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RM Ardani Fitriansyah SY
Penilaian pankreas intraoperatif yang memengaruhi kejadian fistula pankreas pascaoperasi pankreatikoduodenektomi = Pancreatic's assessment intraoperatively incorrelation with pancreatic fistula after pancreaticoduodenectomy
"Pendahuluan. Fistula pankreas masih merupakan komplikasi paling sering setelah pankreatikoduodenektomi yang menyebabkan masa rawat lama dan biaya besar.  Fistula ini terjadi sampai 45%.  Kebocoran anastomosis pankreatikojejunostomi merupakan faktor yang paling penting. Belum ada data tentang faktor pankreas yang dapat memengaruhi fistula pankreas di Jakarta, khususnya RS Cipto Mangunkusumo sehingga dilakukan penelitian ini.

Metode.  Penelitian cross sectional ini dilakukan pada 70 orang penderita yang dilakukan pankreatikoduodenektomi. Data dikumpulkan dari data sekunder rekam medis tahun 2016-2019 berupa tekstur pankreas, diameter duktus pankreatikus, teknik anastomosis pankreatikojejunal, dan penggunaan stent pada pankreatikojejunal sebagai variabel bebas. Fistula pankreas sebagai variabel terikat. Data diuji dengan uji Spearman dikarenakan abnormalitas distribusi data.

Hasil.  Didapatkan 70 subjek. Tidak ada kejadian fistula pankreas sebanyak 21,4% dan ada fistula pankreas sebanyak  78,6%. Diameter duktus pankreatikus tidak melebar sebanyak 78,6% dan melebar sebanyak 21,4%. Tekstur pankreas soft sebanyak 22,9% dan hard sebanyak 77,1%. Penggunaan stent sebanyak 21,4% dan tidak ada penggunaan sebanyak 78,6%. Tipe anastomosis pankreatikojejunal dunking atau invaginasi sebanyak 82,9% dan duck to mucosa sebanyak 17,1%.  Faktor risiko yang bermakna pada analisis bivariat adalah diameter duktus pankreatikus (p=0,007). 

Kesimpulan. Penilaian diameter duktus pankreatikus intraoperatif mempunyai hubungan bermakna dalam memperkirakan kejadian fistula pankreas pascaoperasi pankreatikoduodenektomi.

 

Introduction. Pancreatic fistula is the most common complication after pancreaticoduodenectomy that cause longer hospital stay and higher cost. It happens 45%. Pancreaticojejunostomy anastomosis leakage is the most important factor. No data about pankreas’ factor that can influence pancreatic fistula in Cipto Mangunkusumo hospital so this study is held.

Method. This cross sectional study was done for 70 patients. Data was collected from medical record in 2016-2019.   The data are pancreatic texture, pancreatic duct diameter, pancreaticojejunal anastomotic technique, and use of  stent in pancreaticojejunal as the independent variables. Pancreatic fistula as the dependent variable.   We analyzed  using Spearman test due to abnormality data distribution.

 

Results. There are 70 subjects enrolled. Subjects with no pancreatic fistula about 21,4% and with pancreatic fistula 78,6%.   No dilated pancreatic duct diameter about 78,6% and dilated about 21,4%. Soft texture pancreas about 22,9% and hard 77,1%. Use of stent about 21,4% and no stent 78,6%. Pancreaticojejunal anastomotic type of dunking or invaginating about 82,9% and duck to mucosa about 17,1%.  The significant risk factor in bivariate analysis is diameter of the pancreatic duct (p=0,007). 

Conclusion. Intraoperative assessment of the pancreatic duct diameter associated significantly in predicting pancreatic fistula after pancreaticoduodenectomy.

 

"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Pasihulizan
Hubungan CA 19-9 Praoperasi Terhadap Resektabilitas Adenokarsinoma Kaput Pankreas = Correlation Between Preoperative CA 19-9 Level with Pancreatic Adenocarcinoma Resectability
"CA 19-9 merefleksikan derajat keparahan adenokarsinoma kaput pankreas ditunjukkan oleh beberapa studi berhasil menemukan korelasi peningkatan CA 19-9 dengan resektabilitas adenokarsinoma kaput pankreas. Penelitian ini bertujuan melakukan evaluasi hubungan dan nilai diagnostik CA 19-9 dalam memprediksi resektabilitas adenokarsinoma kaput pankreas. Penelitian dilakukan secara potong lintang mengambil data dari rekam medis Rumah Sakit dr. Cipto Mangunkusumo tahun 2016–2019. Pasien terdiagnosis adenokarsinoma kaput pankreas secara histopatologis atau pencitraan abdomen, berusia ≤65 tahun, dan memiliki catatan pemeriksaan kadar CA 19-9 diikutsertakan dalam penelitian ini. Selain kadar CA 19-9, peneliti juga menilai factor terkait operabilitas. Tercatat 54 subjek dengan rerata usia 53,78±11,13 tahun. Ditemukan adanya korelasi positif (0,850) dan signifikan antara tingginya kadar CA 19-9 dengan resektabilitas tumor kaput pankreas. Untuk operabilitas, ditemukan perbedaan bermakna kadar CA 19-9, albumin, dan skor Karnofsky pada kelompok pasien tumor kaput pankreas resectable dan unresectable. Titik potong kadar CA 19-9 tercatat sebesar 140,65 U/mL, dengan sensitivitas sebesar 82,76% (64,23%–94,15%), spesifisitas sebesar 72,00% (50,61%–87,93%), dan AUC sebesar 0,784. CA 19-9 berhubungan secara signifikan dengan resektabilitas tumor kaput pankreas. CA 19-9 memiliki nilai diagnostik yang baik dalam mempredisksi resektabilitas tumor ini.
CA 19-9 reflects the degree of severity of pancreatic head adenocarcinoma shown by several studies to find a correlation of elevated CA 19-9 with resectability of pancreatic head adenocarcinoma. This study aimed to evaluate the relationship and diagnostic value of CA 19-9 in predicting resectability of pancreatic head adenocarcinoma. The study was conducted in a cross-sectional manner, taking data from the medical records of dr. Cipto Mangunkusumo 2016–2019. Patients diagnosed with adenocarcinoma of the head of the pancreas by histopathologic or abdominal imaging, aged ≤65 years, and who had a record CA level of 19-9 were included in this study. In addition to CA levels of 19-9, the investigators also assessed operability-related factors. There were 54 subjects with a mean age of 53.78 ± 11.13 years. Found a positive correlation (0, 850) and significant between high levels of CA 19-9 with resectability of head tumors of the pancreas. For operability, there were significant differences in CA 19-9 levels, albumin, and Karnofsky scores in the resectable and unresectable group of pancreatic head tumors. The cut-off point for CA 19-9 levels was recorded at 140.65 U / mL, with a sensitivity of 82.76% (64.23% -94.15%), a specificity of 72.00% (50.61% -87.93 %), and AUC of 0.784. CA 19-9 was significantly associated with pancreatic head tumor resectability. CA 19-9 has a good diagnostic value in predicting the resectability of these tumors. The cut-off point for CA 19-9 levels was 140.65 U / mL, with a sensitivity of 82.76% (64.23% -94.15%), a specificity of 72.00% (50.61% -87.93 %), and AUC of 0.784. CA 19-9 was significantly associated with pancreatic head tumor resectability. CA 19-9 has a good diagnostic value in predicting the resectability of these tumors. The cut-off point for CA 19-9 levels was 140.65 U / mL, with a sensitivity of 82.76% (64.23% -94.15%), a specificity of 72.00% (50.61% -87.93 %), and AUC of 0.784. CA 19-9 was significantly associated with pancreatic head tumor resectability. CA 19-9 has a good diagnostic value in predicting the resectability of these tumors"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Eko Ristiyanto
Stres Psikologis Sebagai Faktor Risiko Tukak Peptikum Perforasi di Masa Pandemi COVID-19 = Psychological Stress as a Risk Factor for Perforated Peptic Ulcers during the COVID-19 Pandemic
"Latar Belakang: Peningkatan insiden tukak peptikum perforasi (TPP) Divisi Bedah digestif RSUPN Dr. Cipto Mangunkusumo Jakarta. Selama enam bulan awal pandemi Covid-19, naik empat kali lipat, dibandingkan enam bulan sebelum pandemi Covid-19. Penelitian ini bertujuan untuk menilai peran stres psikologis sebagai faktor risiko tukak peptikum perforasi.
Metodologi: Merupakan studi retrospektif potong lintang, membandingkan 2 kelompok subjek penelitian, TPP pandemi Covid-19 Maret 2020 hingga Maret 2021 dan non-pandemi Covid-19 Juli 2017 hingga Februari 2020. Data demografi, klinis, dan tingkat stres psikologis yang diukur dengan Perceived Stress Scale (PSS-10) merupakan variabel yang diperiksa.
Hasil: Tercatat 53 TPP, 28 subjek pada pandemi, pria 11, wanita 17, rerata usia 63 tahun, pemakaian obat antiinflamasi nonsteroid atau jamu 80%, komorbid 92,8%, lama rawat 23,6 hari, morbiditas 78,5%, infeksi daerah operasi 17%, pneumonia 38,9%, dan mortalitas 46,4%. 25 subjek pada non-pandemi, pria 21, wanita 4, rerata usia 53 tahun, penggunaan obat antiinflamasi nonsteroid atau jamu 85%, komorbid 48%, rerata skor boey 1,3, PULP 6,8, ASA 3, lama rawat 16,2 hari, morbiditas 52%, infeksi daerah operasi 12%, pneumonia 36%, dan mortalitas 28%. Penilaian PSS-10 pada 37 subjek, pada pandemi, stres berat delapan, stres sedang tujuh, stres ringan empat. Pada non-pandemi stres berat satu, stres sedang delapan, stres ringan sembilan. Uji Fischer exact didapatkan perbedaan antara stres ringan-sedang dengan stres berat pada kedua kelompok, p = 0,019. Uji Spearman didapatkan korelasi moderat (rs = 0,422) antara stres psikologis dengan pandemi, p = 0,009.
Simpulan: Pandemi Covid-19 memperberat stres psikologis, meningkatkan morbiditas dan mortalitas tukak peptikum perforasi.
Background: Increased incidence of perforated peptic ulcer (PPU) Digestive Surgery Division, Dr. Cipto Mangunkusumo Hospital, Jakarta. During early of six months Covid-19 pandemic, increased four times, compared to six months before Covid-19 pandemic. This study aims to evaluate the role of psychological stress as a risk factor for perforated peptic ulcer.
Methodology: a cross-sectional retrospective study, compare 2 groups on the PPU subjects of COVID-19 pandemic March 2020 to March 2021 and non-pandemic Covid-19 July 2017 to February 2020. Demographic, clinical, and psychological stress data as measured by Perceived Stress Scale (PSS-10) were variables to be evaluated.
Results: Registered 53 PPU, 28 subjects in Covid-19 pandemic, 11 males, 17 females, 63 years mean age, 80% used of nonsteroidal anti-inflammatory drugs or Indonesian herbs, 92.8% comorbidities, 23.6 days length of stay, 78,5% morbidity, 17% surgical site infection, 38.9% pneumonia, and 46,4% mortality. 25 subjects in non-pandemic, 21 males, 4 females, 53 years mean age, 85% non-steroidal anti-inflammatory drugs or Indonesian herbs, 48% comorbidity, 1.3 mean boey score, 6.8 PULP, 3 ASA, 16.2 days length of stay, 52% morbidity, 12% surgical site infection, 36% pneumonia, and 28% mortality. PSS-10 evaluated on 37 subjects, in pandemic, eight severe stress, seven moderate stress, four mild stress. In non-pandemic, one severe stress, eight moderate stress, and nine mild stress. Fischer's exact test found a difference between mild-moderate stress and severe stress in both groups, p = 0.019. Spearman's test found a moderate correlation (rs=0.422) between psychological stress and the pandemic, p = 0.009.
Conclusion: Covid-19 pandemic exacerbates psychological stress, increasing morbidity and mortality of perforated peptic ulcer."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Raya Henri Batubara
Kolesistektomi laparoskopi di Rumah Sakit Cipto Mangunkusumo 2014 : Studi retrospektif observasional = Laparoscopic cholecystectomy experience at Cipto Mangunkusumo Hospital 2014 : A retrospective study
"ABSTRAK
Latar belakang: Kolesistektomi merupakan tindakan abdomen tersering dan saat ini
kolesistektomi laparoskopi (KL) merupakan baku emas dan telah dilakukan pada 90% kasus
kolesistitis simtomatik. Tujuan penelitian ini adalah untuk mengetahui hasil KL di RSCM,
Jakarta.
Metode: Penelitian retrospektif observasional ini menggunakan data dari departemen bedah
divisi digestif RSCM dari bulan Januari hingga Desember 2014. Partisipan penelitian ini
adalah pria atau wanita yang berusia 23-66 tahun yang menjalani KL. Tindakan bedah
dilakukan baik berupa perawatan 1 hari (one day care (ODC)) maupun elektif. Data yang
dikaji adalah temuan preoperatif dan intraoperatif, durasi operasi, lama rawat inap, dan angka
konversi ke tindakan kolesistektomi terbuka (open). Kemudian kami menganalisis faktor
yang mempengaruhi angka konversi.
Hasil: Jumlah pasien yang masuk inklusi adalah 90 orang. Usia rata-rata 43,9 tahun (SE=1,26
tahun) dengan jumlah pasien wanita 61 orang (67,8%). Median durasi operasi adalah 90±36,9
menit dimana pasien yang konversi membutuhkan operasi lebih dari 2 jam lebih banyak
(12% vs 1,5%), namun tidak bermakna secara statistik (p= 0,63). Median lama rawat inap
adalah 9±27.2 hari dan meningkat bermakna pada kasus yag konversi (24±9 hari, p = 0.011).
Median lama pre-operasi = 7±26,8 hari, dan pasca-operasi = 2±3.8 hari, dengan 13,3% pasien
dilakukan endoscopic retrograde cholangio-pancreatography (ERCP) sebelum KL. Cedera
duktus biliaris komunis (CBDK) ditemukan pada 3 kasus (3,33%). Konversi menjadi
laparotomi dibutuhkan pada 4,44% kasus. Faktor yang mempengaruhi angka konversi hanya
pada kasus adhesi (RR (95%IK) = 25,7 (2,4-273,5); p=0,007.
Kesimpulan temuan: kolesistektomi laparoskopi menawarkan lama rawat inap yang lebih
singkat. Durasi operasi pendek dan prosedur ini standard, aman, dan efektif di institusi kami. ABSTRACT
Background: Cholecystectomy is the most frequently performed abdominal operation and
currently laparoscopic cholecystectomy (LC) is considered gold standard being performed in
90% cases of symptomatic gallstones. The aim of the study was to determine results obtained
with LC at our hospital, RSCM, Jakarta.
Methods: This retrospective observational study was conducted in digestive divison in
surgery department of RSCM using data from January to December 2014. The study
participants were patients of both gender aged 23?66 years undergoing LC. Surgery was
performed either in one day care (ODC) or elective schedule. Demographic variables,
preoperative and intraoperative findings, mean operation time, hospital stay, and conversion
rate were evaluated. Factors influencing rate of conversion were also studied.
Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) with
a female 61 (67.8%). Median operative time was 90±36.9 minutes which converted cases
patient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant
(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in converted
cases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation
= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography
(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).
Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate of
conversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007.
Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time is
short and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation and
currently laparoscopic cholecystectomy (LC) is considered gold standard being performed in
90% cases of symptomatic gallstones. The aim of the study was to determine results obtained
with LC at our hospital, RSCM, Jakarta.
Methods: This retrospective observational study was conducted in digestive divison in
surgery department of RSCM using data from January to December 2014. The study
participants were patients of both gender aged 23?66 years undergoing LC. Surgery was
performed either in one day care (ODC) or elective schedule. Demographic variables,
preoperative and intraoperative findings, mean operation time, hospital stay, and conversion
rate were evaluated. Factors influencing rate of conversion were also studied.
Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) with
a female 61 (67.8%). Median operative time was 90±36.9 minutes which converted cases
patient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant
(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in converted
cases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation
= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography
(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).
Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate of
conversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007.
Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time is
short and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation and
currently laparoscopic cholecystectomy (LC) is considered gold standard being performed in
90% cases of symptomatic gallstones. The aim of the study was to determine results obtained
with LC at our hospital, RSCM, Jakarta.
Methods: This retrospective observational study was conducted in digestive divison in
surgery department of RSCM using data from January to December 2014. The study
participants were patients of both gender aged 23?66 years undergoing LC. Surgery was
performed either in one day care (ODC) or elective schedule. Demographic variables,
preoperative and intraoperative findings, mean operation time, hospital stay, and conversion
rate were evaluated. Factors influencing rate of conversion were also studied.
Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) with
a female 61 (67.8%). Median operative time was 90±36.9 minutes which converted cases
patient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant
(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in converted
cases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation
= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography
(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).
Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate of
conversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007.
Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time is
short and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation and
currently laparoscopic cholecystectomy (LC) is considered gold standard being performed in
90% cases of symptomatic gallstones. The aim of the study was to determine results obtained
with LC at our hospital, RSCM, Jakarta.
Methods: This retrospective observational study was conducted in digestive divison in
surgery department of RSCM using data from January to December 2014. The study
participants were patients of both gender aged 23?66 years undergoing LC. Surgery was
performed either in one day care (ODC) or elective schedule. Demographic variables,
preoperative and intraoperative findings, mean operation time, hospital stay, and conversion
rate were evaluated. Factors influencing rate of conversion were also studied.
Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) with
a female 61 (67.8%). Median operative time was 90±36.9 minutes which converted cases
patient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant
(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in converted
cases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation
= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography
(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).
Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate of
conversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007.
Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time is
short and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation and
currently laparoscopic cholecystectomy (LC) is considered gold standard being performed in
90% cases of symptomatic gallstones. The aim of the study was to determine results obtained
with LC at our hospital, RSCM, Jakarta.
Methods: This retrospective observational study was conducted in digestive divison in
surgery department of RSCM using data from January to December 2014. The study
participants were patients of both gender aged 23?66 years undergoing LC. Surgery was
performed either in one day care (ODC) or elective schedule. Demographic variables,
preoperative and intraoperative findings, mean operation time, hospital stay, and conversion
rate were evaluated. Factors influencing rate of conversion were also studied.
Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) with
a female 61 (67.8%). Median operative time was 90±36.9 minutes which converted cases
patient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant
(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in converted
cases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation
= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography
(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).
Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate of
conversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007.
Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time is
short and procedure is standard, safe and effective in our institution."
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Sony Gunawan Victoria
Karsinoma Rektum: Aplikasi Klasifikasi Clavien-Dindo dan Analisa Faktor Risiko di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo = Rectal Carcinoma Aplication of Clavien Dindo Classification and Analyze Risk Factors in Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo
"Komplikasi dan mortalitas pada pasien karsinoma rektum yang menjalani operasi masih cukup tinggi. Analisa faktor-faktor risiko dan klasifikasi komplikasi paska operasi yang terjadi diharapkan dapat menurunkan angka komplikasi yang dapat terjadi. Pada penelitian ini kami menggunakan suatu sistem klasifikasi komplikasi Clavien-Dindo, menstrafikasi komplikasi menjadi lima grade dan melakukan analisa faktor-faktor resiko yang mempengaruhi timbulnya komplikasi paska operasi secara signifikan. Penelitian ini merupakan suatu studi kohort retrospektif yang melibatkan 65 pasien yang menjalani operasi karsinoma rektum di RSCM selama periode Januari 2012 dan Desember 2015. Review rekam medis pasien karsinoma rektum pada semua stadium yang menjalani pembedahan dan variabel lainnya termasuk jenis kelamin, body mass index BMI , riwayat tranfusi preoperatif, jenis pembedahan, setting operasi dan tujuan operasi. Hasil penelitian menunjukkan 55,4 grade I, 15.4 grade II, 3,1 grade IIIA, 6,2 grade IIIB, 13,8 grade IV, dan grade V sebesar 6,2 . Transfusi darah preoperatif menunjukkan adanya hubungan yang bermakna terhadap risiko komplikasi pascabedah karsinoma rektum P = 0,04 . Studi ini menunjukkan bahwa faktor risiko yang berpengaruh pada komplikasi pascaoperasi kanker rektum adalah transfusi preoperasi.
Postoperative morbidity and mortality is a burden in patients with rectal cancer. Analyzing as well as classifying postoperative complication into a universal and standardized method could minimize this burden. Using Clavien Dindo postoperative complication grading system, we stratify complications into five grades and analyze the contributed risk factors in order to identify significant risk factors in reducing patient morbidity and mortality. This retrospective cohort study involved 65 patients which surgery was done between January 2012 and December 2015. It reviewed the medical records of patients diagnosed with rectal carcinoma at any stage and obtain another variable including sex, age, body mass index BMI , preoperative transfusion history, procedure, intention, and approach of the surgery. The result shows 55,4 of the patient was grade I, 15.4 grade II, 3,1 grade IIIA, 6,2 grade IIIB, 13,8 grade IV, and grade V was 6,2 of all patients. Among all of the risks, preoperative transfusion history was the only one statistically significant risk that affect severity of grade P 0,04 ."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
T58932
UI - Tesis Membership  Universitas Indonesia Library
cover
Febiansyah Ibrahim
Faktor-faktor yang mempengaruhi invasi limfovaskular pada adenokarsinoma kolorektal = Factors effect lymphovascular invasion in adenocarcinoma colorectal
"Latar belakang. Adenokarsinoma kolorektal AKR merupakan keganasan gastrointestinal yang sering ditemukan dan mempengaruhi lebih dari satu juta individu di seluruh dunia. Identifikasi histologis invasi limfovaskular telah dikenali sebagai indikasi potensial untuk metastasis KGB dan indikasi prognostik dan prediktor dari luaran pasien.Metode.Penelitian ini adalah penelitian retrospektif dengan regresi logistik multivariat.Hasil. Hasil penelitian didapatkan faktor usia, diferensisasi tumor, pT, dan jenis kelamin tidak mempengaruhi kejadian invasi limfovaskular. AKR diferensiasi sedang dan jenis kelamin laki-laki didapatkan kejadian invasi limfovaskular yang lebih besar dibanding diferensiasi lain dan jenis kelamin perempuan.Kesimpulan. Faktor-faktor yang mepengaruhi invasi limfovaskular yaitu diferensiasi tumor, usia, jenis kelamin, lokasi tumor dan derajat patologis T tidak bermakna secara statistik. Invasi limfovaskular merupakan prediktor terjadinya metastasis KGB.
Background. Adenocarcinoma colon and rectum are the most common gastrointestinal malignancy and afflict more than one million individual worlds wide. Histologic finding of limphovascular invasion has known as potensial indication for lymphatic metastatic and prognostic indication and predictor of patient outcome.Methods. This studi was retrospective, logistic regression test was used for multivariate analysis.Result. Result of this study ara gender, age, tumor differentiation and pT not significantly related to lymphovascular invasion. Mild differentiation and male gender recorded had bigger risk to had lymphovascular invasion descriptively.Conclusion. Factors affecting lymphovascular invasion ie tumor differentiation, age, sex, tumor location and pathologic T degree were not statistically significant. Lymphovascular invasion is a predictor of limph nodes metastasis."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Perwira Widianto
Evaluasi keluaran donor post transplantasi hati donor hidup berdasarkan klasifikasi Clavien-Dindo = Evaluation of donor morbidity in living donor liver transplantation based on the Clavien-Dindo classification system
"Pendahuluan: Hal yang penting untuk transplantasi hati donor hidup (LDLT) yaitu risiko morbiditas dan mortalitas minimal terhadap donor hidup yang sehat. Tujuan dari penelitian ini yaitu untuk menganalisis seluruh komplikasi pascadonor dengan derajat beratnya komplikasi dikelompokkan berdasarkan klasifikasi Clavien-Dindo yang dikombinasikan dengan Comprehensive Complication Index (CCI) dan untuk menganalisis faktor-daktor yang berhubungan dengan komplikasi pascaoperasi.
Metode: Penelitian ini menggunakan desain potong lintang. Terdapat 53 pasien dengan rekam medis lengkap dan menjalani LDLT di RSUPN Cipto Mangunkusumo, Jakarta, pada Desember 2010 dan Januari 2019. Seluruh subjek penelitian dianalisis secara retrospektif. Penelitian ini telah lolos kaji etik dengan nomor surat No 93/UN2.F1/ETIK/2019.
Hasil: Dari 53 pasien yang menjalani LDLT di RSCM, terdapat 7 pasien yang menjalani prosedur transplan hati adult-to-adult dan 46 pasien menjalani prosedur transplan hati adult-to-child. Pada kelompok pasien transplan adult-to-child, sebanyak 43 pasien merupakan donor lobus kiri lateral, 4 pasien donor lobus kiri, 2 pasien donor lobus kiri total, dan 4 pasien donor lobus kanan total. Komplikasi pascaoperasi dilaporkan pada 18 donor (33%). Terdapat 3 (5,6%) pasien dengan klasifikasi Clavien-Dindo derajat IIIa atau lebih berat dengan skor CCI keseluruhan yaitu 10,45 (8,7-55,8). Terdapat 1 dari 53 donor (1,8%) dengan komplikasi bilier derajat III yang membutuhkan ERCP dan ditata laksana dengan stenting bilier dan sfingterektomi. Reoperasi terkati hepatektomi donor dilakukan pada 1 donor akibat infeksi daerah operasi dalam. Tidak ada insidensi gagal hati pascahepatektomi dan mortalitas perioperatif sejak awal prosedur transplantasi hati dilakukan.
Kesimpulan: Morbiditas pasca-LDLT berhubungan dengan pengalaman pelaksana. Sistem klasifikasi Clavien-Dindo yang dikombinasikan dengan CCI bermanfaat dalam memperkirakan hasil prosedur.
Introduction: The crucial prerequisite for living donor liver transplantation (LDLT) is minimal morbidity and mortality risk to the healthy living donor. The purposes of this study were to analyze all post donor complications according to severity using Clavien-Dindo Classification (CDC) integrated with Comprehensive Complication Index (CCI) and to identify factors related to post-operative complications.
Methods: The cross-sectional design was used. A total of 53 patients, with complete medical records, who underwent LDLT in Cipto Mangunkusumo Hospital Jakarta (RSCM) between Desember 2010 and January 2019 were retrospectively analyzed. Ethical approval No 93/UN2.F1/ETIK/2019.
Results: Of 53 patients underwent LDLT at RSCM, 7 patients underwent adult-to-adult liver transplant and 46 patients underwent adult-to-child liver transplant. Of these, 43 were donors of the left-lateral lobe, 4 were of the left lobe, 2 were full-left lobes, and 4 were of the full-right lobe. Postoperative complications were reported in 18 (33%) donors. There were 3 (5.6%) patients in CDC grade IIIa or greater and the overall CCI was 10.45 (8.7-55.8). Only 1 out of the 53 donors (1.8%) had a grade III biliary complication requiring ERCP and managed with biliary stenting and sphincterotomy. Re-operation related to donor hepatectomy was done in 1 donor due to deep incisional surgical site infection. No incidence of post hepatectomy liver failure and perioperative mortality were recorded since inception of the liver transplantation program.
Conclusions: Morbidity after LDLT strongly correlates to center experience. The CDC grading system integrates with CCI is useful to comprise surgical outcomes."
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
T57637
UI - Tesis Membership  Universitas Indonesia Library
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Wendy Primadhani
Faktor-faktor yang mempengaruhi low anterior resection syndrome pada pasien kanker rektum paska prosedur preservasi sfingter ani = Low anterior resection syndrome that influence rectal carcinoma patients after procedure of anal sphincter preservation
"ABSTRAK
Latar Belakang : Gangguan fungsi defeksi, yang diketahui sebagai sindrom Low Anterior Resection (LARS) menjadi masalah utama paska pembedahan kanker rektum yang akan berpengaruh pada kualitas hidup. Studi ini bertujuan untuk menngetahu insidens LARS pada pasien paska prosedur preservasi sfingter ani dan faktor- faktor yang mempengaruhi LARS.
Metode : Pasien kanker rektum yang menjalani eksisi total mesorektal dan anastomosis colorectal selama periode 2017-2018 berpartisipasi dalam pengisian kuesioner LARS. Parameter klinis yang dianalisis dan untuk perbandingan fisiologi anorektal antara mayor LARS dan no LARS atau minor LARS menggunakan pengukuran biofeedback.
Hasil: Studi ini melibatkan 40 pasien, mayor LARS didapatkan pada 42,5% pada pasien yang menjalani low anterior resection (LAR). Radioterapi preoperatif dan level anastomosis berhubungan dengan major LARS dengan odd ratio 0,1 (95% CI : 0,02- 0,49) and 0,07 (95% CI 0,01- 0,39). Dilakukan penghitungan luasan dibawah kurva (AUC) dengan cara receiver operating characteristic (ROC) sebesar 0,77 dan didapatkan titik potong level anastomosis di 5 cm dengan nilai ramal negative 88,23%. Pengukuran biofeedback menunjukkan perbedaan signifikan pada tekanan anal istirahat (resting anal pressure) dan tekanan kontraksi maksimal (maximal squeeze pressure) diperkirakan terjadi gangguan pada fungsi sfingter dan terapi preoperatif berperan untuk terjadinya LARS.
Kesimpulan: LARS merupakan masalah signifikan yang diteukan pada hampir sepertiga pasien kanker rektum paska pembedahan. Resiko terkena mayor LARS meningkat dengan adanya terapi preoperatif dan rendahnya level anastomosis.
ABSTRACT
Background : Defective defecation n function, also known as low anterior resection syndrome (LARS), is common problem after surgical treatment of rectal cancer that has a detrimental effect on quality of life. This study aimed to look for the incidence of LARS in patients whose native rectum could not be kept and determine factors influencing major LARS.
Methods : Retal cancer patients who underwent tumor removal with mesorectal excision and colorectal anastomosis during the years 2017-2018 were asked to participate a structured interview using the verified version of the LARS questionnaire. Clinical parameters were analyzed and anorectal physiology was compared between those with major LARS and those without LARS by biofeedback measurement.
Results : This study included 40 patients ,major LARS was found at 42,5% in those who underwent low anterior resection , which incidence 22% than other group. Preoperative radiotherapy and level of the anastomosis associated with major LARS at an odd ratio 0,1 (95% CI : 0,02- 0,49) and 0,07 (95% CI 0,01- 0,39). The receiver operating characteristic curve showed an area under the curve of 0,77. The cut-off anastomotic level was at 5 cm, which gave a negative predictive value of 88,23%. Biofeedback measurement showed a significant difference in the resting anal pressure and maximal squeeze pressure, which suggests that dearrangement in sphincteric function and preoperative therapy may contribute to the LARS.
Conclusion : LARS is significant problem found in about one third of rectal patients after surgery. Risk of having major LARS increases with preoperative treatment and lower anastomotic level."
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
T55579
UI - Tesis Membership  Universitas Indonesia Library
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Khalikul Razi
Pengaruh suplementasi vitamin D terhadap kadar CEA pada keganasan kolorektal stadium I-III = Analysis of vitamin D supplementation impact on Carcinoembryonic Antigen (CEA) levels in stage I-III colorectal cancer
"Latar belakang: Kanker kolorektal adalah salah satu kanker paling mematikan dan umum di seluruh dunia. Suplemen vitamin D dapat mempengaruhi risiko kanker, tetapi belum jelas efeknya pada pasien kanker kolorektal stadium awal hingga III. Penelitian ini diharapkan dapat memberikan pemahaman lebih lanjut tentang manfaat vitamin D dalam pengobatan kanker kolorektal di Indonesia.
Metode: Penelitian ini merupakan uji klinis acak terkontrol yang dilaksanakan pada September 2022–November 2023 di Poliklinik Bedah Rumah Sakit Cipto Mangunkusumo (RSCM) dengan kriteria inklusi berusia di atas 18 tahun, memiliki diagnosis kanker kolorektal stadium I–III, serta belum menjalani operasi dan kemoterapi untuk kanker kolorektal. Kriteria eksklusi meliputi pasien dengan Skor Karnofsky <60%, merokok, memiliki inflammatory bowel disease, serta pasien dengan jenis keganasan selain karsinoma kolorektal.
Hasil: Rerata kadar vitamin D pada semua subjek sebelum intervensi adalah sebesar 16,66±6,23 ng/mL. Median kadar CEA pre intervensi sebesar 4,70 (min-max 1,30– 59,40). Terdapat perubahan yang signifikan dalam kadar CEA dalam kelompok eksperimental (median delta CEA: -0,20) dan respons terhadap suplementasi vitamin D bervariasi tergantung pada tingkat diferensiasi sel kanker.
Kesimpulan: Temuan penelitian ini menunjukkan bahwa suplementasi vitamin D secara signifikan dapat menurunkan kadar CEA pada pasien dengan kanker kolorektal stadium I-III yang belum menjalani tindakan medis.
Background: Colorectal cancer is a globally prevalent and highly lethal malignancy. While vitamin D supplementation may impact cancer risk, its precise effect remains unclear, especially in patients with early to stage III colorectal cancer. This research aims to enhance our understanding of the potential advantages of vitamin D in colorectal cancer treatment in Indonesia.
Methods: This study is a randomized controlled clinical trial conducted from September 2022 to November 2023 at Cipto Mangunkusumo Hospital's Surgical Polyclinic (RSCM). Inclusion criteria encompass individuals aged 18 and above, diagnosed with stage I–III colorectal cancer, and without a history of surgical or chemotherapeutic colorectal cancer treatment. Exclusion criteria entail patients with a Karnofsky score below 60%, smokers, individuals with inflammatory bowel disease, and those diagnosed with malignancies other than colorectal carcinoma.
Results: The mean vitamin D level in all subjects before the intervention was 16.66 ± 6.23 ng/mL. The median pre-intervention CEA level stood at 4.70 (min-max 1.30–59.40). There was a notable change in CEA levels within the experimental group (median delta CEA: -0.20), and the response to vitamin D supplementation exhibited variations depending on the degree of cancer cell differentiation.
Conclusion: The outcomes of this study indicate that vitamin D supplementation can significantly reduce CEA levels in patients with stage I-III colorectal cancer who have not received prior medical treatment."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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Sihotang, Ely Sakti Panangian
Uji Prognostik Nilai Carcinoembrionic Antigen Terhadap Insiden Metastasis Hepar Pada Kasus Kanker Kolorektal Usia Dewasa Muda Di RSUPN Dr Cipto Mangunkusumo Jakarta = Prognostic value of Serum Carcinoembryonic Antigen Level in Predicting Liver Metastases of Colorectal Cancer Among Young Adult Patient in Cipto Mangunkusumo Hospital Jakarta
"Tujuan. Penelitian ini bertujuan untuk mengetahui nila diagnostic kadar CEA serum sebagai indikator terjadinya metastasis hepar dari kanker kolorektal (KKR) pada usia dewasa muda Metode. Studi potong lintang dilakukan dengan menggunakan data sekunder berupa catatan pasien dalam rekam medis. Pasien berusia <50 tahun yang terdiagnosis kanker kolorektal primer secara histopatologis di Cipto Mangunkusumo Hospital direkrut dalam penelitian ini. Kami mengeksklusi pasien dengan riwayat keganasan lain, telah menjalani tatalaksana operatif untuk kanker kolorektal, dan memiliki komorbiditas penyakit hati. Luaran akhir dari penelitian ini adalah cut off nilai CEA yang didapat dengan kurva ROC, sensitivitas, dan spesifisitas nilai CEA dalam memprediksi metastasis hepar KKR. Hasil. Kami merekrut 181 pasien dengan proporsi 43.6% perempuan. 59 pasien (32.6%) diketahui memiliki metastasis hepar pada saat intraoperatif. Kadar CEA pasien metastasis ditemukan sebesar 208.1 (2.1–12503.2) ng/mL, angka ini jauh lebih tinggi dibandingkan pasien non-metastasis 6.27 (0.8–1099.4) ng/mL (p<0.001). Nilai AUC tercatat sebesar 0,904, dan cut off optimal didapat pada kadar CEA ≥38,765 ng/mL (Indeks Youden = 1,718). Peneliti mencatat sensitivitas dan spesifisitas niali CEA serum ≥38,765 ng/mL, secara berturut-turut, sebesar 91,53% (IK 95%, 81,32%–97,19%) dan 80,3% (72,16%–86,97%). Rasio odds pasien kanker kolorektal usia muda untuk mengalami metastasis hepar adalah sebesar 44,10 (IK 95%, 15,92–122,20) bila nilai CEA serum pasien sebesar ≥38,765 ng/mL. Simpulan. Kadar CEA ≥38,765 ng/mL memiliki sensitivitas dan spesifisitas yang baik, sehingga cukup efektif untuk digunakan sebagai prediktor metastasis hepar pada penderita KKR.
Introduction. This study aims to determine the diagnostic value of serum CEA levels as the liver metastases predictor of colorectal cancer (CRC) in young adults.. Method. A cross-sectional study was conducted using secondary data (patient medical records) from 2015–2021. Patients aged <50 years who were diagnosed histopathologically with primary colorectal cancer at Cipto Mangunkusumo General Hospital were recruited in this study. We excluded patients with a history of other malignancies, who had undergone operative management for colorectal cancer, and preexisting liver disease. The outcome of this study is the cut-off of the CEA value obtained by the ROC curve, the sensitivity and specificity of the CEA value in predicting CR liver metastases. Results. We recruited 181 patients with a proportion of 43.6% women. Fifty-nine patients (32.6%) had liver metastases. The CEA level of metastatic patients was 208.1 (2.1–12503.2) ng/mL; this was much higher than the non-metastatic group, which was recorded at 6.27 (0.8–1099.4) ng/mL (p<0.001). The AUC value was recorded at 0.904, and the optimal cut-off was obtained at CEA levels 38.765 ng/mL (Youden's Index = 1.718). We noted the sensitivity and specificity of serum CEA values 38.765 ng/mL, respectively, of 91.53% (91.5 CI, 81.32%–97.19%) and 80.3% (72.16%– 86.97%). The odds ratio of young colorectal cancer patients to have liver metastases was 44.10 (95% CI, 15.92–122.20) if the patient's serum CEA value was 38.765 ng/mL. Conclusion. CEA level ≥38,765 ng/mL has good sensitivity and specificity in predicting liver metastases among young adults with CRC."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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UI - Tesis Membership  Universitas Indonesia Library
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