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"Persalinan prematur definisi adalah persalinan prematur adalah persalinan masa kehamilan kurang dari 37 minggu (WHO, 1993), penelitian Rooney B & Calhoun B.C, (2003) menjelaskan bahwa prematur terjadi masa kehamilan antara 20 minggu sampai kurang 37 minggu.Penelitian dilakukan untuk mengetahui risiko penyakit periodontal terhadap kejadian persalinan prematur berdasarkan pemeriksaan klinis, antara lain Level perlekatan klinis (Clinical Attachment Level/CAL), Periodontal poket dalam (Periodontal Pocket in Depth/PPD), Perdarahan probing (Bleeding on Probing/BOP) dan mengetahui ibu hamil menderita penyakit periodontal lebih berisiko terjadi persalinan prematur daripada tidak menderita penyakit periodontal.Penelitian observasional dengan disain kasus kontrol yang dilakukan di fasilitas kesehatan (hospital based). Penelitian dilaksanakan pada beberapa rumah sakit di Pontianak seperti RSUD dr Soedarso, RSIA Anugrah Bunda Khatulistiwa, RSIA Jeumpa dan RS Kharitas Bakti. Besar sampel minimal dalam penelitian dengan kasus 87 responden dan kontrol 98 responden, pengumpulan data dilakukan bulan agustus 2014 s/d mei 2015.Hasil penelitian diperoleh bahwa proporsi penyakit periodontal dengan persalinan prematur sebesar 71,40% dan pada persalinan aterm 49,00%. Sedangkan proporsi yang tidak menderita penyakit periodontal dengan persalinan prematur 28,60%, pada persalinan aterm 51,00%. Penyakit periodontal berhubungan bermakna dengan resiko 2,4 lebih besar dibandingkan tidak menderita penyakit periodontal. Sebagai konfonder berhubungan bermakna antara lain faktor resiko ANC dan Pekerjaan.Saran penelitian ini, ibu hamil dapat melakukan pemeriksaan penyakit periodontal pada tata laksana ANC baik pada pelayanan dasar maupun rujukan pada ibu hamil.

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Preterm labor is the definition of preterm labor is labor gestation less than 37 weeks (WHO, 1993), research Rooney B.C B & Calhoun (2003) explain that premature occur between 20 weeks gestation until less than 37 weeks.The study was conducted to determine the risk of periodontal disease on the incidence of preterm birth based on clinical examination, including Clinical Attachment Level (CAL), Periodontal Pocket in Depth (PPD), Bleeding on Probing (BOP) that pregnant women suffer from periodontal disease is a risk of premature delivery than not suffer from periodontal disease.Observational study with case control design conducted in health facilities (hospital based). The experiment was conducted at several hospitals in Singapore as dr Soedarso, RSIA Anugrah Mother Equator, RSIA JEUMPA and RS Kharitas Bakti. Minimum sample size in the study with the case of 87 respondents and 98 control respondents, data collection conducted in August 2014 s / d of May, 2015.The result showed that the proportion of periodontal disease and preterm labor at 71.40% and 49.00% of term deliveries. While the proportion who do not suffer from periodontal disease and preterm labor 28.60%, 51.00% in labor at term. Periodontal disease significantly associated with the risk greater than 2.4 do not suffer from periodontal disease. As confounder significant relationship between other risk factors ANC and Employment.Suggestion of this study, pregnant women can conduct examination of periodontal disease in ANC governance both at primary and referral services to pregnant women."

"Latar Belakang: Penyakit periodontal merupakan penyakit inflamasi yang memengaruhi jaringan penyangga gigi. Patogen memicu sistem imun bawaan ada jaringan periodontal untuk melepaskan mediator proinflamasi dan sitokin, salah satunya yaitu Prostaglandin E2 (PGE2). Periodontitis diketahui memiliki pengaruh dua arah dengan beberapa penyakit sistemik. salah satunya COVID-19 yang disebabkan oleh virus SARS-CoV-2 yang berkaitan dengan sindrom badai sitokin. Tujuan: Penelitian ini dilakukan untuk melihat korelasi respons imun individu penyintas COVID-19 dalam hal ini mediator inflamasi PGE2 dengan kondisi jaringan periodontal berdasarkan parameter klinis periodontal yaitu BOP, PD, dan CAL. Metode: Desain penelitian potong lintang pada 38 orang subjek dengan membagi dua kelompok subjek berdasarkan riwayat COVID-19. Dilakukan pemeriksaan parameter klinis periodontal BOP, PD, CAL dan pengambilan sampel GCF untuk mengukur kadar PGE2 menggunakan metode ELISA. Analisis data dilakukan dengan SPSS 25 dan GraphPad 10.0.0 Hasil: Terdapat perbedaan kadar PGE2 (p<0,05) antara penyintas dan bukan penyintas COVID-19. Tidak terdapat perbedaan parameter klinis periodontal (p>0,05) antara penyintas dan bukan penyintas COVID-19. Terdapat hubungan linear positif (p<0,05; r>0) antara kadar PGE2 dengan PD dan BOP. Kesimpulan: Kadar PGE2 pada subjek penyintas COVID-19 diindikasikan berkorelasi positif terhadap parameter klinis periodontal PD dan BOP.

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Background: Periodontal disease is an inflammatory condition that affects the supporting tissues of the teeth. In periodontitis, pathogens trigger the innate immune system to release proinflammatory mediators and cytokines in the periodontal tissues, one of which is Prostaglandin E2 (PGE2). Periodontitis is known to have a bidirectional relationship with several systemic diseases, one of them is COVID-19 which caused by the SARS-CoV-2 and associated with a cytokine storm syndrome. Objective: This research is conducted to examine the correlation between the immune response of individuals who have survived COVID-19, specifically the inflammatory mediator PGE2, and the condition of periodontal tissues based on clinical periodontal parameters, namely BOP, PD, and CAL. Methods: The design of this study was cross-sectional on 38 subjects by dividing two groups of subjects based on history of COVID-19. Periodontal clinical parameters BOP, PD, CAL were examined and GCF samples were taken to measure PGE2 levels using the ELISA method. Data analysis was carried out with SPSS 25 and GraphPad 10.0.0. Results: There is a significant difference in PGE2 levels (p<0.05) between former COVID-19 patients and non-COVID-19. No significant differences in clinical periodontal parameters (p>0.05) were found between two groups. A positive linear relationship (p<0.05; r>0) was observed between PGE2 levels and PD, as well as BOP. Conclusions: PGE2 levels in subjects who survived COVID-19 were indicated to be positively correlated with the periodontal clinical parameters of PD and BOP."