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"Nanomedicine is defined as the application of nanobiotechnology in clinical medicine, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development, and delivery of drugs. "

"This book about functional polymer conjugates for medicinal nucleic acid delivery, biodegradable nanoparticles as vaccine adjuvants and delivery systems : regulation of immune responses by nanoparticle-based vaccine, biodegradable polymeric assemblies for biomedical materials, PEGylation technology in nanomedicine, cytocompatible hydrogel composed of phospholipid polymers for regulation of cell functions, design of biointerfaces for regenerative medicine, advances in tissue engineering approaches to treatment of intervertebral disc degeneration : cells and polymeric scaffolds for nucleus pulposus regeneration, and functionalized biocompatible nanoparticles for site-specific imaging and therapeutics."

"These two related volumes in the Modern Aspects of Electrochemistry Series review recent developments and breakthroughs in the specific application of electrochemistry and nanotechnology to biology and medicine. Internationally renowned experts contribute chapters that address both fundamental and practical aspects of several key emerging technologies in biomedicine, such as the processing of new biomaterials, biofunctionalization of surfaces, characterization of biomaterials, discovery of novel phenomena and biological processes occurring at the molecular level."

"This book presents the laboratory, scientific and clinical aspects of nanomaterials used for medical applications in the fields of regenerative medicine, dentistry and pharmacy. It gives a broad overview on the in vitro compatibility assessment of nanostructured materials implemented in the medical field by the combination of classical biological protocols and advanced non-destructive nano-precision techniques with special emphasis on the topographical, surface energy, optical and electrical properties. Materials in the physical form of nanoparticles, nanotubes, and thin films are addressed in terms of their toxicity. The different pillars of the Nanomedicine field are also highlighted. The book takes an interdisciplinary approach of medicine, biology, pharmacy, physics, chemistry, engineering, nanotechnology and materials science. "

"This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism."

"This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy."

"Nanotechnology and nanomaterials in the treatment of life-threatening diseases takes a scientific approach to nanotechnology and nanomaterials applications in medicine, while also explaining the core biological principles for an audience of biomedical engineers, materials scientists, pharmacologists, and medical diagnostic technicians. The book is structured by major disease groups, offering a practical, application-based focus for scientists, engineers, and clinicians alike. The spectrum of medical applications is explored, from diagnostics and imaging to drug delivery, monitoring, therapies, and disease prevention. It also focuses specifically on the synthesis of nanomaterials and their potential health risks (particularly toxicity).Nanomedicine. The application of nanomaterials and devices for addressing medical problems, has demonstrated great potential for enabling improved diagnosis, treatment, and monitoring of many serious illnesses, including cancer, cardiovascular and neurological disorders, HIV/AIDS, and diabetes, as well as many types of inflammatory and infectious diseases."

"ABSTRAKAgen theranostic merupakan agen yang berfungsi menggabungkan kemampuan diagnostik dan terapeutik menjadi agen tunggal. Emas radioaktif 198Au sebagai pemancar radiasi ? 961 keV yang mampu membunuh sel kanker dan sinar ? 412 keV yang memberikan citra emas dalam tubuh. Adanya konjugasi agen terapi kanker seperti antibodimonoklonal nimotuzumab dengan nano partikel emas radioaktif yang distabilisasi dengan dendrimer PAMAM G4 dapat secara aktif berinteraksi spesifik dengan sel kanker. Penelitian ini dimulai dengan sintesis konjugat198AuNp-PAMAM G4-nimotuzumab dan kemudian dilakukan uji stabilitas, klirens serta analisa hasil urin dan fesestikus yang telah diinjeksikan konjugat. Stabilitas konjugat198AuNp-PAMAM G4-nimotuzumab dianalisis meliputi pengamatan stabilitas in vitro dengan analisis meliputi pengamatan menggunakan spektrofotometer UV-Vis, kromatografi lapis tipis KLT , elektroforesis kertas, serta kromatografi filtrasi gel kolom PD-10 sphadex G25 medium memberikan hasil spesifik yang stabil . Total klirens yang diperoleh sekitar 47,38 darikonjugat198AuNP-PAMAM G4-Nimotuzumab yang telah diekskresikan melalui urin 18,26 dan feces 29,11 . . Urin dan feses tersebut dianalisa dengan SDS-PAGE memberikan yang memberikan spot diatas pita 150 Kd dan menunjukkan berat molekul konjugat. Analisis FTIR urin dan feses dengan menunjukkan gugus fungsi aldehid C=O , gugus alkohol O-H , gugus amina C-N , serta gugus amina N-H yang menandakan adanya konjugat AuNP-PAMAM G4-Nimotuzumab dalam urin maupun feses tikus.

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ABSTRACTTherapeutic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. Radioactive gold 198Au radiate a radiation transmitter 961 keV that is capable of killing cancer cells and rays 412 keV that provide a golden image in the body. Conjugation cancer therapeutic agents such as monoclonal antibodies nimotuzumab with radioactive gold nanoparticles that is stabilized with G4 PAMAM dendrimer can actively interact specifically with cancer cells. This study begins with the synthesis of the conjugate 198AuNp PAMAM G4 nimotuzumab and then the test of stability, clearance and analysis of the urine and feces of mice that have been injected conjugates. Analysing of Stability conjugate 198AuNp PAMAM G4 nimotuzumab include observation of stability in vitro analysis covering the observation using UV Vis spectrophotometer, thin layer chromatography TLC , electrophoresis paper and gel filtration chromatography column PD 10 sphadex G25 medium that give a specific result which is stable. Total clearance is obtained approximately 47.38 of the conjugate 198AuNP PAMAM G4 nimotuzumab that have been excreted in the urine 18.26 and feces 29.11 . . Urine and feces were analyzed by SDS PAGE that give spot on the ribbon 150 Kd and show the molecular weight of the conjugate. FTIR analysis of urine and demonstrate the functional groups of aldehyde C O , alcohol group O H , amine group C N , and amine group N H which indicates a conjugate Aunp PAMAM G4 nimotuzumab in the urine and feces of rats."

"Nanomaterial technologies can be used to fabricate high-performance biomaterials with tailored physical, chemical, and biological properties. They are therefore an area of interest for emerging biomedical technologies such as scaffolding, tissue regeneration, and controlled drug delivery. Nanomaterials in tissue engineering explores the fabrication of a variety of nanomaterials and the use of these materials across a range of tissue engineering applications.Part one focuses on the fabrication of nanomaterials for tissue engineering applications and includes chapters on engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials. Part two goes on to highlight the application of nanomaterials in soft tissue engineering and includes chapters on cardiac, neural, and cartilage tissue engineering. Finally, the use of nanomaterials in hard tissue engineering applications, including bone, dental and craniofacial tissue engineering is discussed in part three."