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Ditemukan 2 dokumen yang sesuai dengan query
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Hasan Basri, 1967-
Perbaikan pola sirkadian tekanan darah donor ginjal dengan ambulatory blood pressure monitoring pada 12 minggu pasca nefrektomi = Normalization of blood pressure circadian rhythm in kidney donors within 12 weeks post nephrectomy
"[ABSTRAK
Latar Belakang : Isu yang berkembang pada donor ginjal hidup adalah penurunan fungsi ginjal dan terjadinya hipertensi setelah dilakukan nefrektomi. Satu minggu setelah nefrektomi pola tekanan darah sirkadian berubah menjadi non dipper. Selanjutnya terjadi kompensasi sehingga fungsi ginjal akan stabil dalam 12 minggu. Namun belum diketahui apakah perbaikan fungsi ginjal akan diikuti oleh pola tekanan darah sirkadian kembali menjadi dipper.
Tujuan : Untuk mengetahui perubahan pola sirkadian tekanan darah donor ginjal hidup setelah 12 minggu nefrektomi unilateral.
Metode Penelitian : Studi Pre-experimental dengan before and after design. Subyek sebanyak 18 orang donor ginjal hidup sehat yang berusia 18-50 tahun . Peneltian dilakukan di RSCM pada bulan Januari 2015 sampai dengan Mei 2015. Tekanan darah diukur dengan 24 jam ABPM . Pemeriksaan kreatinin darah, eLFG epi dan uACR dilakukan sebelum nefrektomi, pada 1 minggu dan 12 minggu setelah nefrektomi.
Hasil :Terdapat 18 subyek yang memiliki pola dipper sebelum dilakukan nefrektomi unilateral. Tujuh belas subyek mengalami pola non dipper setelah 1 minggu nefrektomi. Pada 12 minggu setelah nefrektomi 16 diantaranya kembali menjadi pola dipper yang bermakna secara statistik (p<0.001).
Simpulan : Terdapat perubahan pola sirkadian tekanan darah non dipper kembali menjadi pola dipper pada donor ginjal hidup 12 minggu setelah nefrektomi unilateral.ABSTRACT Background : The issue of post nephrectomy in living kidney donor is kidney function decrease and hypertension. One week after nephrectomy circadian pattern of blood pressure becomes non dipper. Then there will be a compensatory of renal function that becomes stable within 12 weeks after nephrectomy. However, whether the improvement of renal function is followed by the circadian pattern of blood pressure becomes dipper is still unknown.
Aims : To know the changes circadian pattern of blood pressure among living kidney donors 12 weeks after unilateral nephrectomy.
Methods : A pre-experimental study with before and after design. The subjects were 18 healthy living kidney donors aged 18 to 50 years old , conducted in RSCM hospital between January 2015 to May 2015. Blood pressure was measured by 24 hours ABPM. Serum creatinine, e-GFR epi and uACR were taken before nephrectomy, 1 week and 12 weeks after nephrectomy.
Results : There were 18 subjects had dipper pattern before unilateral nephrectomy. Seventeen of them exhibited a pattern became non dipper on one week after nephrectomy. Sixteen subjects showed the pattern returned to dipper after 12 weeks nephrectomy that statistically significant (p<0.01)
Conclusions : The circadian pattern of blood pressure returned to dipper from non dipper on living kidney donors after 12 weeks unilateral nephrectomy., Background : The issue of post nephrectomy in living kidney donor is kidney function decrease and hypertension. One week after nephrectomy circadian pattern of blood pressure becomes non dipper. Then there will be a compensatory of renal function that becomes stable within 12 weeks after nephrectomy. However, whether the improvement of renal function is followed by the circadian pattern of blood pressure becomes dipper is still unknown.
Aims : To know the changes circadian pattern of blood pressure among living kidney donors 12 weeks after unilateral nephrectomy.
Methods : A pre-experimental study with before and after design. The subjects were 18 healthy living kidney donors aged 18 to 50 years old , conducted in RSCM hospital between January 2015 to May 2015. Blood pressure was measured by 24 hours ABPM. Serum creatinine, e-GFR epi and uACR were taken before nephrectomy, 1 week and 12 weeks after nephrectomy.
Results : There were 18 subjects had dipper pattern before unilateral nephrectomy. Seventeen of them exhibited a pattern became non dipper on one week after nephrectomy. Sixteen subjects showed the pattern returned to dipper after 12 weeks nephrectomy that statistically significant (p<0.01)
Conclusions : The circadian pattern of blood pressure returned to dipper from non dipper on living kidney donors after 12 weeks unilateral nephrectomy.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Farida Farah Adibah
Pengaruh pemberian angiotensin receptor blocker dan statin terhadap gambaran histopatologi jantung pada tikus model penyakit ginjal kronik dengan 5/6 nefrektomi = The effect of angiotensin receptor blocker and statins on cardiac histopathology in a rat model of chronic kidney disease with 5/6 nephrectomy
"Latar belakang: Prevalensi penyakit ginjal kronis (PGK) adalah sebesar 13,4% dari seluruh populasi global. Sindrom kardiorenal (SK) tipe 4 menyebabkan 40% mortalitas pada pasien PGK. Salah satu mediator dalam patogenesis SK adalah stres oksidatif yang dapat mengakibatkan disfungsi endotel, fibrosis miokardial dan penebalan dinding ventrikel. Terapi obat golongan penghambat reseptor angiotensin (ARB) dan statin mempunyai efek antiinfalamasi dan antioksidan terhadap jantung. Hal ini menjadi pertimbangan penggunaannya untuk memperbaiki kondisi stres oksidatif pada SK. Hingga saat ini belum banyak diketahui pengaruh pemberian ARB dan statin pada jantung dengan SK.
Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi ARB + statin terhadap fibrosis miokardial dan tebal dinding ventrikel jantung pada tikus PGK dengan metode 5/6 nefrektomi.
Metode: Penelitian ini menggunakan organ jantung tersimpan dari tikus jantan Sprague-Dawley yang terdiri atas 5 kelompok perlakuan dan masing-masing terdiri atas 4 sampel: kelompok kontrol (sham), 5/6 nefrektomi (Nx), 5/6 nefrektomi dengan terapi irbersatan 20mg/kgBB/hari selama 4 minggu (Nx + Ir), 5/6 nefrektomi dengan terapi simvastatin 10mg/kgBB/hari selama 4 minggu (Nx + S), dan 5/6 nefrektomi dengan terapi irbersatan 20mg/kgBB/hari dan simvastatin 10mg/kgBB/hari selama 4 minggu (Nx + Ir-S). Sampel organ jantung tersimpan dipotong secara cross-sectional dan diamati gambaran histopatologinya (HE dan Masson’s trichrome) menggunakan aplikasi ImageJ. Data kemudian dianalisis secara statistik menggunakan One-Way Anova.
Hasil: Pemberian terapi baik irbersatan, simvastatin, maupun kombinasi keduanya selama 4 minggu menunjukkan persentase luas area fibrosis miokardial dan tebal dinding ventrikel jantung yang cenderung lebih kecil dibanding kontrol namun tidak bermakna secara statistik. Terapi irbesartan, kombinasi irbesartan dan simvastatin, dan simvastatin menunjukkan persentase luas area fibrosis dan tebal dinding ventrikel jantung yang paling kecil secara berurutan.
Kesimpulan: Pemberian kombinasi ARB dan statin selama 4 minggu belum dapat memperbaiki fibrosis miokardial dan hipertropi dinding ventrikel jantung pada tikus model PGK. Diperlukan penelitian lebih lanjut dengan menggunakan dosis yang lebih besar, dengan perlakuan lebih lama serta jumlah sampel yang lebih banyak agar efek kombinasi lebih nyata terlihat
Background: The prevalence of chronic kidney disease (CKD) is 13.4% of the entire global population. Cardiorenal syndrome (SK) type 4 causes 40% mortality in CKD patients. One of the mediators in the pathogenesis of SK is oxidative stress which can lead to endothelial dysfunction, myocardial fibrosis and ventricular wall thickening. Angiotensin receptor blocker (ARB) and statin inhibitor class drugs have anti-inflammatory and antioxidant effects on the heart. This is a consideration for its use to improve oxidative stress conditions in SK. Until now, it has not been widely known the effect of ARB and statin administration on the heart with SC.
Objective: This study aims to determine the effect of ARB + statin combination on myocardial fibrosis and ventricular wall thickness in CKD rats using the 5/6 nephrectomy method.
Methods: This study used stored heart organs from male Sprague-Dawley rats consisting of 5 treatment groups and each consisting of 4 samples: control group (sham), 5/6 nephrectomy (Nx), 5/6 nephrectomy with radiation therapy. 20mg / kgBW / day for 4 weeks (Nx + Ir), 5/6 nephrectomy with simvastatin therapy 10mg / kgBW / day for 4 weeks (Nx + S), and 5/6 nephrectomy with 20mg / kgBW / day irresistible therapy and simvastatin 10mg / kgBB / day for 4 weeks (Nx + Ir-S). Stored cardiac samples were cut cross-sectional and observed histopathologically (HE and Masson's trichrome) using ImageJ application. Data were then analyzed statistically using One-Way Anova.
Results: The treatment of both irbers, simvastatin, and a combination of both for 4 weeks showed that the percentage of myocardial fibrosis area and the thickness of the heart ventricles tended to be smaller than the control but not statistically significant. Irbesartan therapy, a combination of irbesartan and simvastatin, and simvastatin showed the smallest percentage of fibrosis area and ventricular wall thickness, respectively.
Conclusion: The combination of ARB and statin for 4 weeks has not been able to improve myocardial fibrosis and ventricular wall hypertrophy in CKD mice. Further research is needed using a larger dose, with a longer treatment and a larger number of samples so that the combined effect is more visible"
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library