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"Pendahuluan: Hiperhidrasi meningkatkan risiko kematian pada pasien hemodialisis (HD) kronik. Hiperhidrasi berdasarkan brain-type natriuretic peptide(BNP) plasma >356 pg/ml berisiko tinggi kematian pada pasien dengan HD kronik. Pengeluaran akumulasi air berlebih seminggu pada prosedur HD kronik dua kali seminggu lebih sedikit dibandingkan HD kronik tiga kali seminggu sehingga berpotensi lebih mudah mengalami hiperhidrasi. Penelitian ini bertujuan mengetahui proporsi pasien dengan hiperhidrasi serta hubungan usia, tekanan darah sistolik(TDS)pradialisis, interdialytic weight gain(IDWG), dan ultrafiltrasi(UF) dengan hiperhidrasipada pasien HD kronik dua kali seminggudi Rumah Sakit Umum Pusat Nasional(RSUPN)Dr. Cipto Mangunkusumo.Metode: Penelitian ini merupakan studi potong lintang untuk mengetahui proporsi pasien dengan hiperhidrasi,serta hubungan usia, TDS pradialisis, IDWG, dan UF dengan hiperhidrasi pasien HD kronik dua kali seminggu di RSUPNCiptoMangunkusumo. Hiperhidrasi berdasarkan BNP plasma >356 pg/ml. Analisis bivariat dan multivariat dilakukan untuk mengetahui hubungan usia, TDS pradialisis, IDWG, dan UF dengan hiperhidrasi. Hasil: Sebanyak 129 pasien yang dianalisis. Hiperhidrasi didapatkan sebesar 62%. Pada analisis multivariat menunjukkan bahwa TDS pradialisis berhubungan dengan hiperhidrasi (adjusted OR=3,84; IK 95%: 1,51-9,74; p<0,005) Kesimpulan: Proporsi pasien dengan hiperhidrasi pada HD kronik dua kali seminggu sebesar 62%. Pada analisis multivariat didapatkan hanya TDS pradialisis berhubungan dengan hiperhidrasi.

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Introduction: Hyperhydration is an independent higher mortality risk factor in maintenance hemodialysis (MHD) patients. In Indonesia, twice-weekly HD is the most common of MHD. Twice-weekly HD patients may have higher risk of interdialytic water accumulation lead hyperhydration than thrice-weekly HD patients.The aim of study was identifying the proportion of patients with hyperhydration, and relationship of age, predialytic systolic blood pressure (SBP), interdialytic weight gain (IDWG), and ultrafiltration (UF) to hyperhydration in twice-weekly HD patients at Dr. Cipto Mangunkusumo National General Hospital. Methods: A cross sectional study in twice-weekly HD patients at Dialysis Unit-Dr. Cipto Mangunkusumo National General Hospital. Hyperhydration was based on plasma brain-type natriuretic peptide (BNP) >356 pg/ml. Bivariate and multivariate analysis was done to analyze relationship of age, predialytic SBP, IDWG, and UF with hyperhydration. Results:One hundred twenty-nine patients were analyzed, proportion of patients with hyperhydration in twice--weekly HD patients was 62%. In multivariate analysis, predialytic SBP was related to hyperhydration (adjusted OR= 3.84; 95% CI, 1.51-9.74; p=0.005).

Conclusion: The proportion of patients with hyperhydration in twice-weekly HD patients was 62%. In multivariate analysis the predialytic SBP was related to hyperhydration in twice-weekly HD patients at Dr. Cipto Mangunkusumo National General Hospital."

"Latar Belakang: Periostin memainkan peran sebagai mediator proses inflamasi termasuk inflamasi dan fibrosis ginjal. Namun, data signifikansi periostin pada acute kidney injury terbatas. Kami meneliti korelasi kadar periostin urin dengan fungsi ginjal pada pasien keganasan yang mendapat terapi cisplatin dosis tinggi. Metode: Penelitian kohort prospektif ini dilakukan di n ruang rawat HOM lantai 8 gedung A, di RSCM dari November 2019 hingga jumlah sampel minimal terpenuhi dengan cara consecutive sampling. Data dianalisis menggunakan SPSS versi 23.0 sesuai tujuan penelitian. Hasil: Dari 37 responden diketahui 70,3% laki-laki, 29,7% berusia 41-50 tahun, 59,5% menderita KNF, serta 64,9% memiliki Skor Karnofsky 80. Kadar ureum dan kreatinin darah responden meningkat dari pra kemoterapi hingga 1 minggu paska kemoterapi I. Begitu juga dengan nilai eGFR yang makin menurun. Perubahan kadar periostin menurun selama kemoterapi I dan II, naik kembali 1 minggu paska kemoterapi III dengan nilai p>0,05. Pada uji korelasi kadar periostin urin dengan variabel fungsi ginjal lainnya tidak didapatkan domain yang signifikan bermakna (p>0,05) dengan nilai koefisien korelasi lemah (r = 0,017-0,254) dan beberapa domain memiliki arah korelasi negatif.Simpulan: Tidak didapatkan korelasi bermakna kadar periostin urin dengan kadar ureum darah, kreatinin darah serta laju filtrasi glomerulus pasien keganasan dengan terapi cisplatin dosis tinggi.

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Background: Periostin plays role as mediator of inflammatory processes including inflammation and kidney fibrosis. However, data on the significance of periostin in acute kidney injury are limited. We investigated the correlation of urine periostin levels with kidney function in malignant patients receiving high-dose cisplatin therapy. Methods: This prospective cohort study was conducted in the 8th floor HOM care room in building A, in the RSCM from November 2019 until the minimum sample size was fulfilled by consecutive sampling. Data were analyzed using SPSS version 23.0 according to the purpose of study. Results: Of the 37 respondents known to be 70.3% male, 29.7% aged 41-50 years, 59.5% suffer from NPC, and 64.9% have Karnofsky score of 80. Urea levels and blood creatinine of respondents increased from pre-chemotherapy to 1 week after chemotherapy I. Likewise, the eGFR value decreases. Changes in periostin levels decreased during chemotherapy I and II, rising again 1 week after chemotherapy III with a p value> 0.05. In the correlation test of urinary periostin levels with other kidney function variables, no significant domain was found (p> 0.05) with a weak correlation coefficient (r = 0.017-0.254) and some domains had a negative correlation direction.

Conclusion: No significant correlation was found in urine periostin levels with blood urea levels, blood creatinine and glomerular filtration rates of malignant patients with high-dose cisplatin therapy."