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Hafizar
Karakteristik dan kesintasan pasien larsinoma sel ginjal dengan terapi nefrektomi di Jakarta, Indonesia: sebuah studi multicenter = Characteristics and survival of patients with renal cell carcinoma undergoing nephrectomy in Jakarta, Indonesia: a multicenter study
"Pendahuluan dan tujuan: Renal cell carcinoma (RCC) adalah tumor paling umum kedua pada sistem urologi. Sampai saat ini, satu-satunya pendekatan kuratif bagi mereka yang memiliki RCC lokal adalah operasi radikal; namun, kejadian rekurensi setelah nefrektomi memadai telah dilaporkan terjadi sebanyak 20 hingga 40% dari pasien dengan RCC lokal. Penelitian ini bertujuan untuk menyelidiki karakteristik dan kesintasan hidup pasien dengan RCC yang menjalani nefrektomi.
Metode: Kami menggunakan desain studi retrospektif dengan mengevaluasi rekam medis pasien yang didiagnosis dengan RCC yang menjalani tindakan bedah di Rumah Sakit Cipto Mangunkusumo, Rumah Sakit Kanker Dharmais, Rumah Sakit Medistra, dan Rumah Sakit Metropolitan Medical Centre, Jakarta, Indonesia selama periode Januari 1994 hingga Desember 2016.
Hasil: Usia rata-rata pasien saat operasi dilakukan adalah 52,92 ± 14,85, dan 114 (71,7%) subyeknya adalah laki-laki. Lima puluh dua (32,7%) subyek dengan pT2 RCC, dan tiga puluh lima (22%) subyek dengan patologis stadium 2. Seratus empat puluh tujuh (92,4%) subyek memiliki clear cell RCC. Kesintasan hidup rata-rata adalah 8,37 (0,1-143) bulan.
Kesimpulan: Angka median kesintasan pasien karsinoma sel ginjal (RRC) yang menjalani nefrektomi adalah 8,37 bulan, yang menunjukkan bahwa perawatan lebih lanjut diperlukan untuk meningkatkan tingkat kelangsungan hidup populasi ini. Namun, penelitian ini dibatasi oleh sifat studi retrospektif dan jumlah subjek yang terbatas. Studi acak, terkontrol, multicenter, yang lebih besar diperlukan untuk mengevaluasi angka kesintasan pasien RCC.
Introduction and objectives: Renal cell carcinoma (RCC) is the second most common urologic tumour. To this date, the only curative approach for those with localised RCC is radical surgery; yet, the development of disease recurrence after adequately performed nephrectomy has been reported in 20 to 40% of those with localised RCC. The present study aims to investigate the characteristics and survival of those with RCC undergoing nephrectomy.
Methods: We used retrospective study design by evaluating the medical records of patients diagnosed with RCC who were treated surgically at Cipto Mangunkusumo Hospital, Dharmais Cancer Hospital, Medistra Hospital, and Metropolitan Medical Centre Hospitals, Jakarta, Indonesia during the period from January 1994 to December 2016.
Results: The mean age at surgery of the subjects was 52.92 ± 14.85, and 114 (71.7%) subjects were male. Fifty-two (32.7%) subjects had pT2 RCC, and thirty-five (22%) of the subjects had pathologic stage of 2. One hundred and forty-seven (92.4%) subjects had clear cell RCC. The median survival was 8.37 (0.1-143) months.
Conclusion: The median survival of those with renal cell carcinomas (RCCs) who underwent nephrectomy was 8.37 months, which demonstrate that further treatment is required to increase the survival rate of these population. However, this study was limited by its retrospective nature and limited subjects. Larger multicenter controlled randomised studies are required to evaluate the survival of those with RCC."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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UI - Tugas Akhir  Universitas Indonesia Library
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Tri Yuliani
Efek kuersetin terhadap jantung tikus pasca nefrektomi 5/6 tinjauan pada fibrosis dan stres oksidatif = The effect of quercetin on heart tissue in rat with 5/6 nephrectomy overview on fibrosis and oxidative stress
"Latar Belakang: Kardiomiopati uremikum adalah kelainan jantung yang didasari oleh kelainan pada ginjal dan merupakan penyebab kematian tertinggi pada pasien penyakit ginjal kronik (PGK). Overload cairan dan stres oksidatif berperan dalam patogenesis penyakit ini. Kuersetin adalah antioksidan yang bersifat kardioprotektif, namun belum ada data tentang efeknya pada kardiomiopati uremikum. Penelitian ini bertujuan untuk mengetahui efek kuersetin pada kardiomiopati uremikum menggunakan model nefrektomi 5/6 pada tikus.
Metode: Uremia diinduksi pada 3 kelompok tikus jantan Sprague-Dawley dengan nefrektomi 5/6, satu kelompok kontrol tanpa nefrektomi 5/6, masing-masing 6 ekor/kelompok dan diamati selama 8 minggu. Kelompok SNX tidak diberi pengobatan. Kelompok SNX+Q mendapat quersetin per oral dengan dosis 100 mg/kgBB/hari dan kelompok SNX+Cap mendapat kaptopril 10 mg/kgBB/hari. Hewan uji dikorbankan untuk diukur kadar malondialdehid (MDA) plasma dan jantung, aktivitas glutation peroksidase (GPX) jantung, NT-proBNP plasma, dan fibrosis jantung. Data dianalisis dengan uji ANOVA.
Hasil: Nefrektomi 5/6 menimbulkan sedikit fibrosis jantung, tidak mempengaruhi NT-proBNP, tidak mempengaruhi MDA jantung dan plasma dan meningkatkan secara bermakna aktivitas GPX jantung (p<0.05) sedangkan pemberian kuersetin dan kaptopril tidak mempengaruhi fibrosis jantung, tidak mempengaruhi NT-proBNP (p>0.05), tidak mempengaruhi MDA jantung dan plasma (p>0.05) dan tidak mempengaruhi aktivitas GPX jantung pada tikus uremia yang diinduksi dengan nefrektomi 5/6 (p>0.05).
Kesimpulan: Kuersetin tidak mempengaruhi fibrosis jantung dan fungsi jantung tikus uremia pasca nefrektomi 5/6. Peningkatan secara bermakna aktivitas GPX jantung pada semua kelompok pasca nefrektomi 5/6 (p<0.05) dibandingkan kelompok kontrol normal menunjukkan bahwa jantung tikus uremia masih berada pada fase kompensasi, yaitu mekanisme adaptasi jantung dan fungsi jantung belum terganggu meskipun terjadi sedikit fibrosis jantung.
Background: Uremic cardiomyopathy is a heart disease because of abnormalities in the kidneys that is the leading cause of death in patients with chronic kidney disease (CKD). Fluid overload and oxidative stress play an important role in its pathogenesis. Quercetin, as an antioxidant, has cardioprotective effect. To the best of our knowledge, its effect on uremic cardiomyopathy has not been investigated yet. This study aims to determine the effect of quercetin on uremic cardiomyopathy using 5/6 nephrectomy model in rats.
Methods: Uraemia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy (SNX). Quercetin was administered per orally at a dose of 100 mg/kgBW/day for 8 weeks prior to sacrifice. Meanwhile captopril was administered per orally at a dose of 10 mg/kgBW/day. Oxidative stress was assessed using tiobarbituric acid reactive substances reaction then glutathione peroxidase (GPX) activity was determined to study on antioxidant mechanism. Myocardial fibrosis was analyzed using Massons? Trichrome staining and NTproBNP was measured as a marker of cardiac function. Data was analyzed using ANOVA.
Results: Nephrectomy 5/6 had no effects on plasma NT - proBNP, cardiac and plasma MDA, but induced mild myocardial fibrosis and increased cardiac GPX activity significantly (p<0.05). However, administration of quercetin and captopril had no effects on plasma NT - proBNP, cardiac and plasma MDA, myocardial fibrosis and GPX activity in uremic rats? heart induced by 5/6 nephrectomy.
Conclusion: Uremic rats? heart induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preserved in vivo cardiac function. Increased GPX activity in uremic rats? heart compared to normal control (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet highlighting a compensatory phase which was unchanged following chronic either quercetin or captopril administration."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tesis Membership  Universitas Indonesia Library
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Hasan Basri, 1967-
Perbaikan pola sirkadian tekanan darah donor ginjal dengan ambulatory blood pressure monitoring pada 12 minggu pasca nefrektomi = Normalization of blood pressure circadian rhythm in kidney donors within 12 weeks post nephrectomy
"[ABSTRAK
Latar Belakang : Isu yang berkembang pada donor ginjal hidup adalah penurunan fungsi ginjal dan terjadinya hipertensi setelah dilakukan nefrektomi. Satu minggu setelah nefrektomi pola tekanan darah sirkadian berubah menjadi non dipper. Selanjutnya terjadi kompensasi sehingga fungsi ginjal akan stabil dalam 12 minggu. Namun belum diketahui apakah perbaikan fungsi ginjal akan diikuti oleh pola tekanan darah sirkadian kembali menjadi dipper.
Tujuan : Untuk mengetahui perubahan pola sirkadian tekanan darah donor ginjal hidup setelah 12 minggu nefrektomi unilateral.
Metode Penelitian : Studi Pre-experimental dengan before and after design. Subyek sebanyak 18 orang donor ginjal hidup sehat yang berusia 18-50 tahun . Peneltian dilakukan di RSCM pada bulan Januari 2015 sampai dengan Mei 2015. Tekanan darah diukur dengan 24 jam ABPM . Pemeriksaan kreatinin darah, eLFG epi dan uACR dilakukan sebelum nefrektomi, pada 1 minggu dan 12 minggu setelah nefrektomi.
Hasil :Terdapat 18 subyek yang memiliki pola dipper sebelum dilakukan nefrektomi unilateral. Tujuh belas subyek mengalami pola non dipper setelah 1 minggu nefrektomi. Pada 12 minggu setelah nefrektomi 16 diantaranya kembali menjadi pola dipper yang bermakna secara statistik (p<0.001).
Simpulan : Terdapat perubahan pola sirkadian tekanan darah non dipper kembali menjadi pola dipper pada donor ginjal hidup 12 minggu setelah nefrektomi unilateral.ABSTRACT Background : The issue of post nephrectomy in living kidney donor is kidney function decrease and hypertension. One week after nephrectomy circadian pattern of blood pressure becomes non dipper. Then there will be a compensatory of renal function that becomes stable within 12 weeks after nephrectomy. However, whether the improvement of renal function is followed by the circadian pattern of blood pressure becomes dipper is still unknown.
Aims : To know the changes circadian pattern of blood pressure among living kidney donors 12 weeks after unilateral nephrectomy.
Methods : A pre-experimental study with before and after design. The subjects were 18 healthy living kidney donors aged 18 to 50 years old , conducted in RSCM hospital between January 2015 to May 2015. Blood pressure was measured by 24 hours ABPM. Serum creatinine, e-GFR epi and uACR were taken before nephrectomy, 1 week and 12 weeks after nephrectomy.
Results : There were 18 subjects had dipper pattern before unilateral nephrectomy. Seventeen of them exhibited a pattern became non dipper on one week after nephrectomy. Sixteen subjects showed the pattern returned to dipper after 12 weeks nephrectomy that statistically significant (p<0.01)
Conclusions : The circadian pattern of blood pressure returned to dipper from non dipper on living kidney donors after 12 weeks unilateral nephrectomy., Background : The issue of post nephrectomy in living kidney donor is kidney function decrease and hypertension. One week after nephrectomy circadian pattern of blood pressure becomes non dipper. Then there will be a compensatory of renal function that becomes stable within 12 weeks after nephrectomy. However, whether the improvement of renal function is followed by the circadian pattern of blood pressure becomes dipper is still unknown.
Aims : To know the changes circadian pattern of blood pressure among living kidney donors 12 weeks after unilateral nephrectomy.
Methods : A pre-experimental study with before and after design. The subjects were 18 healthy living kidney donors aged 18 to 50 years old , conducted in RSCM hospital between January 2015 to May 2015. Blood pressure was measured by 24 hours ABPM. Serum creatinine, e-GFR epi and uACR were taken before nephrectomy, 1 week and 12 weeks after nephrectomy.
Results : There were 18 subjects had dipper pattern before unilateral nephrectomy. Seventeen of them exhibited a pattern became non dipper on one week after nephrectomy. Sixteen subjects showed the pattern returned to dipper after 12 weeks nephrectomy that statistically significant (p<0.01)
Conclusions : The circadian pattern of blood pressure returned to dipper from non dipper on living kidney donors after 12 weeks unilateral nephrectomy.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Rinto Hariwibowo
Skor Nefrometri R.E.N.A.L. pada Pasien Kanker Ginjal di Rumah Sakit Cipto Mangunkusumo = R.E.N.A.L. Nephrometry Scores of Kidney Cancer Patients in Cipto Mangunkusumo Hospital
"Variasi ukuran, bentuk, dan lokasi dapat mempersulit dalam penentuan tindakan pembedahan kanker ginjal. Skor R.E.N.A.L. telah lama digunakan untuk menentukan teknik mana yang digunakan. Penelitian ini dilakukan untuk mengevaluasi profil skor R.E.N.A.L. pasien dengan tumor ginjal. Data dikumpulkan dari pasien yang menjalani prosedur Nefrektomi Radikal (RN) dan Nefrektomi Parsial (PN) secara terbuka atau laparoskopi dari tahun 2014-2017. Skor R.E.N.A.L. dihitung berdasarkan (R)adius of renal, (E)xophytic/ Endophytic properties, (N)earness to the collecting system, (A)nterior or Posterior position of the tumor, dan (L)ocation of the tumor. Diklasifikasikan menjadi tiga kompleksitas: rendah (4-6 poin), sedang (7-9 poin), dan tinggi (10-12 poin). Subjek kemudian dibagi berdasarkan jenis prosedur yang dilakukan. Gambaran skor R.E.N.A.L. di perlihatkan berdasarkan tiap prosedur.
Pada penelitian ini, 63 pasien di inklusi: 52 pasien menjalani RN dan 11 menjalani PN. Pada tumor dengan kompleksitas rendah, semua pasien dilakukan PN. Pada kompleksitas sedang, 22 (78,5%) pasien dilakukan RN dan 6 (21.5%) pasien dilakukan PN. Semua tumor dengan kompleksitas tinggi dilakukan RN. Rerata skor R.E.N.A.L. adalah 9.03 (+1.72) untuk semua pasien, 9.59 (+1.11) untuk kelompok RN, dan 6.36 (+1.6) untuk kelompok PN. Semakin tinggi skor (R), (N), dan (L), semakin tinggi juga kemungkinan untuk dilakukan RN. Tumor dengan kompleksitas tinggi lebih besar peluang untuk dilakukan RN. Selanjutnya, skor (R), (N), dan (L) dapat digunakan untuk menentukan RN atau PN sebagai pilihan terapi. Penelitian ini dapat dijadikan dasar dalam penelitian lain mengenai skor R.E.N.A.L. di Indonesia.
The variation of sizes, shapes, and location of kidney cancers complicate the choices of surgical treatment. To determine which technique to use, R.E.N.A.L. nephrometry scoring systems were established. This study was conducted to evaluate R.E.N.A.L.-NS profile in kidney cancer patients at CMH. Data were collected from patients that underwent both open and laparoscopic Radical (RN) and Partial Nephrectomy (PN) procedures from 2014-2017. R.E.N.A.L.-NS was calculated based on (R)adius of renal, (E)xophytic/ Endophytic properties, (N)earness to the collecting system, (A)nterior or Posterior position of the tumor, and (L)ocation of the tumor. It was categorized into three complexity: low (4-6 points), medium (7-9 points), and high (10-12 points). Subjects then grouped based on the procedure given. Profile of R.E.N.A.L.-NS was shown based on each procedure.
In this study, 63 patients were included: 52 underwent RN and 11 underwent PN. In low complexity tumors, all patients received PN. In medium complexity tumors, 22 (78.5%) patients received RN and 6 (21.5%) received PN. All high complexity tumors received RN. Mean renal score was 9.03 (+1.72) in all patients, 9.59 (+1.11) in RN group, and 6.36 (+1.6) in PN group. Higher (R), (N), and (L) scores mean higher prevalence of RN. Tumors with higher complexity were more likely to be treated with RN. Furthermore, (R), (N), and (L) score can be useful to determine treatment of choice in kidney cancers. This study could be used as a reference to another study regarding R.E.N.A.L.-NS in Indonesia."
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Tesis Membership  Universitas Indonesia Library
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Senohadi Boentoro
Transfusi Darah pada Laparoscopic Living Donor Nephrectomy: Pengalaman Satu Pusat dari 500 Kasus = Blood Transfusions in Laparoscopic Living Donor Nephrectomy: Single Center Experience from 500 Cases
"Pendahuluan dan tujuan: Pembedahan laparoskopi telah diakui dapat mengurangi tingkat morbiditas sehingga meningkatkan keselamatan pasien. Saat tindakan LLDN, komplikasi yang paling sering adalah cedera pembuluh darah ginjal, yang sering membutuhkan transfusi darah. Selain perlunya transfusi darah, pendarahan berat yang disebabkan oleh cedera pembuluh ginjal membutuhkan konversi dan perbaikan terbuka. Dengan demikian, penelitian ini ingin mendeskripsikan dan menganalisis kebutuhan transfusi darah dalam operasi laparoscopic living donor nephrectomy di pusat kami.
Bahan dan metode:  Studi kohort retrospektif ini dilakukan di Departemen Urologi di Rumah Sakit Nasional Cipto Mangunkusumo. Rekam medis semua pasien donor ginjal yang menjalani prosedur LLDN di institusi kami dari November 2011 hingga Oktober 2017 ditinjau. Data termasuk usia donor, kadar hemoglobin sebelum operasi, kadar hemoglobin pasca operasi, jumlah pendarahan intraoperatif, jumlah arteri renalis, jumlah vena renalis, sisi donor, konversi ke operasi terbuka, durasi operasi, dan BMI donor dikumpulkan dan dianalisis. Data-data ini selanjutnya dikorelasikan dengan tingkat transfusi.
Hasil: Terdapat 500 pasien yang menjalani tindakan laparoscopic living donor nephrectomy di institusi kami. Semua pasien menjalani prosedur LLDN dengan pendekatan transperitoneal. Perbedaan proporsi tingkat transfusi darah antara pasien pria 0,9% dibandingkan dengan 0,6% pada pasien wanita tidaklah signifikan (p=0,782). Tidak ada perbedaan yang signifikan dalam proporsi tingkat transfusi darah dengan sisi ginjal (p=0,494), jumlah arteri (p=0,362), usia (p=0,978), BMI (p=0,569), dan kadar hemoglobin sebelum operasi (p=0,766). Median perkiraan jumlah pendarahan pada pasien yang menerima transfusi darah intraoperatif secara signifikan lebih besar daripada pasien yang tidak menerima transfusi darah (p <0,001).
Kesimpulan: Berdasarkan penelitian ini, kami menyarankan bahwa di institusi kami, penggunaan produk darah pra operasi tidak selalu diperlukan. Kurva pembelajaran dan teknik ahli bedah memiliki peran penting dalam mencegah komplikasi intraoperatif dan kehilangan darah.
Introduction and objectives: Laparoscopic surgery has been acknowledged to reduce the morbidity rate thus improving patient safety. During the LLDN, the most frequent complication is renal vessels injuries, which often requires a blood transfusion. Besides the need for a blood transfusion, major bleeding caused by renal vessels injuries require open conversion and repair. Thus, this study would like to descript and analyze the need for blood transfusion in laparoscopic living donor nephrectomy surgery in our center.
Materials and methods: We performed a retrospective cohort study in the Department of Urology at Cipto Mangunkusumo National Hospital. The records of all kidney transplantation donor patients who underwent LLDN procedures carried out at our institution from November 2011 to October 2017 were reviewed. Data including donor age, preoperative hemoglobin level, postoperative hemoglobin level, intraoperative bleeding, number of artery(ies), number of vein(s), donor side, conversion to open surgery, surgery duration, and donor BMI were collected and analyzed. These data were further correlated with transfusion rate.
Results: There were 500 patients underwent laparoscopic living donor nephrectomy procedure at our institution. All of the patients had LLDN with a transperitoneal approach. The difference in blood transfusion rate proportion between male patients with 0.9% compared to 0.6% in female patients was not significant (p=0.782). There are no significant difference in blood transfusion rate proportion regarding to renal side (p=0.494), number of artery (p=0.362), age (p=0.978), BMI (p=0.569), and preoperative hemoglobin (p=0.766). Median estimated blood loss in patients who received intraoperative blood transfusion was significantly much greater than in patients who did not receive a blood transfusion (p<0.001).
Conclusion: Based on this study, we suggest that in our institution, preoperative blood products are not necessarily needed. The surgeon's learning curve and technique play a significant role in preventing intraoperative complications and blood loss."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Tesis Membership  Universitas Indonesia Library
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Farida Farah Adibah
Pengaruh pemberian angiotensin receptor blocker dan statin terhadap gambaran histopatologi jantung pada tikus model penyakit ginjal kronik dengan 5/6 nefrektomi = The effect of angiotensin receptor blocker and statins on cardiac histopathology in a rat model of chronic kidney disease with 5/6 nephrectomy
"Latar belakang: Prevalensi penyakit ginjal kronis (PGK) adalah sebesar 13,4% dari seluruh populasi global. Sindrom kardiorenal (SK) tipe 4 menyebabkan 40% mortalitas pada pasien PGK. Salah satu mediator dalam patogenesis SK adalah stres oksidatif yang dapat mengakibatkan disfungsi endotel, fibrosis miokardial dan penebalan dinding ventrikel. Terapi obat golongan penghambat reseptor angiotensin (ARB) dan statin mempunyai efek antiinfalamasi dan antioksidan terhadap jantung. Hal ini menjadi pertimbangan penggunaannya untuk memperbaiki kondisi stres oksidatif pada SK. Hingga saat ini belum banyak diketahui pengaruh pemberian ARB dan statin pada jantung dengan SK.
Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi ARB + statin terhadap fibrosis miokardial dan tebal dinding ventrikel jantung pada tikus PGK dengan metode 5/6 nefrektomi.
Metode: Penelitian ini menggunakan organ jantung tersimpan dari tikus jantan Sprague-Dawley yang terdiri atas 5 kelompok perlakuan dan masing-masing terdiri atas 4 sampel: kelompok kontrol (sham), 5/6 nefrektomi (Nx), 5/6 nefrektomi dengan terapi irbersatan 20mg/kgBB/hari selama 4 minggu (Nx + Ir), 5/6 nefrektomi dengan terapi simvastatin 10mg/kgBB/hari selama 4 minggu (Nx + S), dan 5/6 nefrektomi dengan terapi irbersatan 20mg/kgBB/hari dan simvastatin 10mg/kgBB/hari selama 4 minggu (Nx + Ir-S). Sampel organ jantung tersimpan dipotong secara cross-sectional dan diamati gambaran histopatologinya (HE dan Masson’s trichrome) menggunakan aplikasi ImageJ. Data kemudian dianalisis secara statistik menggunakan One-Way Anova.
Hasil: Pemberian terapi baik irbersatan, simvastatin, maupun kombinasi keduanya selama 4 minggu menunjukkan persentase luas area fibrosis miokardial dan tebal dinding ventrikel jantung yang cenderung lebih kecil dibanding kontrol namun tidak bermakna secara statistik. Terapi irbesartan, kombinasi irbesartan dan simvastatin, dan simvastatin menunjukkan persentase luas area fibrosis dan tebal dinding ventrikel jantung yang paling kecil secara berurutan.
Kesimpulan: Pemberian kombinasi ARB dan statin selama 4 minggu belum dapat memperbaiki fibrosis miokardial dan hipertropi dinding ventrikel jantung pada tikus model PGK. Diperlukan penelitian lebih lanjut dengan menggunakan dosis yang lebih besar, dengan perlakuan lebih lama serta jumlah sampel yang lebih banyak agar efek kombinasi lebih nyata terlihat
Background: The prevalence of chronic kidney disease (CKD) is 13.4% of the entire global population. Cardiorenal syndrome (SK) type 4 causes 40% mortality in CKD patients. One of the mediators in the pathogenesis of SK is oxidative stress which can lead to endothelial dysfunction, myocardial fibrosis and ventricular wall thickening. Angiotensin receptor blocker (ARB) and statin inhibitor class drugs have anti-inflammatory and antioxidant effects on the heart. This is a consideration for its use to improve oxidative stress conditions in SK. Until now, it has not been widely known the effect of ARB and statin administration on the heart with SC.
Objective: This study aims to determine the effect of ARB + statin combination on myocardial fibrosis and ventricular wall thickness in CKD rats using the 5/6 nephrectomy method.
Methods: This study used stored heart organs from male Sprague-Dawley rats consisting of 5 treatment groups and each consisting of 4 samples: control group (sham), 5/6 nephrectomy (Nx), 5/6 nephrectomy with radiation therapy. 20mg / kgBW / day for 4 weeks (Nx + Ir), 5/6 nephrectomy with simvastatin therapy 10mg / kgBW / day for 4 weeks (Nx + S), and 5/6 nephrectomy with 20mg / kgBW / day irresistible therapy and simvastatin 10mg / kgBB / day for 4 weeks (Nx + Ir-S). Stored cardiac samples were cut cross-sectional and observed histopathologically (HE and Masson's trichrome) using ImageJ application. Data were then analyzed statistically using One-Way Anova.
Results: The treatment of both irbers, simvastatin, and a combination of both for 4 weeks showed that the percentage of myocardial fibrosis area and the thickness of the heart ventricles tended to be smaller than the control but not statistically significant. Irbesartan therapy, a combination of irbesartan and simvastatin, and simvastatin showed the smallest percentage of fibrosis area and ventricular wall thickness, respectively.
Conclusion: The combination of ARB and statin for 4 weeks has not been able to improve myocardial fibrosis and ventricular wall hypertrophy in CKD mice. Further research is needed using a larger dose, with a longer treatment and a larger number of samples so that the combined effect is more visible"
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library