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Abstrak :
Melanoma malignum (MM) kulit merupakan tumor ganas dengan mortalitas tinggi. Karakteristik histopatologik merupakan faktor prediktif prognostik MM kulit, tebal tumor >2 mm dan jumlah mitosis ≥5/mm² berkorelasi dengan angka kesintasan yang lebih buruk. Mutasi pada MM antara lain terjadi pada promoter telomerase reverse transcriptase (TERT), sehingga proliferasi sel menjadi tidak terbatas. Telomerase juga meningkatkan risiko metastasis. Penelitian ini bertujuan untuk mengetahui hubungan karakteristik histopatologik dan imunoekspresi TERT dengan angka kejadian metastasis pada MM kulit. Sampel penelitian adalah 30 kasus MM kulit dengan metastasis dan 30 kasus tanpa metastasis di Departemen Patologi Anatomik FKUI/RSCM, periode Januari 2011 sampai Juli 2023. Dilakukan penilaian karakteristik histopatologik (tebal tumor, indeks mitosis, invasi limfovaskular, invasi perineural) dan pulasan imunohistokimia TERT menggunakan antibodi TERT. Data karakteristik histopatologik dan imunoekspresi TERT dianalisis untuk mengetahui hubungannya dengan angka kejadian metastasis. Karakteristik histopatologik yang berhubungan secara signifikan dengan kejadian metastasis adalah tebal tumor >2 mm (p=0,006) dan indeks mitosis ≥5/mm² (p=0,008). Hasil analisis multivariat mendapatkan hubungan antara imunoekspresi TERT tinggi dengan metastasis yang bermakna secara statistik (p<0,001, aOR=56,1). Kesimpulan penelitian ini adalah imunoekspresi TERT tinggi meningkatkan angka kejadian metastasis pada MM kulit. Terdapat hubungan antara tebal tumor dan indeks mitosis dengan angka kejadian metastasis pada MM kulit. ......Cutaneous malignant melanoma (MM) is a malignant tumor with high mortality rate. Histopathological characteristics are prognostic predictive factors of cutaneous MM, tumor thickness >2 mm and mitotic rate ≥5/mm² correlate with worse survival rate. Mutation in MM can occur at telomerase reverse transcriptase (TERT) promoter, which lead to unlimited cell proliferation. Telomerase also increases metastatic risk. This study aims to determine the association between histopathological characteristics and TERT immunoexpression with metastasis in cutaneous MM. The study samples are 30 metastatic and 30 non-metastatic cutaneous MM in Anatomical Pathology Department FKUI/RSCM, from January 2011 to Juli 2023. Histopathological characteristics (tumor thickness, mitotic index, limfovaskular invasion, perineural invasion) were assessed and anti-TERT antibodies were used for immunohistochemistry staining. Histopathological characteristics and TERT immunoexpression data were analyzed to determine their association with metastasis. Histopathological features that correlate significantly with metastasis are tumor thickness >2 mm (p=0,006) and mitotic index ≥5 mitosis/mm² (p=0,008). Multivariate analysis showed significant association between high TERT immunoexpression and metastasis in cutaneous MM (p<0,001, aOR=56,1). This study concludes that high TERT immunoexpression increases metastatic rate in cutaneous MM. Tumor thickness and mitotic index are associated with metastasis in cutaneous MM.

Abstrak :
"Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. Features: More than 3000 full-color photographs ; DVD with image bank includes downloadable figures from the text ; New illustration style makes difficult concepts easier to understand ; Therapeutic ladders with first, second, and third line therapies ; New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation ; Expanded medical and surgical therapeutics sections guide you through all treatment options."--Publisher's website.

Abstrak :
"Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. Features: More than 3000 full-color photographs ; DVD with image bank includes downloadable figures from the text ; New illustration style makes difficult concepts easier to understand ; Therapeutic ladders with first, second, and third line therapies ; New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation ; Expanded medical and surgical therapeutics sections guide you through all treatment options."--Publisher's website.

Abstrak :
The updated second edition of Cutaneous manifestations of infection in the immunocompromised host is an invaluable reference for physicians and ancillary medical professionals involved in the care of patients with impaired immune systems due to cancer, chemotherapy, systemic steroids and other immunosuppressive drugs, HIV/AIDS or organ transplantation. This volume will help you recognize skin lesions and diagnose their infectious cause. Textbook features include, over 350 color images demonstrating pathognomonic, atypical, rare and routine skin lesions. Tables for differential diagnosis of different skin lesions in the immunocompromised host. Complete coverage of infectious pathogens with the patterns of infection and the likely causes in different clinical settings (HIV/AIDS versus solid organ transplantation versus neutropenia post-chemotherapy versus bone marrow recovery post hematopoietic stem cell transplantation. New chapter discussing the role of viruses causing malignancies with cutaneous signs in the immunocompromised patient.