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"Industri farmasi adalah induslri yang berbasis pada regulasi, semakin berkembangnya teknologi teknik pengobatan dan proses manufaktur rnenuntut adanya perbaikan standar regulasi yang harus dipenuhi oleh setiap industri farmasi, karena setiap negara memiliki standard acuan yang berbeda-beda maka pengenalan standard intemasional sangat dibutuhkan. Sistem HVAC merupakan prasarana yang sangat vital dalam proses pembuatan obat dirnana dibuluhkan bukan hanya sebagai sarana kenyamanan operator melainkan juga sebagai sarana untuk menghindari kontarninasi produk serta sebagai sarana pengaman operator selama proses produksi. Perancangan layout dan jenis sistem distribusi udara pada sistem HVAC perlu diperhitungkan secara matang agar didapat kondisi udara ruangan yang diinginkan tampa harus mengeluarkan beaya yang terlalu besar serta meminimalkan beaya operasional. Setiap jenis peralatan, material dan desain memiliki kelebihan aan kekurangan masing-rnasing, maka pemilihannya harus disesuaikan dengan kondisi kebutuhan. Penentuan sistem kontrol temperatur dan kelembaban Serta perhitungan beban pendinginan didasarkan pada estimasi kondisi aktual selama proses produksi sehingga tidak terjadi over desain tanpa harus mengorbankan pemenuhan spesiiikasi yang diinginkan. Setian perancangan pasti akan ada penyimpangan, analisa dari setiap penyimpangan tersebut perlu dianalisa secara mendalam sehingga pada perancangan berikutnya dapat diminimalkan penyimpangannya. Agar dapat memberikan jaminan kualitas/performa sistem yang dirancang perlu dilakukan kualilikasi baik tcrhadap instalasi maupun operasionalnya."

"[ABSTRAKAngka kecelakaan kerja di Indonesia masih menempati urutan tertinggi untuk wilayah Asia Tenggara. Berdasarkan data kasus kecelakaan yang ditangani di IGD Rumah sakit Dr.Cipto Mangunkusmo pada bulan Juli sampai September 2012 terdapat 12,6 % kasus kecelakaan kerja. Penelitian bertujuan untuk mengetahui faktor risiko kecacatan antomi pada kecelakaan kerja yang ditangani di RSUPN dr.Cipto mangunkusumo. Desain penelitian ini adalah potong lintang komparatif dengan sampel penelitian pasien kecelakaan kerja yang ditangani di IGD RSUPN Dr.Cipto Mangunkusumo. Sebanyak 173 sampel dari rekam medis yang memenuhi kriteria. Didapatkan 57,2% pasien kecelakaam kerja mengalami kecacatan anatomi. faktor risiko usia, jenis kelamin, pendidikan, status pernikahan, jenis kecelakaan, kecepatan transportasi tidak memiliki hubungan bermakna secara statistik. Faktor determinan kecacatan anatomi pada kecelakaan kerja adalah tidak mendapat tindakan P3K segera (p= 0,04; RRsuaian = 1,57; CI 95% : 1,01 - 2,44) setelah dilakukan adjusment terhadap jenis kelamin, pekerjaan dan status pernikahan.

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ABSTRACTOccupational accident in indonesia is highest in Southeast Asia. Based on data that were menage in RSUPN Dr.Cipto Mangunkusomo there is 12,6% occupational accidents. This study aims to determine risk factors of anatomical impairment in occupational accident cases that were managed in RSUPN Dr.Cipto Mangunkusomo. The study design is a cross-sectional comparative which includes patients who underwent medical care in the emergency room RSUPN Dr.Cipto Mangunkusomo due to occupational accidents. A total of 173 samples of medical records meet the criteria. This study found 57.2% of occupational accident have anatomical impairment. Risk factors of age, gender, educational level, marital status, types of accident and speed of transport used at the time of incidence apparently does not have a statistically significant relationship. Determinant factors for anatomical impairment in occupational accidents are first aid performed (p = 0.04; adjusted RR = 1.57; 95% CI: 1.01-2.44) after adjustment for gender, occupation dan marital status.;Occupational accident in indonesia is highest in Southeast Asia. Based on data that were menage in RSUPN Dr.Cipto Mangunkusomo there is 12,6% occupational accidents. This study aims to determine risk factors of anatomical impairment in occupational accident cases that were managed in RSUPN Dr.Cipto Mangunkusomo. The study design is a cross-sectional comparative which includes patients who underwent medical care in the emergency room RSUPN Dr.Cipto Mangunkusomo due to occupational accidents. A total of 173 samples of medical records meet the criteria. This study found 57.2% of occupational accident have anatomical impairment. Risk factors of age, gender, educational level, marital status, types of accident and speed of transport used at the time of incidence apparently does not have a statistically significant relationship. Determinant factors for anatomical impairment in occupational accidents are first aid performed (p = 0.04; adjusted RR = 1.57; 95% CI: 1.01-2.44) after adjustment for gender, occupation dan marital status., Occupational accident in indonesia is highest in Southeast Asia. Based on data that were menage in RSUPN Dr.Cipto Mangunkusomo there is 12,6% occupational accidents. This study aims to determine risk factors of anatomical impairment in occupational accident cases that were managed in RSUPN Dr.Cipto Mangunkusomo. The study design is a cross-sectional comparative which includes patients who underwent medical care in the emergency room RSUPN Dr.Cipto Mangunkusomo due to occupational accidents. A total of 173 samples of medical records meet the criteria. This study found 57.2% of occupational accident have anatomical impairment. Risk factors of age, gender, educational level, marital status, types of accident and speed of transport used at the time of incidence apparently does not have a statistically significant relationship. Determinant factors for anatomical impairment in occupational accidents are first aid performed (p = 0.04; adjusted RR = 1.57; 95% CI: 1.01-2.44) after adjustment for gender, occupation dan marital status.]"

"[ABSTRAKLatar Belakang: Pasca mengalami cacat anatomi akibat kecelakaan kerja, waktu yang dibutuhkan pekerja untuk kembali bekerja bervariasi, dengan berbagai faktor risiko yang berperan terhadap waktu kembali bekerja. Penelitian ini bertujuan membandingkan waktu kembali bekerja antara pekerja sektor ekonomi formal dengan informal dan faktor lainnya.Metodologi: Penelitian retrospektif, dengan sampel pekerja yang mengalami cacat anatomi akibat kecelakaan kerja yang ditangani di Rumah Sakit Dr. Cipto Mangunkusumo, periode 1 Januari 2013 - 31 Desember 2014. Klasifikasi kecelakaan, tindakan medis, penyakit penyerta serta pembiayaan diperoleh melalui rekam medik. Sosiodemografi, sektor pekerjaan, masa kerja, waktu kembali bekerja diperoleh dari kuesioner. Analisa korelasi dilakukan untuk melihat hubungan usia, masa kerja dengan waktu kembali bekerja. Pada faktor risiko juga dilakukan analisa bivariat menggunakan uji-t tidak berpasangan dan ANOVA. Faktor risiko yang memiliki (p<0,25) dilakukan analisa multivariat dengan regresi berganda.Hasil : Diperoleh 61 subyek, mayoritas pria (95,1%), berpendidikan dasar-menengah (85,2%), tidak mendapat jaminan pembiayaan (57,4%), cacat anatomi pada ekstremitas atas (85,2%), melakukan kontrol luka (88,5%), mendapat tindakan bedah amputasi tertutup (91,8%), tanpa penyakit penyerta (88,5%). Sebanyak 33 (54,1%) subyek adalah pekerja sektor ekonomi formal. Waktu kembali bekerja pada pekerja sektor ekonomi formal lebih cepat dibandingkan dengan pekerja sektor ekonomi informal dengan rata-rata perbedaan waktu 9 hari (p<0,01). Tindakan bedah amputasi tertutup mengurangi waktu kembali bekerja selama rata-rata 11 hari (p<0,01).Kesimpulan: Sektor ekonomi adalah determinan utama waktu kembali bekerja. Pekerja sektor formal mempunyai rerata waktu kembali bekerja lebih cepat dibandingkan dengan pekerja informal, kemungkinan berkaitan dengan sosio-ekonomi dan akses pelayanan kesehatan yang memadai pada pekerja sektor formal. Tindakan bedah amputasi tertutup mengurangi waktu kembali bekerja secara signifkan.

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ABSTRACTIntroduction: Return to work time for workers with anatomical impairment due to occupational accident is varied as there are many risk factors associated with it. This study aimed to compare the mean differences return to work time between formal and informal workers and other factors.Methods: This study was a retrospective study, using sample of workers with anatomical impairment due to occupational accident who received medical care at the Cipto Mangunkusumo hospital, during the period of 1st January 2013 - 31st December 2014. Accident classification, medical procedure, healhtcare coverage, other accompanying health conditions were obtained from the medical records. Sosiodemography, working sector, working period, return to work time were obtained through a questionnaire. Correlation analysis was performed to observe the relationship between age, working period with the return to work time. Bivariate analysis was also performed by using unpaired t-test and ANOVA. Multivariate analysis using multiple regression was then performed in risk factors known to have (p < 0,25).Results : Sixty-one subjects were obtained consisted of male (95.1%), with basic and intermediate educational level (85.2%), did not possesed healthcare coverage (57,4%), had upper extremities anatomical impairment (85.2%), received wound control care (88.5%), underwent closed amputation procedure (91.8%), and did not have other accompanying health conditions (88.5%). Thirty-three (54.1%) subjects were categorized in a formal working group. Formal workers had a significantly shorter mean return to work time compared to informal workers with mean differences of 9 days (p< 0,01). Closed amputation procedure reduced 11 days of return to work time (p< 0,01).Conclusion: Working sector was the main determinant for the return to work time. The formal workers had a significantly shorter return to work time compared to the informal workers, which might be associated with better socioeconomical status and access of healthcare. In addition, closed amputation procedure significantly reduced the return to work time., Introduction: Return to work time for workers with anatomical impairment dueto occupational accident is varied as there are many risk factors associated withit. This study aimed to compare the mean differences return to work timebetween formal and informal workers and other factors.Methods: This study was a retrospective study, using sample of workers withanatomical impairment due to occupational accident who received medical care atthe Cipto Mangunkusumo hospital, during the period of 1vii st January 2013 - 31December 2014. Accident classification, medical procedure, healhtcare coverage,other accompanying health conditions were obtained from the medical records. Sosiodemography, working sector, working period, return to work time wereobtained through a questionnaire. Correlation analysis was performed to observethe relationship between age, working period with the return to work time.Bivariate analysis was also performed by using unpaired t-test and ANOVA.Multivariate analysis using multiple regression was then performed in risk factorsknown to have (p < 0,25).Results : Sixty-one subjects were obtained consisted of male (95.1%), with basicand intermediate educational level (85.2%), did not possesed healthcare coverage(57,4%), had upper extremities anatomical impairment (85.2%), received woundcontrol care (88.5%), underwent closed amputation procedure (91.8%), and didnot have other accompanying health conditions (88.5%). Thirty-three (54.1%)subjects were categorized in a formal working group. Formal workers had asignificantly shorter mean return to work time compared to informal workers withmean differences of 9 days (p< 0,01). Closed amputation procedure reduced 11days of return to work time (p< 0,01). Conclusion: Working sector was the main determinant for the return to worktime. The formal workers had a significantly shorter return to work timecompared to the informal workers, which might be associated with bettersocioeconomical status and access of healthcare. In addition, closed amputation procedure significantly reduced the return to work time.]"

"This volume presents information on stem cells and cancer stem cells, therapeutic applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are, human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier’s disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained; these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated."

"Kedokteran Okupasi memiliki peran penting dalam aspek psikososial untuk meningkatkan produktivitas pekerja menghadapi bonus demografi tahun 2045yang sudah dimulai sejak tahun 2020. Dokter bidang kedokteran okupasi memberikan evaluasi kesehatan mental dan fisik kepada pekerja dengan melakukan identifikasi bahaya potensial di lingkungan kerja (terutama bahaya potensial aspek psikososial), pemeriksaaan kesehatan pekerja; menentukan Diagnosis Penyakit Akibat Kerja atau bukan, menentukan laik kerja atau Kembali kerja, serta memberikan rekomendasi/solusi yang dibutuhkan untuk mengatasi stress kerja, kelelahan akibat kerja, dan masalah kesehatan kerja lainnya. Dengan pendekatan yang holistik, Kedokteran Okupasi dapat membantu pekerja mempertahankan kesehatan mental dan fisiknya, sehingga meningkatkan produktivitas dan kontribusi mereka dalam lingkungan kerja. Selain itu, Dokter bidang Kedokteran Okupasi Bersama dengan tenaga kesehatan lainnya juga dapat memberikan pelatihan dan workshop mengenai manajemen stres, keseimbangan kehidupan kerja, dan strategi untuk meningkatkan kesejahteraan pekerja dalam menghadapi perubahan lingkungan kerja dan tuntutan kerja di masa datang."

"Latar Belakang: Diabetes Melitus tipe 2 diketahui sebagai ancaman serius bagi kesehatan masyarakat karena dampaknya yang sangat luas bagi kehidupan masyarakat dan perekonomian. Data dari International Diabetes Federation (IDF) menunjukkan prevalensi diabetes di Indonesia tahun 2021 mencapai 19,5 juta. Sejumlah review menunjukkan bekerja dengan waktu kerja yang panjang (long working hours) memiliki efek yang buruk bagi kesehatan, khususnya gangguan metabolik.Tujuan: Mendapatkan bukti apakah waktu kerja yang panjang merupakan faktor risiko yang meningkatkan kejadian diabetes melitus pada pekerja non sedentary.Metode: Penelusuran literatur dilakukan melalui PubMed, Scopus, dan Proquest. Seleksi pertama dilakukan dengan menelusuri artikel sesuai kata kunci. Dari Pubmed didapatkan 61 artikel, dari Proquest 242 artikel, dan melalui Scopus didapatkan 437 artikel. Berikutnya dilakukan skrining berdasarkan judul dan abstrak, kriteria inklusi dan eksklusi, kemudian dilakukan dengan melihat teks penuh dan didapatkan 3 artikel yang relevan dan paling sesuai mendekati PICO dan menjawab pertanyaan klinis.Hasil: Setelah dilakukan penelusuran dari tiga artikel, yang paling relevan dan cukup valid diperoleh hanya satu artikel. Berdasarkan penelitian Bannai, et al dengan studi cohort di Jepang didapatkan HR 2.28; 95% CI, 1.13–4.82 untuk pekerja non-clerical dan shift dengan number needed to harm (NNH) 12. Namun, penelitian ini tidak menunjukkan hubungan sebab akibat yang jelas. Penelitian lainnya dari Kuwahara, et al, untuk jenis kategori pekerjaan field work didapatkan nilai nilai OR 1.02 (95% CI 0.55-1.92), sedangkan penelitian Baek, et al menunjukkan pekerja blue collar memiliki kemungkinan terjadi prediabetes lebih tinggi jika waktu kerja lebih banyak dengan aOR=1.54 (95% CI 1.15 to 2.06). Dua penelitian ini tidak cukup valid dijadikan dasar karena merupakan studi cross sectional.Kesimpulan: Pada pekerja non-sedentary, belum didapatkan cukup bukti yang mendukung hubungan waktu kerja panjang dengan meningkatnya risiko diabetes melitus tipe 2.

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Background: Type 2 Diabetes Mellitus is known as a serious threat to public health because of its very broad impact on people's lives and the economy. Data from the International Diabetes Federation (IDF) shows the prevalence of diabetes in Indonesia in 2021 has reached 19.5 million. A number of reviews show that working long hours (long working hours) has a negative effect on health, especially metabolic disorders.

Objective: Determine whether long working hour is a risk factor that increases the incidence of diabetes mellitus in non-sedentary workers.

Method: Literature search was conducted through PubMed, Scopus, and Proquest. The first selection is made by searching for articles according to keywords. From Pubmed, 61 articles were obtained, from Proquest 242 articles, and through Scopus, 437 articles were obtained. Next, screening was carried out based on title and abstract, inclusion, and exclusion criteria, then carried out by looking at the full text and obtained 3 articles that were relevant and most suitable to approach PICO and answer clinical questions.

Result: After searching the three articles, the most relevant and valid enough was obtained only one article. Based on research by Bannai, et al with cohort study in Japan, HR was found to be 2.28; 95% CI, 1.13–4.82 for non-clerical and shift workers with number needed to harm (NNH) 12. However, this study did not show a clear causal relationship. Another study from Kuwahara, et al, for the type of field work category obtained an OR value of 1.02 (95% CI 0.55-1.92 ), while the study by Baek, et al showed that blue collar workers had a higher likelihood of developing prediabetes if they worked longer hours with an aOR = 1.54 (95% CI 1.15 to 2.06). These two studies were not sufficiently valid because they were cross-sectional studies.

Conclusion: In non-sedentary workers, there is not enough evidence to support the relationship between long working hours and an increased risk of type 2 diabetes mellitus."

"This book discusses the latest findings on ensuring employees safety, health, and welfare at work. It combines a range of disciplines - e.g. work physiology, health informatics, safety engineering, workplace design, injury prevention, and occupational psychology - and presents new strategies for safety management, including accident prevention methods such as performance testing and participatory ergonomics. The book, which is based on the AHFE 2018 International Conference on Safety Management and Human Factors, held on July 21-25, 2018, in Orlando, Florida, USA, provides readers, including decision makers, professional ergonomists and program managers in government and public authorities, with a timely snapshot of the state of the art in the field of safety, health, and welfare management. It also addresses agencies such as the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH), as well as other professionals dealing with occupational safety and health."

"Buku yang berjudul "Encyclopaedia of occupational health and safety" ini membahas tentang kesehatan dan keselamatan dalam bekerja. Buku ini terdiri dari 4 volume."