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"Maraknya penyalahgunaan narkoba di kalangan pelajar dan mahasiswa tentu perlu mendapat perhatian yang serius. Diperlukan sebuah langkah strategis guna mengatasi permasalahan demand ini, salah satunya adalah melalui pendidikan karakter dan pemberian motivasi. Untuk itu, penelitian ini bertujuan untuk melihat pengaruh pendidikan karakter dan motivasi terhadap perubahan perilaku pelajar penyalahguna narkoba. Fokus dalam penelitian ini adalah pelajar SMP Master Kota Depok yang pernah menyalahgunakan narkoba. Penelitian ini menggunakan pendekatan kuantitatif melalui alat ukur berupa 53 item pertanyaan yang tertuang dalam kuesioner, yang dilanjutkan dengan pendekatan kualitatif melalui alat berupa wawancara (mixed-methods explanatory). Sampel yang digunakan dalam penelitian ini berjumlah 34 pelajar menggunakan purposive sampling. Data kuantitatif yang didapat akan diuji dengan uji regresi linear berganda menggunakan aplikasi SPSS 23.0. Data kualitatif yang didapat akan digunakan sebagai pelengkap data kuantitatif. Terdapat dua temuan dalam penelitian ini, dimana temuan pertama didapat bahwa variabel pendidikan karakter dan motivasi memengaruhi variabel perubahan perilaku sebesar 59.7%. Artinya masih ada variabel lain yang juga memengaruhi perubahan perilaku sebesar 40,3%. Melalui pendekatan kualitatif, penulis mencoba menggali variabel lain tersebut dan didapatkan temuan yang kedua bahwa ada variabel dukungan sosial yang juga memengaruhi perubahan perilaku namun belum diketahui seberapa besar variabel dukungan sosial memengaruhi perubahan perilaku.

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The rise of drug abuse among students and students certainly needs serious attention. A strategic step is needed to overcome this demand problem, one of which is through character education and motivation. For this reason, this study aims to see the effect of character education and motivation on changes in behavior of drug abusers. The focus of this research was Depok Middle School students who had abused drugs. This study uses a quantitative approach through measuring instruments in the form of 53 items in the questionnaire, followed by a qualitative approach through mixed-methods explanatory. The sample used in this study amounted to 34 students using purposive sampling. The quantitative data obtained will be tested by multiple linear regression tests using the SPSS 23.0 application. Qualitative data obtained will be used as a complement to quantitative data. There are two findings in this study, where the first finding is that character education and motivation variables influence the behavior change variable by 59.7%. This means that there are still other variables that also affect behavior change by 40.3%. Through a qualitative approach, the author tries to explore other variables and found the second finding that there are social support variables that also influence behavior change but it is not yet known how much the social support variable influences behavior change."

"Pasien dengan gangguan fungsi ginjal rentan mengalami akumulasi obat dalam tubuh yang dapat berisiko toksik sehingga diperlukan penyesuaian dosis obat. Akan tetapi, masih banyak kasus obat yang tidak disesuaikan dosisnya pada pasien PGK di Indonesia. Penelitian ini bertujuan untuk mengevaluasi pengetahuan, sikap, dan praktik apoteker Indonesia terhadap penyesuaian dosis obat pada pasien dengan gangguan fungsi ginjal. Desain observasional-cross sectional dipilih dalam penelitian ini dengan metode pengambilan data melalui survei daring. Kriteria sampel yang digunakan dalam penelitian ini adalah apoteker rumah sakit yang masih aktif bertugas di bagian pelayanan pasien pada periode Januari 2023-Juni 2024. Data yang diperoleh dianalisis secara univariat dan bivariat. Penelitian ini diikuti oleh sebanyak 139 apoteker rumah sakit dari seluruh Indonesia sebagai responden, yang mayoritas berasal dari Pulau Jawa (71,9%). Frekuensi melayani pasien gangguan ginjal merupakan faktor yang mempengaruhi ketiga aspek pengetahuan, sikap, dan praktik. Dapat disimpulkan bahwa apoteker Indonesia telah memiliki pengetahuan, sikap, dan praktik yang baik terkait penyesuaian dosis pada gangguan ginjal dengan jumlah sebanyak 96,4%, 98,6%, 65,1% secara berturut-turut. Perlu ditingkatkan lagi pengetahuan terkait cara menghitung eGFR, obat yang memerlukan penyesuaian dosis, cara memperoleh rekomendasi dosis dari literatur, dan penyesuaian dosis pada pasien dialisis. Praktik yang perlu ditingkatkan adalah pemberian rekomendasi alternatif obat, edukasi obat kepada tenaga kesehatan lain, serta pemantauan terapi disertai pemeriksaan fungsi ginjal pasien. Kendala terbesar yang dihadapi apoteker adalah keterbatasan waktu akibat beban kerja yang tinggi. Responden mengharapkan adanya program praktik apoteker tingkat lanjut serta sistem digital yang dapat mendeteksi kesalahan peresepan.

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Patients with renal function impairment are at risk for drug accumulation, which can be toxic, necessitating dose adjustment. However, in Indonesia, many cases still lack appropriate dose adjustment for chronic kidney disease (CKD) patients. This study aimed to evaluate the knowledge, attitude, and practice of Indonesian pharmacists regarding dose adjustment in patients with renal impairment. An observational cross-sectional design was used, with data collected through an online survey. The sample consisted of hospital pharmacists actively serving in patient care from January 2023 to June 2024. Data were analyzed using univariate and bivariate tests. A total of 139 hospital pharmacists from across Indonesia participated, with the majority from Java (71.9%). Frequency of serving patients with renal impairment influenced all three aspects of knowledge, attitude, and practice. Results showed that pharmacists had good knowledge, attitude, and practice with percentages of 96.4%, 98.6%, and 65.1%, respectively. Knowledge need to be improved regarding how to calculate eGFR, drugs that require dose adjustment, how to obtain dose recommendations from the literature, and dose adjustment for dialysis patients. Practice that required improvement included providing alternative drug recommendations, educating other healthcare professionals, and monitoring therapy with renal function evaluation. The main barrier identified was limited time due to a high workload. Respondents expect advanced pharmacist practice programs and a digital system capable of detecting prescription errors."

"Telah dilakukan penelitian untuk memperoleh distribusi dosis sumber brakiterapi Ir-192 HDR (High Dose Rate) Mikroselektron Klasik dalam medium air dengan Monte Carlo EGSnrc. Parameter dosis dikalkulasi sesuai dengan rekomendasi AAPM TG 43 seperti: kekuatan kerma udara, konstanta laju dosis, fungsi dosis radial, dan fungsi anisotropi. Hasil kalkulasi diperoleh nilai kekuatan kerma udara (Sk/A) sebesar 9,65 x 10-8 U.Bq-1 dengan nilai konstanta laju dosis (Λ) sebesar 1,121 cGy h-1 U-1. Dalam klinis, brakiterapi umumnya menggunakan distribusi dosis dari multi sumber. Distribusi dosis tersebut sangat ditentukan oleh interval antar sumber. Dengan mengambil referensi dosis di titik sumbu utama pada jarak 1,0 cm dari sumber maka distribusi dosis mulai tidak homogen bila interval antar sumber ≥ 1,5 cm terutama untuk r ≤ 1,0 cm.

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This study presents the results of EGSnrc Monte Carlo calculations of the dose distribution of Ir-192 brachytherapy HDR (High-Dose Rate) Microselectron Classic sources in water medium. Parameters of dose were calculated according to AAPM TG 43 recommendations such as air kerma strength, dose rate constant, radial dose function and anisotropy function. The results of calculations obtained air kerma strength (Sk/A) of 9.65 x 10-8 U.Bq-1 with dose rate constant (Λ) of 1.121 cGy.h-1.U-1. In clinical, brachytherapy generally used dose distribution from multi-sources. The dose distribution is mostly determined by the interval between sources. By taking reference dose at the point of the main axis at a distance of 1.0 cm from the source dose distribution started not homogeneous when the interval between sources ≥ 1.5 cm especially for r ≤ 1.0 cm."

"There are unique challenges in the formulation, manufacture, analytical chemistry, and regulatory requirements of low-dose drugs. This book provides an overview of this specialized field and combines formulation, analytical, and regulatory aspects of low-dose development into a single reference book. It describes analytical methodologies like dissolution testing, solid state NMR, Raman microscopy, and LC-MS and presents manufacturing techniques such as granulation, compaction, and compression. Complete with case studies and a discussion of regulatory requirements."

"This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments."