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Abstrak :
Karya ilmiah ini merupakan analisis pelaksanaan praktik residensi keperawatan anak selama dua semester. Kegiatan utama yang dilakukan antara lain memberikan asuhan keperawatan pada bayi prematur dan praktik keperawatan berbasis pembuktian. Asuhan keperawatan pada bayi prematur menggunakan teori comfort Kolcaba. Diagnosis keperawatan yang sering muncul pada bayi prematur adalah nyeri prosedural, gangguan termoregulasi, nutrisi kurang dari kebutuhan tubuh dan risiko infeksi. Intervensi dengan teknik mengukur kenyamanan, edukasi pada orangtua, dan melalui tindakan menenangkan jiwa. Praktik keperawatan berbasis pembuktian dilakukan melalui facilitated tucking disertai "hadir-berbicara" untuk menurunkan skor nyeri prosedural. Hasil menunjukkan bahwa intervensi berbasis teori comfort Kolcaba efektif untuk meningkatkan kenyamanan. Disarankan agar teori comfort Kolcaba dapat diterapkan dalam pemberian asuhan keperawatan pada bayi prematur.

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This scientific paper is an analysis of the implementation of pediatric nursing practice residency during two semesters. Main activities were providing nursing care to premature`s infant and doing evidence based nursing practice. Nursing care had been premature`s infant using a Kolcaba comfort`s theory. Nursing problem usually occured in premature`s infant were acute procedural pain, ineffective thermoregulation, imbalanced nutrition: less than body, risk for infection. Intervention done by technical comfort measures, parent`s coaching, and comfort food the soul. Evidence done by doing facilitated tucking and "talking to-being with" to decrease score of acute procedural pain. The result showed the evidence based on Kolcaba comfort`s theory effective to increase comfort. It is suggested that Kolcaba comfort`s theory can applied in the provision of nursing care to premature`s infant.

Abstrak :
ABSTRAK
Bayi prematur sangat sensitif terhadap stimulus nyeri. Tujuan dari studi kasus ini adalah menganalisis efektivitas penerapan asuhan keperawatan pada bayi dengan gangguan pemenuhan kebutuhan kenyamanan melalui intervensi stimulasi multisensori menggunakan model Comfort Kolcaba di ruang perinatologi. Lima kasus terpilih menunjukkan terjadinya gangguan kenyamanan dan nyeri akut pada bayi prematur akibat terpapar dengan prosedur invasif. Intervensi dilakukan dengan mengkaji skor nyeri, pemberian stimulasi multisensori, serta perlibatan orang tua dalam intervensi melalui sentuhan dan kontak kulit ke kulit. Intervensi keperawatan berdasarkan evidence based nursing melalui tindakan stimulasi multisensori dilakukan untuk menurunkan skor nyeri. Hasil menunjukkan bahwa intervensi berbasis teori Comfort Kolcaba efektif untuk meningkatkan kenyamanan. Disarankan agar teori Comfort Kolcaba dapat diterapkan dalam pemberian asuhan keperawatan pada bayi prematur.

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ABSTRACT
Premature infants are particularly sensitive to pain stimulus. The purpose of this case study is to analyze the effectiveness of nursing care in infants with impaired fulfillment of comfort through multisensory stimulation intervention in the perinatology room using Comfort Kolcaba model. Five cases selected show disruption of comfort and acute pain in preterm infants from exposure to invasive procedures. The intervention is done by assessing pain scores, multisensory stimulation, as well as the involvement of parents in the intervention through touch and skin-to-skin contact. Nursing interventions based on evidence based nursing through multisensory stimulation measures taken to decrease the pain score. The results show that the theory-based intervention Comfort Kolcaba effective to increase comfort. Application of Comfort Kolcaba theory can be applied in the provision of nursing care in premature infants. ;;

Abstrak :

Latar belakang: Penggunaan aminofilin intravena masih merupakan terapi pilihan untuk mengatasi apnea of prematurity (AOP) pada bayi prematur di Indonesia karena obat tersebut lebih mudah diperoleh dan harganya lebih murah walaupun mempunyai jendela terapi yang sempit. Pemeriksaan kadar teofilin serum perlu dilakukan untuk menilai efektifitas dan keamanan obat tersebut. Faktor-faktor yang memengaruhi efektifitas dan keamanan penggunaan aminofilin intravena pada bayi prematur dalam pengobatan apnea of prematurity di unit Neonatologi belum jelas. 

Tujuan: Mengetahui efektifitas dan keamanan penggunaan aminofilin sebagai terapi apnea of prematurity dan faktor-faktor yang memengaruhinya.

Metode: Penelitian ini merupakan penelitian analitik dengan desain cohort prospektif. Subjek penelitian adalah 40 bayi prematur dengan usia gestasi kurang atau sama dengan 30 minggu di Unit Neonatologi Rumah Sakit Cipto Mangunkusumo (RSCM) di Jakarta pada bulan April 2019 hingga Oktober 2019. Bayi tersebut mendapat terapi aminofilin intravena dosis rumatan sebanyak lima kali dan dilakukan pemeriksaan kadar teofilin serum dengan menggunakan metode reversed phase high performance liquid chromatography diode array detector (RP-HPLC-DAD). Selanjutkan dilakukan pemantauan efektifitas dan efek samping yang terjadi selama pemberian aminofilin intravena. Analisis data dengan uji Kai kuadrat dan regresi logistik, hasil signifikan bila nilai p < 0,05.

Hasil: Pemberian aminofilin intravena 67,5% efektif sebagai terapi AOP pada bayi usia gestasi kurang dari 30 minggu. Faktor-faktor yang memengaruhi efektifitas penggunaan aminofilin intravena sebagai terapi AOP adalah berat lahir dan kadar teofilin serum dengan nilai p = 0,006 dan 0,022. Efek samping yang ditemukan pada pemberian aminofilin intravena adalah takikardi (37,5%) dan peningkatan diuresis (27,5%) pada kadar teofilin serum lebih dari 12 mg/mL. Faktor yang memengaruhi keamanan penggunaan terapi aminofilin intravena pada bayi prematur adalah kadar teofilin serum dengan nilai p < 0,001. 

Simpulan: Pemberian aminofilin intravena sebagai terapi AOP pada bayi prematur dengan usia kurang dari 30 minggu efektif dan aman. Namun perlu dilakukan pemantauan kadar teofilin serum mengingat pemberian aminofilin intravena sering menimbulkan efek samping.

 

Keywords: apnea of prematurity, aminofilin, efektifitas dan keamanan

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Background: Intravenous aminophylline still plays the role as the therapy of choice for apnea of prematurity (AOP) in Indonesia because the drug is easier
to obtain and the price is cheaper despite having a narrow window of therapy. An examination of serum theophylline levels needs to be performed to assess the effectiveness and safety of the drug. Factors that influence the effectiveness and safety in the treatment of apnea of prematurity in the Neonatology Unit remain unclear.

Aim: To determine the effectiveness and safety of using aminophylline as apnea of prematurity therapy and their influencing factors.

Methods: This research is an analytical study with a prospective cohort design. Subjects were 40 premature infants with gestational age less than or equal to 30 weeks in the Neonatology Unit of Cipto Mangunkusumo Hospital (RSCM) in Jakarta from April 2019 to Oktober 2019. The infants received intravenous 
aminophylline maintenance dosages five times and the levels of serum theophylline were examined using the reversed phase high performance liquid chromatography diode array detector (RP-HPLC-DAD) method. The follow up was set to monitor the effectiveness and side effects that occur during intravenous aminophylline administration. Data were analyzed using the Chi-square test and logistic regression. The results were considered significant if the p-value < 0,05.

Results: The administration of intravenous aminophylline 67.5% was effective as AOP therapy in infants of less than 30 weeks gestation. Factors that 
influence the effective use of intravenous aminophylline as AOP therapy are birth weight and serum theophylline levels with p = 0,006 and 0,022. Side effects that occurred were tachycardia (37.5%) and increased diuresis (27.5%) in serum theophylline levels of more than 12 mcg/mL. Factors that influence the safety of the use of intravenous aminophylline therapy in preterm infants are serum theophylline levels with p < 0,001.

Conclusion: Administration of intravenous aminophylline as AOP therapy in premature infants less than 30 weeks of age is effective and safe. However, it is necessary to monitor serum theophylline levels due to its frequent side 
effects occurence.

 

Keywords: apnea of prematurity, aminophylline, effectiveness and safety