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Abstrak :
Tujuan: mengetahui pengaruh pemberian diet rendah kalori seimbang yang dihitung berdasarkan defisit 1000 kkal/hari dari diet dan olahraga erobik yang disesuaikan dengan kemampuan maksimal berolahraga masing-masing individu terhadap berat badan (BB), indeks massa tubuh (MT), tebal lipatan Kulit total (TLK), massa lemak (ML), profil lipid, dan volume oksigen maksimal (VO2max). Tempat : Pusat kebugaran Fit'n Chic, Kelapa Gading. Metodologi : Setelah mendapat persetujuan etik dari Panitia Penilai Etik Penelitian, FKUI diperoleh 26 orang perempuan peserta program penurunan berat badan yang bersedia mengikuti penelitian Penelitian ini merupakan studi eksperimental pre- dan pasca- tes dengan menggunakan subyek yang sama sebagai kontrol dan perlakuan. Masing-masing individu mendapat diet rendah kalori seimbang dan olahraga erobik selama 12 minggu. Diet rendah kalori seimbang diberikan berdasarkan pengurangan pemberian kalori/defisit sebesar 1000 kkal/hari dengan perhitungan diet dikurangi rata-rata antara 600 sampai dengan 800 kkal dan energi yang dikeluarkan selama olahraga erobik yang diprogramakan rata-rata antara 200 sampai dengan 400 kkal. Sebelum diberikan olahraga erobik dilakukan tes Cooper untuk menilai kemampuan maksimal masing-masing individu dalam berolahraga. Olahraga erobik diberikan dengan intensitas 60-80% kemampuan maksimal, frekuensi 5 kali seminggu, lama 60 menit. Diet yang diberikan rata-rata 900 - 1100 kkal/hari. Hasil : Terjadi penurunan berat badan secara bermakna (p < 0,05) dari 73,6 ± 11,17 kg menjadi 64,9 ± 10,08 kg (penurunan 11,81%); Penurunan IMT secara bermakna (p < 0,05) dari 29,62 ± 4,53 menjadi 26,10 ± 4.0 kg/m2 (perubahan 11,88%); Penurunan TLK secara bermakna (p < 0,05) dari 103,31 ± 18,39 mm menjadi 64,53 ± 14,13 mm (perubahan 37,54%); penurunan ML secara bermakna (p < 0,05) dari 35,60 ± 3,07 menjadi 24,96 ± 4,46 % (perubahan sebesar 29,89%); penurunan TG secara bermakna (p < 0,05) dari 126,23 ± 44,82 menjadi 109,89 ± 32,89 mg/dL (perubahan 12,94%); penurunan KT secara bermakna (p < 0,05) dart 206,15 ± 22,93 menjadi 182,12 ± 14,09 mg/dL (perubahan 11,66%); penurunan LDL secara bermakna (p < 0,05) dart 130,77 ± 25,11 menjadi 109,27 ± 17,83 mg/dL (perubahan sebesar 16,44%). Terjadi peningkatan VO2max secara bermakna (p < 0,05) dari 27,87 ± 2,75 menjadi 33,70 ± 2,75 ml/kg BB/min (perubahan 20,92%). Terjadi sedikit peningkatan HDL sebesar 0,62 mg/dL (1,24%) yang secara statistik tidak bermakna. Kesimpulan: Dengan diet rendah kalori seimbang dan olahraga erobik dengan dosis yang disesuaikan kemampuan masing-masing individu sangat efektif untuk menurunkan berat badan, IMT, tebal lemak bawah kulit, persentase massa lemak, memperbaiki profil lipid, dan meningkatkan VO2maks.

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Objective: To determine the effects of balanced LCD and endurance exercise with appropriate individual maximal capacity on body weight, body mass index (BM), total skin fold (TSF), percent body fat (BF), lipid profiles, and V02 max Location: Fit'n Chic fitness centre, Kelapa Gading. Methods: Twenty six overweight women were studied in a pre and post test, using control group as the same subjects as the treatment group. Subjects received a balanced LCD and endurance exercise for 12 weeks. Balanced LCD was given based on energy deficit 1000 kkal/day from diet and exercise. Deficit from diet was 600 to 800 kkal. The calorie from the diet was given within 900 - 1100 kkal/day and energy expenditure from endurance exercise was 200 to 400 kkal. All subject bad to undergo Cooper test for designing the intensity of the endurance program. Endurance exercise 60 - 80% V02max for 60 minutes, 5 days a week. The procedures followed were in accordance with the ethical Committee of the Department of Medicine, University of Indonesia. Results: Balanced LCD and endurance exercise, decreased body weight 8,7 kg (11,81%) (p< 0,05) from 73,6 ± 11,17 to 64,9 t 10,08 kg BM1 decreased 11,88% (p < 0,05) from 29,62 t 4,53 to 26,10 ±4.0 kglm2), TSF decreased 37,54% (p < 0,05) from 103,31 t 18,39 to 64,53 ± 14,13 mm , percent BF decreased 29,89% (p < 0,05) from 35,60 t 3,07 to 24,96 ± 4,46 % , TG decreased 12,94% (p < 0,05) from 126,23 t 44,82 to 109,89 t 32,89 mg/dL, total cholesterol decreased 11,66% (p < 0,05) from 206,15 ± 22,93 to 182,12 ± 14,09 mg/dL, LDL decreased 16,44% (p < 0,05) from 130,77 ±25,11 to 109,27 ± 17,83 mg/dL, VO2max increased significantly (p < 0,05) before 27,87 ± 2,75 , after 33,70 t 2,75 ml/kg BW/min (changed 20,92%). IIDL increased not significantly (p > 0,05) from 32 ± 14 to 37 ± 16 mg/dL. The balanced LCD and endurance exercise with exact dose appropriate to individual performance resulted in significant weight loss, reduced BMI, TSF, percent BF, and improved lipid profiles and VO2max.

Abstrak :
Uji klinis acak tersamar ganda paralel ini merupakan penelitian pendahuluan, bertujuan mengetahui pengaruh suplementasi serat larut dan diet rendah kalori seimbang (DRKS) selama 4 minggu terhadap kadar kolesterol low-density lipoprotein (LDL) serum pada obes I usia 30−50 tahun. Sejumlah 31 subyek dipilih dengan kriteria tertentu dan dibagi menjadi dua kelompok dengan randomisasi blok, 15 orang kelompok perlakuan (KP) dan 16 orang kelompok kontrol (KK). Subyek KP mendapat serat larut psyllium husk (PH) 8,4 g/hari dan DRKS 1200 kkal/hari, sedangkan subyek KK mendapat plasebo dan DRKS 1200 kkal/hari. Data terdiri atas usia, indeks massa tubuh (IMT), asupan zat gizi, serta kadar kolesterol LDL serum. Pemeriksaan kolesterol LDL dilakukan pada awal dan akhir penelitian. Analisis data menggunakan uji t tidak berpasangan dan Mann-Whitney, batas kemaknaan 5%. Karakteristik data dasar dan sebaran subyek kedua kelompok sebanding. Analisis lengkap dilakukan pada 28 subyek (KP dan KK masing-masing 14 subyek). Suplementasi ditoleransi baik dan tidak ditemukan efek samping serius. Median usia subyek KP dan KK berturut-turut 35,0 (30−45) tahun dan 34,50 (30−48) tahun serta rerata IMT 28,0 ± 1,1 kg/m2 dan 27,2 ± 1,4 kg/m2. Rerata kadar kolesterol LDL serum awal KP 137,0 ± 37,0 mg/dL dan KK 134,4 ± 29,1 mg/dL. Defisit energi KP lebih rendah tidak signifikan (p = 0,62) dibandingkan KK, berturut-turut -282,0 ± 482,6 kkal/hari dan -331,8 ± 578,3 kkal/hari. Persentase asupan energi terhadap anjuran KP (94,2 ± 18,5%) lebih tinggi signifikan (p = 0,02) daripada KK (85,4 ± 22,9%). Asupan karbohidrat (KH) total KP (613,1 ± 134,5 kkal/hari) lebih tinggi signifikan (p = 0,02) dibandingkan KK (545,4 ± 161,1 kkal/hari). Asupan protein, lemak total, dan kolesterol KP dan KK sesuai rekomendasi NCEP-ATP III. Pada kedua kelompok, asupan asam lemak jenuh cenderung tinggi, tetapi asupan asam lemak tak jenuh tunggal dan jamak rendah. Asupan serat subyek KP 17,2 ± 2,8 g/hari dan KK 8,6 (5,2−15,2) g/hari. Dengan suplementasi PH tidak tercapai rekomendasi asupan serat. Persentase asupan KH sederhana terhadap energi total KP 11,5±5,4% lebih tinggi signifikan (p = 0,00) dibandingkan KK 6,0 (1,2524,2)%. Penurunan kadar kolesterol LDL serum KP -2,1 ± 16,2 mg/dL lebih sedikit tidak signifikan (p = 0,15) dibandingkan pada KK -10,9 ± 15,3 mg/dL. Penelitian ini belum dapat membuktikan suplementasi PH 8,4 g/hari dan DRKS 1200 kkal/hari selama 4 minggu lebih baik dalam menurunkan kadar kolesterol LDL serum dibandingkan plasebo pada subyek obes I. ...... This parallel double blind randomized clinical trial is a preliminary study that aims to investigate the effect of soluble fiber supplementation 8.4 g/day and lowcalorie balanced diet (LCBD) for 4 weeks on serum low-density lipoprotein (LDL) cholesterol level in obese I, aged 30−50 years old. A total of 31 subjects were selected using certain criteria and randomly allocated to one of two groups using block randomization; 15 subjects for treatment (T) group and 16 subjects for control (C) group, respectively. The T group received psyllium husk (PH) 8.4 g/day and LCBD 1200 kcal/day, and the C group received placebo and LCBD 1200 kcal/day. Data include age, body mass index (BMI), intake of energy, macronutrient, and fiber, as well as serum LDL cholesterol level. Serum LDL cholesterol level was examined before and after treatment. Statistical analyses include independent t-test and Mann-Whitney with significance level of 5%. Subjects characteristics of the two groups at baseline was not statistically different. Twenty eight subjects (14 subjects in each group) completed the intervention. Supplementation was well tolerated and there were no serious adverse events. The mean age in T and C group was 35.0 (30.0−45.0) and 34.5 (30.0−48.0) years, respectively, and BMI was 28.0 ± 1.1 and 27.2 ± 1.4 kg/m2, respectively. The pretreatment serum LDL cholesterol level in T and C group was 137.0 ± 37.0 and 134.4 ± 29.1 mg/dL, respectively. Energy deficit in T group was insignificantly lower (p = 0.62) than in C group; -282.0 ± 482.6 and -331.8 ± 578.3 kcal/day, respectively. Percentage of energy intake to recommendation in T group (94.2 ± 18.5%) was significantly higher (p = 0.02) than that in C group (85.4 ± 22.9%). Total carbohydrate (CHO) intake in T group (613.1 ± 134.5 kcal/day) was significantly higher (p = 0.02) than in C group (545.4 ± 161.1 kcal/day). Total protein, fat, and cholesterol intake were similar to the NCEP-ATP III recommendation in both groups. Intake of SAFA was higher than recommended, meanwhile PUFA and MUFA intake were lower than those recommended in both groups. Dietary fiber intake in T and C group was 17.2 ± 2.8 and 8.6 (5.2−15.2) g/day, respectively. During the intervention, PH supplementation did not meet the recommendation. Percentage of simple CHO to total energy in T group 11.5±5.4% was significantly higher (p = 0.00) than in C group 6.0 (1.2524.2)%. PH supplementation decreased serum LDL cholesterol level (-2.1 ± 16.2 mg/dL) lower than placebo (-10.9 ± 15.3 mg/dL), but not significant different (p = 0.15). This study shows that PH supplementation 8.4 g/day in combination with LCBD 1200 kcal/day for 4 weeks in obese I aged 30−50 years old is not proven to decrease the serum LDL cholesterol level.

Abstrak :
ABSTRAK
Penelitian dengan rancangan uji klinis paralel acak tersamar ganda ini bertujuan mengetahui perubahan kadar apo B pada penyandang obes I setelah suplementasi serat psyllium husk (PH) 8,4 g/hari dan diet rendah kalori seimbang (DRKS) 1200 kkal/hari selama 4 minggu. Berdasarkan kriteria penelitian, didapat 31 orang subyek yang dibagi menjadi dua kelompok, 15 orang kelompok perlakuan (KP) dan 16 orang kelompok kontrol (KK). Subyek KP mendapat PH 8.4 g/hari dan DRKS, sedangkan KK mendapat plasebo dan DRKS. Data yang diperoleh meliputi sebaran dan karakteristik subyek, asupan energi, makronutrien, serat, dan air, serta kadar apo B awal dan akhir penelitian. Analisis data menggunakan uji t tak berpasangan dan Mann-Whitney, batas kemaknaan 5%. Sejumlah 28 subyek dapat mengikuti penelitian hingga selesai (KP dan KK masing-masing 14). Tidak dilaporkan efek samping berbahaya selama perlakuan. Sebagian besar subyek perempuan, median usia subyek KP dan KK berturut-turut 35,0 (30−45) tahun dan 34,50 (30−48) tahun, IMT 28,0 ± 1,1 kg/m2 dan 27,2 ± 1,4 kg/m2. Jumlah asupan energi total subyek KP 1130,9 ± 221,9 kkal/hari lebih tinggi signifikan (p = 0,02) daripada KK 1024,3 ± 269,9 kkal/hari. Karbohidrat sederhana pada KP (35,6 (8,3−69,9)) g/hari lebih tinggi signifikan dibandingkan KK (13,8 (3,4−55,5)) g/hari. Asupan serat subyek belum mencukupi anjuran (20–35 g/hari), yaitu KP 17,2 ± 2,8 g/hari dan KK 8,6 (5,2−15,2) g/hari walaupun dengan suplementasi PH. Asupan protein, lemak total, dan kolesterol dalam rentang yang dianjurkan, tetapi tidak pada asupan asam lemak tak jenuh tunggal dan jamak. Penurunan kadar apo B pada KK (-6,1 ± 8,9 mg/dL) lebih besar tidak signifikan (p = 0,13) dibandingkan pada KP (-1,3 ± 7,3 mg/dL). Dari penelitian ini disimpulkan suplementasi PH 8,4 g/hari dan DRKS 1200 kkal/hari selama 4 minggu tidak lebih baik dalam menurunkan kadar apo B dibandingkan plasebo dan DRKS 1200 kkal/hari penyandang obes I.

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ABSTRACT
This double blind randomized clinical trial aims to investigate the change of apo B level in obese I after given supplementation psyllium husk (PH) 8.4 g/day and low-calorie balanced diet (LCBD) for 4-weeks. By study criteria, 31 subjects were randomly allocated to one of two groups; 15 subjects for treatment (T) group and 16 subjects for plasebo (P) group. The T subjects received psyllium husk (PH) 8.4 g/day and LCBD 1200 kcal/day and the P subjects received placebo and LCBD 1200 kcal/day. Data collected in this study consist of subject distribution and characteristic, intake of energy, macronutrient, fiber, water and apo B level that assessed before and after treatment. Level of statistical analyses significance was 5%, independent t-test and Mann-Whitney. A total 28 subjects (14 subjects in each group) had completed the intervention. There were no serious adverse events were reported along the intervention. Mean of age in T and P groups respectively was 35.0 (30.0−45.0) years and 34.5 (30.0−48.0) years, and BMI was 28.0 ± 1.1 kg/m2 and 27.2 ± 1.4 kg/m2. The energy intake in T group 1130.9 ± 221.9 kcal/day was significantly higher (p = 0.02) than P group 1024.3 ± 269.9 kcal/day. Simple carbohydrate intake in T group (35.6 (8.3−69.9) g/day) was significantly higher (p <0.000) than in P group (13.8 (3.4−55.5) g/day). Intake of dietary fiber in T group was 17.2 ± 2.8 g/day had significantly higher than P group 8.6 (5.2−15.2) g/day, even adding PH supplementation cannot meet the recommendation of fiber intake (20-35 g/day). Intake protein and fat in both groups was meet recommendation, differ for intake of mono and polyunsaturated fatty acids. Decreasing of apo B level in P group was -6.1 ± 8.9 mg/dL that statistically insignificant difference (p = 0.13) with T group -1.3 ± 7.3 mg/dL. As a conclusion in this study shows, that PH supplementation 8.4 g/day and LCBD 1200 kcal/day in obese I for 4 weeks wasn’t proven to decrease the apo B level.

Abstrak :
Obesitas merupakan masalah yang umum terjadi di dunia. Sebanyak 12,8 persen penduduk berusia 18 tahun ke atas di Indoensia menyandang berat badan berlebih. Dari angka tersebut, 20,7 persen penyandang obesitas. Obesitas dapat meningkatkan risiko penyakit kronis seperti penyakit hipertensi, kardiovaskular, dan penyakit tidak menular lainnya. Untuk mengatasi obesitas, dilakukan penurunan berat badan dengan berbagai cara. Namun, penurunan berat badan pada penyandang obesitas sering naik kembali dan tidak bisa dipertahankan pada hasil penurunan tersebut. Hal ini disebut sebagai weight cycling. Pada keadaan weight cycling, massa lemak lebih rendah dari massa bebas lemak yang ada di dalam tubuh. Hal ini meningkatkan risiko penyakit kardiovaskular dan diabetes mellitus tipe 2. Untuk mengatasi weight cycling, dianjurkan diet yang teratur. Diet kalori rendah protein tinggi sering dianggap dapat menurunkan berat badan dengan hasil yang memuaskan. Pada subjek obesitas, terjadi hipoksia pada jaringan lemak. Keadaan ini meningkatkan kemungkinan terjadinya stres oksidatif. Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan aktivitas antioksidan SOD total plasma yang diukur pada subjek penyandang obesitas dengan weight cycling pada kelompok yang diberi edukasi diet kalori rendah protein tinggi dengan diet kalori rendah protein standar. Metode: Subjek adalah karyawan Pusat Pelayanan Kesehatan di Balai Kota DKI Jakarta yang berumur 20-50 tahun penyandang obesitas dengan weight cycling. Subjek dibagi menjadi kelompok kontrol yang mendapatkan edukasi diet kalori rendah protein standar dan kelompok perlakuan yang mendapatkan edukasi diet kalori rendah protein tinggi. Aktivitas SOD diukur setelah subjek mendapat perlakuan selama 8 minggu. Hasil: Hasil penelitian menunjukkan tidak terdapat perbedaan aktivitas SOD total plasma yang bermakna antara kelompok subjek yang diedukasi diet kalori rendah protein tinggi dengan diet kalori rendah protein standar. Kesimpulan: pemberian edukasi diet protein tinggi dan standar tidak mempengaruhi aktivitas SOD total plasma pada subjek obesitas dengan weight cycling. ...... Obesity is a common problem around the globe. In Indonesia, 12.8 percent of above 18 years old population has excess body weight. From the mentioned number, 20.7 percent counts as obesity. Obesity can increase the risk of chronic diseases such as hypertension, cardiovascular, and other non-communicable diseases. To treat obesity, several ways have been done to lose body weight. However, weight loss in obesity is difficult to retain and often comes back to the starting point. This fluctuation on body weight is called weight cycling. In weight cycling, lipid mass level is lower than free lipid mass level, which can lead to increased risk of cardiovascular disease and type 2 diabetes mellitus. Well-managed diet has been prescribed to treat weight cycling, in which low calorie high protein diet is often recommended for best result. In obesity, oxidative stress occurred in the fat tissue because of hypoxia. This study aims to observe the difference in total plasma SOD activity between the subject groups with low calorie high protein diet and low calorie standard protein diet. Methods : Subjects are 20-50 years old workers at Pusat Pelayanan Kesehatan in Balai Kota DKI Jakarta and are obese with weight cycling. Subjects are divided into the control group, which receives low calorie standard protein diet education, and the treatment group, which reveives low calorie high protein diet education. Results : The result showed no significant difference in total plasma SOD activity between the low calorie high protein diet group and low calorie standard protein group. Interpretation & conclusion : high protein and standard protein diet educations do not impact total plasma SOD activity in obese subjects with weight cycling.

Abstrak :
Perilaku fad diets (FD) berdampak pada berbagai risiko kesehatan, seperti gangguan metabolisme, meningkatnya risiko anemia, meningkatnya risiko paparan infeksi, dan mempengaruhi kinerja kognitif. Lebih lanjut, dapat menurunkan performa dan prestasi belajar di sekolah dan mempengaruhi gangguan perilaku makan sehingga meningkatkan risiko perilaku makan menyimpang. Beberapa penelitian terdahulu di Indonesia menunjukkan angka remaja putri di Indonesia yang berisiko terlibat dalam perilaku FD termasuk tinggi, namun jumlah penelitian yang mengkaji faktor-faktor yang berkaitan dengan perilaku tersebut masih jarang. Tujuan utama dari penelitian ini adalah mengetahui faktor-faktor yang berhubungan terhadap perilaku FD pada siswa-siswi SMAS Bunda Mulia Jakarta tahun 2019. Desain penelitian yang digunakan adalah cross sectional melibatkan sebanyak 212 siswa-siswi kelas X dan XI SMA. Data diambil dengan melakukan proses pengukuran tinggi badan dan berat badan serta pengisian kuesioner online. Data diolah secara univariat dan bivariat (chi square). Prevalensi perilaku FD sebesar 43,9%. Faktor yang berhubungan dengan perilaku FD adalah jenis kelamin, status gizi, distorsi citra tubuh, dorongan keluarga, dorongan teman, dan pengaruh media sosial. Siswa perempuan, yang berstatus gizi gemuk, dan mengalami distorsi citra tubuh berisiko masing-masing 1,9 kali; 4,8 kali; dan 2,5 kali lebih besar untuk melakukan perilaku FD. Siswa yang mendapat dorongan dari keluarga, dorongan teman, dan pengaruh media sosial berisiko masing-masing 2,6 kali; 2,2 kali; dan 3,2 kali untuk menerapkan FD. Perlu dilakukan upaya edukasi perilaku makan yang tepat dan sehat untuk siswa serta promosi PGS di sekolah dan media sosial. ......Fad diets lead to various health risks, such as the increased risk of metabolic disorders, increased risk of anemia, increased risk of exposure to infection, and affect cognitive performance which in turn can reduce performance and learning achievement in school. The further impact that can also arise from FD is that it can aggravate eating disorders which increases the risk of eating disorder. Data regarding eating behavior on a national basis in Indonesia is still not available. Several studies conducted in several regions in Indonesia show the high number of young women in Indonesia who are involved and who are at risk of being involved in FD behavior, however, the number of studies that examine the factors associated with these behaviors is still limited. The main objective of this study was to find out the factors related to FD on students at Bunda Mulia Jakarta Senior High School in 2019. The research design used was cross sectional. The number of respondents involved was 212 students of grade X and XI in high school. The data was taken by measuring body height and weight as well as filling in the online questionnaire. The collected data will be processed in univariate and bivariate (chi square). FD prevalence in Bunda Mulia Jakarta Senior High School in 2019 is 43.9%. Factors related to FD behavior are gender, nutritional status, body image distortion, family’s encouragement, friend's encouragement, and social media influence. Female students, who are overweight or obese, with body image distortion are 1.9 times; 4.8 times; and 2.5 times more likely to carry out FD behavior. Students who are encouraged by families, friends, and social media are 2.6 times; 2.2 times; and 3.2 times at risk to FD. Efforts to educate appropriate and healthy eating behaviors as well as promotion of PGS in schools and through social media are needed.