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"Praktek Kerja Profesi Apoteker (PKPA) adalah program kerja yang bertujuan untuk membekali mahasiswa calon apoteker mengenai peran, fungsi, dan tanggung jawab apoteker di sarana pekerjaan kefarmasian, yaitu rumah sakit, industri farmasi, apotek, puskesmas, dan Pedagang Besar Farmasi (PBF). Mahasiswa calon apoteker diharapkan memiliki wawasan, pengetahuan, keterampilan, dan pengalaman untuk melakukan pekerjaan kefarmasian secara profesional. Kegiatan PKPA dilakukan di industri farmasi dan apotek, yaitu PT Clinisindo Laboratories dan Apotek Kimia Farma Utama Raya secara berturut-turut. PKPA di PT Clinisindo Laboratories dilaksanakan pada periode Januari - Februari 2022, sementara PKPA di Apotek Kimia Farma Utama Raya dilaksanakan pada periode Maret 2022. Pada PKPA di PT Clinisindo Laboratories, penulis melaksanakan pengkajian terhadap beberapa software yang dapat digunakan dalam sistem manajemen informasi laboratorium, yaitu LabSolution CS, NuGenesis SDMS, dan Agilent SLIMS. Pada PKPA di Apotek Kimia Farma Utama Raya, penulis melaksanakan analisis Pareto ABC dan kegiatan pelayanan farmasi klinik di apotek. Dengan demikian, mahasiswa calon apoteker memeperoleh ilmu yang bermanfaat untuk pengabdiannya kelak sebagai seorang apoteker yang profesional.

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Professional pharmacist work practice is a work program that aims to equip prospective pharmacist students about the roles, functions, and responsibilities of pharmacists in pharmaceutical work facilities, namely hospitals, pharmaceutical industries, pharmacies, health centers, and pharmaceutical wholesalers. Pharmacist students are expected to have the insight, knowledge, skills, and experience to do pharmacy work professionally. Professional pharmacist work practice activities are carried out in the pharmacy store and pharmacy industry, namely PT Clinisindo Laboratories and Apotek Kimia Farma Utama Raya, respectively. Professional pharmacist work practice at PT Clinisindo Laboratories was carried out in the period January - February 2022, while professional pharmacist work practice at Apotek Kimia Farma Utama Raya was carried out in the period March 2022. In PT Clinisindo Laboratories, the authors carried out an assessment of several software that can be used in laboratory information management systems, namely LabSolution CS, NuGenesis SDMS, and Agilent SLIMS. In Apotek Kimia Farma Utama Raya, the authors carried out Pareto ABC analysis and clinical pharmacy service activities at pharmacy store. Thus, pharmacist students gain useful knowledge for their future service as a professional pharmacist."

"Insiden inflammatory bowel disease (IBD) terus meningkat pada negara berkembang dan dipertimbangkan menjadi penyakit global. Deksametason dipilih karena memiliki efek glukokortikoid yang poten dan anti-inflamasi. Namun, penggunaan kortikosteroid jangka panjang menimbulkan efek samping sistemik sehingga diperlukan sediaan tertarget kolon. Sediaan tertarget kolon dibuat dengan memformulasikan probiotik pada tablet inti yang kemudian disalut dengan penyalut primer dan sekunder. Probiotik berfungsi untuk menjamin pelepasan obat di kolon. Alginat dipilih sebagai penyalut primer karena memiliki sifat biodegradable pada mikroflora kolon, sedangkan kombinasi Eudragit L100 dan Eudragit S100 dipilih sebagai penyalut sekunder karena mampu melindungi obat dari asam. Formulasi tablet inti dilakukan dengan metode granulasi basah, lalu dikempa menjadi tablet. Tablet disalut menggunakan larutan alginat 3% dan larutan campuran Eudragit 10%. Penyalutan dilakukan hingga diperoleh kenaikan bobot sebesar 6,5% untuk alginat dan 8,7% untuk campuran Eudragit. Berdasarkan hasil evaluasi, tablet multisalut F3 memiliki karakteristik dan profil disolusi terbaik. Tablet multisalut F3 memiliki diameter 7,30±0,06 mm; tebal 3,71±0,06 mm; bobot 123,25±1,82 mg; kandungan 104,59±1,63%; kekerasan 14,24±1,30 Kp; keregasan 0,01%, dan kadar 104,18±0,63%. Hasil analisis SEM menunjukkan tablet multisalut memiliki morfologi permukaan dengan pori-pori yang lebih sedikit. Profil uji disolusi menunjukkan tablet multisalut F3 mengalami pelepasan obat yang lebih sedikit pada medium asam dibandingkan formulasi lain.

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The incidence of inflammatory bowel disease (IBD) increases in developing countries and is regarded as a global disease. Dexamethasone was chosen because it has potent glucocorticoid and anti-inflammatory effects. However, long-term use of corticosteroids causes systemic side effects, so colon-targeted preparations are needed. Colon-targeted drug delivery was made by formulating probiotics in core tablets which are then coated with primary and secondary coatings. Probiotics ensure the release of drugs in the colon. Alginate was chosen as the primary coating because it has biodegradable properties on the colonic microflora. While the combination of Eudragit L100 and Eudragit S100 was selected as the secondary coating because it can protect the drug from acid. Core tablet formulation was carried out by the wet granulation method, then compressed into tablets. Tablets were coated using 3% alginate solution and 10% Eudragit combination solution. Coating was carried out until 6.5% weight gain for alginate, and 8.7% weight gain for Eudragit was obtained. Based on the evaluation results, F3 has the best characteristics and dissolution profile. The multicoated tablet has a diameter of 7.30±0.06 mm, 3.71±0.06 mm of thickness, 123.25±1.82 mg of weight, 104.59±1.63% of content uniformity, 14.24±1.30 Kp of hardness, 0.01% of friability and 104.18±0.63% of drug content. SEM analysis showed that the multicoated tablets had fewer pores. Dissolution test showed that F3 multicoated tablets experienced less drug release in acidic medium than other formulations. "