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"Diabetes melitus merupakan salah satu penyakit yang memberikan kontribusi besar dalam jumlah kematian di Indonesia. Besarnya jumlah penderita diabetes, berkorelasi langsung dengan besarnya kebutuhan obat, hal tersebut mendorong berbagai upaya untuk mencari sumber obat baru, baik dalam bentuk obat sintesis maupun obat yang bersumber dari sumber daya alam, khususnya sumber daya alam dalam bentuk tumbuhan. Salah satu wilayah yang mempunyai kekayaan sumber daya alam berlimpah, banyak terdapat spesies endemik dan mempunyai potensi yang besar, berada di wilayah timur Indonesia, khususnya di wilayah yang dikenal sebagai wilayah Wallace.Pada penelitian ini, tumbuhan yang menjadi subjek adalah tumbuhan yang berasal dari genus Macaranga yaitu Macaranga magna Turrill yang di koleksi dari hutan Mekongga, Kabupaten Kolaka, Sulawesi Tenggara. Dari hasil uji pendahuluan aktivitas antidiabetes yang dilakukan terhadap Macaranga magna Turrill diketahui bahwa tumbuhan tersebut mempunyai potensi besar dengan IC50 = 6.49 μg/mL. Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi senyawa aktif antidiabetes dari daun Macaranga magna Turrill. Metode yang digunakan meliputi ekstraksi, fraksinasi, isolasi dan purifikasi menggunakan teknik- teknik kromatografi, dan identifikasi struktur kimia berdasarkan metoda spektroskopi yang meliputi : UV/Vis, FT-IR, LC-MS dan FT-NMR. Hasil yang diharapkan dalam penelitian ini adalah senyawa metabolit sekunder yang mempunyai aktivitas antidiabetes, dengan harapan dapat dijadikan sebagai bahan baku obat secara langsung, maupun sebagai senyawa pemandu (lead compound) untuk merancang obat antidiabetes baru yang potensial.Kata kunci: Diabetes mellitus, Macaranga magna Turrill, kromatografi, spektroskopi, senyawa aktif antidiabetes.Diabetes mellitus is one of the biggest contributors in the number of deaths in Indonesia. The large number of diabetic sufferers, was correlated directly with the number of diabetic drugs demand. Its was led to find a new sources for anti-diabetic drug, synthetic or derived from natural resources. Eastern Indonesia region known as Wallace region is one part of Indonesia which has a wealth of natural resources, and some of them were endemic bio-resources.In this study, we used Macaranga magna Turrill plant, one of the Macaranga species, collected from Kolaka District, Southeast Sulawesi Province as a subject. Previous anti-diabetic activity preliminary test results showed that Macaranga magna Turrill has a high potential with IC50 = 6.49 μg /mL. Based on the preliminary data above, our study aims are to isolate and identify the anti-diabetic active compound from the Macaranga magna Turrill leaves. The isolation process will used serial chromatographic methods start from extraction, fractionation, isolation and purification, follow by serial spectroscopic analysis (UV/Vis, FT-IR, LC-MS and FT-NMR) to determine and elucidate the chemical structure of secondary metabolite compound. The results expected in this study are anti-diabetic active secondary metabolite compounds which can be used directly as traditional anti-diabetic drug, or as anti-diabetic drugs raw material, as well as lead compounds for develop a new anti-diabetic potential drugs"

"[Latar Belakang: Diabetes melitus (DM) tipe 1 merupakan penyakit kronik yang sering ditemukan pada anak dan remaja yang disebabkan oleh proses autoimun terhadap sel β sehingga sel β tidak mampu memproduksi insulin. Salah satu komplikasi dari DM tipe 1 adalah nefropati diabetik. Sampai saat ini, tidak ada data mengenai prevalens dan faktor risiko nefropati diabetik pada DM tipe 1 di Indonesia. Metode: Dalam penelitian ini, variabel yang diteliti hubungannya dengan nefropati diabetik ialah terapi yang digunakan, kadar HbA1C, mikroalbuminuria, durasi DM tipe 1, umur saat awitan DM tipe 1, jenis kelamin, dan riwayat diabetik ketoasidosis (DKA). Penelitian ini menggunakan desain potong lintang retrospektif dengan 51 subjek. Data berasal dari rekam medik Rumah Sakit Cipto Mangunkusumo dan diperoleh menggunakan metode consecutive sampling.Hasil: Prevalens nefropati diabetik adalah sebesar 17,6%. Satu – satunya faktor yang berhubungan dengan nefropati diabetik adalah mikroalbuminuria (p=0,008; PR=5,29; IK95%=1,53-18,30), sedangkan terapi yang digunakan, kadar HbA1C, durasi DM tipe 1, umur saat awitan DM tipe 1, jenis kelamin, dan riwayat DKA tidak berhubungan bermakna dengan nefropati diabetik.Kesimpulan: Berdasarkan penelitian ini, prevalens nefropati diabetik sebagai komplikasi DM tipe 1 pada anak di RSCM adalah 17,6%. Faktor yang berhubungan dengan nefropati diabetik adalah mikroalbuminuria.Saran: Perlu ditingkatkan pencatatan dan pemantauan pasien di RSCM untuk memudahkan proses pengobatan dan penelitian. Selain itu, perlu dilakukan penelitian prognostik multivariat lebih lanjut dengan sampel yang lebih banyak, Background:Type 1 diabetes mellitus (DM) is a chronic disease which has high prevalence among pediatric patients. It is caused by β cells autoimmunity which cause inability to produce insulin. One of the complications of type 1 DM is diabetic nephropathy. Until now, there is no information about prevalence and risk factor of diabetic nephropathy in Indonesia.Methods:We calculated diabetic nephropathy prevalence in Indonesia and analyzed the relation between diabetic nephropathy and type 1 DM therapy, HbA1C concentration, microalbuminuria, type 1 DM duration, age at diagnosis, gender, and diabetic ketoacidosis history. This was a retrospective cross sectional study, consist of 51 subjects. Data was collected from patient’s medical record in Rumah Sakit Cipto Mangunkusumo using consecutive sampling.Results:The prevalence of diabetic nephropathy was 17.6%. Bivariate analysis showed that microalbuminuria has a statistically significant relation with diabetic nephropathy (p=0,008; PR=5,29; IK95%=1,53-18,30) while type 1 DM therapy, HbA1C concentration, type 1 DM duration, age at diagnosis, gender, and diabetic ketoacidosis history didn’t have a statistically significant relation with diabetic nephropathy.Conclusion: The prevalence of diabetic nephropathy was 17.6%. Factor that is associated with diabetic nephropathy was microalbuminuriaSuggestion: Medical records recording and patient monitoring improvement in RSCM is needed. Moreover, further multivariate prognostic research with a larger subjects and improvement in medical record recording is also necessary]"

"Aim: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer.

Methods: a cohort study (February-October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase. The studied variables were clinical characteristics, complete peripheral blood count (CBC) and differential count, levels of HbA1c, ureum, creatinine, lipid profile, fasting blood glucose (FBG), marker of endothelial dysfunction (asymmetric dimethylarginine/ADMA, endothelin-1/ET-1, and flow-mediated dilation/FMD of brachial artery), and marker of vascular calcification (osteoprotegerin/OPG).

Results: median of time achieving 50% granulation tissue in our study was 21 days. There were nine factors that contribute in the development of 50% granulation tissue, i.e. family history of diabetes mellitus (DM), previous history of wound, wound area, duration of existing wound, captopril and simvastatin medications, levels of ADMA, ET-1, and OPG. There were three out of the nine factors that significantly correlated with wound healing, i.e. wound area, OPG levels, and simvastatin medications.

Conclusion: in acute diabetic foot ulcers, wound area and OPG levels had positive correlation with wound healing, whereas simvastatin medications had negative correlation with wound healing."

"ABSTRAKPenelitian ini bertujuan untuk mengetahui hubungan aktivitas fisik, self-care diabetic, dan distress diabetic dengan kualitas hidup diabetisi tipe 2 di Kecamatan Kalideres Jakarta Barat. Penelitian menggunakan metode cross sectional, dengan jumlah sampel 333 diabetisi tipe 2. Teknik pengambilan sample dilakukan secara probability sampling dengan teknik proporsi sampling dan metode random sampling. Sample penelitian ini adalah berusia lebih dari 45 tahun yang mengalami diabetes melitus tipe 2 dan tinggal di tengah masyarakat serta dapat membaca dan menulis dan tidak mengalami amputasi yang mengganggu mobilitas. Analisis bivariat menggunakan uji Anova, Uji pearson corelation, dan Uji t independen. Hasil penelitian menunjukkan ada hubungan aktivitas fisik, self-care diabetic, dan distress diabetic dengan kualitas hidup lansia yang mengalami diabetes melitus tipe 2 di masyarakat p

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ABSTRACTThis study to determine the relationship of physical activity, self care diabetic, and diabetic distress with the quality of life of people with type 2 diabetes in Kalideres Sub district, West Jakarta. The research used cross sectional method, with 333 samples of people with type 2 diabetes. Sampling technique was done by probability sampling with technique of proportion of sampling and random sampling method. The sample of this study is over 45 years old who have type 2 diabetes mellitus and live in the community and can read and write and do not experience amputations that interfere with mobility. Bivariate analysis using Anova test, Pearson correlation test, and independent t test. The results showed that there was an association of physical activity, self care diabetic, and diabetic distress with the quality of life of elderly with type 2 diabetes mellitus in society p "