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"Analisis antara kesejahteraan dengan kesehatan pada negara berkembang menjadi fokus dalam berbagai kebijakan. Kesehatan penduduk yang buruk akibat penyakit kronis dapat menjadi bahaya dan ancaman bagi kestabilan perekonomian suatu negara. Salah satu penyakit kronis penyebab morbiditas dan mortalitas terbesar di dunia adalah hipertensi. Beban atau cost akibat hipertensi tidak hanya merugikan bagi penderita saja namun juga art lainnya yang turut menanggung biaya pengobatan bagi si penderita. Sehingga tujuan penelitian ini adalah melakukan estimasi kerentanan (forward looking) sebagai dampak hipertensi dengan mengunakan metode kerentanan vulnerability expected to poverty (VEP). Studi ini menggunakan data IFLS wave 4 dan 5. Penghitungan VEP diselesaikan dengan menggunakan metode estimasi Feasible Generalized Least Square (FGLS). Hasil penelitian menunjukkan rumah tangga yang terkena hipertensi cenderung memiliki expected consumption yang lebih rendah dibandingkan rumah tangga yang tidak hipertensi dan signifikan memengaruhi peningkatan peluang terjadinya kerentanan rumah tangga.......Analysis among the well beings and the health on the developed countries have become as the main focus on th evarious policies. The poor of the health population due to the chronic diseases appear as the hazard and the threat to the countries stability economy. One of the chronic diseases cause the largest morbidity and mortality in the world namely as hypertension. The burden or the cost happened after hypertension is not only affected to the victims and the others received the impact, as example is to pay the health treatment for the sufferer. Thus the purpose of this study is to estimate vulnerability as the result of hypertension with using the methods of the vulnerability expected to poverty (VEP). This study utilize the data from IFLS waves 4 and 5. The VEP calculation is completed by adding the method of three-step feasible generalized least squares (FGLS). The results have shown that the households in which retrieve the impact of the hypertensions tend to have a lower of expected consumption compared to the other households that have not hypertensions and it is significantly increasing the opportunities for household vulnerability influence."

"Melanoma malignum (MM) kulit merupakan tumor ganas dengan mortalitas tinggi. Karakteristik histopatologik merupakan faktor prediktif prognostik MM kulit, tebal tumor >2 mm dan jumlah mitosis ≥5/mm² berkorelasi dengan angka kesintasan yang lebih buruk. Mutasi pada MM antara lain terjadi pada promoter telomerase reverse transcriptase (TERT), sehingga proliferasi sel menjadi tidak terbatas. Telomerase juga meningkatkan risiko metastasis. Penelitian ini bertujuan untuk mengetahui hubungan karakteristik histopatologik dan imunoekspresi TERT dengan angka kejadian metastasis pada MM kulit. Sampel penelitian adalah 30 kasus MM kulit dengan metastasis dan 30 kasus tanpa metastasis di Departemen Patologi Anatomik FKUI/RSCM, periode Januari 2011 sampai Juli 2023. Dilakukan penilaian karakteristik histopatologik (tebal tumor, indeks mitosis, invasi limfovaskular, invasi perineural) dan pulasan imunohistokimia TERT menggunakan antibodi TERT. Data karakteristik histopatologik dan imunoekspresi TERT dianalisis untuk mengetahui hubungannya dengan angka kejadian metastasis. Karakteristik histopatologik yang berhubungan secara signifikan dengan kejadian metastasis adalah tebal tumor >2 mm (p=0,006) dan indeks mitosis ≥5/mm² (p=0,008). Hasil analisis multivariat mendapatkan hubungan antara imunoekspresi TERT tinggi dengan metastasis yang bermakna secara statistik (p<0,001, aOR=56,1). Kesimpulan penelitian ini adalah imunoekspresi TERT tinggi meningkatkan angka kejadian metastasis pada MM kulit. Terdapat hubungan antara tebal tumor dan indeks mitosis dengan angka kejadian metastasis pada MM kulit.......Cutaneous malignant melanoma (MM) is a malignant tumor with high mortality rate. Histopathological characteristics are prognostic predictive factors of cutaneous MM, tumor thickness >2 mm and mitotic rate ≥5/mm² correlate with worse survival rate. Mutation in MM can occur at telomerase reverse transcriptase (TERT) promoter, which lead to unlimited cell proliferation. Telomerase also increases metastatic risk. This study aims to determine the association between histopathological characteristics and TERT immunoexpression with metastasis in cutaneous MM. The study samples are 30 metastatic and 30 non-metastatic cutaneous MM in Anatomical Pathology Department FKUI/RSCM, from January 2011 to Juli 2023. Histopathological characteristics (tumor thickness, mitotic index, limfovaskular invasion, perineural invasion) were assessed and anti-TERT antibodies were used for immunohistochemistry staining. Histopathological characteristics and TERT immunoexpression data were analyzed to determine their association with metastasis. Histopathological features that correlate significantly with metastasis are tumor thickness >2 mm (p=0,006) and mitotic index ≥5 mitosis/mm² (p=0,008). Multivariate analysis showed significant association between high TERT immunoexpression and metastasis in cutaneous MM (p<0,001, aOR=56,1). This study concludes that high TERT immunoexpression increases metastatic rate in cutaneous MM. Tumor thickness and mitotic index are associated with metastasis in cutaneous MM."

"Transmisi utama penyakit menular seksual adalah perilaku seksual berisiko. Pengetahuan yang adekuat mengenai penyakit menular seksual mampu meminimalisir perilaku seksual berisiko remaja. Penelitian ini bertujuan untuk mengetahui perbedaan tentang pengetahuan penyakit menular seksual di sekolah dengan dan tanpa program Pusat Informasi Konseling-Remaja. Penelitian ini menggunakan desain cross-sectional dengan teknik pemilihan sampel berupa random sampling pada 216 murid. Penelitian ini menggunakan instrumen Sexually Transmitted Diseases Knowledge-Questionnaire. Hasil penelitian menunjukkan terdapat perbedaan signifikan pengetahuan murid tentang penyakit menular seksual di kedua sekolah (p<0.05) dan pengetahuan murid di sekolah dengan Pusat Informasi Konseling-Remaja lebih rendah dbandingkan sekolah tanpa Pusat Informasi Konseling-Remaja. Peningkatan efektifitas pelaksanaan Pusat Informasi Konseling-Remaja secara konsisten perlu dilakukan melalui seminar, konseling dan publikasi media cetak sebagai upaya peningkatan pengetahuan penyakit menular seksual. ......Teens are susceptible on sexually transmitted disease (STD). An adequate knowledge about sexually transmitted disease can decrease sexual risk behavior in adolescent. This study aims to determine difference of knowledge about sexually transmitted diseases among student in Pusat Informasi Konseling-Remaja school and non Pusat Informasi Konseling-Remaja school. This study used cross-sectional design, sampling technique used is random sampling on 216 student in Senior High School. This study used Sexually Transmitted Diseases Knowledge-Questionnaire instrument. The result showed, there was a significant difference of knowledge about sexually transmitted disease of student in both schools (p<0.05) and knowledge of student in Pusat Informasi Konseling-Remaja less than student in non Pusat Informasi Konseling-Remaja school. Increasing of effectiveness Pusat Informasi Konseling-Remaja program is needed by seminars, counseling and media publication as effort of increasing in knowledge about sexually transmitted diseases."

"This book aims to present the first comprehensive synthesis of the context and impact of non-communicable diseases (NCDs) in low- and middle-income countries (LMICs) and to offer insights on successful and sustainable interventions and policies that work for at-risk populations. It includes 12 chapters divided into 3 parts. Part I focuses on the state of the problem and state of knowledge on the epidemiology and burden of the major NCDs. Three chapters review the epidemiology and burden of cardiovascular diseases and diabetes (Chapter 1), cancers (Chapter 2) and neurodegenerative diseases such as dementia and Parkinson's disease (Chapter 4). Two chapters focus on the co-morbid and multi-morbid interactions between the major NCDs and infectious diseases like HIV, tuberculosis and malaria (Chapter 3) and mental health disorders (Chapter 5). Part II focuses on best practices and innovation in research and intervention. Four chapters discuss key issues on this theme including health systems strengthening (Chapter 6), population surveillance (Chapter 7), community-based interventions (Chapter 8) and self-help approaches to NCD care (Chapter 9). Part III focuses on policy development and implementation. Three chapters offer a comprehensive analysis of existing policies relevant to NCD prevention and control. They focus on policies that work, as well as discussing the lessons that can be learned from infectious disease control (Chapter 10), NCD control in high-income countries (Chapter 11) and the current policy issues and activities arising from the 2011 UN High Level Meeting on NCDs and leading to a post-2015 global health agenda (Chapter 12)."

""In the fourteenth century the Old World witnessed a series of profound and abrupt changes in the trajectory of long-established historical trends. Transcontinental networks of exchange fractured and an era of economic contraction and demographic decline dawned from which Latin Christendom would not begin to emerge until its voyages of discovery at the end of the fifteenth century. In a major new study of this 'Great Transition,' Bruce Campbell assesses the contributions of commercial recession, war, climate change, and eruption of the Black Death to a far-reaching reversal of fortunes from which no part of Eurasia was spared. The book synthesises a wealth of new historical, palaeo-ecological and biological evidence, including estimates of national income, reconstructions of past climates, and genetic analysis of DNA extracted from the teeth of plague victims, to provide a fresh account of the creation, collapse and realignment of Western Europe's late medieval commercial economy"-- Provided by publisher"