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Abstrak :
Buah delima (Delima (Punica granatum L.) diketahui memiliki aktivitas estrogenik dan berpotensi untuk digunakan dalam pengobatan osteoporosis. Penelitian ini bertujuan untuk mengetahui potensi fraksi air kulit buah delima sebagai Selective Estrogen Receptor Modulator (SERMs) alami melalui penghitungan osteoblas, pengamatan uterus dan payudara. Metode ovariektomi digunakan sebagai model yang mewakili kondisi osteoporosis yang dilakukan pada 42 ekor tikus betina galur sprague dawley usia 50 hari yang terbagi dalam 7 kelompok. Yaitu sham, OVX, OVX + Estradiol (0,1 mg/KgBB), OVX + Tamoxifen (10 mg/KgBB), OVX + Fraksi air Kulit buah delima dosis 50, 100 dan 200 mg/KgBB yang diberikan secara oral. Hasil yang didapatkan menunjukkan jumlah osteoblas pada kelompok OVX + fraksi air kulit buah delima dosis 50, 100 dan 200 mg/KgBB meningkat secara bermakna dibandingkan kelompok OVX tergantung dosis, yaitu berturut-turut sebanyak 175,32, 188,63 dan 215,90. Fraksi air kulit buah delima tidak menunjukkan adanya peningkatan berat dan ketebalan uterus dan jumlah duktus kelenjar payudara. Hal ini menunjukkan bahwa fraksi air kulit buah delima berpotensi untuk digunakan sebagai terapi alternatif osteoporosis pada wanita menopause.

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Pomegranate (Pomegranate (Punica granatum L.) is known to have estrogenic activity and has the potential to be used in the treatment of osteoporosis. This present study aims to determine the potential of water fraction from methanolic extract of pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through the counting of osteoblasts, observation of uterine and mammary histology. The method ovariectomy used as a model representing osteoporosis conducted on 42 female rats Sprague Dawley strain aged 50 days were divided into 7 groups, SHAM, OVX, OVX + estradiol (0.1 mg / kg), OVX + Tamoxifen (10 mg / kg), OVX + Water Fraction of Pomegranate Peel doses of 50, 100 and 200 mg / kg administered orally. The results obtained showed that administration of water fraction of pomegranate peel doses of 50, 100 and 200 mg/KgBB can significantly increase the number of osteoblasts than ovariectomized rats in a dose-dependent, with the osteoblast number consecutively 175,32, 188,63 and 215,9. Water fraction of pomegranate peel did not show any increase in the weight and thickness of the uterus and the ductus number of mammary gland. This indicates that the water fraction pomegranate peel potential to be used as an alternative therapy for osteoporosis in postmenopausal women.

Abstrak :
Ruang Lingkup dan Cara Penelitian : Untuk Mengetahui hubungan kuat penerangan dengan kelelahan mata dan produktivitas kerja, telah dilakukan penelitian kross seksional terhadap 264 tenaga kerja wanita yang bekerja sebagai penjahit di Industri Konveksi PT. Busana Rama Tekstil & Garment. Pengumpulan data dilakukan dengan cara Anamnesa, pemeriksaan fisik, khususnya kelelahan mata dengan menggunakan near point ruler serta pemeriksaan lingkungan terutama yang menyangkut penerangan tempat kerja dengan menggunakan lux meter. Hasil dan Kesimpulan : Hasil penelitian mencatat kuat penerangan rata-rata di seluruh tempat kerja adalah 238.50 lux, dengan simpang baku 77.36. Prevalensi rate kelelahan mata setelah 4 jam adalah 84.5%. Tidak ditemukan hubungan antara timbulnya kelelahan mata dengan kuat penerangan, warna bahan pakaian, lama kerja, pendidikan, serta golongan umur. Produktivitas rata-rata seluruh pekerja setelah bekerja selama 4 jam adalah 72,65 potong pakaian per jam dengan simpang baku 38.47. Hasil uji statistik memperlihatkan hubungan yang bermakna antara produktivitas kerja dengan warna bahan pakaian serta dengan kuat penerangan, tetapi tidak mempunyai hubungan yang bermakna dengan kelelahan mata, lama kerja, pendidikan, dan golongan umur.

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The Relationship between Light Intensity and Asthenopia as well as Working Productivity of the Labor Working at Garment Industry of PT. Busana Rama Textile & Garment TangerangThe Scope and Method of Study. In order to find out the relationship between the light intensity with asthenopia and working productivity, a cross sectional study is conducted toward 264 female worker who are working as tailor in the garment industry of PT. Busana Rama Textile and Garment. The collection of data is carried out by anamneses, physical examination, especially related to asthenopia by using near point ruler, and environment examination regarding the light intensity at the working place by using the lux meter. Results and Conclusion: The study find out that the average light intensity for all working places is 238,50 lux, with standard deviation of 77.36. The prevalence rate of asthenopia after working for 4 hours is 84,5%. There are no relationship between asthenopia and light intensity, color of clothes raw-material, length of work, educational level, and age group of the female workers. The average productivity for all workers after working for 4 hours is 72,65 pieces of cloth per hour with the standard deviation of 38,47. The result of statistic shown that there are relationship between working productivity and color of cloths raw-material and light intensity. However with regards of asthenopia, length of work, educational level, and age group of the female workers there are no relationship with working productivity.