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"Asam azelat (1,7-heptanedicarboxilic acid) merupakan suatu asam dikarboksilat yang diduga memiliki aktivitas anti tirosinase dengan menghambat reaksi oksidasi l-tirosin dan l-DOPA dalam pembentukan melanin. Penelitian ini dilakukan untuk melihat aktivitas asam azelat murni dan krim asam azelat dalam menghambat tirosinase. Asam azelat diformulasikan menjadi krim dengan konsentrasi 5 dan 10 %. Uji kestabilan fisik dan kimia dilakukan dengan penyimpanan sediaan pada tiga suhu yang berbeda yaitu suhu 4 ± 2, 27 ± 2 dan 40 ± 2oC. Pengukuran penghambatan tirosinase dilakukan dengan pengukuran dopakrom yang terbentuk secara in vitro. Hasil uji stabilitas fisik kedua krim asam azelat tidak menunjukkan pemisahan fase pada setiap suhu penyimpanan, pada uji mekanik memperlihatkan krim tahan pada gaya sentrifugasi selama satu tahun. Hasil uji stabilitas kimia menunjukkan bahwa kadar asam azelat yang terkandung didalam krim cenderung memperlihatkan penurunan. Hasil pengukuran penghambatan aktivitas tirosinase krim asam azelat 5 % dan 10 % berturut yaitu 26,50 % dan 51,54 %. Penghambatan aktivitas tirosinase krim mengalami penurunan setelah penyimpanan selama dua bulan pada suhu kamar. Krim asam azelat 5 % menurun aktivitasnya menjadi 22,44 % dan krim asam azelat 10 % menurun aktivitasnya menjadi 46,54 %. Penurunan aktivitas penghambatan tirosinase disebabkan karena asam azelat di dalam krim mengalami oksidasi selama penyimpanan.

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Azelaic acid (1,7-heptanedicarboxilic acid) is a dicarboxylic acid which is have to considered activity as tyrosinase inhibitors by inhibit is oxidation of l-tyrosine and l-DOPA in mechanism of melanogenesis. The study was conducted to investigate the inhibition tyrosinase activity of pure azelaic acid and azelaic acid in cream. Azelaic acid was formulated into creams with the concentration of 5 % and 10 %.

Physical and chemical stability test of cream was conducted with storing the creams at three different temperatures, 4 ± 2, 27 ± 2 and 40 ± 2oC respectively. Tyrosinase inhibitory activity was measured in vitro by measuring dopachrome.

The result of physical stability test showed no phase separation on storage and endure with centrifugation energy in one year. The chemical stability test showed that azelaic acid was not stable stored at any temperature. The tyrosinase inhibition activity of creams 5 % and 10 % azelaic acid were 26,50 % and 51,54 % respectively. Tyrosinase inhibition activity of creams decreased after two month stored at ambient temperature. Tyrosinase inhibition activity of cream 5 % azelaic acid decreased to 22,44 %, and cream 10 % azelaic acid decreased to 46,54 %. The decreasing of tyrosinase inhibition activity is caused by azelaic acid oxidation in cream."

"Praktek Kerja Profesi Apoteker di Apoteker di Apotek Keselamatan Jalan Keselamatan No. 27 Manggarai Jakarta Selatan bertujuan untuk mengetahui peran dan fungsi apoteker di apotek terutama dalam aspek profesional yang mencakup mencakup ilmu kefarmasian dan pelayanan kefarmasian dan aspek managerial. Tugas khusus yang diberikan berupa analisis Penentuan Persediaan Minimum Obat Diare dan Tukak Lambung Sebagai Bagian Manajemen Pengadaan Barang Di Apotek Keselamatan. Tujuan dari tugas khusus ini adalah untuk mengetahui jumlah persediaan minimum untuk seluruh obat diare dan tukak lambung yang ada di Apotek Keselamatan sebagai upaya pengendalian persediaan di Apotek.

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Pharmacist Internship Program in Keselamatan Apothecary aims aims to determine the role and functions of pharmacists in pharmacies primarily in the professional aspects of pharmacy which includes covers science and pharmaceutical services and managerial aspects. Given a special assignment is analysis Determination of Minimum Inventory Diarrhea and Peptic Ulcers Drugs as Part Procurement Management in Pharmacy Safety. The purpose of this special assignment is to determine the minimum amount of inventory for all medicines diarrhea and peptic ulcers pharmacy safety is in an effort to control inventory at the pharmacy.

;Pharmacist Internship Program in Keselamatan Apothecary aims aims to determine the role and functions of pharmacists in pharmacies primarily in the professional aspects of pharmacy which includes covers science and pharmaceutical services and managerial aspects. Given a special assignment is analysis Determination of Minimum Inventory Diarrhea and Peptic Ulcers Drugs as Part Procurement Management in Pharmacy Safety. The purpose of this special assignment is to determine the minimum amount of inventory for all medicines diarrhea and peptic ulcers pharmacy safety is in an effort to control inventory at the pharmacy.

;Pharmacist Internship Program in Keselamatan Apothecary aims aims to determine the role and functions of pharmacists in pharmacies primarily in the professional aspects of pharmacy which includes covers science and pharmaceutical services and managerial aspects. Given a special assignment is analysis Determination of Minimum Inventory Diarrhea and Peptic Ulcers Drugs as Part Procurement Management in Pharmacy Safety. The purpose of this special assignment is to determine the minimum amount of inventory for all medicines diarrhea and peptic ulcers pharmacy safety is in an effort to control inventory at the pharmacy."

"Praktek Kerja Profesi Apoteker dilaksanakan di PT. AstraZeneca Indonesia. Kegiatan PKPA ini bertujuan agar mahasiswa profesi apoteker memahami tugas beserta peran apoteker di industri farmasi baik dalam proses produksi, penyimpanan, distribusi dan pengendalian kualitas. Tugas khusus yang diberikan berupa Analisis Trending Keluhan Periode 2010 hingga 2012 Serta Pengelolaan Keluhan di PT. AstraZeneca Indonesia yang bertujuan memperoleh hasil analisis trending keluhan serta memahami sistem pengelolaan keluhan yang dilaksanakan di industri farmasi.

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Pharmacist Internship Program held in PT. AstraZeneca Indonesia. The activity is intended that students understand the task and their professional role of pharmacist pharmacy in the pharmaceutical industry both in the process of production, storage, distribution and quality. Student given a special assignment is Complaint Trending Analysis period 2010 to 2012 and Complaint management at PT. AstraZeneca Indonesia aimed to obtaining a complaint trending analysis and understand the complain management system is implemented in the pharmaceutical industry."

"Praktek Kerja Profesi Apoteker di Suku Dinas Kesehatan Kota Administrasi Jakarta Barat bertujuan untuk memahami tugas dan fungsi struktur organisasi Suku Dinas Kesehatan Kota Administrasi Jakarta Barat khususnya Seksi Sumber Daya Kesehatan. Tugas khusus yang diberikan berupa Sinkronisasi Data Induk dengan Hasil Permohonan Surat izin Praktik Apoteker (SIPA) yang bertujuan untuk melakukan sinkronisasi data induk dengan hasil permohonan Surat Izin Praktik Apoteker (SIPA).

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Pharmacist Internship Program at Health Agency of West Jakarta, aims to understand the duties and functions of the organizational structure of the Health Agency of West Jakarta in particular section administration health resource. A special assignment that is given to Synchronization Database Application for Surat Izin Praktik Apoteker (SIPA), which aims to synchronize database with the results of Surat Izin Praktik Apoteker (SIPA).

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