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Abstrak :
Advances in stem cell research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research.

Abstrak :
This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine.

Abstrak :
ABSTRACT
Penelitian ini menganalisis kemampuan Human Serum Albumin (HSA), Umbilical cord blood (UCB) serum dan Fetal Bovine Serum (FBS) dalam menjaga stabilitas ekspansi ex vivo kultur sel punca hematopoetik (SPH). Sel yang digunakan adalah sel mononuklear dan sel CD34+ dari darah tali pusat yang disimpan beku dalam lingkungan nitrogen. Medium basal kultur yang digunakan adalah RPMI 1640 Biowest dan Stemspan. Jumlah sel hidup dihitung menggunakan metode eksklusi tryphan blue dan fenotipe sel CD34+ dianalisis menggunakan flow cytometry. Pewarnaan Giemsa dilakukan pada sel-sel yang dipanen pada hari ketujuh kultur untuk menganalisis morfologi sel. Besar sampel dalam penelitian ini adalah tiga dan jumlah pengulangan adalah dua kali. Penelitian ini menunjukkan bahwa kultur dengan suplementasi HSA menghasilkan jumlah sel yang lebih rendah namun memiliki persentase CD34+ yang lebih tinggi dibandingkan UCB serum dan FBS. Pewarnaan Giemsa menunjukkan sel-sel darah yang terdiferensiasi paling sedikit ditemukan pada HSA. Hasil tersebut menunjukkan bahwa, medium dengan suplementasi HSA lebih unggul dari UCB serum dan FBS dalam mempertahankan kepuncaan sel punca hematopoetik.

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ABSTRACT
This study analyzed the ability of serum Human Serum Albumin (HSA), Umbilical cord blood (UCB) and Fetal Bovine Serum (FBS) to maintain the stability of ex vivo expansion of hematopoietic stem cell (SPH) cultures. The cells used are mononuclear cells and CD34 + cells from cord blood which are frozen in a nitrogen environment. The basal culture medium used was RPMI 1640 Biowest and Stemspan. The number of living cells was calculated using the tryphan blue exclusion method and the CD34 + cell phenotype was analyzed using flow cytometry. Giemsa staining was carried out on cells harvested on the seventh day of culture to analyze cell morphology. The sample size in this study was three and the number of repetitions was twice. This study shows that culture with HSA supplementation results in lower cell counts but has a higher CD34 + percentage compared to serum UCB and FBS. Giemsa staining shows the least differentiated blood cells are found in HSA. These results indicate that, medium with HSA supplementation is superior to serum UCB and FBS in maintaining hematopoietic stem cell stem cells.

Abstrak :
The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine.

Abstrak :
Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed, embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

Abstrak :
[This volume will cover a series of reviews on stem cells including adult and embryonic stem cells. Speakers were invited to present these talks during the Stem Cell Symposia in fall of 2010, in Samsun, Turkey. Unique aspect of this volume is that it brings a multidisciplinary aspect of stem cells extracted from a symposium., This volume will cover a series of reviews on stem cells including adult and embryonic stem cells. Speakers were invited to present these talks during the Stem Cell Symposia in fall of 2010, in Samsun, Turkey. Unique aspect of this volume is that it brings a multidisciplinary aspect of stem cells extracted from a symposium.]

Abstrak :
This book reports on CXCR4 antagonists, an exciting new class of compounds that aid in use of stem cells for treatment of leukemia and other cancers. Includes coverage of plerixafor, now approved for stem cell mobilization of lymphoma and myeloma patients.