Hasil Pencarian  ::  Simpan CSV :: Kembali

"Inflammatory bowel disease (IBD) adalah penyakit dengan gejala peradangan kronis pada saluran gastrointestinal yang mencakup dua kondisi, Crohn’s disease dan colitis ulserativa. Pengobatan farmakologis lini pertama untuk IBD adalah golongan kortikosteroid. Deksametason yang termasuk dalam kortikosteroid memiliki bioavailabilitas yang relatif buruk dan spesifisitas yang kurang. Untuk mengatasi kelemahan dan mengurangi efek samping sistemik yang dihasilkannya, perlu diformulasikan pengobatan dengan sistem penghantaran tertarget kolon. Penelitian ini memiliki tujuan untuk mendapatkan formulasi beads zink alginat yang mengandung deksametason dan kombinasi deksametason-probiotik, serta memperoleh karakteristik dan profil pelepasannya. Jenis probiotik yang digunakan adalah Lactobacillus acidophilus dan Bifidobacterium longum. Beads dibentuk menggunakan metode gelasi ionik zink alginat yang kemudian disalut dengan Eudragit®L100 atau Eudragit®S100, sehingga didapatkan empat jenis formulasi. Uji pelepasan in vitro dilakukan pada beads tersalut dalam medium HCl pH 1,2 selama 2 jam, medium dapar fosfat pH 7,4 selama 3 jam, dan medium dapar fosfat pH 6,8 selama 3 jam secara kontinyu. Didapatkan persentase profil pelepasan obat berturut-turut sebesar -0.11% (1A), 0.42% (2A), 0.50% (1B), dan 0.50% (2B). Berdasarkan hasil pengujian, beads zink alginat, dengan atau tanpa probiotik, belum optimal sebagai sediaan tertarget kolon karena pelepasan obatnya belum maksimal dalam kondisi pH kolon.

---

Inflammatory bowel disease (IBD) is a disease with symptoms of chronic inflammation of the gastrointestinal tract which includes two conditions, Crohn's disease and ulcerative colitis. The first line pharmacological treatment for IBD is corticosteroids. Dexamethasone, which is a corticosteroid, has relatively poor bioavailability and less specificity. To overcome weakness and reduce the resulting systemic side effects, it is necessary to formulate medication with a colon-targeted delivery system. This research aimed to obtain a zinc alginate beads formulation containing dexamethasone and a combination of dexamethasone-probiotic, and obtain its characteristics along with its release profile. The types of probiotics used are Lactobacillus acidophilus and Bifidobacterium longum. Beads are formed using the ionic gelation method which are then coated with Eudragit®L100 or Eudragit®S100, resulting in four types of formulations. The in vitro release test was carried out on beads coated in HCl medium pH 1.2 for 2 hours, phosphate buffer medium pH 7.4 for 3 hours, and phosphate buffer medium pH 6.8 for 3 hours continuously. The drug release profile percentages were -0.11% (1A), 0.42% (2A), 0.50% (1B), and 0.50% (2B), respectively. Based on the test results, zinc alginate beads, with or without probiotics, are not optimal as colon-targeted preparations because the drug release is not optimal under colonic pH conditions."

"Inflammatory bowel disease (IBD) has begun to emerge in Indonesia. The disease is further classified into two types, ulcerative colitic (UC) and crohn's disease (CD). Diagnosis of IBD is initiated from symptom findings such as diarrhea, abdominal pain, bleeding diarrhea, and weight loss, and supported by physical examination and additional tests. The options for additional examinations of IBD are mainly endoscopy (esophagogastroduodenoscopy, colonoscopy, and also intestinal endoscopy), imaging the techniques and laboratory examinations either from blood or feces. The application of these modalities should be prompted by sufficient clinical suspicion to promote their efficiency as well as prevent underdiagnosis or overdiagnosis. In primary health care settings, patients with IBD are expected to be recognized for therapy or to use appropriate referral system to warrant a proper treatment."

"Penyakit Inflammatory Bowel Disease (IBD) atau radang usus merupakan peradangan pada saluran gastrointestinal, IBD dibagi menjadi dua, yaitu kolitis ulseratif dan penyakit crohn. Gejala yang sering muncul pada IBD yaitu nyeri abdomen. Nyeri abdomen adalah perasaan tidak nyaman subjektif di abdomen yang dapat disebabkan oleh berbagai masalah. Tiga proses berikut dapat menyebabkan nyeri abdomen, seperti ketegangan pada dinding saluran gastrointestinal (GI) akibat kontraksi atau distensi otot, iskemia, dan peradangan pada peritoneum. Salah satu upaya untuk mengatasi nyeri abdomen pada pasien yaitu dengan kompres hangat. Kompres hangat dapat menurunkan tingkat nyeri abdomen pada pasien dengan masalah pencernaan. Kompres hangat dapat melebarkan pembuluh darah, sehingga dapat meningkatkan sirkusai drah ke area yang nyeri, dan dapat merelaksasikan otot. Karya ilmiah ini bertujuan untuk memaparkan hasil praktik keperawatan pada pasien dengan inflammatory Bowel Disease yang mengalami nyeri akut. Hasil implementasi kompres hangat selama 15 menit selama 2 hari efektif mengurangi nyeri abdomen pada pasien IBD, hal ini dibuktikan dengan menurunnya skala nyeri dari skala VAS 4 menjadi VAS 0 pada hari ke-4.

---

Inflammatory Bowel Disease (IBD) or inflammation of the intestine is an inflammation of the gastrointestinal tract, IBD is divided into two, namely ulcerative colitis and Crohn’s disease. Symptoms that often appear in IBD are abdominal pain. Abdominal pain is a subjective feeling of discomfort in the abdomen that can be caused by various problems. The following three processes can cause abdominal pain, such as tension in the walls of the gastrointestinal tract (GI) due to muscle contraction or distension, ischemia, and inflammation of the peritoneum. One effort to overcome abdominal pain in patients is with warm compresses. Warm compresses can reduce the level of abdominal pain in patients with digestive problems. Warm compresses can dilate blood vessels, thereby increasing blood circulation to the painful area, and can relax muscles. This scientific paper aims to describe the results of nursing practice in patients with inflammatory bowel disease who experience acute pain. The results of the implementation of warm compresses for 15 minutes for 2 days effectively reduce abdominal pain in IBD patients, this is evidenced by a decrease in the pain scale from the VAS scale 4 to VAS 0 on the 4th day. "