"We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy
revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different
test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used
polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type
cagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorized
in to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor and standard triple therapy regimens eradication of H. pylori.
Kami melaporkan sebuah kasus seorang laki-laki, 72 tahun, etnis Tionghoa dengan keluhan utama buang air besar berwarna hitam lembek. Pemeriksaan fisik menunjukkan warna pucat pada konjungtiva palpebra yang dikonfirmasi dengan hasil hitung darah lengkap. Pemeriksaan gastroduodenoskopi menemukan adanya ulkus berukuran 3 mm di antrum (Forrest stage III). Infeksi H. pylori dinyatakan positif berdasarkan lima metode berbeda (urinary antibody tests, rapid urease test, kultur, histologi dan imunohistokimia). Analisisdengan sequencing berbasis polymerase chain reaction didapatkan bahwa pasien terinfeksi oleh strainberjenis East-Asian-type cagA dan vacA s1m1. Analisis lanjutan dengan menggunakan tujuh housekeepinggen mengkonfirmasikan bahwa strain tersebut tergolong dalam kelompok hspEAsia. Pasien diberikan infusintravena kontinyu pompa proton inhibitor dan standar triple therapy regimens untuk terapi eradikasi H. pylori."
Jakarta: Universitas Airlangga. Institute of Tropical Disease ; Universitas Airlangga. Faculty of Medicine ; Oita University. Faculty of Medicine, 2016