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Abstrak :
ABSTRAK
Gangguan fungsi ginjal merupakan komplikasi yang sering terjadi pada pasien diabetes melitus tipe 2 yang dapat ditandai oleh senyawa 8-iso-Prostaglandin F2a. Pada penelitian ini, dilakukan analisis hubungan antara kadar 8-iso-Prostaglandin F2a dengan estimasi Laju Filtrasi Glomerulus (eLFG). Sampel yang dianalisis adalah 50 pasien diabetes melitus tipe 2 di RSK Dr. Sitanala Tangerang yang terbagi menjadi dua yaitu kelompok sulfonilurea dan kombinasi biguanid-sulfonilurea dengan teknik total sampling. Penelitian ini merupakan penelitian observasional dengan metode kohort retrospektif. Nilai eLFG diperoleh berdasarkan kadar kreatinin serum, sedangkan kadar 8-iso-Prostaglandin F2a diukur dengan metode Enzyme Linked Immunosorbent Assay (ELISA). Uji beda dilakukan terhadap nilai eLFG antara kedua kelompok, yaitu Cockroft Gault (p = 0,961), MDRD (p = 0,567), CKD-EPI (p = 0,443), serta pada kadar 8-iso-Prostaglandin F2a (p = 0,070). Hubungan antara kadar 8-iso-Prostaglandin F2α dengan nilai eLFG dianalisis pada seluruh sampel (n=48), yaitu Cockroft-Gault (r = 0,329; p = 0,023), MDRD (r = 0,231; p = 0,115) dan CKD-EPI (r = 0,256; p = 0,079). Sehingga, tidak terdapat perbedaan nilai eLFG dan kadar 8-iso-Prostaglandin F2a di antara kedua kelompok. Terdapat hubungan yang bermakna antara kadar 8-iso-Prostaglandin F2a dengan nilai eLFG berdasarkan Cockroft-Gault, namun tidak terdapat hubungan pada nilai eLFG MDRD dan CKD-EPI.

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ABSTRACT
Renal dysfunction is a common complication in type 2 diabetes mellitus patient that can be characterized by 8-iso-prostaglandin F2a compound. The aim of this study was to analyze the correlation between the level of 8-iso-prostaglandin F2a and estimated Glomerular Filtration Rate (eGFR). Samples analyzed were 50 patients with type 2 diabetes mellitus in Dr. Sitanala Tangerang Hospital were divided into two groups of sulfonylurea and combination of biguanide-sulfonylurea using total sampling technique. This study was an observasional study using cohort retrospective method. The value of eGFR obtained by serum creatinine levels, while the level of 8-iso-Prostaglandin F2a measured by the method of Enzyme Linked Immunosorbent Assay (ELISA). Different test carried out on eGFR values ​​between the two groups, those were Cockroft-Gault (p = 0,961), MDRD (p = 0,567), CKD-EPI (p = 0,443), as well as on the level of 8-iso-prostaglandin F2a (p = 0.070). The correlation between the levels of 8-iso-prostaglandin F2a with eGFR was analyzed on all samples (n=48), those are Cockroft-Gault (r = 0,329; p = 0,023), MDRD (r = 0,231; p = 0,115) and CKD-EPI (r = 0,256; p = 0,079). Thus, there was no difference in eGFR values ​​and levels of 8-iso-Prostaglandin F2a between the two groups. There was significant correlation between the levels of 8-iso-Prostaglandin F2a and eGFR values were calculated by Cockroft-Gault equation, meanwhile there was no correlation in eGFR values were calculated by MDRD and CKD-EPI equation.

Abstrak :
ABSTRAK
Nefropati diabetika dapat dideteksi melalui nilai UACR. Di sisi lain, 8-iso- Prostaglandin F2α sedang diteliti perannya sebagai penanda awal disfungsi ginjal. Penelitian ini bertujuan untuk menganalisis kadar 8-iso-Prostaglandin F2α, UACR serta hubungan 8-iso-Prostaglandin F2α dan UACR pada 72 orang pasien diabetes melitus tipe 2 (usia 33-75 tahun) di Puskesmas Kecamatan Pasar Minggu. Sampel penelitian dibagi menjadi 2 kelompok, yaitu kelompok biguanid (n = 36) dan kelompok biguanid-sulfonilurea (n = 36). Kadar 8-iso-Prostaglandin F2α urin diukur menggunakan ELISA dan albumin urin diukur menggunakan kit BCG Albumin. Hasil uji beda rata-rata menunjukkan tidak terdapat perbedaan kadar 8-iso- Prostaglandin F2α (p = 0,083) dan UACR (p = 0,509) pada kedua kelompok sampel. Hasil uji beda rata-rata pada kelompok sampel dengan albuminuria (n = 33) juga menunjukkan tidak terdapat perbedaan kadar 8-iso-Prostaglandin F2α (p = 0,532) dan UACR (p = 0,067). Hubungan antara kadar 8-iso-Prostaglandin F2α dengan UACR pada seluruh sampel (r = 0,120; p = 0,315), sedangkan antara 8-iso- Prostaglandin F2α dengan UACR pada kelompok albuminuria (r = 0,534; p = 0,001). Jadi, tidak terdapat hubungan yang signifikan antara kadar 8-iso-Prostaglandin F2α dengan UACR pada seluruh sampel, tetapi terdapat hubungan yang cukup kuat dan signifikan antara kadar 8-iso-Prostaglandin F2α dengan UACR pada sampel dengan albuminuria.

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ABSTRACT
Diabetic nephropathy can be detected by UACR value. Meanwhile, 8-iso- Prostaglandin F2α is being studied for its role as early marker for renal dysfunction. This study were to analize 8-iso-Prostaglandin F2α, UACR, and the correlation between 8-iso-Prostaglandin F2α and UACR on 72 type 2 diabetes mellitus patient (from ages: 33-75 years) at Pasar Minggu Community Health Center. Samples were divided into two groups, which was biguanid group (n = 36) and biguanidsulfonylurea group (n = 36). Urinary 8-iso-Prostaglandin F2α was measured by ELISA and urinary albumin by BCG Albumin kit. The results of mean different test showed there were no difference for 8-iso-Prostaglandin F2α (p=0,083) and UACR (p=0,509) in two group samples. The results of mean different test showed there were also no difference for 8-iso-Prostaglandin F2α (p=0,532) and UACR (p=0,067) in group samples with albuminuria (n=33). The correlation between 8-iso- Prostaglandin F2α and UACR on total samples (r = 0,120; p = 0,315), meanwhile the correlation between 8-iso-Prostaglandin F2α with UACR on samples with albuminuria (r = 0,534; p = 0,001). So, there was no significant correlation between 8-iso-Prostaglandin F2α and UACR on total samples, meanwhile there was strong enough and significant correlation between 8-iso-Prostaglandin F2α and UACR on samples with albuminuria.