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Abstrak :
ABSTRAK
Diabetes Melitus Tipe 2 (DMT2) adalah masalah global yang sangat serius. Penyakit ini menyerang pada usia yang paling produktif sehingga dapat menurunkan derajat ekonomi dan mengurangi usia harapan hidup. Patogenesis DM sangat erat kaitannya dengan inflamasi, ditandai dengan peningkatan kadar sitokin proinflamasi seperti IL-6, IL-8 dan TNF. Namun, belum ada agen antiinflamasi yang terbukti berperan dalam tatalaksana DMT2. Butirat merupakan asam lemak rantai pendek yang diproduksi dari fermentasi pati resisten di lumen usus. Dalam kondisi normal butirat diserap dan digunakan sebagai sumber energi bagi sel kolonosit, hati dan otot. Butirat mampu berikatan dengan reseptor GPR41 dan GPR43 pada monosit sehingga mampu mengubah pola ekspresi sitokin, aktivasi, migrasi dan diferensiasi sel. Sehingga menarik untuk meneliti pengaruh butirat terhadap migrasi dan sitokin yang diekspresikan oleh monosit pada pasien DMT2. Kadar sitokin dihitung dari supernatan yang diambil dari kultur monosit . Sebanyak 37 subJek dibagi menjadi dua perlakuan yaitu kontrol dan dengan penambahan butirat. Monosit hari pertama diisolasi dalam gel kolagen tipe 1 untuk dilakukan uji migrasi menggunakan μ-slide chemotaxis IBIDI. Analisis gambar menggunakan software ImageJ dan Chemotaxis tool. Terdapat adanya perbedaan yang bermakna pada rasio TNF/IL 10 antara kelompok sehat dan DMT2. Butirat juga terlihat menekan produksi sitokin TNF dan meningkatkan produksi IL10. Indikator migrasi monosit seperti jarak akumulasi dan kecepatan migrasi memiliki perbedaan bermakna antara kelompok sehat dan DMT2. Butirat dapat menekan laju migrasi monosit diikuti dengan penurunan jarak dan kecepatan migrasi monosit

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ABSTRACT
Type 2 Diabetes Mellitus (DMT2) is a very serious global problem. This disease attacks at the most productive age so that it can reduce economic status and reduce life expectancy. The pathogenesis of DM is very closely related to inflammation. characterized by increased levels of proinflammatory cytokines such as IL-6, IL-8 and TNF. However, no anti-inflammatory agent has been proven to play a role in the management of T2DM. Butyrate is a short chain fatty acid produced from resistant starch fermentation in the intestinal lumen. In normal conditions the butyrate is absorbed and used as an energy source for colonocytes, liver and muscle cells. Butirate is able to bind to GPR41 and GPR43 receptors on monocytes so that it can change the pattern of cytokine expression, activation, migration and cell differentiation. So it is interesting to examine the effect of butyrate on migration and cytokines expressed by monocytes in T2DM patients. Cytokine levels were calculated from supernatants taken from monocyte cultures. A total of 37 subjects were divided into two treatments, namely control and with addition of butyrate. The first day monocytes were isolated in type 1 collagen gel for migration testing using the slide chemotaxis IBIDI. Image analysis using ImageJ and Chemotaxis tool software. There was a significant difference in the TNFα / IL 10 ratio between healthy groups and T2DM. Butyrate also appears to suppress TNF cytokine production and increase IL10 production. Monocyte migration indicators such as accumulation distance and migration speed have significant differences between healthy groups and T2DM. Butirat can reduce inflammation responds and the distance and speed of monocyte migration

Abstrak :
Nama : NurchajatieProgram Studi : Ilmu Kesehatan MasyarakatJudul :Model Prediksi Perubahan Status Gizi Pasien Diabetes MelitusTipe 2 Di Ruang Rawat Inap RSUP Fatmawati Tahun 2018.Pembimbing : Ir. Ahmad Syafiq, M.Sc, Ph.dStatus gizi kurang akibat malnutrisi rumah sakit merupakan penurunan statusgizi karena kurangnya asupan atau daya terima makanan selama perawatan, danmenjadi masalah gizi pasien di rawat inap dan sering mendapat sorotan. Statusgizi kurang seringkali dijadikan prediksi lama rawat pasien di rumah sakit.Malnutrisi rumah sakit atau penurunan status gizi selain akibat dari kekuranganasupan makanan, peningkatan kebutuhan sehubungan dengan kondisipenyakitnya dan juga kepuasan terhadap pelayanan gizi, umur, jenis kelamin,selera makan, dan kepatuhan diet. Tujuan penelitian adalah mengetahui modelprediksi perubahan status gizi pasien diabetes melitus tipe 2. Penelitian iniadalah penelitian observasional analitik dengan pendekatan cross sectional.Hasil penelitian perubahan status gizi berdasarkan IMT rata-rata -0,2 0,3kg/m2. Dari hasil analisis regresi linier multivariate diperoleh model prediksiperubahan status gizi = - 0,764 0,004 Asupan Makan - 0,01 Kepatuhan diet ndash;0,014 Kepuasan terhadap pelayanan gizi 0,011 Selera makan. Kesimpulan:Apabila asupan makan , nilai skor kepatuhan diet, nilai skor kepuasan terhadappelayanan gizi serta nilai skor selera makan menurun, maka perubahan statusgizi akan semakin negatif menurun dan asupan makan merupakan variabelyang berpengaruh dalam perubahan status gizi pasien DM tipe 2.Kata kunci: perubahan status gizi, diabetes melitus , malnutrisi rumah sakit.

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ABSTRACTName NurchajatieStudy Program Public HealthTitle Prediction Model of the Change in Nutritional Status ofHospitalized Diabetes Melitus type 2 Patients inFatmawati General Hospital in 2018.Counsellor Ir. Ahmad Syafiq, M.Sc, Ph.dLack of nutrition caused by malnutrition during hospitalization is a decreasingnutritional status which is caused by lack of intake or the decreasing ability toaccept food intake during hospitalization and become a nutrition problem for apatient of which often becomes focus of attention. Patient 39 s lack of nutrition isoften used to predict the length of treatment in the hospital. Malnutrition ordecreasing nutrition status caused by lack of food intake, moreover caused byincreasing need related to the condition of the sickness and also the satisfactiontoward the services in nutrition provision, age, sex, appetite, and diet obedience.The main research objective is to know the model of prediction in the change ofnutritional status of diabetes mellitus type 2. This research is an analyticalobservational research using cross sectional approach. The research result in thechange of nutritional status is based on average IMT 0.2 0.3 kg m2. From theresult of multivariate linear regression, it is obtained the prediction model of thechange in nutritional status 0.764 0.004 Food intake 0.01 Diet obedience 0.014 Satisfaction towards services in nutrition provision 0.011 Appetite.Conclusion if the food intake, the score of satisfaction towards services innutrition provision, and the score of eating appetite are decreasing, then thechange in nutritional status tends to be more negative decreasing and the foodintake is an influential variable in the change of DM type 2 patient 39 s nutritionalstatus.Key words change in nutritional status, diabetes mellitus, hospital malnutrition