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Abstrak :
Timbal dapat menimbulkan gangguan kesehatan pada manusia walaupun dalam kadar yang lebih rendah dari kadar maksimum dalam darah yang diperbolehkan. Karena itu, perlu dicari suatu cara yang dapat menurunkan kadar timbal dalam darah, khususnya pada orang dewasa. Kelompok masyarakat yang mempunyai risiko tinggi terhadap keracunan timbal kronis dari udara ambien adalah pekerja yang bekerja di pinggir jalan raya. Penelitian ini bertujuan untuk menganalisis efek suplemen kalsium terhadap kadar timbal dalam darah pada pekerja dewasa. Penelitian ini menggunakan rancangan kuasi eksperimen dengan community trial design dimana subyek penelitian sebanyak 150 orang, terdiri atas 75 orang kelompok kontrol dan 75 orang kelompok perlakuan dengan memberikan suplemen kalsium dengan dosis 3 kali 500 mg per hari selama tiga bulan. Pengukuran kadar timbal dalam darah dilakukan dengan mempergunakan Spectrofotometer oleh petugas Laboratorium Klinik sebelum pemberian kalsium dan tiga bulan sesudahnya. Partisipan yang mengikuti penelitian secara teratur sebanyak 87 orang, terbagi atas kelompok kontrol sebanyak 46 orang dan kelompok perlakuan sebanyak 41 orang. Hasil penelitian menunjukkan bahwa (1) Kadar timbal dalam darah (KTD) awal pada kelompok perlakuan 10,35 μg/dL dan KTD akhir 3,2 μg/dL; (2) pemberian kalsium dengan dosis 3 x 500 mg sehari selama 3 bulan dapat menurunkan KTD secara bermakna. Penelitian ini menemukan bahwa tablet kalsium dapat dipergunakan untuk menurunkan kadar timbal dalam darah pekerja dewasa.

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Lead can cause health disorders in humans, albeit at a lower level than the permitted maximum blood lead level. Therefore, a treatment should be sought that will reduce lead in the blood, especially in adults. Communities who have a high risk for chronic lead poisoning from the ambient air are employees who work on the road. This study aims to analyze the effects of calcium supplementation on blood lead levels in adult workers. This research uses quasi-experimental design with a community trial design for as many as 150 people, the group consisted of 75 control and 75 treated groups which were given calcium supplements at a dose of 500 mg 3 times daily for three months. Measurements of blood lead levels were taken before consuming calcium and three months afterwards by using Spectrofotometer at Clinical Laboratory. Subjects who completed the study on a regular basis totaled 87 people, divided into a control group of 46 people and the treated group of 41 people. The results showed that: (1) the initial blood lead levels in the control group 6.11 μg/dL and 4.16 μg/dL after treatment. Initial blood lead levels in the treated group 10.35 μg/dL and 3.2 8 μg/dL after treatment; (2) calcium treatment with a dose of 3 x 500 mg a day orally for 3 months can reduce blood lead levels significantly. This study found that calcium tablets can be used to reduce blood lead levels in adult workers.

Abstrak :
Latar belakang dan Tujuan Indonesia saat ini masih mcnggunakan bensin bertimbal dengan tingkat pencemaran timbal di udara tinggi. Jakarta Barat merupakso wilayab di DKI Jakarta yang paling padat dilalul kendaraan bermotor. Tujuan penelitian ini adalah diketahuinya hubungan kadar timbal di dalam darah terbadap terjadinya hipertensi pada polisi yang bekerja di jalan dan faktor-faktor lain, seperti obesitas, riwayat keluarga hipertensi, kebiasaan merokok. konsmnsi kopi, perilaku memakai masker dan olahraga dengan terjadinya hipertensi. Metode penelitian Penelitian ini dilakukan di wilayab kerja polsek Jakarta Barat. Populasi penelitian adalah polisi yang bekerja di jalan. Disain penelitian adalah studi Cross Sectional, dengan analisis kasus konlrol, 30 kasus dan 60 konlrol dillrutsertakan ) da1am penelitian ini. Kastt; diperoleh dengan cam consecuiive sampling. Pengumpulan data dilakukan dengan cara wawancara, pengukuran berat badan, pengukuran tinggi badan, pengukuran tekanan darab dan analisis kadar timbal dalam darah. Hasil penelitian Rerata kadar timbal di dalam darah adalab 19.83 , dengan nilai median 18.80. Terdapat hubungan yang signifikan antarn faktor obesitas (OR = 5,1) riwayat keluarga hipcrtensi (OR=l7,68) dan kadar Pb dalam darab (OR=4,5) dengan kejadian hipertensi. Kesimpulan dan Saran Ada pengarah kadar timbal di dalam darah, dengan kejadian hipertensi. Saran yang diajukan adalah melakukan pemeriksaan kadar timbal dalam darah minimal sekali setahun, termasuk melakukan upaya penurunan pajanan timbal, dan menurunkan berat badan polisi yang bekerja di jalan.

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Tile Background and Tbe Objectives Most of the cities in Indonesia are still using head gases which causes high lead level pollution. West Jakarta is one of the .areas that high burden of motor vehicles and is among the worst polluted area in Jakarta city. The aim of this study is to identify the relation of blood lead levels and hypertension among traffic police and other related factors such as obesity ,family history of hypertension, smoking,. consumption of coffee, use of mask as protection and physical exercise. The Research Method This research was carried out in the work territory Sector Police West Jakarta. The research population was traffic police assigned on the road. A cross sectional study design was used with case control analysis. Sixty cases and 30 controls Were recruited for this study Cases were recruited consecutively. Data was'collected by interviews, physical examination and measuring blood lead level. The Conclusion and the Reccomendation A significant relationship was'found between blood lead level and hypertension incident. Police with the blood lead level ?: 18,80 JWdL had a risk almost of 6,5 times higher to get hypertension. It is recommended that blood lead level should be measured at least once a year and reduce police weight that worked in the road.

Abstrak :
Beban penyakit akibat pajanan timbel terus meningkat. Timbel mengganggu hidroksilasi 25(OH)D dan transportasi kalsium sehingga aktivitas osteoklastik dan resorpsi tulang meningkat. Pyridinoline crosslinks (PYD) sebagai indikator kerusakan tulang lebih dini dari pencitraan. Penelitian ini merupakan penelitian sekunder dari penelitian primer yang berjudul Korelasi Kadar Serum 25(OH)D dengan Penanda Biologis Kardiovaskular pada Pekerja Terpajan Timbel. Penelitian berdesain potong lintang ini dilakukan untuk mengetahui hubungan kadar 25(OH)D serum dengan rasio PYD/kreatinin urin pada pekerja terpajan timbel. Penelitian berlokasi di Kabupaten Tegal, Kabupaten Tangerang, Kota Surabaya, dan Kabupaten Bogor. Subjek adalah bagian dari seluruh pekerja terpajan timbel yang terdaftar sebagai responden dalam penelitian primer dan memenuhi kriteria, didapatkan total 104 subjek. Instrumen yang digunakan adalah formulir karakteristik subjek, pemeriksaan fisik, Global Physical Activity Questionnaire, Semi-Quantitative Food Frequency Questionnaire, hasil pemeriksaan fungsi ginjal dan hepar, kadar timbel dalam darah, kadar 25(OH)D serum, dan sampel urin pagi. Median kadar timbel dalam darah 6,3 (1,2-35,5) µg/dL, indeks pajanan timbel kronik 35,3 (1,2-535,8) tahun µg/dL, kadar 25(OH)D serum 22 (8-52) ng/mL, dan rasio PYD/kreatinin urin 5,3 (3,6-28,1).10^-6. Sebagian besar (86,5%) subjek memiliki kadar 25(OH)D serum yang tidak adekuat. Studi menunjukkan terdapat hubungan negatif yang signifikan antara kadar 25(OH)D serum dengan rasio PYD/kreatinin urin pada pekerja terpajan timbel (r = -0,39, p < 0,001), dan terdapat hubungan positif yang signifikan antara indeks pajanan timbel kronik dengan rasio PYD/kreatinin urin (r = 0,21, p = 0,036). ......The burden of disease due to lead exposure continues to increase. Lead interferes with 25(OH)D hydroxylation and calcium transport, increasing osteoclastic activity and bone resorption. Pyridinoline crosslinks (PYD) as an indicator of bone damage that can be seen earlier than imaging. This study is a secondary study of the primary study entitled Correlation of Serum 25(OH)D Levels with Cardiovascular Biological Markers in Workers Exposed to Lead. This cross-sectional study was conducted to determine the correlation between serum 25(OH)D levels and the urinary PYD/creatinine ratio in workers exposed to lead. The study was located in Tegal Regency, Tangerang Regency, Surabaya City, and Bogor Regency. The subjects were part of all lead-exposed workers who were registered as respondents in the primary study and met the criteria, resulting in a total of 104 subjects. The instruments used were subject characteristic form, physical examinations, Global Physical Activity Questionnaire, Semi-Quantitative Food Frequency Questionnaire, kidney and liver function test results, blood lead levels, serum 25(OH)D levels, and morning urine samples. Median blood lead levels were 6.3 (1.2-35.5) µg/dL, chronic lead exposure index 35,3 (1,2-535,8) years µg/dL, serum 25(OH)D levels were 22 (8-52) ng/mL, and urinary PYD/creatinine ratio was 5.3 (3.6-28.1).10^-6. Among the most population (86.5% of subjects) had inadequate serum 25(OH)D  the study showed a significant negative correlation between serum 25(OH)D levels and urinary PYD/creatinine ratio in workers exposed to lead (r = -0.39, p < 0.001). There was also a significant positive correlation between chronic lead exposure index and the urinary PYD/creatinine ratio (r = 0.21, p = 0.036).

Abstrak :
Penggunaan BBM di Indonesia masih didominasi oleh penggunaan bensin bertimbal, sehingga makin besar konsumsi energi BBM dari bensin bertimbal, maka makin tinggi tingkat pencemaran timbal (Pb) di udara ambien. Efek Pb terhadap sistem haemapoietic menyebabkan berkurangnya synthesis haemoglobin dan rnenyebabkan anemia. Di Kota Sukabumi saat ini penggunaan bahan bakar minyak (BBM) masih didominasi oleh penggunaan bensin bertimbal. Salah satu pekerja yang memiliki resiko tinggi terpapar Pb adalah pegawai UPTD Terminal Dinas Perhubungan Kota Sukabumi. Tujuan dari penelitian ini adalah untuk mengetahui Pb di udara ambien dan hubungannya dengan Pb dalam darah serta kejadian anemia pada pegawai UPTD Terminal Dinas Perhubungan Kota Sukabumi Tahun 2007. Desain penelitian yang digunakan adalah cross sectional. Populasi dan sampel adalah pegawai UPTD Terminal, dengan besar sampel sebanyak 44 pegawai yang diambil secara total sampling. Data yang diperoleh selanjutnya diolah secara statistik menggunakan teknik analisis distribusi frekuensi dan uji chi square. Dari hasil penelitian diperoleh bahwa : ada hubungan yang signifikan antara kadar Pb di udara ambien pada lingkungan kerja dengan kadar Pb dalam darah pada pegawai, ada hubungan yang signifikan antara kadar Pb dalam darah dengan kadar Hb darah pada pegawai, dan ada hubungan yang signiiikan antara umur dengan kadar Pb dalam darah pada pegawai UPTD Terminal. Selanjutnya, didapat bahwa tidak ada hubungan yang signifikan antara; kebiasaan merokok, memakai masker, dengan kadar Pb dalam darah pada pegawai UPTD Temainal. Hasil penelitian ini semakin memperjelas betapa pentingnya pengendalian pencemaran udara khususnya pencemaran Pb di udara Upaya penghapusan bensin bertimbal sudah tidak dapat ditunda lagi untuk mencegah dampak kesehatan dan kerugian biaya yang ditanggung oleh masyarakat.

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BBM usage in Indonesia still dominated by lead gasoline, so that consumption of BBM energy from lead gasoline increasing, then lead (Pb) pollution level in ambient air is more and more increasing. Pb effect toward haemopoietic system caused the decreasing of hemoglobin synthesis and causing anemia. At Sukabumi recently, BBM usage still dominated by lead gasoline usage. One of the workers that has high risk of exposed to Pb is Terminal UPTD employee of Sukaburni City Transportation Department. The purpose of the study is to find out the relation between Pb in the ambient air and Pb in blood and anemia cases of transportation department a employees of UPTD terminal at Sukabumi 2007. Research design used is cross sectional. Population and sample are Tenninal UPTD employee, with total samples of 44 employees that gathered by total sampling. Further obtained data processed statistically using analysis technique of frequency distribution and chi square test. From research result, obtained that: there is significant relation between Pb level in ambient air of working environment with Pb level in employees blood, there is significant relation between Pb level in blood and blood Hb in employees, and there is significant relation between age and Pb level in employees blood of Terminal UPTD. Accumulation of Pb level could not define in those employees blood because exposed to Pb in ambient air of work environment Furthermore, obtained that there are no signiiicant relations between smoking behaviors along as well as using mask with Pb level in employees? blood of Terminal UPTD. The result of this research clarifies the importance of controlling air pollution especially from Pb contamination. The effort for elimination of gasoline containing Pb can not be delay to prevent the impact to health and the loss of expense that burden by the people.