Hasil Pencarian  ::  Simpan CSV :: Kembali

"Xilitol merupakan gula poliol yang memiliki kemanisan mirip dengan sukrosa namun jalur metabolismenya tidak terikat dengan keberadaan insulin, sehingga baik untuk penderita diabetes. Selain itu xilitol tidak menyebabkan karies pada gigi. Produksi xilitol dengan proses fermentasi menggunakan mikroorganisme dinilai lebih praktis dan ekonomis salah satunya dengan menggunakan Debaryomyces hansenii. Khamir ini tahan terhadap kondisi osmotik tinggi, sering dimanfaatkan pabrik anggur dan industri makanan sebagai perasa. Untuk mendapatkan galur murni yang tahan kondisi osmotik tinggi, diperlukan pra-perlakuan dengan memaparkan khamir pada kondisi osmotik tinggi dalam jangka waktu tertentu. Tujuan penelitian ini dilakukan untuk mengetahui pengaruh pemberian pra-perlakuan osmotik tinggi terhadap kemampuan biokonversi Debaryomyces hansenii dan mengetahui pengaruh konsentrasi substrat xilosa terhadap produksi xilitol. Garam NaCl dan KCl masing-masing dengan konsentrasi 2, 2,5, dan 3 M ditambahkan pada media prakultur dan diinkubasi selama 14 hari. Kondisi pra-perlakuan terpilih didapatkan berdasarkan nilai yield xilitol tertinggi dari fermentasi menggunakan substrat xilosa 10%. Hasil terbaik yang didapatkan berdasarkan nilai yield xilitol tertinggi adalah Debaryomyces hansenii yang diberikan pra-perlakuan menggunakan NaCl 3 M (Yield xilitol 13,83%). Uji coba dengan variasi konsentrasi substrat (xilosa) 5%, 10%, dan 15% menunjukkan hasil berupa penurunan nilai yield xilitol seiring dengan meningkatnya konsentrasi substrat.

---

Xylitol is a sugar polyol which has a sweetness similar to sucrose metabolism pathway but not tied to the presence of insulin, so it is good for diabetics. Besides that xylitol does not cause dental caries. Xylitol production with fermentation process using microorganism is more efficient and economical either by using Debaryomyces hansenii. This yeast is resistant to high osmotic condition, often used in wine industries and food industries as flavouring agent. To get pure strains which resistant to high osmotic condition, needs pre-treatment by exposing yeast to high osmotic condition in a period of time.

The goal of this research is to determine the effect of giving high osmotic pre-treatment to bioconversion ability of Debaryomyces hansenii and to determine the effect xylose substrate concentration to the production of xylitol. NaCl and KCl salt are used with the concentration of 2, 2,5, and 3 M. The addition of salt is used on preculture medium and incubated for 14 days. Pre-treatment condition is chosen based on the highest number of xylitol's yield value.

The result based from the highet number of xylitol's yield value is Debaryomyces hansenii which is given pre-treatment using NaCl 3M (xylitol's yield value 13,83%). The test by using variation of substrate (xylose) concentration 5%, 10%, and 15% shows the decreasing number of xylitol's yield value and the increasing number substrate concentration in a row."

"[ABSTRAKPusat Kesehatan Masyarakat atau disebut juga Puskesmas berdasarkan Peraturan Menteri Kesehatan Nomor 30 Tahun 2014 tentang Standar Pelayanan Kefarmasian di Puskesmas merupakan unit pelaksana teknis dinas kesehatan kabupaten/kota yang bertanggung jawab menyelenggarakan pembangunan kesehatan di suatu wilayah kerja. Pembangunan kesehatan yang dilakukan di Puskesmas salah satunya ditunjang oleh pelayanan kefarmasian.Sebagai dasar untuk menjamin pelayanan kefarmasian yang bermutu di Puskesmas, pemerintah telah menetapkan standar pelayanan kefarmasian di Puskesmas berdasarkan Peraturan Menteri Kesehatan No 30 Tahun 2014 Tentang Standar Pelayanan Kefarmasian di Puskesmas, yaitu standar pengelolaan obat dan bahan medis habis pakai serta pelayanan farmasi klinik. Selain menjamin mutu pelayanan kefarmasian, standar pelayanan tersebut bertujuan untuk menjamin kepastian hukum bagi tenaga kefarmasian dan melindungi pasien dan masyarakat dari penggunaan obat yang tidak rasional dalam rangka keselamatan pasien (patient safety). Pengelolaan obat dan bahan medis habis pakai meliputi kegiatan perencanaan kebutuhan, permintaan, penerimaan, penyimpanan, pendistribusian, pengendalian, pencatatan, pelaporan, pengarsipan, dan pemantauan serta evaluasi pengelolaan. Sedangkan pelayanan farmasi klinik meliputi pengkajian resep, penyerahan obat, dan pemberian informasi obat; Pelayanan Informasi Obat (PIO); konseling; ronde/visite pasien (khusus Puskesmas rawat inap); pemantauan dan pelaporan efek samping obat; pemantauan terapi obat; dan evaluasi penggunaan obat

---

ABSTRACTBased on Minister of Health Regulation No. 30 of 2014 on Standards of Pharmaceutical Services at the health center, Community Health Center also called Puskesmas is the technical implementation unit health districts which responsible for organizing health development in a work area. Health development conducted at the health center one of which is supported by the pharmaceutical services. As a basis for guaranteeing quality pharmacy services in health centers, the government has set the standard pharmacy services at the health center by Health Minister Regulation No. 30 Year 2014 About Standards of Pharmaceutical Services at the health center, which is the standard management of drugs and medical materials consumables and clinical pharmacy services. In addition to guaranteeing the quality of pharmaceutical services, service standards are intended to ensure legal certainty for pharmacy workers and protect patients and the public from the use of drugs that are not rational in the context of patient safety. Management of drugs and medical consumables materials includes planning needs, demand, acceptance, storage, distribution, control, record keeping, reporting, archiving, and monitoring and evaluation of management. While clinical pharmacy services include assessment prescription, drug delivery, and administration of drug information; Drug Information Service (PIO); counseling; round / visite patients (inpatient specialized health centers); monitoring and reporting drug side effects; monitoring drug therapy; and evaluation of drug use;Based on Minister of Health Regulation No. 30 of 2014 on Standards of Pharmaceutical Services at the health center, Community Health Center also called Puskesmas is the technical implementation unit health districts which responsible for organizing health development in a work area. Health development conducted at the health center one of which is supported by the pharmaceutical services. As a basis for guaranteeing quality pharmacy services in health centers, the government has set the standard pharmacy services at the health center by Health Minister Regulation No. 30 Year 2014 About Standards of Pharmaceutical Services at the health center, which is the standard management of drugs and medical materials consumables and clinical pharmacy services. In addition to guaranteeing the quality of pharmaceutical services, service standards are intended to ensure legal certainty for pharmacy workers and protect patients and the public from the use of drugs that are not rational in the context of patient safety. Management of drugs and medical consumables materials includes planning needs, demand, acceptance, storage, distribution, control, record keeping, reporting, archiving, and monitoring and evaluation of management. While clinical pharmacy services include assessment prescription, drug delivery, and administration of drug information; Drug Information Service (PIO); counseling; round / visite patients (inpatient specialized health centers); monitoring and reporting drug side effects; monitoring drug therapy; and evaluation of drug use;Based on Minister of Health Regulation No. 30 of 2014 on Standards of Pharmaceutical Services at the health center, Community Health Center also called Puskesmas is the technical implementation unit health districts which responsible for organizing health development in a work area. Health development conducted at the health center one of which is supported by the pharmaceutical services. As a basis for guaranteeing quality pharmacy services in health centers, the government has set the standard pharmacy services at the health center by Health Minister Regulation No. 30 Year 2014 About Standards of Pharmaceutical Services at the health center, which is the standard management of drugs and medical materials consumables and clinical pharmacy services. In addition to guaranteeing the quality of pharmaceutical services, service standards are intended to ensure legal certainty for pharmacy workers and protect patients and the public from the use of drugs that are not rational in the context of patient safety. Management of drugs and medical consumables materials includes planning needs, demand, acceptance, storage, distribution, control, record keeping, reporting, archiving, and monitoring and evaluation of management. While clinical pharmacy services include assessment prescription, drug delivery, and administration of drug information; Drug Information Service (PIO); counseling; round / visite patients (inpatient specialized health centers); monitoring and reporting drug side effects; monitoring drug therapy; and evaluation of drug use, Based on Minister of Health Regulation No. 30 of 2014 on Standards of Pharmaceutical Services at the health center, Community Health Center also called Puskesmas is the technical implementation unit health districts which responsible for organizing health development in a work area. Health development conducted at the health center one of which is supported by the pharmaceutical services. As a basis for guaranteeing quality pharmacy services in health centers, the government has set the standard pharmacy services at the health center by Health Minister Regulation No. 30 Year 2014 About Standards of Pharmaceutical Services at the health center, which is the standard management of drugs and medical materials consumables and clinical pharmacy services. In addition to guaranteeing the quality of pharmaceutical services, service standards are intended to ensure legal certainty for pharmacy workers and protect patients and the public from the use of drugs that are not rational in the context of patient safety. Management of drugs and medical consumables materials includes planning needs, demand, acceptance, storage, distribution, control, record keeping, reporting, archiving, and monitoring and evaluation of management. While clinical pharmacy services include assessment prescription, drug delivery, and administration of drug information; Drug Information Service (PIO); counseling; round / visite patients (inpatient specialized health centers); monitoring and reporting drug side effects; monitoring drug therapy; and evaluation of drug use]"