Ditemukan 4 dokumen yang sesuai dengan query
Marianne Wiguna
"Kasus resistensi terhadap antibakteri memicu kebutuhan akan adanya antibakteri baru. Kuinazolin-4-on memiliki spektrum aktivitas biologi yang luas, salah satunya adalah antibakteri. Dihidrofolat reduktase merupakan enzim yang penting dalam biosintesis asam nukleat bakteri. Senyawa turunan kuinazolin-4-on dengan substitusi pada posisi 2- dan 6- dapat menghambat aktivitas dihidrofolat reduktase. Penambahan gugus stiril pada posisi 2- dapat menyebabkan kerusakan sel mikroorganisme. Adanya gugus amina pada posisi 6- bersifat aktif sebagai antimikroba.
Dalam rangka memperoleh senyawa turunan kuinazolin-4-on lainnya telah dilakukan sintesis senyawa baru 6-amino-2-[(E)-2-(4-hidroksifenil)etenil]-3,4-dihidrokuinazolin-4-on yang dilakukan dalam empat tahap. Tahap pertama adalah sintesis 2-metil-3,4-dihidrokuinazolin-4-on dari antranilamida dan asetamida menggunakan microwave. Tahap kedua adalah sintesis 2-metil-6-nitro-3,4-dihidrokuinazolin-4-on menggunakan asam nitrat berasap dan asam sulfat pekat. Tahap ketiga adalah sintesis 2-[(E)-2-(4-hidroksifenil)etenil]-6-nitro-3,4-dihidrokuinazolin-4-on dari 2-metil-6-nitro-3,4-dihidrokuinazolin-4-on dan 4-hidroksibenzaldehida dalam asam asetat glasial menggunakan microwave. Tahap keempat adalah sintesis 6-amino-2-[(E)-2-(4-hidroksifenil)etenil]-3,4-dihidrokuinazolin-4-on menggunakan serbuk besi dalam asam klorida pekat dengan sonikasi. Struktur molekul senyawa produk tahap satu dan dua dikonfirmasi dengan FT-IR, sedangkan senyawa tiga dan empat dikonfirmasi dengan FT-IR dan 1H NMR. Hasil penelitian menunjukkan bahwa produk sintesis telah sesuai dengan senyawa yang diharapkan dengan persen perolehan tahap satu 90,19%, tahap dua 79,61%, tahap tiga 67,45% dan tahap empat 52,91%.
Antibacterial resistance cases have triggered the necessity of new antibacterial agents. Quinazolin-4-one has a wide spectrum of biological activities, one of them is antibacterial. Dihydrofolate reductase is the important enzyme in the biosynthesis of nucleic acid. Inhibition of dihydrofolate reductase will cause cell death. The series of 2,6-substitued-quinazolin-4-one have the inhibition activities of dihydrofolate reductase. Addition of styryl compound in 2-substitued-quinazolin-4-on can cause the damage of microorganism cells. Amine group in 6-substitued-quinazolin-4-one have the characteristic as antibiotic. In order to obtain another derivate of quinazolin-4-one, a new 6-amino-2-[(E)-2-(4-hydroxyphenyl)ethenyl]-3,4-dihydroquinazolin-4-one had been synthesized in four stages. First stage was microwave-assisted synthesis of 2-methyl-3,4-dihydroquinazolin-4-one from anthranilamide and acetamide. Second stage was synthesis of 2-methyl-6-nitro-3,4-dihydroquinazolin-4-one using fuming nitric acid and concentrated sulfuric acid. Third stage was microwave-assisted synthesis of 2-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-nitro-3,4-dihydroquinazolin-4-one from 2-methyl-6-nitro-3,4-dihydroquinazolin-4-one and 4-hydroxybenzaldehide in glacial acetic acid. Fourth stage was synthesis of 6-amino-2-[(E)-2-(4-hydroxyphenyl)ethenyl]-3,4-dihydroquinazolin-4-one using iron powder in concentrated hydrochloride acid with sonication. Molecular structure of the first and second compound was confirmed by using FT-IR while the third and fourth compound was confirmed by using FT-IR and 1H NMR. Result of the research shows that the final product is in conformity with the expected compound with 90,19% yield for first stage, 79,61% second stage, 67,45% third stage, and 52,91% fourth stage."
Depok: Fakultas Farmasi Universitas Indonesia, 2014
S56580
UI - Skripsi Membership Universitas Indonesia Library
Marianne Wiguna
"[
ABSTRAK Upaya peningkatan derajat kesehatan tersebut berkembang ke arah upaya promotif atau promosi kesehatan preventif atau pencegahan penyakit kuratif atau pengobatan penyakit dan rehabilitatif atau pemulihan kesehatan Salah satu bidang yang bergerak dalam pengobatan adalah bidang kefarmasian Bidang kefarmasian yang bertindak langsung dengan masyarakat adalah pelayanan kefarmasian Dalam rangka menyelenggarakan pelayanan kefarmasian tersebut oleh apoteker diperlukan fasilitas pelayanan kefarmasian salah satu fasilitas tersebut adalah apotek Peranan apoteker di apotek adalah memberikan pelayanan kefarmasian kepada pasien dan mengatur pengelolaan sediaan farmasi mulai dari pengadaan hingga pemusnahan sediaan farmasi
ABSTRACT The health status enhancement effort is progressing to health promotive preventive curative and rehabilitative effort Pharmacy is one of the medication fields The field of pharmacy that acts directly to people is pharmacy service Pharmacy facility which is pharmacy is needed in order to carry out the pharmacy service by pharmacist The roles of pharmacist in pharmacy is giving the pharmacy services to people and organizing the pharmaceutical stock from doing stock procurement to stock extermination Peranan apoteker di apotek adalah memberikan pelayanan kefarmasian kepada pasien dan mengatur pengelolaan sediaan farmasi mulai dari pengadaan hingga pemusnahan sediaan farmasi ;The health status enhancement effort is progressing to health promotive preventive curative and rehabilitative effort Pharmacy is one of the medication fields The field of pharmacy that acts directly to people is pharmacy service Pharmacy facility which is pharmacy is needed in order to carry out the pharmacy service by pharmacist The roles of pharmacist in pharmacy is giving the pharmacy services to people and organizing the pharmaceutical stock from doing stock procurement to stock extermination Peranan apoteker di apotek adalah memberikan pelayanan kefarmasian kepada pasien dan mengatur pengelolaan sediaan farmasi mulai dari pengadaan hingga pemusnahan sediaan farmasi ;The health status enhancement effort is progressing to health promotive preventive curative and rehabilitative effort Pharmacy is one of the medication fields The field of pharmacy that acts directly to people is pharmacy service Pharmacy facility which is pharmacy is needed in order to carry out the pharmacy service by pharmacist The roles of pharmacist in pharmacy is giving the pharmacy services to people and organizing the pharmaceutical stock from doing stock procurement to stock extermination Peranan apoteker di apotek adalah memberikan pelayanan kefarmasian kepada pasien dan mengatur pengelolaan sediaan farmasi mulai dari pengadaan hingga pemusnahan sediaan farmasi , The health status enhancement effort is progressing to health promotive preventive curative and rehabilitative effort Pharmacy is one of the medication fields The field of pharmacy that acts directly to people is pharmacy service Pharmacy facility which is pharmacy is needed in order to carry out the pharmacy service by pharmacist The roles of pharmacist in pharmacy is giving the pharmacy services to people and organizing the pharmaceutical stock from doing stock procurement to stock extermination Peranan apoteker di apotek adalah memberikan pelayanan kefarmasian kepada pasien dan mengatur pengelolaan sediaan farmasi mulai dari pengadaan hingga pemusnahan sediaan farmasi ]"
Depok: Fakultas Farmasi Universitas Indonesia, 2015
PR-Pdf
UI - Tugas Akhir Universitas Indonesia Library
Marianne Wiguna
"[
ABSTRAK Perwujudan kesehatan masyarakat Indonesia melibatkan berbagai profesional kesehatan di antaranya apoteker Apoteker dituntut untuk memiliki keahlian dan kewenangan dalam melaksanakan pekerjaan kefarmasian Di samping pekerjaan kefarmasian yang dilakukan diperlukan adanya suatu pengawasan terhadap produk obat dan makanan yang beredar terkait mutu keamanan dan manfaat produk Badan POM memiliki tugas untuk melakukan pengawasan di bidang obat dan makanan Peranan tugas dan tanggung jawab apoteker di Badan POM adalah melakukan pengawasan obat dan makanan agar sesuai dengan ketentuan yang berlaku mulai dari produksi hingga distribusi produk terapetik narkotika psikotropika zat adiktif obat tradisional kosmetik produk komplemen dan pangan baik penilaian pre market maupun pengawasan post market
ABSTRACT The manifestation of Indonesian public health involves many health professionals including pharmacist Pharmacist is insisted to have specialty and authority in implementing the pharmacy jobs Aside from doing pharmacy jobs there is a needed to control the marketed drugs and foods related to product quality safety and benefit Indonesia National Agency of Drugs and Foods Controls have duty to control the marketed drugs and foods The roles and responsibilities of pharmacist in Indonesia National Agency of Drugs and Foods Controls are to control the drugs and foods start from therapeutic drugs production until the distribution narcotics phycotrophics addictive substances traditional dugs cosmetics complement product dan foods either pre market approval or post market surveillance ;The manifestation of Indonesian public health involves many health professionals including pharmacist Pharmacist is insisted to have specialty and authority in implementing the pharmacy jobs Aside from doing pharmacy jobs there is a needed to control the marketed drugs and foods related to product quality safety and benefit Indonesia National Agency of Drugs and Foods Controls have duty to control the marketed drugs and foods The roles and responsibilities of pharmacist in Indonesia National Agency of Drugs and Foods Controls are to control the drugs and foods start from therapeutic drugs production until the distribution narcotics phycotrophics addictive substances traditional dugs cosmetics complement product dan foods either pre market approval or post market surveillance ;The manifestation of Indonesian public health involves many health professionals including pharmacist Pharmacist is insisted to have specialty and authority in implementing the pharmacy jobs Aside from doing pharmacy jobs there is a needed to control the marketed drugs and foods related to product quality safety and benefit Indonesia National Agency of Drugs and Foods Controls have duty to control the marketed drugs and foods The roles and responsibilities of pharmacist in Indonesia National Agency of Drugs and Foods Controls are to control the drugs and foods start from therapeutic drugs production until the distribution narcotics phycotrophics addictive substances traditional dugs cosmetics complement product dan foods either pre market approval or post market surveillance ;The manifestation of Indonesian public health involves many health professionals including pharmacist Pharmacist is insisted to have specialty and authority in implementing the pharmacy jobs Aside from doing pharmacy jobs there is a needed to control the marketed drugs and foods related to product quality safety and benefit Indonesia National Agency of Drugs and Foods Controls have duty to control the marketed drugs and foods The roles and responsibilities of pharmacist in Indonesia National Agency of Drugs and Foods Controls are to control the drugs and foods start from therapeutic drugs production until the distribution narcotics phycotrophics addictive substances traditional dugs cosmetics complement product dan foods either pre market approval or post market surveillance , The manifestation of Indonesian public health involves many health professionals including pharmacist Pharmacist is insisted to have specialty and authority in implementing the pharmacy jobs Aside from doing pharmacy jobs there is a needed to control the marketed drugs and foods related to product quality safety and benefit Indonesia National Agency of Drugs and Foods Controls have duty to control the marketed drugs and foods The roles and responsibilities of pharmacist in Indonesia National Agency of Drugs and Foods Controls are to control the drugs and foods start from therapeutic drugs production until the distribution narcotics phycotrophics addictive substances traditional dugs cosmetics complement product dan foods either pre market approval or post market surveillance ]"
Depok: Fakultas Farmasi Universitas Indonesia, 2015
PR-Pdf
UI - Tugas Akhir Universitas Indonesia Library
Marianne Wiguna
"[
ABSTRAK Industri farmasi merupakan badan usaha yang memiliki izin dari Kementerian Kesehatan untuk melakukan kegiatan pembuatan obat atau bahan obat Dalam pembuatan obat tersebut terdapat suatu Cara Pembuatan Obat yang Baik CPOB Apoteker bertanggung jawab dalam pelaksanaan pekerjaan kefarmasian dalam hal pembuatan obat Peranan penting Apoteker di industri farmasi yaitu bertanggung jawab dalam produksi pengawasan mutu dan pemastian mutu produk yang dibuat dalam industri farmasi Permasalahan kefarmasian yang dapat terjadi adalah pada proses produksi adanya keluhan pelanggan maupun adanya target hasil yang harus dicapai dalam jangka waktu yang singkat
ABSTRACT Pharmaceutical industry is a business entity which has permission from Ministry of Health to produce drug or drug raw material In the drug production there is a Good Manufacturing Product GMP Pharmacist has responsibility in the implementation of pharmacy jobs especially in drug production The important roles of pharmacist in pharmaceutical industry are having responsibility for drug production quality control and quality assurance The pharmaceutical problems which can be occurred are in the drug production customer complaint and the target to be achieved in the short period of time ;Pharmaceutical industry is a business entity which has permission from Ministry of Health to produce drug or drug raw material In the drug production there is a Good Manufacturing Product GMP Pharmacist has responsibility in the implementation of pharmacy jobs especially in drug production The important roles of pharmacist in pharmaceutical industry are having responsibility for drug production quality control and quality assurance The pharmaceutical problems which can be occurred are in the drug production customer complaint and the target to be achieved in the short period of time ;Pharmaceutical industry is a business entity which has permission from Ministry of Health to produce drug or drug raw material In the drug production there is a Good Manufacturing Product GMP Pharmacist has responsibility in the implementation of pharmacy jobs especially in drug production The important roles of pharmacist in pharmaceutical industry are having responsibility for drug production quality control and quality assurance The pharmaceutical problems which can be occurred are in the drug production customer complaint and the target to be achieved in the short period of time , Pharmaceutical industry is a business entity which has permission from Ministry of Health to produce drug or drug raw material In the drug production there is a Good Manufacturing Product GMP Pharmacist has responsibility in the implementation of pharmacy jobs especially in drug production The important roles of pharmacist in pharmaceutical industry are having responsibility for drug production quality control and quality assurance The pharmaceutical problems which can be occurred are in the drug production customer complaint and the target to be achieved in the short period of time ]"
Depok: Fakultas Farmasi Universitas Indonesia, 2015
PR-Pdf
UI - Tugas Akhir Universitas Indonesia Library
