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Abstrak :
Tamoksifen merupakan pilihan terapi hormon pertama dan utama yang digunakan pada pasien kanker payudara estrogen positif. Tamoksifen memiliki efek klinis yang bergantung pada pembentukan salah satu metabolitnya, yaitu 4-hidroksi-N-desmetiltamoksifen endoksifen . Metode yang sensitif dan selektif, serta tervalidasi menggunakan kromatografi cair ndash; tandem spektrometri massa dikembangkan pertama kali di Indonesia untuk menganalisis tamoksifen, endoksifen, dan klomifen sebagai baku dalam. Metode telah divalidasi penuh mengacu pada ketentuan dari European Medicines Agency EMEA . Adapun pemisahan secara kromatografi fase terbalik dilakukan pada kolom Acquity UPLC BEH C18 column 1,7 ?m, 2,1 mm x 100 mm , dengan laju alir 0,200 mL/menit dan kondisi gradien dari asam formiat 0,2 dan asetonitril selama 6,50 menit. Preparasi sampel menggunakan ekstraksi cair-cair dengan etil asetat dan analisis kuantitatif analit dilakukan menggunakan spektrometri massa triple quadrople dengan electrospray ionization ESI mode ion positif. Nilai transisi pada multiple reaction monitoring MRM diatur pada 372,22 > 72,22 m/z untuk tamoksifen, 374,29 > 58,20 m/z untuk endoksifen, dan 406,28 > 100,17 m/z untuk klomifen. Secara keseluruhan, metode yang telah divalidasi memiliki akurasi diff -10,82 hingga 13,10 dan presisi KV antar-hari: 5,19-12,38 yang baik, serta sensitif dengan nilai batas kuantifikasi lebih rendah LLOQ yang diperoleh 0,625 ng/mL dan 0,125 ng/mL untuk tamoksifen dan endoksifen. ...... Tamoxifen is the first and most commonly used hormonal therapy among estrogen positive breast cancer patients. Tamoxifen clinical efficacy is also depended on one of its metabolites formation, 4 hydroxy N desmethyltamoxifen endoxifen . A highly sensitive, selective, and validated liquid chromatography ndash tandem mass spectrometry method was developed first time in Indonesia to analyze tamoxifen, endoxifen, and clomiphene as the internal standard. The analytical method had been fully validated according to European Medicines Agency EMEA guidelines. A reverse phase chromatography separation was performed on an Acquity UPLC BEH C18 column 1,7 m, 2,1 mm x 100 mm , eluted at a flow rate 0,200 mL min under a gradient of 0,2 formic acid and acetonitrile within 6,50 minutes. Plasma samples were purified using ethyl acetate liquid liquid extraction method and analytes quantification was performed by a triple quadrupole mass spectrometry with electrospray ionization ESI in positive ion mode. The multiple reaction monitoring MRM was set at 372,22 72,22 m z for tamoxifen, 374,29 58,20 m z for endoxifen, and 406,28 100,17 m z for clomiphene. Overall, the validated method was accurate diff 10,82 to 13,10 , precise between run CV 5,19 12,38 , and sensitive with the lower limit of quantification LLOQ at 0,625 ng mL and 0,125 ng mL for tamoxifen and endoxifen, respectively.

Abstrak :
Praktek kerja profesi PKPA di Apotek Kimia Farma No. 254 Jakarta Barat periode Februari tahun 2018 bertujuan untuk memahami tugas dan tanggung jawab Apoteker dalam pengelolaan Apotek, serta melakukan praktik pelayanan kefarmasian sesuai dengan ketentuan perundang-undangan dan etika yang berlaku, memiliki wawasan, pengetahuan, keterampilan dan pengalaman praktis untuk melakukan praktik kefarmasian di Apotek, memiliki gambaran nyata tentang permasalahan praktik kefarmasian serta mempelajari strategi dan kegiatan-kegiatan yang dapat dilakukan dalam rangka pengembangan praktik kefarmasian. Selama menjalani PKPA, penulis belajar melakukan kegiatan manajerial Apotek dan pelayanan farmasi klinik. Penulis juga mendapatkan tugas khusus mengenai analisa dan pengkajian resep pasien jantung. Adapun tujuan dari tugas khusus iniadalah agar calon Apoteker dapat mengetahui penyakit jantung serta algoritma pengobatannya, menganalisis kelengkapan resep, serta melatih calon Apoteker untuk dapat memberikan pelayanan kefarmasian terkait pengobatan jantung. Secara keseluruhan, penulis telah mendapatkan pengalaman dan wawasan yang cukup dalam menjalani praktik kefarmasian di Apotek.

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Study Apprenticeship PKPA in Kimia Farma No. 254 West Jakarta February 2018 period aims to understand the duties and responsibilities of Pharmacists in the management of a community pharmacy, as well as to gain experience in doing a clinical pharmaceutical practice in accordance with the applicable laws and ethics, get the insight, knowledge, skill and practical experience to undertake pharmaceutical practices in community pharmacies, as well as have the brief view about pharmaceutical practice issues and learn the strategies or activities that can be taken in the course of pharmaceutical practice development. While doing the apprenticeship, author learned about doing managerial activities of the community pharmacy and clinical pharmaceutical practices. Author also got a special assignment about perscriptions analysis/assessment for cardiovascular patients. The purpose of the assignment itself was to improve Pharmacist rsquo;s knowledge about cardiovascular disease and its treatment algorithm, perscription analysis, and clinical pharmaceutical practice related to cardiovascular patients rsquo; treatment. In general, author has had enough knowledge and experience in doing pharmaceutical practices in community pharmacies.

Abstrak :
Praktek kerja profesi PKPA di Suku Dinas Kesehatan Kota Administrasi Jakarta Timur periode Januari tahun 2018 bertujuan untuk mengetahui tugas dan tanggung jawab Apoteker di Instansi Pemerintahan, memiliki pengetahuan terkait tugas pokok dan fungsi Suku Dinas Kesehatan di bidang farmasi, memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis melakukan pekerjaan kefarmasian di Suku Dinas Kesehatan, serta mendapatkan gambaran nyata tentang permasalahan kefarmasian di Suku Dinas Kesehatan. Selama menjalani PKPA, penulis ditempatkan di Puskemas Kecamatan Jatinegara untuk merekap dan membuat laporan rata-rata penggunaan obat generik; data pelayanan kefarmasian meliputi kunjungan resep per tahun, tenaga kefarmasian, dan layanan farmasi klinik; serta ketersediaan obat dan vaksin esensial selama setahun. Secara umum, persentase penggunaan obat generik yang didapatkan sebesar 87,23 , beban kerja Apoteker didapati tidak seimbang dilihat dari total resep, serta disimpulkan bahwa Puskesmas Kecamatan Jatinegara memiliki stok yang hampir lengkap selama setahun untuk 20 jenis obat indikator. Di sisi lain, penulis telah mendapatkan pengetahuan, pengalaman dan wawasan yang cukup dalam melakukan pekerjaan kefarmasian, khususnya di Puskesmas dan Suku Dinas Kesehatan.

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Study Apprenticeship PKPA in East Jakarta Sub Department for Health January 2018 period aims to understand the duties and responsibilities of Pharmacists in Goverment Agencies, know the main duties and functions of Sub Department for Health related to Pharmacy, get insights, knowledge, skills and field experience to undertake pharmaceutical practice in Sub Department for Health, have a real experience related to challenges in pharmaceutical practices in Sub Department for Health. While doing the apprenticeship, author was placed in Jatinegara Communiy Health Center to compile and write a report about the use of generic drugs; pharmaceutical practices data, namely total perscriptions per year, working Pharmacists, and clinical practices in a year period; and essential drugs and vaccines availability within a year. In general, the use of generic drugs in Jatinegara Communiy Health Center was 87,23 , pharmacists rsquo; responsibilities was found higher than required considering the total income of perscriptions, and 20 indicator drugs was seen to be in a complete stock for almost a year round full. In addition, author has also gained enough knowledge as well as experience in doing pharmaceutical practices, especially in Communiy Health Center and Sub Department for Health.

Abstrak :
Praktek kerja profesi PKPA di PT Kalbe Farma, Tbk. periode Maret - April 2018 bertujuan untuk mengetahui tugas dan tanggung jawab Apoteker di Industri Farmasi, memiliki wawasan dan pengalaman praktis untuk melakukan pekerjaan kefarmasian di Industri Farmasi, memahami penerapan GMP CPOB , serta memiliki gambaran nyata mengenai permasalahan pekerjaan kefarmasian di Industri Farmasi. Dalam proses pembuatan obat, obat hanya boleh diproduksi oleh Industri Farmasi yang menerapkan 12 aspek CPOB yang ditandai dengan sertifikat CPOB. Selama menjalani PKPA, penulis membandingkan penerapan CPOB dan melakukan kegiatan di departemen Quality Control. Adapun tugas khusus yang diberikan terkait dengan pemenuhan standar WHO, berupa perbaikan Standar Prosedur Operasional, Metode Analisis, dan Spesifikasi, serta pembuatan Lembar Kerja Analisis. Secara umum, PTKalbe Farmatelah menerapkan 12 aspek CPOB dengan baik dan benar, penulis juga telah mendapatkan kemampuan untuk memahami peran, tugas, wawasan dan tanggung jawab Apoteker dan memberikan solusi pada permasalahan di Industri Farmasi. ...... Study Apprenticeship PKPA in PT Kalbe Farma, Tbk. March - April 2018 Period aims to understand the duties and responsibilities of Pharmacists in Pharmaceutical Industries, gain the insight, knowledge, skills and field experience to undertake pharmaceutical practice in Pharmaceutical Industries, understand the implementation of GMP CPOB , and have a real experience related to challenges in pharmaceutical practices in Pharmaceutical Industries. Within drugs production, only a certified Pharmaceutical Industry can conduct such process, marked with the implementation of the 12 aspects of GMP through its certification. While doing the apprenticeship, author conducted a gap analysis of GMP implementation as well as worked in Quality Control department. Another assignment given was related to WHO standard compliances regarding Standard Operating Porcedure, Analysis Method, and Specification, and Analytical Worksheet. In general, PT Kalbe Farma, Tbk. has implemented the 12 aspects of GMP well. In addition, author also understood the roles, duties, insights and responsibilities of Pharmacists, as well as provided solutions for problems or challenges encountered within the Pharmaceutical Industry.