paling tinggi terjadi pada formulasi tablet dispersi padat dengan perbandingan glimepirid-PEG 6000-Poloxamer 188 (1:1:1) dengan efisiensi disolusi mencapai 3,52 kali tablet glimepirid murni. Dari hasil penelitian ini disimpulkan bahwa tablet yang mengandung dispersi padat dan kokristal glimepirid mampu meningkatkan laju disolusi dibandingkan tablet glimepirid murni.Glimepiride is classified as a BCS class II drug which has low solubility and high permeability. An attempt has been made to increase the solubility of this model drug by formulating solid dispersion using PEG 6000 and Poloxamer 188 as polymer with 1:2 weight ratio and compared with co-crystal of glimepiride using nicotinamide as polymer with 1:2 molar ratio. This study aims at comparing the dissolution eficiency of solid dispersion and co-crystal in tablets. The solid dispersions was prepared by fusion method and co-crystal was prepared by solvent drop grinding method. Solid dispersions and co-crystal were evaluated for Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, X-Ray Difraction, and moisture content. Tablet formulations were evaluated for various pharmaceutical characteristics viz. hardness, % friability, weight variation, drug content, disintegration time, and in vitro dissolution profiles. Solid dispersion tablet with containing drug is glimepiride-PEG 6000-Poloxamer 188 (1:1:1) gives best dissolution eficiency up to 3,52 folds compared to pure glimepiride tablet. In conclusion, solid dispersion tablet and co-crystal tablet of glimepirid could increase dissolution eficiency of pure glimepirid tablet."

"Apoteker mempunyai peranan penting terutama di apotek, industri farmasi, maupun di pedagang besar farmasi. Untuk menjalankan peran penting tersebut, apoteker harus mempunyai kompetensi yang mumpuni sebagai syarat melakukan praktik kefarmasian. World Health Organization mengeluarkan istilah seven-stars pharmacist consept, yang merupakan peran penting bagi seorang apoteker. Salah satu peran seorang apoteker tersebut adalah life long learner, yaitu apoteker harus selalu memperbarui pengetahuan dan keterampilannya seiring dengan perubahan tren dari waktu ke waktu. Pada kesempatan kali ini, penulis berkesempatan mengikuti Praktik Kerja Profesi Apoteker (PKPA) di Apotek Atrika, PT. Harsen Laboratories, dan PT. SamMarie Tramedifa selama periode bulan Agustus – Desember 2020. Selama PKPA diharapkan calon apoteker dapat meningkatkan wawasannya di dunia kefarmasian sebagai bekal memasuki dunia kerja.......Pharmacists have an important role, especially in pharmacy, pharmaceutical industry, and pharmaceutical wholesalers. To carry out this important role, pharmacists must be qualified competencies as a requirement for practicing pharmacy. World Health Organization issued the seven-stars pharmacist concept, which is an important role for a pharmacist. One of the roles of a pharmacist is a life-long learner, where pharmacists must always update their knowledge and skills in line with changing trends from time to time. On this occasion, the author had the opportunity to participate in the Pharmacist Professional Work Practice (PKPA) at Apotek Atrika, PT. Harsen Laboratories, and PT. SamMarie Tramedifa during the period from August - December 2020. During PKPA, it is hoped that prospective pharmacists can improve their horizons in the world of pharmacy as a provision to enter the world of work."