Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Maraknya penutupan berbagai gerai ritel di Asia Tenggara menimbulkan dampak terhadap kondisi finansial emiten ritel, yang juga akan memberi pengaruh pada kondisi finansial investor. Penelitian ini secara spesifik ditujukan untuk menganalisis dampak finansial penutupan gerai ritel terhadap imbal hasil saham dan kinerja keuangan emiten ritel. Pendekatan empiris menggunakan Fama French three-factor model dipilih untuk menghitung imbal hasil abnormal yang disebabkan oleh kejadian ini. Rasio profitabilitas dan nilai pasar relatif digunakan untuk menilai kinerja keuangan tiap emiten. Studi memperlihatkan adanya nilai cumulative abnormal return negatif yang signifikan secara statistik sejak pengumuman hingga hari pertama setelah pengumuman. Cumulative abnormal return dengan nilai negatif terjadi sampai hari kelima setelah pengumuman, akan tetapi sudah tidak signifikan secara statistik. Adapun, kondisi kinerja keuangan emiten ritel sebelum dan sesudah penutupan gerai tidak berbeda signifikan secara statistik. ......The spreading news of retail store closure in Southeast Asia brings the impact toward the financial condition of the retail listed companies as well as of the investors’. The specific objective of this study is to examine the financial impact of closing retail outlets on stock return and the financial performance of retail listed companies. Empirical approach is used in this study, using the Fama French three-factor model to calculate stock return that occur due to this event. Profitability and relative market value ratios are used to evaluate the financial performance. An interesting finding from this study is that there is an abnormal and negative return from the closure of retail stores. It is showed by the negative cumulative abnormal return (CAR), that is significant statistically, until the first day after the store closure announcement is announced. The negative abnormal return occurs until the fifth day after announcement that is not significant statistically anymore. However, the financial performances before and after store closure are not different statistically.

Abstrak :
ABSTRAK
Akumulasi radikal bebas dalam tubuh manusia memiliki peran besar dalam prevalensi dan perkembangan penyakit degeneratif. Siklovalon adalah analog kurkumin monokarbonil yang memiliki aktivitas antioksidan yang termasuk sedang. Substitusi basa Mannich pada cincin benzena dari siklovalon diketahui dapat meningkatkan aktivitas antioksidan senyawa ini. Pada penelitian ini dilakukan sintesis dan uji aktivitas antioksidan siklovalon yang tersubstitusi basa Mannich pirolidin. Pengerjaan dilakukan melalui 2 tahap, yaitu sintesis siklovalon, dengan mereaksikan vanilin dan sikloheksanon. Kemudian siklovalon direaksikan dengan pirolidin dan paraformaldehid, dan diperoleh siklovalon tersubstitusi basa Mannich pirolidin. Hasil sintesis kemudian dikonfirmasi identitasnya dengan data IR, HRMS, 13C-NMR, dan 1H-NMR. Berdasarkan data tersebut,siklovalon tersubstitusi basa Mannich pirolidin telah berhasil disintesis. Senyawa ini kemudian diuji aktivitas antioksidannya dengan metode uji DPPH Radical Scavenger. Senyawa siklovalon tersubstitusi basa Mannich pirolidin memiliki nilai IC50 2,297 ?M, 30 kali lebih tinggi dibandingkan senyawa pemulanya, siklovalon.

---

ABSTRACT
Accumulation of free radicals in human body plays a big role in the prevalence and progression of degenerative disease. Cyclovalone is mono carbonyl curcumine analog with a medium antioxidant activity. Mannich base substitution to the benzene ring of cyclovalone can increase its antioxidant activity of this compound. In this experiment, synthesis and antioxidant activity test of cyclovalone substituted with pyrollidine Mannich base have been done. The experiment has been done through two stages, synthesizing cyclovalone by reacting vanillin and cyclohexanone. Then, cyclovalone was reacted with pyrollidine and paraformaldehyde in order to synthesize cyclovalone substituted Mannich base pyrollidine. The identity of product was confirmed by IR spectra, data of HRMS, 13C NMR, and 1H NMR. According to the data, cyclovalone substitutedMannich base pyrollidine has been synthesized. The product also went through DPPH Radical Scavenger Test to know its antioxidant activity. Cyclovalone substituted Mannich base pyrollidine IC50 is 2.297 M, 30 times higher than its pioneer, cyclovalone