Ditemukan 2 dokumen yang sesuai dengan query
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The challenge remains to find the proper combination of these techniques in view of their respective potential, limitations, and costs, in order to pick up the right compounds quickly while keeping the risk of eliminating ‘good’ candidates as low as possible. Potential and limitations of a number of approaches to get early information on solubility and permeability, the main factors governing absorption via passive diffusion, will be discussed with practical examples.
It aims at offering longlasting ...
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Weinheim, Germany: Wiley-VCH, 2001
e20394491
eBooks Universitas Indonesia Library
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The profiling of ADME properties (absorption, distribution, metabolism, and excretion) is the topic of this book. In this unique work, international authorities and practicing experts from academia and industry offer state-of-the-art presentations of concepts, methods and technologies now in use or development in drug research. The biological strategies emphasized in the book include cell cultures, drug-metabolizing enzymes, transporters and plasma protein binding. The physicochemical strategies focus on artificial membrane-permeability assays, on solubility and lipophilicity and ...
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Weinheim, Germany: Wiley-VCH, 2006
e20395901
eBooks Universitas Indonesia Library
