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Abstrak :
Latar Belakang: Kerusakan jaringan periodontal terjadi karena inflamasi terhadap invasi bakteri. Human beta defensin-1 adalah peptida antimikroba dan pertahanan pertama terhadap infeksi. Tujuan Penelitian: Membandingkan kadar ekspresi HBD-1 antara kelompok periodontitis kronis, periodontitis agresif dan normal Bahan dan Metode: Kadar HBD-1 dari 94 sampel CKG subjek periodontitis kronis, periodontitis agresif dan normal diukur dengan ELISA Hasil: Analisis Mann-Whitney menunjukkan perbedaan kadar HBD-1 antara periodontitis kronis dengan normal (p<0,05) dan tidak terdapat perbedaan signifikan (p>0,05) antara periodontitis agresif dengan normal, dan antara periodontitis kronis dengan periodontitis agresif. Kesimpulan: Kadar HBD-1 pada CKG menurun pada kondisi periodontitis kronis dan periodontitis agresif. ......Background: Periodontal disease is happened because inflammation reaction ro bacterial invasion. Human beta defensin-1 (HBD-1) is antimicroba peptide which regulate the first defense mechanism. Objectives: To compare level of HBD-1 between chronic periodontitis, aggressive periodontitis, and normal group. Material and Methods: Level of HBD-1 from GCF sample of chronic periodontitis, aggressive periodontitis, and normal group were assessed with ELISA. Results: Mann-Whitney analysis show different level of HBD-1 expression between chronic periodontitis and normal (p<0,05) and there was no significant difference (p>0,05) between aggressive periodontitis and normal, and between chronic periodontitis and aggressive periodontitis. Conclusion: Level of HBD-1 in GCF decreased in chronic periodontitis and aggressive periodontitis.