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"Penelitian ini mencoba meneliti hubungan masing-masing status besi yang terdiri dari hematokrit, hemoglobin, local iron binding capacity, serum iron, feritin dan saturasi transfer in dan faktor-faklor lain yaitu ketekunan, percaya diri, privat les dan menonton televisi dengan prestasi belajar siswa. Prestasi belajar diukur dari nilai rata-rata raport cawu I dan cawu II siswa-siswa kelas I angkatan tahun 1997/1998 SMUK II BPK Pcnabur Jakarta Pusat yang prestasinya bermasalah dan banyak yang kurang dibandingkan dengan Si\IUK lain di Jakarta.Tujuan penelitian adalah mendapat informasi apakah ada hubungan antara status besi dan faktor-faklor lain yang telah disebutkan di atas dengan prestasi belajar siswa. Hal ini akan bermanfaat dalam memberikan bantuann bagi siswa-siswi yang bermasalah dalam prestasi belajarnya dengan mempeibaiki status besi.Desain penelitian adalah cross sectional. Pengambilan sampel sccara acak dari siswa-siswa yang bersedia diamibil darah dan mendapat izin orang lta. Jumlah sanipel 99 orang terdiri dari 38 siswi dan 61 siswa yang berusia antara 15-18 tahun. Analisis menggunakan regresi linear ganda.Hasil penelitian menunjukkan adanya korelasi positif antara kadar Hb dcngan prestasi belajar walaupun tidak bermakna.Kesimpulan:Model terakhir yang didapat dari analisis multivariat adalah : Y - 5,8 + 0.03 Hb - 0,48 sexMemperhatikan model tersebut hemoglobin dapat dipertimbangkan sebagai diagnosa prestasi belajar rendah, dimana setiap kenaikan kadar Hb 1 unit, prestasi belajar hanya bisa ditingkatkan 0 ,03.

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This study tries to examine correlation among iron status respectively a.o. hematocrit, haemoglobin. total iron binding capacity, serum iron, feritin, transferin saturation and the other factors a.o. tenacity. self confidence, lesson privat and television watching with student educational achievement. Educational achievement are measured from mean value report of caw u 1 and cawu II of the first class SMUK II BPK Penabur Jakarta which have the lowest achievement compare with other SMUK BPK Penabur in Jakarta.The aim of the study to get information about the correlation among iron status and other factors which was described above. The result will help the student who have problem of achievement by reparing iron status.Study design is cross-sectional , total sample are 99 people : 38 girls and 61 boys. Range of age between 15 - 18 years old. The sample used simple random sampling from the student who were willing to donate blood for iron status lest. Statistic analysis used multiple linear regression.The result showed that correlation between hemoglobin and educational achievement was positif but not significantConclusion :Multiple regression model is as followedY - 5,8 + 0.03 Hb - 0,48 sexwhich means that haemoglobin could he considered lo be used tool for diagnose educational achievement only 1 unit increased of haemoglobin for an increase of 0,03 unit of achievement."

"Kelainan metabolisme besi dapat terjadi akibat gangguan sintesis heme dan globin. Gangguan sintesis heme dijumpai pada defisiensi besi, anemia penyakit menahun dan anemia sideroblastik. Gangguan sintesis rantai globin dikenal sebagai hemoglobinopati terdiri dari thalassemia dan hemoglobin varian. Defisiensi besi dibedakan menjadi defisiensi besi tahap I, ii, Ilia dan l1ib. Pada defisiensi besi tahap I dan 11 belum dijumpai anemia, sedangkan tahap III a dan b telah dijumpai anemia. Diagnosis kelainan metabolisme besi dilakukan dengan perneriksaan hematologi, status besi tubuh, analisis hemoglobin dan menemukan ringed sideroblast di sum-sum tulang. Pada kasus campuran thalassemia E3 heterozigot dengan anemia defisiensi besi, anaiisis hemoglobin dilakukan setelah perbaikan status besi tubuh untuk mencegah rendah palsu kadar Hb A2 dan F. Besi berperan panting di Susunan Saraf Pusat (SSP) diantaranya untuk mileinisasi saraf, neurotransmiter dan metabolisme katekolamin. Pada penelitian ini dari 150 subyek diperoleh proporsi kelainan metabolisme besi sebesar 94'%. Kelainan metabolisme besi yang diperoleh terdiri dari defisiensi besi tahap I, II, Isla dan IIIb, anemia penyakit menahun, thalassemia 8 heterozigot, kemungkinan thalassemia a 1 atau 2 gen delesi, penyakit Hb H, HPF thalassemia heterozigot ganda serta campuran kelainan tersebut. Kelainan metabolisme besi dibedakan menjadi kelainan metabolisme besi disertai anemia (80.14%) dan tanpa anemia (19.85%). Proporsi hemoglobinopati (39.71%) dan campuran hemoglobinopati dengan defisiensi besi (39%) merupakan kelainan metabolisme besi terbanyak dibandingkan defisiensi besi (19.85%). Pada penelitian ini diperoleh prestasi belajar buruk secara bermakna pada kasus defisiensi besi (p<0.05) dibandingkan dengan kasus bukan defisiensi besi, tErutama pada mata pelajaran matematika dan bahasa Indonesia. Oleh karena proporsi hemoglobinopati yang lebih tinggi dibandingkan defisiensi besi, disarankan untuk diadakan tindak lanjut oleh dinas kesehatan setempat untuk mencegah peningkatan kasus hemoglobinopati homozigot atau heterozigot ganda. Untuk kasus defisiensi besi dilakukan pemeriksaan lanjutan guna mencari penyebab.

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Iron metabolism disorder may caused by defects of heme or globin synthesis. Defect of heme synthesis includes iron deficiency, anemia of chronic disease and siderobistic anemia. Defect of giobin synthesis are called hemoglobinopathies. Hemoglobinopathies may include either thalassemias or hemoglobin variants. Iron deficiency is classified into stage I, stage II, stage ill a and Ilib. Anemia is found in iron deficiency stage llla and 111b_ Diagnosis of iron metabolism disorder were done by hematology examination, iron status, hemoglobin analysis and bone marrow ringed sideroblast. In thalassemia R heterozygote patients with Iron deficiency anemia before hemoglobin analysis, iron status must be corrected to prevent falsey low Hb A2 and F levels. In the central nervous system iron are utilized in myelinisation, neurotransmitter and catecolamine metabolism. In this study on 150 subjects, proportion of iron metabolism disorder was 94%. Iron metabolism disorder were classified into iron deficiency stage I, II, Illa and illb, anemia of chronic disease, thalassemia 13 heterozygote, suspected of thalassemia a 1 or 2 gene deletion and mixed case between iron metabolism disorder. iron metabolism disorder was divided into anemia (80.14%) and non anemia (19.85%). Hemoglobinopathies (39.71%), mixed case between hemoglobinopathies and iron deficiency (39%) comprises biggest proportion compared with iron deficiency (19.85%).This study also found that iron deficiency subjects had significantly worse academic achievement (p<0.05) compared with non iron deficiency subjects especially in math and. bahasa Indonesia. As the proportion of hemoglobinopathies was higher than iron deficiency, we suggest that the district heatlh department to take action to prevent the increase in the prevalence of homozygous or compound heterozygous hemoglobinopathies. For iron deficiency cases, further investigation is needed to find causes of iron deficiency."

"Iron physiology and pathophysiology in humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions.Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. "

"ABSTRAKZat besi dapat mempengaruhi berat badan dan perkembangan bayi. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara kadar zat besi dengan berat badan pada bayi usia 8-10 bulan di Jakarta Pusat. Metode: Studi cross-sectional digunakan pada 75 bayi yang memenuhi kriteria penelitian. Kadar zat besi diukur menggunakan metode LC-MS/MS Liquid Chromatography ndash; Tandem Mass Spectometry , sedangkan berat badan menggunakan penilaian klinis oleh tenaga terlatih dengan timbangan badan elektronik dengan akurasi 10g. Data dianalisis normalitasnya dengan uji Kolmogorov-Smirnov dan korelasinya dengan uji Spearman. Hasil: Hasil menunjukan tidak terdapat korelasi bermakna antara kadar zat besi dan berat badan bayi 8-10 bulan di Jakarta Pusat p=0,483 . Diskusi: Disimpulkan bahwa hubungan antara kadar zat besi dengan berat badan pada bayi usia 8-10 bulan di Jakarta Pusat bernilai positif, namun secara statistik tidak bermakna.

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ABSTRACTIron can affect the body weight of infants and their development. Objective This research is intended to analyze the correlation between level of iron and body weight in infant aged 8 10 months in Central Jakarta. Method A cross sectional study was conducted in 75 infants that fulfills the criteria for this research. The level of iron was measured by using LC MS MS Liquid Chromatography ndash Tandem Mass Spectrometry method, while the body weight was measured by a trained clinician with an electronic scale. The scale has an accuracy of 10 g. Afterwards the data was analyzed for normality by using Kolmogorov Smirnov test and tested for correlation through Spearman test. Result There is no significant correlation between level of iron and body weight of infants aged 8 10 months in Central Jakarta p 0.483 . Discussion In conclusion, there is a positive relationship between the level of iron and body weight in infant aged 8 10 months in Central Jakarta, however there is no significant relationship. "

"This book offers a comprehensive analysis of irons’ various roles in the plant-microbial associations. The introductory chapter stresses the essentiality of iron in biological systems. The second chapter surveys the abundance of information on iron’s pivotal role in microbial plant pathogenesis and defence. Finally, the third chapter reviews the advances in our understanding of iron metabolism in the rhizobia, soil bacteria able to establish a symbiotic association with legumes and carry out nitrogen fixation. "